© 7/22/19 - Recommendations in this table are meant to serve as a guide and should NOT supplant consultation with a pharmacist.

Table was designed for use in the Johns Hopkins Children’s

Key:

Center and may not be appropriate for other settings. Authors have attempted to verify that all information is correct and up to date, but due to new evidence recommendations may change.
methylPREDNISolone
calcium GLUCONATE
C = Compatible

calcium CHLORIDE

sodium bicarbonate
heparin > 1 unit/mL
≤ 1 unit/mL heparin

alprostadil (PGE1)

dexmedetomidine

HYDROmorphone
≤3% saline IV soln

PN (with heparin)
dex/Na/K IV soln
dextrose IV soln

PN (NO heparin)

KCl (potassium)
intralipids (fats)

nitroGLYCERIN
nitroPRUSSIDE
norepinephrine
cycloSPORINE
I = Incompatible

phenylephrine
cisatracurium

DOBUTamine

isoproterenol

niCARdipine
EPINEPHrine

TACROlimus

vasopressin
amiodarone

remifentanil

vecuronium
midazolam

tobramycin
DOPamine

treprostinil
terbutaline
morphine
milrinone
lidocaine
CS = Compatible Only

fentaNYL

naloxone

Y-Site compatibility: compatibility of a single drug that is administered simultaneously at a Y-site connection with another drug or solution
ketamine

labetalol
esmolol

insulin
if Drugs mixed in NaCl
CD = Compatible Only
if Drugs mixed in Dextrose
Rx =Conc/Time dependent,
CALL PHARMACY
Blank: insufficient evidence

acyclovir C C C C I I I C I C C I C I I I I C C C I C I C I I C I C I C C I I C C I C C
alprostadil (PGE1) C C C C C C I C Rx C C C C C C C C C C C C C C C
amikacin C C C C C C I Rx C C C C C C C C C I C CS C C C C C C C C C C C C C C C C C C C C
aminophylline C C C C C C C C I C C C C I C I C C C C C I C C C C I C C C I C C I C C C C C C C
amiodarone Rx Rx Rx Rx Rx Rx Rx Rx Rx Rx Rx Rx I Rx Rx Rx Rx Rx Rx Rx Rx Rx Rx Rx Rx Rx I Rx Rx Rx Rx

Bloomberg Children's Center Y-Site Compatibility Chart

amphotericin B C I I CD I I I CD I I CD I I I I I CD CD CD I I I I I I I I I CD I I I I CD I I
ampicillin I C I CS I I I CS CS CS CS CS I I CS CS CS CS CS CS CS I CS CS CS I I CS CS CS I CS CS CS CS CS I CS I
azithromycin C C C C C I I I C C
aztreonam C C C C C C C C C C C C C C C C C C C C C C C C C C C C C C C C C C C C C C C C
bactrim (cotrimoxazole) C C C C C C C I I I I C I I I I I I Rx I I I I I I I C I I I I I I I C I C C I C
bivalirudin C C C C I C C C C C Rx C C C C C C C C C I C C C C C C C C C C C C C C C C C
bumetanide C C C C C C C Rx C C C C C C C C C C C C C C C C C I C C C C C C C C C C C
caffeine C C C C C C C C C C C C C C C C C C I C C C
calcium CHLORIDE C C C C I I I C Rx C C C C C C C C C C C C C C C I C C C C C C C C I C C C C C
calcium GLUCONATE C C C C I I C Rx C C C C C C C C C C C C C C C C C I C C C C C C C C C C I C C C C
ceFAZolin C C C C C C C C CS I C I C C I I C C C C C C C C C I C C C C C C C C C C C C C C C I C
cefEPIME C C C C C C C C C I I C C C C C C I C I I C C I C I C
cefotAXIME C C C C C C C C C C I C I C C C C C C C C C C I C I C C C C C C C C C I C C I C
cefotETAN C C C C C C C C C C C I C C I C C C CD C C I C C CS C C C C C C C I C I C
ceftazidime Rx Rx C C C I I C Rx C I C C C C C C C C C C C C I C C C I C I C C C C C C C C
cefTRIAXone C C C C I I C Rx I I C C I C C C C C C C C I C I C C C C C C C C C C C C C I C
ciprofloxacin C C C I I I C Rx C C C C Rx C I C C C I C C C C C C C
cisatracurium C C C C Rx C C C C C C C Rx C C C C C C C C C C I C
clindamycin C C C C C C C C Rx C C C C C C C C C C C C C C C C C I C C C C C C C C C C C C C C
cycloSPORINE C C C C C C C C C C C C C C C C C CD C C C C C C C C C C C C C C C C C C C
dexamethasone C C C C C C C C I I C C C I C C I C C C C C C I C C I C C C C C C C C C C C I C
dexmedetomidine C C C C Rx C C C C C C C C C C C C C I C C C C C C C C C C C C C C C C CS C C C
diAZEPam C C I I I I I I I I I I I I I I I I I I I I I I I I I I I I I I I I I I
digoxin C C C C C C C C I C C C C C C C C C C C C C C C C C C C C C C C C C C C C C C C C
diphenhydrAMINE C C C C C C C C C C C C C C C C I I I C C C C C I C I C C C I C C I C C
DOBUTamine C C C C Rx Rx C C C C C C C C C C I C I C C C Rx C C Rx Rx C C C Rx C C C I C CS C C C
DOPamine C C C C C C C C Rx C C C C C C C C C C C CS C C C C C C C C C C C C C C C C CD C C I C C C
doxycycline C C C I C I I Rx C C C C C C C C C C I C C C C C C I C C C C C C C C C C I C C C C
EPINEPHrine C C C C C C C Rx C C C C C C C C C C C CS C C C C C C C C C C C C C C C C I C I C C C
ertapenem I C I C I CS CS CS I CS CS CS C CS CS CS CS CS CS I CS CS CS I CS CS CS CS CS CS CS CS CS CS
erythromycin C C C C C C C Rx C C C C C C C C C I C C C CD C C C C C C C C C I C C C C C C C
esmolol C C C C Rx C C C C C C C C C C C C C C C C C CS C I C C C C C C C C C C C C C
famotidine C C C C C C C C C C C C C C C C C Rx C C C C C C C C C C C
fentaNYL C C C C C C C C Rx C C C C C C C C C C C C C C C C C C C C C C C C C C C C C C C CS C C C
flucONAZOLE C C C C C C C Rx C C C C C C C C C C C C C C I C C C CS C C C C C Rx C C C C C C C
furosemide C C C C C C C Rx C C C C I Rx C I C C Rx C CD I C I C C I I C C I C C I Rx C C C C CS C
ganciclovir C C C C I I I C C C C I I I I C C C C I C C I I I C I C C C I I C I I I C
GENTamicin C C C C C C C C Rx C C C C C C C C C C I C CS C C C C C C C C C C C C C C C C C C C C C C
heparin > 1 unit/mL C C C C C C C C I C C Rx C C I C C C C Rx C C C Rx C C C C C C C C C C C C C C CS I C C
hydrALAZINE I C I CS CS I CS CS CS Rx CS CS CS CS CS C CS CS CS CS CS I CS CS CS CS I CS CS CS CS CS
hydrocortisone C C C C C C C C I I C C C I C C I C C C C C C C I C C C C C C C C C C C C C C CS C
HYDROmorphone C C C C C C C C C C C C C C C C C C C C C C C C C C C C C C C C C C C I C C C C
indomethacin C C I I I I C I I I I CS C C I C I C I I I C CD I I C I I
insulin C C C C C C C Rx C C Rx C I CS CS C C C C I I C I C C CD C I C C C I I C C C I I C
Key:

© 7/22/19 - Recommendations in this table are meant to serve as a guide and should NOT supplant consultation with a pharmacist. Table was designed for use in the Johns Hopkins Children’s
C = Compatible

methylPREDNISolone
calcium GLUCONATE

Center and may not be appropriate for other settings. Authors have attempted to verify that all information is correct and up to date, but due to new evidence recommendations may change.
calcium CHLORIDE

heparin > 1 unit/mL

≤ 1 unit/mL heparin

alprostadil (PGE1)

dexmedetomidine

HYDROmorphone
≤3% saline IV soln
I = Incompatible

PN (with heparin)
dex/Na/K IV soln

KCl (Potassium)
dextrose IV soln

PN (NO heparin)

intralipids (fats)

nitroGLYCERIN
nitroPRUSSIDE
norepinephrine
cycloSPORINE

phenylephrine

sodium bicarb.
cisatracurium

DOBUTamine

isoproterenol

niCARdipine
EPINEPHrine

TACROlimus

vasopressin
vecuronium
amiodarone

remifentanil
Cs = Compatible Only

midazolam

tobramycin
DOPamine

treprostinil
terbutaline
morphine
milrinone
lidocaine

naloxone
ketamine

labetalol
fentanyl
esmolol

insulin
if Drugs mixed in NaCl

Y-Site compatibility: compatibility of a single drug that is administered simultaneously at a Y-site connection with another drug or solution
CD = Compatible Only
if Drugs mixed in Dextrose
Rx =Conc./Time
dependent,
CALL PHARMACY
Blank: insufficient evidence
intralipid (Fats) C C C C C C C I C C C C C C C C C C C I C C C C C C C
isoproterenol C C C C C C C C Rx C C C C C C C C C C C I C C C C C C C C C C C C C I C C C C
KCl (potassium) C C C C C C C C Rx C C C C C C C C C C C C C C C C C C C C C C C C C C C C C C C C C
ketamine C C C C C Rx C C I C C C C C I C C Rx Rx C C C C C C I I C C C
ketorolac C C C C I C C C C I C C I C C C C C C C I C C I C C C I C C C C C C C C C I
labetalol C C C Rx C C C C Rx C C C C Rx C I C C C C C C C C C C C C C C C C C C

Bloomberg Children's Center Y-Site Compatibility Chart

lidocaine C C C C C C C C Rx C C C C C C C C C C C C C C C C C C I C C C C C C C C C C C C C C
LORazepam C C C C C C C Rx C C C C C Rx C C C C C C C C I C C C Rx C C C C C C C C C C C I C C
magnesium sulfate C C C C C C C I C C CS C C C C C C C C C C C C C C I C C C CD C C C C C C C C C C C
mannitol C C C C C C C C C C C Rx C C C C C C C C C C C C C C C C C C C C C C C I C C
meropenem C C C C C C C C C Rx C C C C I C C C I C CS C
methylPREDNISolone C C C C C C C C Rx I I C C C C C CS C C C C C Rx C C C C C C C C C CD C C C C C C C C I
metoclopramide C C C C C C C C C I C C C Rx C C C C C C C C C C C C C C C C C C C C C C C C C C
metRONIDAZOLE C C C C C C C C I C C C C C C C C C C C C C C C C C C C C C C C C C C C C C C C C C
midazolam C C C C Rx Rx I C Rx C C C C C C C C C C C CD C C C C C C C C C C C C C C C I C C CS C C C
micafungin C C C C C C I C C I C I C I C C C I I C I C I C I I C C C C C C
milrinone C C C C C C Rx C C C C Rx C C I C C C C C C C C I C C C C C C C C C C C C CS C C C
morphine C C C C C C C C Rx C C C C C Rx C C C C C C I C C C C C C C C C C C C C C C C C C Rx C C C
mycophenolate C I CD I Rx C I CD CD CD CD CD I CD CD CD C CD CD CD I CD CD CD I CD CD I CD CD CD I CD I CD C
naloxone C C C C C C C C C C C C C C C C C C C C C C C C C C C C C C C C C C C C
NICARdipine C C C C C C C C C C C C C C I C C C C C C C I C C C C
nitroGLYCERIN C C C C C C C C Rx C C C C C C C C C C C C C C C C C C C C C C C C C C C C C C C C C
nitroPRUSSIDE C C C C C C C C C C C C Rx C C C C C C C C C C C CD C C C C C C C C C C C C C
norepinephrine C C C C C C C Rx C C C C C C C C C C C C I C C C C C C C C C C C C C C C I C C Rx C C C
octreotide C C C C C C I Rx C C C C C Rx C C C C C C C C C C C C C C C C C C C C C C C C C C
ondansetron C C C C C C I C C C C Rx C C C C C C CD C C C C C C I C C C C C C C I C C C
oxacillin C C C C C C C I I C I C C I C C C C C C C C C C C C C CD C C C C I C
pantoprazole C C C I I C I I I I I I I I I I I I I I I I C I I I I I I I I I I I C I I I I C
penicillIN G K C C C C C C C C Rx C C C I C C C C C C C C C C I C C C C C C C C C C C C C I C
PENTobarbital C C C C I I I C C I C I C I I C C C C I C C I C C I I C C C I C C I I CD
PHENobarbital C C C C I I I C C I C I C I I C C I C I C C I C C I C C C C I C C I C C
phenylephrine C C C C Rx C C C C C C C C C C C C I C C C C C C C C C C C C C C C C C C C
phosphate (Na or K) C C C C I I I I I I C I C C C C I C C C C Rx C C C
piperacillin-tazobactam C C C C C C I C C C C I C C C C C C I C C C I C C I C C C C C C C C C C C I C
PN (+/- Heparin) C C C C C C C C I I C C C C C C C C C C C C Rx C C C C C C I C C C C C
propranolol C C C C C C C C Rx C C C C C C I C C C C C C C C C C C C C C C C C C C
ranitidine C C C C C C C C C C C C C C C C C C C C C C C C C C C C C C C C C C C C C C C C C C C
remifentanil C C C C C C C C C C C C C C C C C C C C C C C C C C C C
rocuronium C C C C I Rx C C C C C C C C C C I C C C C C C C C C C C C C C C C C Rx
sodium bicarbonate C C C C I I C I I I I C C I CD I C C C I C I I C I C C I C C C I C C I C C C C C C C
TACROlimus C C C C C C C Rx C C C C C C C C C C C C C C C C C C C C C C C C C C C C C C C C C
terbutaline C C C C C C C C C C C C C C C C C C C
tobramycin C C C C C C C Rx C C C C C C C C C C I C I C C C C C C C C C C C C C C C C C C C C
vancomycin C C C C C C C Rx Rx C C C C C C C C C C I C C C C C C C C C C C C C C C C C C C C C C C C
vasopressin C C C C C C C Rx C C C C C C C C C C C I C C C C C C C C C C C C C C C C C C C C
vecuronium C C C C C C C Rx C C C C C C C C C C C C C C C C C I C C C C C C C C C C C C C C C
voriconazole C C C C Rx C C I C C C C C C C C C C C C C C C C C I C C C C C C C
zidovudine C C C C C C C C C C C C C C C C C C C C
 Additional information for RX use only. Not available on nursing charts.
Y-Site compatibility: compatibility of a single drug that is administered simultaneously at a Y-site connection with another drug or solution

Key:
C = Compatible
I = Incompatible

methylPREDNISolone
calcium GLUCONATE

sodium bicarbonate
calcium CHLORIDE

heparin > 1 unit/mL

≤ 1 unit/mL heparin

alprostadil (PGE1)

dexmedetomidine

HYDROmorphone
≤3% saline IV soln

PN (with heparin)
CS = Compatible Only

dex/Na/K IV soln
dextrose IV soln

KCl (Potassium)
intralipids (fats)
PN (NO heparin)

nitroGLYCERIN
nitroPRUSSIDE
norepinephrine
cycloSPORINE

phenylephrine
cisatracurium

DOBUTamine

isoproterenol

niCARdipine
EPINEPHrine

TACROlimus

vasopressin
vecuronium
amiodarone

remifentanil
if Drugs mixed in NaCl

midazolam

tobramycin
DOPamine

treprostinil
terbutaline
morphine
milrinone
lidocaine
fentaNYL

naloxone
labetalol
ketamine
esmolol

insulin
CD = Compatible Only
if Drugs mixed in
Dextrose
Rx =Conc/Time
dependent,
CALL PHARMACY
Blank: insufficient
evidence

acetaminophen C C C C C C C C C C C C
acetaZOLAMIDE C C C I I I
albumin C C C I C I
allopurinol C C C C I C C C C C I C C I I I C I
alteplase I C I I I I C I
ambisome C I I CD I I I I I I CD CD CD CD CD CD CD CD I CD I I CD I I CD CD CD I I CD I CD I
argatroban C C C C C I C C C C C C C C C C C C C C C C C C C C C C C C C C C C C C C C
butorphanol C C C C C C C C C C C I C C C Rx C C C C C C C C C C C I C C C C
cefurOXIME C C C C C C C Rx I C I C C I C C C C C C C C C C C I C C I C C C C C C C I C C I C
chlorothiazide C C C I I I I I I C I C
doxapram C C C C C C I C C C C I C C
foscarnet C C C C C C I I I C C C I C C C C C C C C C I C I I C C C I C C I C C C C C C C
fosphenytoin C C C C I C I I C
ibuprofen lysine C C C C I I I I C C C I C I Rx C I
imipenem I C I CS I I I CS CS CS C CS C C C C C CS C C C C C C Rx C C C I C Rx C C CS I CS I C I
levETIRAcetam C C C C
methadone C Rx C C
neostigmine C C C C C C
nesiritide C C C I Rx C C C C C C C I C I C I C C C C C C C C C C C C
pancuronium C C C C C C C C C C C C C C C C C C C C C C C C C C C C C C C C
procainamide I C I CS Rx CS CS C CS CS C C C C C C C C C C C C C C I C C C C C C C C
propofol C C CD C C I CD CD C CD CD CD CD CD CD CD CD CD C CD I CD CD CD CD CD CD I
urokinase C C C C C C C C C C C C C C C C C C C C C C C C C C C C C C
© 7/22/19 - Johns Hopkins Children's Center Pharmacy, Guidelines for Y-Site use only; Recommendations in this table are meant to serve as a guide and should NOT supplant consultation with a pharmacist. Table was designed for use in the Johns
Hopkins Children’s Center and may not be appropriate for other settings. Authors have attempted to verify that all information is correct and up to date, but due to new evidence recommendations may change.