Name of the Drug Dosage Indication and Mechanism of Contraindication Adverse Effects Nursing Responsbilities

Action
Generic Name: Dosage: Indication: Hepatic impairment- Constipation 1. Check baseline vital signs
Tocilizumab 400mg/20ml solution -Tocilizumab is indicated to not recommended with Anxiety such as temperature,
treat moderate to severe active hepatic disease or Diarrhea pulse rate, respiratory
rheumatoid arthritis, giant cell if baseline AST/ALT is Insomnia rate, blood pressure, and
arteritis, polyarticular juvenile more than 1.5 times the Hypertension oxygen saturation.
Brand Name: Route: idiopathic arthritis, and upper limit of normal. Nausea 2. Review patient’s
Actemra Intravenous cytokine release syndrome. Increased levels of liver laboratory results such as
Drug-to-Drug Interaction enzymes. ALT/AST, Creatnine, and
Mechanism of Action: - Acetaminophen- etc.
-Inteluekin 6(IL-6) is an the metabolism 3. Ask patient for history of
Classification: Frequency: inflammatory cytokine of known hypersensitivity
Interleukin-6 blockers STAT produced by cells including T- acetaminophen reactions of the drug
cells, B-cells, lymphocytes, can be increased components.
monocytes and fibroblasts. IL- when combined 4. Monitor patient for
6 rapidly induces C-reactive with the drug. possible adverse effects.
protein, serum amyloid A, - Acyclovir- the
fibrinogen, albumin, and metabolism of
transferrin while inhibiting Acyclovir can be
production of fibroectin, increased when
albumin, transferrin. It also combined with
induces antibody production, the drug.
induces cytotoxic T-cell - Acetylsalicylic
differentiation. Lastly, it binds acid- the
soluble and membrane bound metabolism of
IL-6 receptors , preventing IL- Acyclovir can be
6 mediated inflammation. increased when
combined with
the drug.