Gist of some studies regarding anti-inflammatory properties of Gamma-Oryzanol
S. No. Title / Author / Journal Year
1 Gamma-oryzanol Prevents LPS- 2019
induced Brain Inflammation and
Cognitive Impairment in Adult Mice /
Andrea Mastinu, Sara Anna Bonini,
Wiramon Rungratanawanich,
Francesca Aria, Mariagrazia
Marziano, Giuseppina Maccarinelli,
Giulia Abate, Marika Premoli,
Maurizio Memo, and Daniela Uberti /
2 Nutrientsand
Anti-Inflammatory MDPI
Antioxidative 2017
Stress Effects of Oryzanol in
Glaucomatous Rabbits / Shital S.
Panchal, Rajesh K. Patidar, Abhishek
B. Jha, Ahmed A. Allam, Jamaan
Ajarem and Shital B. Butani1 /
Journal of Ophthalmology
3 2016
Dietary gamma oryzanol plays a
significant role in the anti-
inflammatory activity of rice bran oil
by decreasing pro-inflammatory
mediators secreted by peritoneal
macrophages of rats / Y Poorna
Chandra Rao, D Sugasini, B R Lokesh
/ Biochemical and biophysical
research communications
4 Rice bran prevents high-fat diet- 2015
induced inflammation and macrophage
content in adipose tissue / Maria
Luisa Justo, Carmen Claro,
Maximilian Zeyda, Thomas M Stulnig,
María Dolores Herrera, Rosalía
Rodríguez-Rodríguez / European
Journal of Nutrition
Type of study Findings Link Code
in-vivo The results of this study suggest that chronic https://www.ncbi.nlm. 87
consumption of γ-oryzanol can revert the LPS- nih.gov/pmc/articles/
induced cognitive and memory impairments by PMC6520753/
promoting hippocampal antioxidant and anti-
inflammatory molecular responses.
in-vivo In this study, Oryzanol showed protective effect https://www.hindawi. 84
against glaucoma by its antioxidative stress and com/journals/joph/20
anti-inflammatory property. Treatment with 17/1468716/
oryzanol can reduce optic nerve damage.
in-vivo The results of this study indicated that Gamma https://pubmed.ncbi. 86
Oryzanol supplemented in the dietary oils play a nlm.nih.gov/2769379
significant role in reducing the secretion of pro- 4/
inflammatory mediators by macrophages. Hence
Gamma Oryzanol in RBO significantly
contributed to the anti-inflammatory properties of
RBO.
in-vivo In this study pro-inflammatory biomarkers in https://pubmed.ncbi.
white adipose tissue (WAT) such as IL-6 and IL- nlm.nih.gov/2626693
1β were significantly decreased in high-fat fed 2/
mice treated with rice bran enzymatic extract
(RBEE) containing Gamma Oryzanol. From the
findings of this study, it was concluded that
RBEE containing Gamma Oryzanol may be
considered an alternative nutritional complement
over metabolic syndrome and its complications.
1
5 Antioxidant and anti-inflammatory 2011 in-vitro The results of this study indicate that Gamma https://www.research 83
activities of gamma-oryzanol rich Oryzanol rich extracts from rice bran are acting gate.net/publication/
extracts from Thai purple rice bran / as a lipophilic radical scavenger better than a 271185161_Antioxid
Chalermpong Saenjum, Chaiyavat hydrophilic radical scavenger. Moreover, these ant_and_anti-
Chaiyasut, Sunee Chansakaow, extracts exert a potent anti-inflammatory activity. inflammatory_activiti
Maitree Suttajit and Busaban es_of_gamma-
Sirithunyalug / Journal of Medicinal oryzanol_rich_extrac
Plants Research ts_from_Thai_purple
_rice_bran
6 Anti-inflammatory effects of 2009 in-vivo From the findings of this study it was concluded https://bpspubs.onlin 82
phytosteryl ferulates in colitis induced that phytosteryl ferulates (a component of elibrary.wiley.com/do
by dextran sulphate sodium in mice / Gamma Oryzanol) could be new potential i/full/10.1038/bjp.200
M S Islam T Murata M Fujisawa R therapeutic and/or preventive agents for 8.137
Nagasaka H Ushio A M Bari M gastrointestinal inflammatory diseases. Their
Hori H Ozaki / British Journal of anti-inflammatory effect could be mediated by
Pharmacology inhibition of NF-κB activity, which was at least
partly due to the antioxidant effect of the FA
moiety in the structure of phytosteryl ferulates.
7 Anti-inflammatory effects of γ- 2003 in-vivo In this study γ-oryzanol inhibited the increase in https://www.research
oryzanol /S. Terada and K. Haruta / swelling of the hind paw in a dose dependent gate.net/publication/
Journal of Natural Medicines manner (1-100 mg/kg). These results suggested 286942681_Anti-
that γ-oryzanol had therapeutic potential for inflammatory_effects
inflammatory disease. _of_g-oryzanol