•

forces at Glomerular capillary that favor filtration

renal 1
2
-

Glomerular Blood Hydrostatic Pressure IGBHP) .

.

•
promotes Filtration
-

Capsular Hydrostatic Pressure ( CHD) nprhisi -

ology
•
Opposes Filtration
•
Exerted against filtration by fluid already In the capsular space ( back pressure)
-

Blood colloid osmotic Pressure CBCOP )

•
opposes Filtration
•
Resulting from proteins like albumin , Globulin , ! fibrinogens
0
Net Filtration Pressure INFP)
NFP = ( BHP + I FOP ) -

( BCOP + IF Hp )
& N
Blood Hydrostatic lthterstitlal Blood Interstitial Fluid Hydrostatic Pressure
Pressure Fluid osmotic colloid ( Pushes back to blood )
( promote filtration) pressure osmotic
( Promote Filtration) Pressure
( promote reabsorption)
0 Glomerular filtration Rate (GFR )
Amount of filtrate in all renal corpuscles
-

usually constant ( High =

paid out low not enough Pee 'd out
-

-_
,

Directly related to pressures that determine filtration

0 Auto regulatory control of GFR operates by adjusting ooo

to Flow In ÷ out of Glomerulus

Increase flow → Increase GFR

-

Constrict Afferent Arterial → Decrease blood flow ! vice versa (same for efferent)
2. Change surface Area of Glomerular capillary
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mesang eat cells contract & decrease surface area ( decreasing AFR)

Myogenic Mechanism Of Auto regulation

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Elevates BP
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stretching triggers contraction of smooth muscles

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Narrow lumen
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510W blood flow

Decrease GFR
-

•
TUDUIO glomerular mechanism of autoregulation

macula Densa provides feedback to the Glomerulus

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pet :[OH have less time

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Detect increased delivery of salt 's

.
Chloride ( Happens when GFR Is 9) ( to absorbe- more lost to
-
urine
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Inhibit NO release from juxta lomeruiar cells ( causes vasoconstriction of afferent arteriole )
↳ decreases flow in glomerular us } tr GFR