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  • Addison Pathophysiology

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    kristian markus delos santos
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    Primary Addison disease is caused by autoimmune damage to the adrenal cortex, which decreases production of mineralocorticoids, glucocorticoids, and androgens. This leads to symptoms like fatigue, weight loss, skin pigmentation, low blood pressure, and decreased libido due to deficiencies in these hormones and lack of negative feedback inhibition of CRH and ACTH overproduction. Clinical presentation includes tiredness, weight loss, gastrointestinal issues, dizziness, decreased sex drive, joint/muscle pain, fast heart rate, and postural hypertension.

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    Primary Addison disease is caused by autoimmune damage to the adrenal cortex, which decreases production of mineralocorticoids, glucocorticoids, and androgens. This leads to symptoms like fatigue, weight loss, skin pigmentation, low blood pressure, and decreased libido due to deficiencies in these hormones and lack of negative feedback inhibition of CRH and ACTH overproduction. Clinical presentation includes tiredness, weight loss, gastrointestinal issues, dizziness, decreased sex drive, joint/muscle pain, fast heart rate, and postural hypertension.

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    57 views1 page

    Addison Pathophysiology

    Uploaded by

    kristian markus delos santos
    Primary Addison disease is caused by autoimmune damage to the adrenal cortex, which decreases production of mineralocorticoids, glucocorticoids, and androgens. This leads to symptoms like fatigue, weight loss, skin pigmentation, low blood pressure, and decreased libido due to deficiencies in these hormones and lack of negative feedback inhibition of CRH and ACTH overproduction. Clinical presentation includes tiredness, weight loss, gastrointestinal issues, dizziness, decreased sex drive, joint/muscle pain, fast heart rate, and postural hypertension.

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    © All Rights Reserved
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    of 1

    Primary Addison disease

    (autoimmunity)

    Damage in the adrenal


    cortex

    Mineralocorticoids Glucocorticoids Androgen

    Weight loss
    Decrease Na+, H20 Decrease libido
    Skin pigmentation
    retention
    Fatigue

    Decrease Bp
    No negative feedback
    Increase CRH&ACTH

    Tachycardia

    Clinical presentation
     Tiredness
     Weight Loss
     Vomiting, abdominal pain, diarrhea
     Dizziness, Nausea
     Decrease libido
     Arthralgia / Myalgia
     Tachycardia
     Postural hypertension

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