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PET and SPECT Imaging in ADHD

PET and SPECT in Psychiatry pp 709-730 | Cite as
Gilles N. Stormezand (1)
1. Department of Nuclear Medicine and Molecular Imaging, University Medical Center

Groningen, University of Groningen, , Groningen, The Netherlands
Chapter
First Online: 29 January 2014
1 Citations
1.5k Downloads
Abstract
ADHD is a clinically heterogeneous neuropsychiatric disorder with a childhood onset

and is often accompanied by comorbidities. Symptoms consisting of inattention with
or without hyperactivity or impulsivity may result from disturbances of higher
cognitive control, involving multiple regions of the brain which are functionally
connected. Although the value of PET and SPECT in establishing diagnosis is limited,
it has added to understanding the neurobiological basis of ADHD. Investigations of
cerebral perfusion and glucose metabolism during resting conditions and specific tasks
have led ADHD to be associated with reduced functionality of the prefrontal cortex
and the anterior cingulate cortex, as well as the basal ganglia, cerebellum and the
parietal lobe. In addition, there is a growing body of literature assessing the dopamine
transporter, endogenous levels of dopamine, response to treatment with
methylphenidate and the relationship with genotypes in ADHD.
Keywords
Attention Deficit Hyperactivity Disorder Prefrontal Cortex
Anterior Cingulate Cortex Attention Deficit Hyperactivity Disorder Patient
Attention Deficit Hyperactivity Disorder Subtype
These keywords were added by machine and not by the authors. This process is
experimental and the keywords may be updated as the learning algorithm improves.
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Stormezand G.N. (2014) PET and SPECT Imaging in ADHD. In: Dierckx R., Otte A., de Vries E., van Waarde
A., den Boer J. (eds) PET and SPECT in Psychiatry. Springer, Berlin, Heidelberg.
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PET and SPECT Imaging in ADHD

Gilles N. Stormezand (1)

1. Department of Nuclear Medicine and Molecular Imaging, University Medical Center

ADHD is a clinically heterogeneous neuropsychiatric disorder with a childhood onset

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attention deficit hyperactivity disorder: relating to treatment response to

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Spalletta G, Pasini A, Pau F, Guido G, Menghini L, Caltagirone C (2001) Prefrontal

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