BGS ISBT Antigens Antibodies Type of Ig Effect of Enzymes Associated Diseases

Anti – A, Anti – B, Anti –

ABO 001 A, B, H IgM Enhance activity Transfusion reactions (HTR)
AB, Anti – H, Anti – A1
IgM:
Anti – M
(rarely IgG) Anti – Su, Anti - Ena, Anti S and s: HTR
M, N, S, s Anti – N and HDN
Anti – M, Anti – N, Anti –
MNS 002 Others: Destroy antigens Anti – N: dialysis patients
S, Anti – s
U (Su), Ena, Mk IgG: GPAM: E. coli
Anti – S GPA and GPB: P. falciparum
Anti – s
Anti - Su
Anti – P1: Parasitic infections (Hydatid
IgM: disease, Clonorchis sinensis,
Anti – P1 Anti – P1, Opistorchis viverrini)
P, P1, Pk Anti – PP1Pk (anti-Tja), Alloanti-P Anti – Tja: HDN, HTR, abortion
P1PK 003 Later: Luke (LKE), PX2, Alloanti – P Enhance activity Alloanti-P: habitual early abortion
NOR Autoanti-P (Donath IgG Autoanti-P: Paroxysmal Cold
Landsteiner Ab) Anti-Tja, Hemoglobinuria
Autoanti – P LKE Ag: renal cell CA and Hodgkin’s
Lymphoma
Anti – D, Anti – C, Anti –
Rh 004 D, C, E, c, e E, Anti – c, Anti – e, Anti – IgG Enhance activity HTR, HDFN
G, … (compound Ab)
IgM
Anti – Lua
Anti – Lua, Anti – Lub (rarely IgG) Resistant to
Lutheran 005 Lua, Lub Mild cases of HDN
Anti – Lu3 (rare) enzyme treatment
IgG
Anti - Lub
Destroyed by Anti – K: Fetal anemia, HTR, HDN
K, k, Kpa, Kpb, Kpc, Jsa,
Kell 006 Anti – K IgG trypsin + X Kx: McLeod phenotype and
Js, Kx
chymotrypsin syndrome
Lea, Leb, Leab, LebH, Leb – Helicobacter pylori
Lewis (LE) 007 Anti – Lea, Anti – Leb IgM Enhance activity
ALeb, BLeb Le (a-b-) – prone to CAD
Anti – Fya & Anti - Fyb: Acute and
Fya, Fyb Anti – Fya, Anti – Fyb, Anti delayed HTR
Duffy 008 IgG Destroy antigens
Others: Fy3, Fy5 – Fy3, Anti – Fy5 Fy(a-b-): resistant to malaria
(P. knowlesi/ P. vivax)
Anti – Jka, Anti – Jkb, HTR (A-Jk3: severe, delayed)
Kidd 009 Jka. Jkb, Jk3 IgG Enhance activity
Anti – Jk3 HDFN (mild to severe)
Autoanti – I, Anti – I, Anti-I: Cold Agglutinin Disease
Anti – i, Anti – IT IgG anti – i: HDN
I 027 I, i, IT IgM Enhance activity
Anti – i: Infectious Mononucleosis and
lymphoproliferative disorders