1.

Which of the following are typical characteristic

an acute leukemia?
A. Replacement of normal marrow elements by leukocytic blasts and bleed
episodes

B. Blasts and immature leukocyte forms in the peripheral blood and anemi

C. Leukocytosis

D. All of the above

1. Which of the following are typical characteristics of an

acute leukemia?
A. Replacement of normal marrow elements by leukocytic blasts and bleeding episodes

B. Blasts and immature leukocyte forms in the peripheral blood and anemia

C. Leukocytosis

D. All of the above

2 . _____ Myeloid and monocytic

A. M1
B. M4
C. M5
D. L1

3. _____ Monocytic

A. M1
B. M4
C. M5
D. L1
4. _____ Myeloid without maturation

A. M1
B. M4
C. M5
D. L1

5. _____ Lymphoblastic (one cell population)

A. M1
B. M4
C. M5
D. L1

6. Characteristics of FAB M1 include

A. leukocytosis with maturation of the myeloid cell line

in the peripheral blood

B. leukocytosis with maturation of the lymphocytic cell

line in the peripheral blood

C. leukocytosis without maturation of the myeloid cell

line in the peripheral blood

D. leukocytosis with many mature leukocytes in the peripheral blood

7. The incidence of FAB M1 is

A. high in children younger than 18 months of age

B. high in children between 1.5 and 12 years of age

C. high in middle-aged adults

D. both A and C

8. _____ A mixture of myeloid and monocytic blasts

A. FAB M2
B. FAB M3
C. FAB M4
D. FAB M6
E. FAB M5

9. _____ Blasts of the monocytic type

A. FAB M2
B. FAB M3
C. FAB M4
D. FAB M6
E. FAB M5

10. _____ Many coarsely granular promyelocytes with dumbbell-shaped or bilobed nuclei

A. FAB M2
B. FAB M3
C. FAB M4
D. FAB M6
E. FAB M5

11. _____ Myeloblasts, promyelocytes, and myelocytes

A. FAB M2
B. FAB M3
C. FAB M4
D. FAB M6
E. FAB M5

12. _____ Immature leukocytic and erythrocytic cell

typesA. FAB M2
B. FAB M3

C. FAB M4
D. FAB M6
E. FAB M5

13. _____ Leukemia secondary to Burkitt lymphoma

A. FAB M1
B. FAB L1
C. FAB L2
D. FAB L3

14. _____ Childhood lymphoblastic leukemia

A. FAB M1
B. FAB L1
C. FAB L2
D. FAB L3

15. _____ Older children and adults

A. FAB M1
B. FAB L1
C. FAB L2
D. FAB L3

16. Chloromas are associated with

A. FAB M1
B. FAB M3

C. FAB M4
D. FAB M5

17. A common characteristic of ALL is

A. bone and joint pain

B. many blast cells with Auer rodsC. leukocytopenia

D. a leukemia of older persons

18. _____ t(15q+;17q-)

A. FAB M2
B. FAB M3
C. FAB ALL

19. _____ t(8q-;21q+)

A. FAB M2
B. FAB M3
C. FAB ALL

20. _____ t(9;22)

A. FAB M2
B. FAB M3
C. FAB ALL

21. _____ Sudan black B

A. Glycogen
B. Enzymes
C. Lipids

22. _____ Myeloperoxidase

A. Glycogen
B. Enzymes
C. Lipids

23. _____ PAS

A. Glycogen
B. Enzymes
C. Lipids

24. The Sudan black B cytochemical stain di!erentiates

A. acute myeloid from ALL

B. acute monocytic from AML

C. myeloid leukemia from a leukemoid reaction
D. acute myeloid from acute myelomonocytic
leukemia

25. Myeloperoxidase di!erentiates

A. acute myeloid from chronic myelocytic leukemia
B. acute myeloid and acute monocytic from ALL
C. acute myelomonocytic from acute monocytic
leukemia

D. acute lymphoblastic from acute monocytic leukemia

26. The PAS reaction is

A. positive in the neutrophilic granulocytes, except
blasts

B. positive in a block-like pattern in some lymphoblasts

C. negative in megakaryoblasts
D. negative in myelocytes

27. Esterase (naphthol AS-D chloracetate) di!erentiates

A. granulocytic (promyelocytic to segmented neutrophils) from the monocytic cell line

B. promyelocytes from myelocytes
C. monoblasts from myeloblasts
D. metamyelocytes from myelocytes

28. In the nonspecifi c esterase (alpha-naphthyl acetate)

 staining reaction, the cells of monocytic origin are
A. strongly positive

B. positive initially and positive after sodium fluoride

incubation
C. positive initially and negative after sodium fluoride
incubation
D. negative

29. Specifi c nature B-cell surface marker(s) membrane is

A. CD 79a
B. CD19
C. CD 20

D. all of the above

30. Patients with AML have a good prognosis if

A. Less than 45 years of age
B. Over rods are present in blast cells

C. Ph chromosome
D. all of the above

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