Supplementary Table 1. Healthy children (control) participants.

Healthy participants Sex Age (years)

Control-1 Female 7
Control-2 Female 5
Control-3 Female 4
Control-4 Female 5
Control-5 Male 6
Control-6 Male 6
Control-7 Female 4
Control-8 Male 8
Control-9 Male 5
Control-10 Male 5
Control-11 Male 5
Control-12 Male 4
Control-13 Male 4
Control-14 Male 9
Control-15 Male 11
Control-16 Female 8
Control-17 Female 13
Control-18 Male 8
Control-19 Male 9
Control-20 Female 7
Control-21 Male 10
Control-22 Male 16
Control-23 Male 11
Control-24 Female 4
Control-25 Male 4
Control-26 Male 6
Control-27 Male 6
Control-28 Male 8
Control-29 Male 6
Control-30 Male 5
Control-31 Female 7
Control-32 Male 11
Control-33 Female 9
Control-34 Male 5
Control-35 Male 4

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Supplementary Table 2. Comparison of altered genera in children with chronic pancreatitis (CCP) and healthy controls*.
Mean, Mean, SD, Q Sum of Difference
Taxon SD, CCP P value
CCP Control Control value the mean of the mean
Genera with decreased abundance
Faecalibacterium 2.4871 9.7585 4.7287 8.8672 3.4800×10-5 0.0026 12.2456 -7.2715
Bifidobacterium 5.3840 10.0047 7.1123 12.8103 2.4146×10-2 0.1725 15.3887 -4.6207
Eubacterium 3.3739 7.3544 4.1660 5.7328 1.2073×10-3 0.0204 10.7283 -3.9805
Subdoligranulum 1.1416 3.5880 2.2064 5.0114 2.7663×10-2 0.1765 4.7296 -2.4464
Collinsella 0.2025 2.6187 0.6074 7.9925 1.0846×10-2 0.0957 2.8212 -2.4162
Phascolarctobacterium 0.1148 2.4935 0.3252 5.4275 2.6990×10-3 0.0311 2.6083 -2.3787
Roseburia 0.2589 2.1652 0.4086 4.2354 8.5700×10-5 0.0032 2.4241 -1.9063
Fusicatenibacter 0.4354 1.9135 0.7744 3.1928 9.4908×10-4 0.0204 2.3489 -1.4780
Lachnospiraceae 0.4011 1.2879 0.8463 1.2412 1.4500×10-5 0.0022 1.6890 -0.8868
Ruminococcaceae 0.6683 1.4619 1.0686 1.5207 1.3451×10-3 0.0204 2.1302 -0.7936
Haemophilus 0.0111 0.7065 0.0414 2.1681 1.3592×10-3 0.0204 0.7176 -0.6953
Ruminiclostridium 0.1274 0.4923 0.2089 1.0900 3.0205×10-4 0.0091 0.6197 -0.3649
Butyricicoccus 0.1394 0.4742 0.2388 0.6313 1.0458×10-3 0.0204 0.6136 -0.3348
Parasutterella 0.0358 0.3088 0.0882 0.5634 1.3122×10-2 0.1093 0.3446 -0.2730
Erysipelotrichaceae 0.3961 0.6228 1.0009 1.1833 9.5988×10-3 0.0900 1.0189 -0.2266
Lachnospira 0.0210 0.1982 0.0640 0.4096 2.0191×10-3 0.0252 0.2193 -0.1772
Flavonifractor 0.0812 0.1971 0.1544 0.3474 2.2666×10-2 0.1700 0.2783 -0.1159
Actinobacillus 0.0000 0.0032 0.0000 0.0166 3.3866×10-2 0.1954 0.0032 -0.0032
Holdemania 0.0119 0.0149 0.0234 0.0177 4.4122×10-2 0.2282 0.0268 -0.0029
Genera with increased abundance
Propionibacterium 0.0017 0.0004 0.0045 0.0010 3.7546×10-2 0.2061 0.0021 0.0013
Rhodococcus 0.0037 0.0005 0.0136 0.0022 7.7516×10-3 0.0775 0.0043 0.0032
Alloprevotella 0.0446 0.0000 0.2374 0.0000 2.8125×10-2 0.1765 0.0446 0.0446
Actinomyces 0.1047 0.0443 0.1329 0.1002 3.8480×10-2 0.2061 0.1490 0.0604
Lactobacillus 1.0049 0.3291 4.3753 1.1732 2.8543×10-2 0.1765 1.3340 0.6759
Enterobacter 4.0078 0.2918 9.7555 0.9109 5.1051×10-3 0.0547 4.2996 3.7161
Streptococcus 7.2529 2.1529 11.8885 5.7888 2.9418×10-2 0.1765 9.4058 5.1000
Klebsiella 8.4189 0.3037 19.1241 0.6210 1.7742×10-3 0.0242 8.7226 8.1152
Enterococcus 10.2050 0.0719 26.3748 0.2289 7.3700×10-5 0.0032 10.2769 10.1331
*, Wilcoxon rank-sum tests with p < 0.05; SD, standard deviation.