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(A) P,Q,S
(B) P,Q,R
(C) P,R
(D) Q,S
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Isoniazid, rifampicin, pyrazinamide and ethambutol are first line agents for tuberculosis.
Cycloserine, tetracyclines, fluoroquinolones, macrolides, aminoglycosides, ethionamide
and p-aminosalicylic acid act as second line drugs.
(A) Rifampicin
(B) Ethambutol
(C) Dapsone
(D) Isoniazid
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(A) P
(B) Q
(C) R
(D) S
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Clofazimine is a dye that produces red discoloration of skin and urine. Rifampicin also
produces orange tinge to urine and saliva but it is not a dye and does not effects the
skin.
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Dapsone is a sulfone that acts like sulfonamides and inhibits the conversion of PABA into
folic acid by inhibiting the enzyme dihydropteroate synthase. It is one of the important
drug in treatment of leprosy. It is also the drug of choice in dermatitis herpetiformis
which is a chronic skin disease with rashes and blistering of the skin. This disease
generally coexists with celiac disease, an auto immune disorder that produces sensitivity
to the gluten in diet. Dapsone produces various side effects like hemolytic anemia and
allergic reactions. It increases the inflammation of leprotic lesions. Clofazimine is a dye
which has anti-inflammatory effects and can antagonize the inflammatory side effects of
dapsone therefore generally combined.
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Isoniazid mainly produces two important side effects viz. peripheral neuropathy and
hemolytic anemia. These two side effects are more pronounced in pyridoxine deficient
patients and G-6-P dehydrogenase deficient patients respectively. Pyrazinamide increases
uric acid levels and may predispose to gout. Rifampicin is an enzyme inducer and
increases the metabolism of warfarin.
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