ICO Information Centre on HPV and Cancer

Spain
Human Papillomavirus and Related Cancers, Fact Sheet 2016 (October 7, 2016)
I. Key data on HPV and HPV-related cancers
Spain has a population of 20.17 Figure 1. Comparison of the ten most frequent HPV
millions women ages 15 years and oncogenic types in Spain among women with and
older who are at risk of develop- without cervical lesions
ing cervical cancer. Current es- 16 2.1

Normal cytology(3, 4)
52 1.2
timates indicate that every year 51 1.0

HPV−type
66 0.8
2511 women are diagnosed with 31 0.8

cervical cancer and 848 die from 18

53
0.6
0.5
the disease. Cervical cancer ranks as the 10th most frequent 56 0.4
58 0.4
cancer among women in Spain and the 2nd most frequent 39 0.4

cancer among women between 15 and 44 years of age. About

16 18.5

Low−grade lesions(5, 6)
2.7% of women in the general population are estimated to har- 53 12.8

bour cervical HPV-16/18 infection at a given time, and 62.8% 66 11.6

HPV−type
52 9.6
of invasive cervical cancers are attributed to HPVs 16 or 18. 51 7.8
31 7.3
56 7.2
35 6.0
58 5.6
18 5.4

Table 1. Crude incidence rates of HPV-related 42.6

High−grade lesions(7, 8)
16
52 5.9

cancers 33 5.4

HPV−type
31 4.3
Male Female 51 4.0
18 3.0
Cervical cancer - 10.6 35 2.9
58 2.8
Anal cancer 0.3-1.5 0.1-1.0 56 2.4
68 2.0
Vulva cancer - 1.9-3.6
Vaginal cancer - 0.0-1.1 16 57.8
Cervical Cancer(1, 2)

33 5.1
Penile cancer 1.5-3.9 - 18 5.0
HPV−type

31 3.6
Pharynx (excluding nasopharynx) 5.9 0.7 45 2.8
52 2.2
Please refer to country report for data sources 35 2.0
56 1.4
39 1.0
51 0.9

Table 2. Burden of cervical cancer 0 10 20 30 40 50 60

Incidence Mortality Prevalence (%)

Annual number of new cases/deaths 2511 848

Crude rate 10.6 3.6
Age-standarized rate 7.8 2.1
Cumulative risk 0-74 years (%) 0.8 0.2
Ranking of cervical cancer (all years) 10th 13th
Ranking of cervical cancer (15-44 years) 2nd 3rd

Table 3. Burden of cervical HPV infection Spain

No. Tested % (95% CI)
HPV prevalence in women with normal
cytology 7077 10.7 (10.0-11.5)
HPV 16/18 prevalence:
Normal cytology 5403 2.7 (2.3-3.2)
Low-grade cervical lesions 2186 23.9 (22.1-25.7)
High-grade cervical lesions 838 45.6 (42.2-49.0)
Cervical cancer 1474 62.8 (60.3-65.3)

For data sources and further data on HPV infection in cancer sites other than the cervix, please refer to the specific country summary report.
 ICO Information Centre on HPV and Cancer

Spain
Human Papillomavirus and Related Cancers, Fact Sheet 2016 (October 7, 2016)
II. Complementary data on cervical cancer prevention
Table 4. Factors contributing to cervical cancer (co- Table 7. Cervical screening practices and
factors) recommendations
Smoking prevalence (%), women 27.8 Cervical cancer screen- 72.7% (All women aged 25-64
ing coverage, % (age and screened every 3y, EESE 2014
Total fertility rate (live births per women) 1.3 screening interval, reference) Spain)
Hormonal contraception use (%) (pill, injectable 17.4 Screening ages (years) 25-65 (cytology), 30-65 (HPV test)
or implant), among women
Screening interval (years) or 3 years (cytology), 5 years (HPV
HIV prevalence (%), adults (15-49 years) 0.4 [0.4-0.5]
frequency of screens test)

Table 5. Sexual behaviour Figure 2. Estimated coverage of cervical cancer

MEN screening in Spain, by age and study
Percentage of 15-year-old who have had sexual 23 − All women screened every 3y − All women ever screened
intercourse in 2014 − in 2014 −

100 100
Range of median age at first sexual intercourse 17.0-18.0 88.6 90.0
85.9
78.8
80 76.2 76.4 80 74.2
70.3

WOMEN 60
65.6

60
46.8

Estimated cervical cancer screening coverage (%)

Percentage of 15-year-old who have had sexual 21 40 34.1
36.3 40 35.5
31.8

intercourse
20 20
10.2

Range of median age at first sexual intercourse 16.5-22.7 0

4.0

4
4

4
4

84

84
4

4
85

85
−7

−7
−3

−5

−3

−5
−4

−6

−4

−6
−2

−2
−

−
>=

>=
65

65
25

45
35

55

25

45
35

55
15

15
75

75
− All women screened every 5y − All women screened every 3y
in 2014 − in 2011−2012 −
Table 6. HPV vaccine introduction 100 100

82.6 83.2
HPV vaccination programme National program 80 76.3
73.4 80
71.7
74.6 74.1

61.4

Date of HPV vaccination routine 2008 60

46.2
60

immunization programme start 40 35.3 40 34.6 36.5

HPV vaccination target age for routine 11-14 20 16.1

6.2
20
12.2
5.6

immunization 0 0
4
4

4
24

84
4

85

24 34 44 54 64 74 84 >=85
−7
−3

−5
−4

−6

15− 25− 35− 45− 55− 65− 75−

−

>=
65
25

45
35

55
15

75

Full course HPV vaccination coverage for Please refer to country report for data sources.
routine immunization:
% (calendar year) 73% (2014)

Contact information:

ICO HPV Information Centre

Institut Català d’Oncologia
Avda. Gran Via de l’Hospitalet, 199-203
08908 L’Hospitalet de Llobregat (Barcelona, Spain)
e-mail: info@hpvcentre.net
internet adress: www.hpvcentre.net

For data sources and further data on HPV infection in cancer sites other than the cervix, please refer to the specific country summary report.