Topic :- CELL CYCLE AND CELL DIVISION (Previous Year Questions)

Cell Cycle 11. During which phase(s) of cell cycle, amount of DNA
2017 in a cell remains at 4C level if the initial among
1. The checkpoint in cell cycle plays important role in denoted as 2C?
(a) repairing DNA damage (a) G0 and G1 (b) G1 and S
(b) apoptosis initiation (c) Only G2 (d) G2 and M (AIPMT)
(c) assessing DNA damage
(d) none of these. (AIIMS) 12. In ‘S’ phase of the cell cycle
2016 (a) amount of DNA doubles in each cell
2. During cell growth, DNA synthesis takes place in (b) amount of DNA remains same in each cell
(a) S-phase (b) G1-phase (c) chromosome number is increased
(c) G2-phase (d) M phase. (d) amount of DNA is reduced to half in each cell
(MEET Phase-Il) (A!PMT)
3. When cell has stalled DNA replication fork, which 14. Cell cycle includes the sequence
checkpoint should be predominantly activated? (a) S,G1,G2 , M (b) S,M,G1,G2
(a) G1/S (b) G2/M (c) G1,S,G2 ,M (d) M,G1,G2 ,S (AMU)
(c) M (d) Both G2/M and M 15. Cells in ______ phase of cell cycle are least
(NEET Phase-II) susceptible to radiation damage.
4. Which of the following phases correspond to the (a) M (b) G2
interval between mitosis and initiation of DNA
replication? (c) G1 (d) S (JIPMER)
(a) S phase (b) G1 phase 16. The Centrosome duplicates during the
(c) G2 phase (d) M Phase (a) G2 -phase of cell cycle
(e) Telophase (Kerala PMT) (b) S-phase of cell cycle
2015 (c) Prophase of cell cycle
5. The checkpoint in cell cycle plays important role in
(d) G1 - phase of cell cycle (Karnataka CET)
(a) repair DNA damage
(b) apoptosis initiation 2013
(c) assess DNA damage 17. In a diploid cell, at which stage of cell cycle, the
(d) inhibit cell damage. (AIIMS) amount of DNA is doubled?
6. An example of mitogen is (a) G1 and G2 phase (b) G0 phase
(a) cytokinin (b) glucose (c) S, G2 and M phase (d) S Phase
(c) glycerol (d) fructose. (AMU) 2012
7. Some cells in adult animals do not divide. They exit 18. Which of the following statement is incorrect about
1 phase and enter an inactive stage which is called
G0 phase?
as
(a) G2 phase (b) G0 phase (a) Mitosis occurs after G0 phase.
(c) S phase (d) M phase. (b) Biocatalysts can be used to exit G0 phase.
(COMEDK) (c) Cell volume keeps on increasing during this
8. DNA replication takes place during phase
(a) S-phase (b) G2-phase
(d) Cell metabolism occurs continuously in G0
(c) G1 -phase (d) prophase.
(J&K CET) (AIIMS)
9. In a typicai eukaryotic cell cycie, Gap 1, Synthesis 19. Yeast cell can progress through the cell cycle in
and Gap 2 are the three phases included in the about
(a) prophase (b) metaphase (a) 30 minutes (b) 60 minutes
(c) anaphase (d) interphase (c) 90 minutes (d) 120 minutes (AMU)
(e) telophase. (Kerala PMT) 20. DoubIing of the chromosomes is termed as
10. Which of the following does not occur in the (a) duplication (b) transcription
interphase of eukaryotic cell division? (c) translation (d) none of these
(a) Increase of ATP synthesis (OJEE)
(b) Increase of DNA synthesis 21. The correct sequence of different phases of cell
(c) Increase of RNA synthesis cycle is
(d) Reduction in cell size (WB JEE) (a) S  G1  G2  M (b) S  G1  G2  M
2014 (c) G2  S  G1  M (d) G1  G2  S  M
(WB JEE)
2011

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1
22. The formation of chromatid takes place in 31. G1,G2 and S-phases are seen in which phase of cell
(a) G1 phase (b) G2 phase cycle?
(c) S phase (d) M phase. (OJEE) (a) Metaphase (b) Prophase
2010 (c) Anaphase (d) Interphase (AFMC)
23. DNA replication occurs during which part of cell 32. During the G1 -phase of cell division
cycle? (a) RNA and protein are synthesised
(a) G1 phase (b) S-phase (b) pre-mitotic DNA are synthesised
(c) G2 phase (d) Dividing phase (c) post-mitotic DNA are synthesised.
(AFMC) (d) cell undergoes duplication. (UP CPMT)
24. In a mammalian cell the longest and the most Amitosis
active phase of the cell cycle is 2010
(a) S phase (b) G1 phase 33. Amitosis is shown by
(a) bacteria (b) Euglena
(c) G2 phase (d) M phase. (BHU) (c) Syllis (d) Hydra. (UP CPMT)
25. Compare the statements A and B. Mitosis
Statement A : Synthesis of DNA takes place in the 2017
S-phase of interphase. 34. Which of the following options gives the correct
Statement B : Every chromosome, during sequence of events during mitosis?
metaphase, has two chromatids. (a) Condensation  Nuclear membrane
Choose the correct description. disassembly  Arrangement at equator 
(a) Statement A is wrong and B is correct. Centromere division  Segregation 
(b) Statement A is correct and B is wrong. Telophase
(c) Both the statements A and B are correct and A (b) Condensation  Crossing over  Nuclear
is the reason for B. membrane disassembly  Segregation 
(d) Both the statements A and B are correct and A Telophase
is not the reason for B. (Karnataka CET) (c) Condensation  Arrangement at equator 
26. DNA content is doubled during
Centromere division  Segregation 
(a) metaphase (b) interphase
Telophase
(c) prophase (d) telophase (OJEE)
27. During which phase of cell cycle DNA duplication
(d) Condensation  Nuclear membrane
occurs? disassembly  Crossing over  Segregation 
(a) G1 phase (b) G2 phase Telophase (NEET)
35. Anaphase Promoting Complex (APC) is a protein
(c) S phase (d) G0 phase degradation machinery necessary for proper
(UP CPMT) mitosis of animal cell. If APC is defective in a
28. Which phase comes in between the G1 and G2 human cell, which of the following is expected to
phase of cell cycle? occur?
(a) M-phase (b) G0 -phase (a) Chromosomes will be fragmented.
(b) Chromosomes will not segregate.
(c) S-phase (d) Interphase (WB JEE) (c) Recombination of chromosome arms will occur.
29. Cell division cannot be stopped in which phase of (d) Chromosomes will not condense. (NEET)
the cell cycle? 2016
(a) G1 -phase (b) G2 -phase 36. Which of the following is not a characteristic feature
(c) S-phase (d) Prophase (WB JEE) during mitosis in somatic cells?
30. The given figure is a schematic break-up of the (a) Chromosome movement
phases/stages of cell cycle. Which one of the (b) Synapsis
following is the correct indication of the (c) Spindle fibres
stage/phase in the cell cycle? (d) Disappearance of nucleolus (NEET Phase-I)
2015
37. Find out the correct statement.
(a) During mitosis endoplasmic reticulum and
nucleolus disappear completely at early prophase.
(b) Chromosomes are arranged along the equator
during prophase of mitosis.
(c) Chromosome is made up of two sister
chromatids at anaphase of mitosis.
(d) A cell plate is laid down during interphase.
(e) Small disc shaped structures at the surface of
(a) C-Karyokinesis (b) D-Synthetic phase the centromeres that appear during metaphase are
(c) A-Cytokinesis (d) B-Metaphase kinetochores. (Kerala PMT)
(AIPMT)

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38. Which one of the following is the significance of (d) Late prophase - Chromosomes move to spindle
mitosis? equator. (NEET Karnataka)
(a) Restricted to haploid cells 2012
(b) Cell repair 43. In onion root tip during metaphase stage of mitosis
(c) Increases the genetic variability the number of kinetochores will be
(d) Recombination of chromosomes (a) 4 (b) 8
(e) Leads to evolution of new genotypes (c) 16 (d) 32 (AMU)
(Kerala PMT) 44. Microtubule depolymerising drug such as colchicines
2014 is expected to
39. Select the correct statement related to mitosis. (a) inhibit spindle formation during mitosis
(a) Amount of DNA in the parent cell is first halved (b) inhibit cytokinesis
and then distributed into two daughter cells. (c) allow mitosis beyond metaphase
(b) Amount of DNA in the parent cell is first doubled (d) induce formation of multiple contractile rings.
and then distributed into two daughter cells. (AIIMS)
(c) Amount of DNA in the parent cell is first halved 45. A stage in mitosis that starts towards the middle of
and then distributed into four daughter cells. anaphase and is completed with the telophase is
(d) Amount of DNA in the parent cell is first doubled (a) cytokinesis (b) karyokinesis
and then distributed into four daughter cells. (c) crossing over (d) interkinesis (AFMC)
(WB JEE) 46. The plane of cell wall formation in a dividing cell ‘
2013 determined by
40. A stage in cell division is shown in the figure. (a) Golgi apparatus
Select the answer which gives correct identification (b) microfilaments
of the stage with its characteristics. (c) microtubules
(d) endoplasmic reticulum. (J&K CET)
47. Which of the following events are not characteristic
features of telophase?
A. Chromosome material condenses to form
Compact mitotic chromosomes.
B. Nucleolus, Golgi complex and ER reform.
(a) Cytokinesis : Cell plate formed, mitochondria C. Nuclear envelope assembles around the
distributed between two daughter cells. chromosome clusters.
(b) Telophase : Endoplasmic reticulum and D. Centromeres split and chromatids separate.
nucleolus not reformed yet. E. Chromosomes cluster at opposite, spindle poles
(c) Telophase : Nuclear envelope reforms, Golgi and their identity as discrete elements is lost.
complex reforms. (a) A, B, and D only (b) A and d only
(d) Late anaphase : Chromosomes move away (c) B and C only (d) C, D and E only
from equatorial plate, Golgi complex not present. (e) A and B only (Kerala PMT)
(NEET) 2011
41. During the metaphase stage of mitosis, spindle 48. At metaphase, chromosomes are attached to the
fibres attach to chromosomes at spindle fibres by their
(a) kinetochore (a) satellites
(b) both centromere and kinetochore (b) secondary constrictions
(c) centromere, kinetochore and centromere (c) kinetochores
(d) centromere. (NEET Karnataka) (d) centromeres. (AIPMT Mains)
42. A stage of mitosis is shown in the diagram. Which 49. Select the correct option with respect to mitosis.
stage is it and what are its characteristics? (a) Chromatids separate but remain in the centre of
the cell in anaphase.
(b) Chromatids start moving towards opposite poles
in telophase.
(c) Golgi complex and endoplasmic reticulum are
still visible at the end of prophase.
(d) Chromosomes move to the spindle equator and
(a) Metaphase – Spindle fibres attached to get aligned along equatorial plate in metaphase.
kinetochores, centromeres split and chromatids (AIPMT Prelims)
separate. 50. Syncytium formation occurs if
(b) Metaphase - Chromosomes moved to spindle (a) karyokinesis is not followed by cytokinesis
equator, chromosomes made up of two sister (b) cytokinesis is not followed by karyokinesis
chromatids. (c) no karyokinesis takes place
(c) Anaphase - Centromeres split and chromatids (d) both karyokinesis and cytokinesis are
separate and start moving away. prevented. (AMU)
52. The protein for spindle fibre is

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 (a) glutelin (b) actin (a) Meiosis involves two sequential cycles of
(c) troponin (d) myoglobin (OJEE) nuclear and cell division.
53. Spindle fibre is made up of (b) Meiosis involves pairing of homologous
(a) humulin (b) intermediate filament chromosomes.
(c) flagellin (d) tubulin (WB JEE) (c) Two cycles of DNA replication occur during
2010 meiosis
54. How many equational divisions are necessary in a (d) There is recombination between the paired
cell of onion root tip to form 128 cells? homologous chromosomes.
(a) 64 (b) 128 (e) Four haploid cells are formed at the end of
(c) 7 (d) 127 (OJEE) meiosis II. (Kerala PMT)
2009 2015
55. The shape of chromosome is clearly visible at 64. Arrange the following events of meiosis in correct
(a) prophase (b) anaphase sequence
(c) metaphase (d) telophase (OJEE) (i) Crossing over
56. Best material for the study of mitosis in laboratory (ii) Synapsis
is (iii) Terminalisation of chiasmata
(a) anther (b) root tip (iv) Disappearance of nucleolus
(c) leaf tip (d) ovary (UP CPMT) (a) (i), (ii), (iii), (iv) (b) (ii), (iii), (iv), (i)
2008 (c) (ii), (i), (iv), (iii) (d) (ii), (i), (iii), (iv)
57. Chromosome duplication without nuclear division (AIPMT)
refers to 65. Chromosomes start pairing in which stage of
(a) meiosis (b) mitosis meiosis?
(c) androgenesis (d) endomitosis (AMU) (a) Leptotene (b) Zygotene
58. Chromosomes are visible with chromatids at this (c) Pachytene (d) Diplotene (JIPMER)
phase of mitosis 66. The stage between two meiotic division is called as
(a) interphase (b) prophase (a) diakinesis (b) interkinesis
(c) mctaphase (d) anaphase.(J&K CET) (c) diplotene (d) interphase (JIPMER)
59. There is no division of cytoplasm after mitosis then 67. During meiosis I, the number of chromosomes is
the condition will be (a) halved (b) tripled
(a) one cell one nuclei (c) doubled (d) quadrupled.
(b) one cell with two nuclei (J&K CET)
(c) only one cell 68. Crossing over occurs in the ____ stage of meiosis.
(d) one cell without nucleus. (OJEE) (a) zygotene (b) leptotene
60. In cell cycle, during which phase chromosomes are (c) pachytene (d) diplotene
arranged in equatorial plate? 69. Which one of the following is wrong for meiosis?
(a) Telophase (b) Prophase (a) It leads to formation of sister chromatids.
(c) Metaphase (d) Anaphase (UP CPMT) (b) It occurs in diploid cell.
Meiosis (c) It occurs in haploid cell.
2016 (d) It occurs by splitting of centromeres and
61. Match the stages of meiosis in column I to their separation of sister chromatids.
characteristic features in column II and select the 70. Match the items in column I with those in column II,
correct option using the codes given below. and choose the correct answer.
Column I Column II Column I Column II
A. Pachytene (i)Pairing of homologous P. Mitosis (i) Occurs in diploid cells
chromosomes only
B. Metaphase I (ii) Terminalisation of Q. Meiosis (ii) Occurs in both haploid
chiasmata and diploid cells
C. Diakinesis (iii) Crossing-over takes (iii) Daughter and parent
place cells have same
D. Zygotene (iv) Chromosomes align chromosome numbers
At equatorial plate (iv) Synapsis of
(a) A—(iii), B—(iv), C—(ii), D—(i) Homologous
(b) A—(i), B—(iv), C—(ii), D—(iii) chromosomes
(c) A—(ii), B—(iv), C—(iii), D—(i) (a) P-(i), Q-(ii) (b) P-(ii), Q-(iii)
(d) A-(iv), B-(iii), C-(ii), D-(i) (NEET Phase-II) (c) P-(iii), Q-(iv) (d) P-(iv), Q-(i)
62. In meiosis crossing over is initiated at (WB JEE)
(a) zygotene (b) diplotene 2014
(c) plachytene (d) leptotene 71. The enzyme recombinase is required at which
(NEET Phase-I) stage of meiosis?
63. Which of these in not a key feature of meiosis? (a) Pachytene (b) Zygotene
(c) Diplotene (d) Diakinesis (AIPMT)

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72. The enyzme involved in the crossing over between (a) metaphase-I (b) anaphase-II
two homologous chromosome is (c) prophase-I (d) prophase-II
(a) nuclease (b) RNA polymerase (AIPMT Prelims)
(c) recombinase (d) DNA polymerase 81. The given figure is the representation of a certain
(J&K CET) event a particular stage of a type of cell division.
73. Match the sub-stage of prophase I of meiosis in Which is this state?
column I and the events in column II and choose
the right option.
Column I Column II
A. Leptotene I. Terminalisation of
chiasma
B. Zygotene II. Crossing over and
recombination
C. Pachytene III. Synapsis (a) Prophase-I during meiosis
D. Diakinesis IV. ‘Visibility of (b) Prophase-ll during meiosis
chromosomes (c) Prophase of mitosis
(a) A-I, B-II, C-Ill, D-IV (d) Both prophase and metaphase of mitosis
(b) A-I, B-Ill, C-I, D-IV (AIPMT Prelims)
(c) A-IV, B-III, C-II, D-I 82. The chromosomes become gradually visible with
(d) A-lV, B-I, C-II, D-III compaction of chromatin during the meiotic stage
(e) A-IV, B-II, C-Ill, D-I (Kerala PMT) (a) diplotene (b) leptotene
74. Statement A : For a particular character j individual, (c) zygotene (d) pachytene. (AMU)
each gamete gets only one allele. 83. The term synaptonemal complex refers to site of
Statement B : Chromatids of a chromosome split (a) chromatid separation
(separate) and move towards opposite poles during (b) spindle attachment
anaphase of mitosis. (c) replication
(a) Statement A is correct and statement B is (d) chromosome alignment and recombination.
wrong (BHU)
(b) Both the statements are correct and B is the 84. Find the correctly matched pairs and choose the
reason for A. correct opt
(c) Statement B is correct and statement A is A. Leptotene - The chromosomes become invisible
wrong. B. Zygotene - Pairing of homologous chromosomes
(d) Both the statements are correct and B is not the
reason for A. (Karnataka CET) C. Pachytene- Dissolution of the synaptonemal
75. The complex formed by a pair of synapsed complex takes place
homologous chromosomes is called D. Diplotene - Bivalent chromosomes appear as
(a) bivalent (b) axoneme tetrads
(c) equatorial plate (d) kinetochore (NEET) E. Diakinesis - Terminalisation of chiasmata takes
76. During meiosis I, the chromosomes start pairing at place
(a) zygotene (b) pachytene (a) A and B are correct
(c) diplotene (d) leptotene. (b) B and D are correct.
(NEET Karnataka) (c) B and E are correct
77. During meiosis I, the chromosomes start pairing at (d) B and C are correct.
(a) zygotene (b) pachytene (e) C and D are correct (Kerala PMT)
(c) cliplotene (d) leptotene. 85. Visible expression of the genetic phenomenon of
(NEET Karnataka) crossing over is called
78. A bivalent of meiosis I consists of (a) recombination (b) condensation
(a) four chromatids and two centromeres (c) chiasmata (d) spiralisation
(b) two chromatids and one centromere (Karnataka CET)
(c) two chromatids and two centromeres 86. Terminalisation is seen in
(d) four chromatids and four centromeres (a) leptotene (b) zygotene
(Karnataka CET) (c) pachytene (d) Diakinesis (OJEE)
2012 2011
79. Identify the meiotic stage in which the homologous 87. Select the correct match.
chromosomes separate while the sister chromatids (A) S phase – DNA replication
remain associated at their centromeres. (B) Zygotene – Synapsis
(a) Metaphase I (b) Metaphase II (C) Diplotene- Crossing over
(c) Anaphase I (d) Anaphase II (D) Meiosis – Both haploid and diploid cells
(AIPMT Mains) (E) Gap 2 phase – Quiescent stage
80. During gamete formation, the enzyme recombinase (a) A and B (b) C and D
participates during (c) C and E (d) A, C and E

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 (e) A and D (Kerala PMT) (c) Anaphase-I (d) Anaphase-Il (OJEE)
88. The stage between tow meiotic divisions is called 101. Crossing over occurs at
(a) interphase (b) cytokinesis (a) leptotene (b) zygotene
(c) interkinesis (d) karyokinesis (c) pachytene (d) diplotene
(e) diakinesis. (Kerala PMT) (UP CPMT)
89. The synaptonemal complex is formed during which 2008
phase? 102. Identify the substage of prophase-I of meiosis
(a) Pachytene (b) Diplotene during which synapsis takes place.
(c) Diakinesis (d) Zygotene (OJEE) (a) Diplotene (b) Zygotene
90. 56 cells are produced in meiosis in which (c) Leptotene (d) Pachytene
(a) first division is reductional (Karnataka CET)
(b) first division is equational 103. In meiosis the chromosome replicate during
(c) second division is reductional (a) prophase (b) metaphase
(d) none of these. (OJEE) (c) anaphase (d) interphase (OJEE)
91. Longest phase of meiosis is
(a) prophase I (b) prophase II
(c) anaphase I (d) metaphase II
(WB JEE)
92. In which stage of the first meiotic division two sister
chromatids are formed?
(a) Leptotene (b) Zygotene
(c) Pachytene (d) Diplotene (WB JEE)
2010
93. Chiasmata formation takes place during
(a) prophase I (b) metaphase I
(c) anaphase I (d) telophase I. (AMU)
94. Which of the following is the correct sequence of,
meiosis prophase I?
(a) Leptotene  pachytene  zygotene 
diplotene  diakinesis
(b) Leptotene  zygotene  diplotene 
pachytene  diakinesis
(c) Leptotene  zygotene  pachytene 
diplotene (BHU)
95. Pairing or synapsis between homologous
chromosome occur during
(a) leptotene (b) pachytene
(c) zygotene (d) diplotene. (J&K CET)
96. During meiosis I, the bivalent chromosomes clearly
appear as tetrads during
(a) diakinesis (b) diplotene
(c) leptotene (d) zygotene
(e) pachytene. (Kerala PMT)
2009
97. Synapsis occurs between
(a) mRNA and ribosomes
(b) spindle fibres and centromere
(c) two homologous chromosomes
(d) a male and a female gamete. (AIPMT)
98. The microtubules from opposite poles of the
spindle get attached to the kinetochores of sister
chromatids in
(a) prophase-II (b) metaphase-Il
(c) anaphase-II (d) none of these (AMU)
99. In which stage of meiosis crossing over takes
place?
(a) Prophase- I (b) Prophase
(c) Metaphase (d) Anaphase (OJEE)
100. In which phase of meiosis homologous
chromosomes separates?
(a) Metaphase-I (b) Metaphase-Il

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Q. NO. ANSWER Q. NO. ANSWER Q. NO. ANSWER Q. NO. ANSWER
1 (c) 31 (d) 61 (a) 91 (a)
2 (a) 32 (a) 62 (c) 92 (c)
3 (b) 33 (a) 63 (b) 93 (a)
4 (b) 34 (a) 64 (d) 94 (c)
5 (c) 35 (b) 65 (b) 95 (c)
6 (a) 36 (b) 66 (b) 96 (e)
7 (b) 37 (e) 67 (a) 97 (c)
8 (a) 38 (b) 68 (c) 98 (b)
9 (d) 39 (b) 69 (c) 99 (a)
10 (d) 40 (c) 70 (c) 100 (c)
11 (c) 41 (a) 71 (a) 101 (c)
12 (a) 42 (b) 72 (c) 102 (b)
13 (b) 43 (d) 73 (c) 103 (d)
14 (c) 44 (a) 74 (d)
15 (d) 45 (a) 75 (a)
16 (b) 46 (a) 76 (a)
17 (d) 47 (b) 77 (a)
18 (a) 48 (c) 78 (a)
19 (c) 49 (d) 79 (c)
20 (a) 50 (b) 80 (c)
21 (b) 51 (b) 81 (a)
22 (c) 52 (b) 82 (b)
23 (b) 53 (d) 83 (d)
24 (a) 54 (c) 84 (c)
25 (c) 55 (c) 85 (c)
26 (b) 56 (b) 86 (d)
27 (c) 57 (d) 87 (a)
28 (c) 58 (c) 88 (c)
29 (c) 59 (b) 89 (d)
30 (b) 60 (c) 90 (a)

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