Frequency

Trade Name Generic Name Classification Action Indication Contraindication Nursing Responsibility
/ Route

Thorazine Chlorpromazine Antiemetic, Depresses brain areas that - To manage Comatose states; • Don’t open or crush E.R.
Antipsychotic, control activity and aggression, symptoms of hypersensitivity to capsules.
Tranquilizer including the cerebral cortex, psychotic disorders chlorpromazine, • Chlorpromazine shouldn’t be
Hypothalamus, and limbic or control manic phenothiazines, or their used to treat dementia-related
system, by an unknown manifestations of components; psychosis in the elderly
mechanism. manic-depression in use of large amounts of CNS because of an increased risk of
outpatients depressants death.
- To control acutely • Protect concentrate from
disturbed or manic light.
hospitalized patients • Use cautiously in patients
- To treat nausea with cardiovascular, hepatic, or
and vomiting renal disease because of
increased risk of developing
hypotension, heart failure, and
arrhythmias.

Trilafon Perphenazine Antiemetic, Depresses areas of the brain
Antipyschotic that control activity and
aggression, including cerebral
cortex, hypothalamus, and
limbic system, by an unknown
mechanism.
Also prevents nausea and
vomiting by inhibiting or
blocking dopamine receptors in
medullary chemoreceptor
trigger zone and peripherally
by blocking vagus nerve in the
GI tract.
- To treat psychotic Blood dyscrasias; bone
disorders marrow depression;
- To treat severe cerebral arteriosclerosis;
nausea and coma; concurrent use of
vomiting CNS depressants (large
doses); coronary
artery disease; hepatic
impairment;
hypersensitivity to
perphenazine, other
phenothiazines, or their
components;
myeloproliferative
disorders; severe CNS
depression; severe
hypertension or
hypotension; subcortical
brain damage
•Shouldn’t be used to treat
dementia-related psychosis in
the elderly.
•Use cautiously in patients
with depression or hepatic,
pulmonary, or renal
dysfunction and in elderly
patients
•Monitor temperature
frequently, and notify
prescriber if it rises
•Monitor blood pressure of
patient who takes large doses
especially if surgery is
indicated, because of the
increased risk of hypotension.
Prolixin Fluphenazine Antipsychotic May block postsynaptic
dopamine receptor sites in the
CNS. This action may depress
areas of the brain that control
activity and aggression,
including the cerebral cortex,
hypothalamus, and limbic
system.
Mellaril Thioridazine Antipsychotic Depresses areas of the brain
that control activity and
aggression, including the
cerebral cortex, hypothalamus,
and limbic system by blocking
postsynaptic dopamine2 (D2)
receptors. Drug may relieve
anxiety by indirectly reducing
arousal and increasing filtration
of internal stimuli to the brain
stem reticular activating
system.
To control psychotic Blood dyscrasias, bone
disorders marrow depression,
cerebral arteriosclerosis,
coma, concomitant
use of large amounts of
another CNS
depressant, coronary artery
disease, hepatic
dysfunction, hypersensitivity
to phenothiazines,
myeloproliferative
disorders, severe
CNS depression, severe
hypertension or
hypotension, subcortical
brain damage
To treat Coma; concurrent use of
schizophrenia in drugs that inhibit
patients the metabolism of
unresponsive thioridazine ,concurrent use
to other of drugs that prolong the QT
antipsychotic drugs interval; concurrent use of
high doses of a CNS
depressant; history of
arrhythmias;
hypersensitivity to the drug.
Severe CNS depression;
severe hypertensive.
• Use cautiously in patients
with a history of glaucoma or
renal impairment.
•Monitor temperature; a
significant, unexplained rise
can indicate intolerance and a
need to discontinue drug.
•Notify prescriber immediately
if this occurs.
•Watch for signs of hepatic
failure, such as jaundice.
• Notify prescriber about
worsening psychotic Symptoms
•Advise patient not to mix oral
solution with beverages that
contain caffeine (coffee, cola),
tannins (tea), or pectins (apple
juice).
• Caution patient about
possible dizziness or light-
headedness.
• Be aware that high doses and
large dosage changes in patient
with a seizure disorder may
lower seizure threshold.
• Frequently monitor blood
pressure and assess for chest
pain in patients with heart
disease.
• Administer drug with food,
milk, or a full glass of water to
minimize GI distress.
• Instruct patient to notify
prescriber immediately if she
develops unusual symptoms.
Serentil Mesoridazine Antipsychotic It has a piperidine side-chain
and is a metabolite of
thioridazine. It acts by blocking
postsynaptic CNS dopamine
receptors.
Navane Thiothixene Antipsychotic Increases dopamine turnover
by blocking postsynaptic
dopamine receptors in the
mesolimbic system. Eventually,
dopamine neurotransmission
decreases, resulting in
antipsychotic effects.
Haldol Haloperidol Antidyskinetic May block postsynaptic
, dopamine receptors
Antipsychotic in the limbic system and
increase brain turnover of
dopamine, producing an
antipsychotic effect.
To treat Severe CNS depression and •Monitor serum potassium
schizophrenia in coma; prolonged QT interval level before and during
patients who failed (>450 msec), including therapy, and administer
to respond to other congenital prolongation; potassium supplements as
antipsychotic drugs, history of arrhythmias. prescribed.
either because they Lactation. •Monitor patient for
were ineffective or neuroleptic
because intolerable malignant syndrome
adverse effects •Assess patient for signs of
prevented blood dyscrasias, including
attainment of cellulitis, fever, and pharyngitis.
effective dose • Advise patient to change
position slowly to minimize
orthostatic hypotension.
To treat psychotic Blood dyscrasias, coma, • Administer thiothixene
disorders, such as hypersensitivity to capsules with food or milk if
acute psychosis, thiothixene or its needed to minimize GI distress.
psychotic depression, components, Parkinson’s • Don’t give drug within 1 hr of
and schizophrenia disease, severe CNS an antacid.
depression, shock, use of • Urge patient to avoid
quinidine smoking or to begin a smoking
cessation program while taking
thiothixene.
• Encourage patient to avoid
extreme temperature changes
during drug therapy
- To treat psychotic Comatose conditions, •Use haloperidol cautiously in
disorders severe CNS depression, patients with a history of
- To treat Parkinson's disease, lesion prolonged QT interval, patients
nonpsychotic of the basal ganglia. with uncorrected electrolyte
behavior disorders disturbances,
and Tourette’s •Avoid stopping haloperidol
syndrome abruptly unless severe adverse
- To treat acute reactions occur.
psychotic episodes •Monitor for signs of

Loxitane Loxapine Antipsychotic May treat psychotic disorders
by blocking dopamine at
postsynaptic receptors in the
brain.With prolonged use,
loxapine enhances
antipsychotic effects by causing
depolarization blockade of
dopamine tracts, resulting in
decreased dopamine
neurotransmission.
Moban Molindone Antipsychotic Occupies dopamine receptor
sites in the reticular activating
and limbic systems in the CNS.
By blocking dopamine activity
in these areas, molindone
reduces the symptoms
of psychosis, helping the
patient to think and behave
more coherently.
Inhibits dopamine D2 receptors
Stelazine Trifluoperazine Antianxiety, in the brain. It has weak
Antipsychotic anticholinergic and sedative
effects but strong
extrapyramidal and antiemetic
effects. It controls severely
disturbed, agitated or violent
behaviour but may also be
used for nonpsychotic anxiety.
- To provide long-
term antipsychotic
therapy for
patients who
require parenteral
therapy
- To treat psychotic Blood dyscrasias, bone
disorders and marrow depression,
schizophrenia cerebrovascular disease,
- To treat acute coma, coronary artery
exacerbations of disease, hypersensitivity to
psychotic loxapine or its components,
disorders impaired hepatic function,
myeloproliferative
disorders, severe drug-
induced CNS depression,
severe hypertension or
hypotension.
To manage Hypersensitivity to
symptoms of molindone, its components,
psychotic disorders or other antipsychotic drugs,
including
haloperidol, loxapine,
phenothiazines, and
thioxanthenes
-To treat psychotic Preexisting CNS depression
disorders and coma; bone marrow
-To relieve anxiety depression, blood
dyscrasias, liver disease,
hypersensitivity to
phenothiazines, prolactin
dependent tumours.
Pregnancy (1st trimester),
lactation.
neuroleptic malignant
syndrome.
• Advise patient to take tablets
with food or a full glass of milk
or water to reduce GI distress.
• Tell patient not to take
antacids and antidiarrheals
within 2 hours of loxapine.
• Caution patient to avoid
alcohol while taking loxapine.
• Assess for signs of tardive
dyskinesia, including
involuntary protrusion of
tongue and chewing
movements.
•Assess patient for signs and
symptoms of neuroleptic
malignant syndrome
• Instruct patient to follow
treatment regimen and to
notify prescriber before
discontinuing drug because
gradual dosage reduction may
be needed.
• Use trifluoperazine cautiously
in patients with glaucoma
because of drug’s
anticholinergic effect.
• Advise patient to take drug
with food
• Instruct patient to notify
prescriber immediately if she
experiences difficulty
swallowing or speaking
 May produce antipsychotic
Clozaril Clozapine Antipsychotic effects by interfering
with dopamine binding to
dopamine—especially D4—
receptors in the
limbic region of the brain and
by antagonizing
adrenergic, cholinergic,
histaminic, and serotoninergic
receptors.
To treat severe Angle-closure glaucoma,
schizophrenia coma, history of clozapine-
unresponsive to induced agranulocytosis or
standard drugs; to severe granulocytopenia,
reduce risk of hypersensitivity to clozapine
recurrent suicidal or its components,
behavior in myeloproliferative
schizophrenia or disorders, severe CNS
schizoaffective depression, uncontrolled
disorders epilepsy, WBC count below
3,500/mm3
•Use cautiously in patients
with hepatic, renal, or
cardiovascular disease and in
elderly patients with dementia
related psychosis
•Monitor temperature.
• Inform patient that he’ll need
weekly
blood tests.
• Instruct patient to avoid
hazardous activitiesuntil drug’s
CNS effects are known.

•Monitor for orthostatic

Risperdal Risperidone Antipsychotic Selectively blocks serotonin
and dopamine receptors in the
mesocortical tract of the CNS
to suppress psychotic
symptoms.
To manage psychotic Hypersensitivity to
disorders risperidone or its
components
hypotension
•Monitor patient’s blood
glucose and lipid levels as
ordered
• Urge patient to avoid alcohol
because of its additive CNS
effects.
• Caution diabetic patient to
monitor blood glucose level
closely

Zyprexa Olanzapine Antipsychotic May achieve antipsychotic
effects by antagonizing
dopamine and serotonin
receptors. Anticholinergic
effects may result from
competitive binding to and
antago-nism of the muscarinic
receptors M1 through M5.
-To treat psychosis Angle-closure glaucoma; •Monitor patient’s blood
-To treat manic lactation. IM: History of CVS pressure routinely during
phase of acute disease, heart surgery. therapy
bipolar disorder •Notify prescriber if patient
-As adjunct to treat develops tardive dyskinesia or
acute bipolar urinary incontinence.
disorder • Advise patient to avoid
-To treat agitation alcohol and smoking during
associated with olanzapine therapy.
schizophrenia and •Monitor patient’s blood
bipolar I mania glucose level routinely because
olanzapine may increase risk of
hyperglycemia.
Seroquel Quetiapine Antipsychotic May produce antipsychotic
effects by interfering with
dopamine binding to dopamine
type 2 (D2)-receptor sites in
the brain and by antagonizing
serotonin 5-HT2, dopamine
type 1 (D1), histamine H1, and
adrenergic alpha1 and alpha2
receptors.
Geodon Ziprasidone Antipsychotic Selectively blocks serotonin
and dopamine receptors in the
mesocortical tract of the CNS,
thereby suppressing psychotic
symptoms.
Invega Paliperidone Antipsychotic The main active metabolite of
(Atypical) risperidone, paliperidone
selectively blocks serotonin and
dopamine receptors in
mesocortical tract of CNS to
suppress psychotic symptoms.
-To treat Hypersensitivity to • Monitor patients (particularly
schizophrenia quetiapine or its young
-To manage components adults) closely for suicidal
psychotic disorders tendencies
other than •Monitor patient for
schizophrenia orthostatic hypotension
-To treat depressive • Instruct patient to take
episodes in bipolar quetiapine with food to reduce
disorder stomach upset.
-To treat acute manic • Instruct patient to rise slowly
episodes in bipolar from a seated or lying position
I disorder to reduce the risk of dizziness
or fainting.
•Monitor patient, especially
-To treat Concurrent use of other elderly woman, for involuntary
schizophrenia drugs that prolong QT movements
-To treat acute manic interval, history of •Monitor patient’s blood
or mixed episodes of arrhythmia, hypersensitivity glucose and lipid levels
bipolar disorder to ziprasidone or its routinely, as ordered
-As adjunct to lithium components, history of • Instruct patient to take
or valproate for prolonged QT interval, ziprasidone with food to
maintenance recent acute MI, increase absorption.
treatment of bipolar I uncompensated heart • Advise patient to avoid
disorder failure hazardous activities until CNS
effects are known.
AV block, cardiac • Drug shouldn’t be given if
To treat arrhythmias, congenital patient has a condition that
schizophrenia heart disease, history of severely narrows GI tract
congenital long-QT • Instruct patient to take tablet
syndrome; hypersensitivity whole with liquid.
to paliperidone, • Urge patient to rise slowly
risperidone, or its from sitting or lying to
components minimize orthostatic
hypotension.
Abilify Aripiprazole Atypical May produce antipsychotic
antipsychotic effects through partial agonist
and antagonist actions.
Aripiprazole acts as a partial
agonist at dopamine (especially
D2) receptors and serotonin
(especially 5-HT1A) receptors.
-To treat acute Breast-feeding, • Use cautiously in patients
schizophrenia; to hypersensitivity to with CV disease,
maintain stability in aripiprazole or its cerebrovascular disease, or
patients with components conditions that would
schizophrenia predispose them to
-To treat acute manic hypotension.
and mixed episodes • Also use cautiously in elderly
in bipolar I disorder patients because of increased
-To treat agitation in risk of serious adverse
schizophrenia or cerebrovascular effects, such as
bipolar mania stroke and transient ischemic
- To treat irritability attack.
associated with •Monitor patient for difficulty
autistic disorder swallowing or excessive
somnolence
• Advise patient to get up
slowly from a lying or sitting
position during aripiprazole
therapy to minimize orthostatic
hypotension.
• Urge patient to avoid alcohol
during aripiprazole therapy.