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Diabetes Drugs
QUESTIONS
1. After the discovery of insulin all of the following happened except

a) deaths among diabetic patients reduced slightly.

b) diabetic patients were able to control their blood sugar levels.
c) diabetes was found to have long-term effects on surviving patients.
d) diabetic peripheral neuropathy was revealed as a problem.

2. As a result of peripheral neuropathy

a) Wyeth was asked to research into a drug to cure it.

b) diabetics feel no pain in their limbs.
c) diabetics are particularly affected in lower limbs.
d) half the diabetics in the US need to have a limb amputated.

3. Researchers disagree

a) that high levels of sorbitol in the blood cells are connected with damage to
nervous tissue.
b) that diabetics have high levels of sorbitol in their blood cells.
c) how high levels of sorbitol in the blood and nerve cells cause damage.
d) hew sorbitol is produced in the red blood cells.

4. Studies on rats show that

a) sorbitol levels should be lowered in humans too.

b) sorbitol behaves differently from glucose.
c) sorbitol causes damage to the nervous tissue in humans in the same way.
d) tolrestat would be a suitable drug to use.

5. Clinical trials of sorbinil were

a) successful in 3.8% of patients.

b) carried out by Crabbe.
c) promising in some cases.
d) all of the above.

6. Tolrestat has been licensed in Ireland

a) as a result of clinical trials by Wyeth.

b) because it contains a ‘novel ingredient’.
c) because the NDAB wanted to be the first in the world with the drug.
d) because other countries were unwilling to take the risk.

7. From last month tolrestat may be used by

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a) general practitioners in Ireland.

b) hospitals in Ireland.
c) patients in Britain and Italy.
d) Wyeth-Ayerst in Philadelphia.

8. Raskin found that the level of sorbitol in red blood cells fell

a) in 57 per cent of diabetic patients.

b) in diabetic patients taking 100 milligrams of tolrestat daily.
c) in 23 per cent of diabetic patients taking tolrestat twice daily.
d) by an average of 57 per cent in 23 diabetic patients taking tolrestat.

9. Which statement is not true regarding the side effects of tolrestat

a) They have not yet been found to be serious.

b) All patients experienced side effects, even if minor.
c) Levels of liver enzymes went up in a small number of patients.
d) Some patients experienced dizziness.

10. Crabbe feels that, as far as diabetic peripheral neuropathy is concerned,

a) patients must be discouraged from using tolrestat.

b) the monitoring programme will give useful information.
c) more proof is needed that sorbitol levels need reducing.
d) none of the above.

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