Bioinformatics: Introduction and Methods 生物信息学: 导论与方法

Week 12
Origination of New Genes
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Quiz: Origination of New Genes

5 questions

 Quiz • 30 min

Origination of New Genes

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Due DateJan 11, 7:59 AM CET
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Origination of New Genes
Graded Quiz • 30 min

Due Jan 11, 7:59 AM CET

Origination of New Genes

Total points 5
1.
Question 1

Given the species phylogeny and the existence of genes in the figure, which two of
the following inferences are right according to the parsimony principle?

给定图中的物种系统发生关系和基因在各物种中是否存在，依据最简约原则如
下哪两个推断是正确的？
1 point

MNOP is a new gene, which originated after the divergence of Species 5 and the
ancestor of Species 1, 2, 3, 4

MNOP 是一个在物种 5 和物种 1，2，3，4 的祖先分岐后起源的新基因

IJKL originated 4 times independently in Species 2, 3, 4, 5

IJKL 在物种 2，3，4，5 中独立地起源了 4 次

EFGH is an old gene, which has already existed in the ancestor of Species 1, 2, 3, 4,
and 5

EFGH 是一个在物种 1，2，3，4，5 的祖先中就已存在的老基因

ABCD is a new gene, which originated after the divergence of Species 1 and 2

ABCD 是一个在物种 1 和 2 分岐后起源的新基因

2.
Question 2

Given the DNA sequence of an intact ORF, which two of following mutations will
cause ORF disruption?
给定一个完整 ORF 的 DNA 序列，如下哪两个突变会导致 ORF 破坏？

1 point

ATG GGC CTG TAG ACC CTC GAG CGG GAG CGA CTG TGA

ATG GGC CTG TCG ACC CTC GA- --G GAG CGA CTG TGA

ATG GGC CTG TCG ACC CTC G--CGG GAG CGA CTG TGA

ATG GGC CTG TCG ACC CTC GAG CGG CAG CGA CTG TGA

3.
Question 3

Which of following computational methods cannot give useful information about a

previously unknown de novo gene?

如下哪个计算方法不能对一个之前未知的从头起源基因提供有用的信息？

1 point

mRNA expression pattern inferred from RNA-Seq data

从 RNA-Seq 数据得到的 mRNA 表达特点

Protein physicochemical property (such as pI value) prediction

蛋白理化性质（如 pI 值）预测

Homology annotation to genes with known function

基于已知功能基因的同源注释
Protein secondary structure prediction

蛋白二级结构预测

4.
Question 4

Which one of following sequence alignment methods is not used for searching de
novo genes?

如下哪个序列比对方法没有被用来寻找从头起源基因？

1 point

BWA

Codon-based alignment

Genome alignment

BLAST

5.
Question 5

Which two of following statements about Pearson correlation coefficient (r) are right?

如下哪两个关于 Pearson 相关系数的陈述是正确的？

1 point

r is a measure of the linear correlation between two variables

r 度量两个变量间的线性相关性

r=1 means total positive correlation; r=0 means no linear correlation; and r=-1 means
total negative correlation
r=1 代表完全正相关；r=0 代表没有线性相关性；r=-1 代表完全负相关

r=0.8 means 80% of variability is accounted for by the linear model

r=0.8 意味着 80%的变异可以被线性模型解释

r=0.99 always means the data is fitted well with a linear model

r=0.99 总意味着数据被线性模型很好拟合

Honor Code Agreement

I, MOHAMED CHIHEB BEN CHAABANE, understand that submitting work that
isn’t my own may result in permanent failure of this course or deactivation of my
Coursera account.