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ORIGINAL RESEARCH
INTRODUCTION
ABSTRACT There are relatively few methods of atrophic post-acne scar
revision.
Background: Acne scarring remains a difficult
In simple terms, one may excise the scar when the scar is
problem for patients and physicians. Often it is treated
dystrophic or has a white-scarred base. Common tech-
as a two-dimensional disease with lasers and similar
niques include simple excision and a variety of punch tech-
devices, whereas it is really a three-dimensional
niques such as punch excision, punch grafting and punch
problem. Fillers have been used for many years but
elevation. Alternatively, we attempt to coerce and alter the
recently fillers with more lifting potential have been
body’s healing process to induce collagen formation. Induc-
made available and serve the purpose of the selective
ing collagen formation is a common pathway used by all
elevation of atrophic scars, adding the third dimen-
resurfacing techniques from the most minor home care
sion to treatment.
through to subcision, needling, fractional and non-
Methods: Five patients with atrophic acne scarring
fractional ablative and non-ablative technologies.
were selected in this pilot study. Each patient was
All techniques relying on collagen remodelling have
treated twice with a 3-month follow up from the
several things in common. The degree of collagen remod-
second treatment. A vertical modified tower tech-
elling seems to be proportional to the severity of the injury
nique was used with a hyaluronic acid filler to lift
and the result is hard to judge prospectively. The result is
each scar and support the skin to adopt a more flat-
also delayed and multiple therapies are often required.
tened appearance.
The other underexplored method of scar revision is filling
Results: The mean scar count declined from 48.8 the scar. This method has been employed for over 30 years
scars to 15.4 visible after the second session. The and dates back to collagen injections in the 1980s. However,
mean volume to total correction with filler of all scars the advent of longer lasting hyaluronic acid products with
declined from 1.144 mL to 0.525 mL from the first to more vertical lift characteristics has allowed the authors to
second session. Global subjective improvement was develop a technique that may be expected to vertically
assessed at 5.4 and 5.5 (−3 to +10 scale). The static elevate and improve atrophic scars over 1–2 sessions. It may
objective grading scale showed an improvement from offer the advantages of immediate effect and accuracy of
3.2 at time of first treatment to 3.0 at the second, to 2.6 result that other techniques do not.
at final review.
Conclusions: The relative speed, accuracy and effi-
cacy of high lift hyaluronic acid is shown in this METHODS
small case series with subjective and objective Five patients with atrophic acne scarring on the face, aged
measurement. 19–40 were enrolled in this proof of concept study. All the
patients’ atrophic acne scarring types, which included
Key words: acne scarring, acne, dermal filler, filler,
rolling-type, boxcar, broad atrophic areas and ice-pick
hyaluronic acid, post-acne scarring, tower tech-
scars, were deemed appropriate for treatment with dermal
nique, Voluma.
fillers. Fitzpatrick skin types ranged from I to IV, but higher
skin types were not excluded. Patients were excluded from
the study if they had had treatment with fillers in the pre-
vious 2 years, any resurfacing procedures, isotretinoin
therapy in the previous 6 months or any active acne. The
Correspondence: Professor Greg J Goodman, 8–10 Howitt Street,
following case reflects the treatment, assessment and
South Yarra, Melbourne, Vic 3141, Australia. Email: gg@div.net.au
Greg J Goodman, FACD. Amanda Van Den Broek MBBS. recording methods used for all five patients.
Conflict of interest: none Materials and methods are illustrated using one of the
Submitted 16 June 2015; accepted 30 July 2015. cases studied. A representative case is of a 39-year-old
Table 1 Mean atrophic scar count in and following treatment Table 3 Mean patient global assessment 1 and 3 months following
sessions treatment
Reduction
between several times 3–4 mm apart to create a network of columns
Treatment 1 Treatment 2 treatments
to support the deficit. Areas were massaged as required to
1.144 0.525 0.619 flatten the filler and ensure the correct placement. In the
first treatment a total of 1.05 mL of filler was required to
This reflects indirectly the volume of scarring requiring
treatment.
restore volume to the atrophic scars, 0.55 mL in the right
side and 0.5 mL in the left side.
This process was repeated 2 weeks later for the second
woman who presented for treatment of moderately severe treatment. Both the patient and assessor again determined
facial atrophic acne previously treated with full facial abla- the acne grading to be 3 (scarring visible at conversational
tive carbon dioxide and erbium laser with punch grafting distance but able to be stretched flat manually), with an
and two fractional carbon dioxide treatments, the previous atrophic scar count of 53. 0.8 mL of filler was required to
3 years before this study commenced. The patient had mul- correct the volume deficit of the atrophic scarring, 0.45 mL
tiple rolling-type, small and large boxcar, punched-out ice- in the right side and 0.35 mL in the left.
pick and broad atrophic scars over the forehead, cheeks, One month after the two treatments the patient’s atrophic
and chin which were clearly visible from a social distance scar count was reviewed and she was asked to re-grade her
and not concealable with make-up. skin and assess the global improvement using a scale
Preceding the first treatment the patient and a non- ranging from negative 3 to 10. The total number of atrophic
injecting assessor both graded the acne using the qualita- scars correctable with filler injection had reduced to 10 and
tive grading scale described by Goodman and colleagues.1 the patient reported a global improvement of 8. Both patient
Both the patient and non-injecting assessor graded them as and assessor again recorded an acne grading of 3 (Table 3).
grade 3, moderately atrophic acne (scars visible at a con- Three months following the two treatments the patient
versational distance to others but able to be manually was again required to globally assess the improvement in
stretched flat). Each atrophic scar was then marked and the appearance of her acne scars. At this appointment the
counted by the injector, totalling 58 scars requiring a filler patient recorded a global improvement of 6 – good to excel-
injection (Tables 1,2). lent improvement (Figs 1,2).
Topical lidocaine ointment (Compounded 10% xylocaine,
Compoundia Pharmacies, Melbourne, Victoria, Australia)
RESULTS
was applied to the involved area for 30 min. The area was
then cleansed with 0.1% chlorhexidine solution. Each Other patients in this study showed similar results to our
marked scar was then injected with hyaluronic acid filler, index case (Tables 1–4). Among all the patients the mean
Juvederm Voluma (20 mg/mL, Allergan Australia, Sydney scar count dropped from 48.8 on the first injection to 41.8
New South Wales, Australia) via insulin syringes with a two weeks later, to 15.4 after two injection sessions
swaged 31-gauge needle using a modification of the tower (Table 1). This relates to the volume used at each injection
technique. The hyaluronic acid was placed in the BD Ultra- session with 1.144 mL used on the first and under half of
fine 11 short needle insulin syringe (Becton Dickinson, that (0.525 mL) being necessary at the next session
Sydne New South Wales, Australia) by injecting into the (Table 2). Although the scars were still visible at the second
back end after temporarily removing the injecting stem, treatment session, they were less deep and required less
utilising the technique popularised in Australia by Lim.2 product for treatment. This second session appeared to
This technique optimises injecting control for this thick further address the volume and the number of the residual
form of hyaluronic acid. The injector positioned the needle scars. Fewer than 30% of the scars were still visible after
at 90° through each scar into the deep dermis, injecting these two injection sessions on review 1 month after these
0.02–0.04 mL of product with a gradual tapering retrograde two sessions. The degree of improvement (Table 3) accord-
deposition as the needle was withdrawn. This created an ing to patient global improvement was assessed at +5.4, 1
inverted pyramid-like ‘pillar of filter’, starting deeply in the month after two injection sessions on an indicator ruler (−3
scar with gradually more product deposited as one to +10). This was maintained at the 3-month review post-
approaches the skin surface, acting as a support to each injections (+5.5), indicating good to excellent improvement
layer of the deficit. Broader atrophic scars were injected from the patients’ perspective.
Table 4 Change in grading scale with filler treatments (mean The use of dermal fillers in atrophic acne scaring was first
results) described in 19804 and is accepted as an effective treatment
for rolling, dish and boxcar acne scars, whether used inde-
At 2 weeks,
at the time At 1 month, pendently or in conjunction with other treatments. Its
First of second after two success in the treatment of ice-pick type scars has been
treatment treatment treatments described only once, showing a mild improvement with
Dermicol-p35 (Evolence; Ortho Dermatologics, Skillman,
Patient determined 3.2 3 2.6
qualitative acne grade NJ, USA) a porcine collagen preparation.5 Generally, results
Assessor determined 3 2.6 2.4 with this scar type are best considered to be variable.
qualitative acne grade Dermal and subcutaneous filling for scars is an attractive
choice for both physicians and patients as it offers a simple
Grade 1, macular scarring, Grade 2, scarring present at less than
conversational distance eg in a mirror, Grade 3, scarring present at
and accurate non-surgical correction of atrophic scars that
conversational distance but may be stretched flat, Grade 4, scarring produces immediate improvements. Fillers raise the scar
at conversational distance that cannot be flattened by stretching; for deficit to the level of the surrounding skin thereby working
example, ice-pick scars. to even out skin texture and enhance overall contour.
Numerous types of fillers have been explored for their use
in acne scar treatment. The ideal filler would be one that is
Table 4 shows a commensurate decrease in the grading easy to inject, minimally painful, producing immediate and
scale according to the patient from 3.2 pretreatment, to 3 at long-lasting results and with few side-effects. Unfortu-
the time of the second treatment and 2.6 on final grading 1 nately, immunogenicity and sensitivity and a short duration
month after the two treatments. This is similar to the non- of effect has plagued the use of earlier fillers, in particular
treating investigator assessment (Table 4). those derived from animal collagen.
The use of permanent fillers such as liquid silicon and
later acrylate-based fillers, while producing a permanent
DISCUSSION
result, should be used cautiously due to the ongoing tissue
Acne scarring is a common and persistent complication of loss that will inevitably occur with ageing.6 Any inaccuracy
acne vulgaris affecting a large proportion of the population. of implantation will permanently annoy patient and physi-
Despite its high prevalence there is no single treatment cian alike. The persistence of volume in these fillers relative
modality that has been shown to be universally effective, to natural ongoing losses can cause an undesirable aes-
posing a significant challenge for the treating physician. thetic for patients despite earlier success. Achieving an
Due to the distressing nature of the condition and its psy- optimal result with these products is also often a slow and
chological impact on patients, a quick result is often sought. lengthy process. Multiple injections of small amounts over
Few of the treatments available can produce immediate several months are required to avoid under-correction or
results; however, the use of dermal filler injections has over-correction.7 However, complications with permanent-
been shown to improve the skin contour following the based fillers may become a long-term issue for both the
procedure.3 patient and their treating physician.
correction. After the second injection the number of appar- 4. Stegman SJ, Tromovitch TA. Implantation of collagen for
ent scars was markedly decreased (68%) from the initial depressed scars. J. Dermatol. Surg. Oncol. 1980; 6: 450–3.
count. This was the parameter most noticeable to the 5. Smith KC. Repair of acne scars with dermicol-P35. Aesthet.
Surg. J. 2009; 29 (3 Suppl.): S16–8.
patient and appears to explain the non-linearity of the
6. Epstein RE, Spencer JM. Correction of atrophic scars with
result. It also might explain the slight discrepancy between artefill: an open-label pilot study. J. Drugs Dermatol. 2010; 9:
the investigator and subject evaluation of the global severity 1062–4.
at the time of the second treatment. The evaluator may have 7. Barnett JG, Barnett CR. Treatment of acne scars with liquid
been more objectively been able to assess both volume and silicone injections: a 30-year perspective. Dermatol. Surg.
number than the patient, who may have been more con- 2005; 31: 1542–9.
8. Fife D. Practical evaluation and management of atrophic acne
cerned that the scars were still individually visible.
scars: tips for the general dermatologist. J. Clin. Aesthet.
Dermatol. 2011; 4: 50–7.
9. Hasson A, Romero WA. Treatment of facial atrophic scars with
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