DRUG THERAPEUTIC RECORD

MECHANISM OF CONTRA- SIDE EFFECTS/ NURSING

DRUG NAME DRUG CLASS INDICATIONS
ACTION INDICATIONS ADVERSE EFFECTS CONSIDERATION
Generic: Therapeutic: It inhibits platelet Used to treat the Other indications CNS: Depression, Before:
Antiplatelet agents aggregation by symptoms of include maintenance Dizziness, Fatigue,  Monitor
Clopidogrel selectively acute coronary of arterial and Headache. hemoglobin
preventing the syndrome such venous grafts, EENT: Epistaxis. and
binding of adenosine as a stroke, preventing Resp: Cough, Dyspnea. hematocrit
diphosphate to its blood clot or cerebrovascular periodically.
platelet receptor. It serious heart occlusion, and CV: Chest Pain,  Monitor
is an analogue of problem after a including them as Edema, Hypertension. patient for
Brand: ticlopidine. The heart attack, adjunct to GI: GI Bleeding, unusual
Plavix drug's effect on the severe chest thrombolytic therapy Abdominal Pain, bleeding or
adenosine pain or for treatment of Diarrhea, Dyspepsia, bruising; drug
diphosphate circulation myocardial infarction Gastritis. significantly
receptor of a platelet problems Derm: Pruritus, increases risk
is irreversible. Pregnancy Purpura, Rash. of bleeding.
Category: B Hemat: Bleeding,  Assess for
Therapeutic Neutropenia, occult GI
Effects: Decreased Thrombotic blood loss if
occurrence of Thrombocytopenic patient is
atherosclerotic Purpura. receiving
events in patients at Metab: naproxen
risk. Hypercholesterolemia. concurrently
MS: Arthralgia, Back with
Pain. clopidogrel.
Misc: Fever, During:
Hypersensitivity  Tell patient to
Reactions. take tablets
with or
without food.
 Advise patient
to
immediately
report
unusual or
acute chest
pain,
 respiratory
difficulty,
rash, purplish
bruises on
skin or in
mouth, purple
skin patches,
unusual
fatigue, fast
heart rate,
confusion,
signs and
symptoms of
stroke
(including
weakness on
one side,
speech
changes), low
urine output,
unresolved
bleeding,
diarrhea, GI
distress,
nosebleed, or
acute
headache.
 Instruct
patient not to
discontinue
drug without
consulting
prescriber.
 Instruct
patient to tell
all health care
providers that
he’s taking
clopidogrel,
especially if
surgery is
 scheduled or
new drugs are
prescribed.
After:
 Advise patient
to contact
prescriber
before taking
over-the-
counter
products,
particularly
nonsteroidal
anti-
inflammatory
drugs.
 Tell patient
drug may
cause
headache and
dizziness.
Caution him
to avoid
driving and
other
hazardous
activities until
he knows how
drug affects
con-
centration and
alertness.
 Advise patient
to minimize
adverse GI
effects by
eating small,
frequent
meals or
chewing gum.
 As
 appropriate,
review all
other
significant
and life-
threatening
adverse
reactions and
interactions,
especially
those related
to the drugs,
tests, and
herbs
mentioned
above.

Reference: Hodgson, B. B., & Kizior, R. J. (2018). Saunders nursing drug handbook. Philadelphia: Saunders.