DRUG STUDY

(CELECOXIB)

Princess Brigitte R. Pateña

BSN – 3F
 Celecoxib 01
TABLE OF
CONTENTS
BIOGRAPHICAL DATA
PATIENT’S DATA

NAME: S. D. P. SEX: F AGE: 50 ROOM NO.: 0001

CHIEF COMPLAINTS: Loss of consciousness

DIAGNOSIS: Mild head injury secondary to mauling

VITAL SIGNS: T= 37.2 ˚C, P= 60 bpm, R= 22bpm, BP= 120/70 mmHg

MEDICATION:
Celecoxib 400mg/cap 1 cap at bedtime PTOR
 CELECOXIB

Generic name Classification Action

Celecoxib Pharmacologic: Thought to inhibit

Cyclooxgenase-2 prostaglandin
Brand Name inhibitors synthesis, impeding
cyclooxygenase-2, to
CeleBREX Therapeutic: produce anti-
NSAIDs inflammatory,
analgesic and
antipyretic effects.
 INDICATIONS AND DOSAGES
Celecoxib 400mg/cap 1 cap at bedtime PTOR
Osteoarthritis
Rheumatoid arthritis
Ankylosing spondylitis
Acute pain, including dysmenorrhea
Adults: 200 mg once daily or 100 mg
twice daily.  
Adults: 100–200 mg twice daily. 
Adults: 200 mg once daily or 100 mg
twice daily; may ↑ dose after 6 wk to
400 mg daily.  
Adults: 400 mg initially, then a 200-
mg dose if needed on the first day;
then 200 mg twice daily as needed.
NSAIDs have been shown to
reduce VAS scores and reduce
opioid requirements by 20-30% in
some studies. Celecoxib differs
from other NSAIDs in that it causes
less inflammation and ulceration in
the stomach and intestine and does
not interfere with the clotting of
blood.

SIDE EFFECTS
dizziness, headache, insomnia, rash , edema,
hypertension, hyperkalemia, abdominal pain,
diarrhea, dyspepsia, flatulence, nausea
ADVERSE EFFECTS
HF, Myocardial
Infarction, Stroke, Thrombosis,
 Exfoliative Dermatitis, Stevens-
Johnson Syndrome, Toxic Epidermal
Necrolysis, GI Bleeding
 CONTRAINDICATIONS
● Hypersensitivity;
● Cross-sensitivity may exist with other NSAIDs, including aspirin;
● History of allergic-type reactions to sulfonamides;
● History of asthma, urticaria, or allergic-type reactions to aspirin or other NSAIDs,
including the aspirin triad (asthma, nasal polyps, and severe hypersensitivity
reactions to aspirin);
● Advanced renal disease;
● Severe hepatic dysfunction;
● Coronary artery bypass graft (CABG) surgery;
● OB:  Should not be used in late pregnancy (may cause premature closure of the
ductus arteriosus).
NURSING RESPONSIBILITY
Assessment
• History: Renal impairment, impaired hearing, allergies, hepatic and CV
conditions, lactation, pregnancy
• Physical: Skin color and lesions; orientation, reflexes, ophthalmologic
and audiometric evaluation, peripheral sensation; P, edema; R,
adventitious sounds; liver evaluation; CBC, LFTs, renal function tests;
serum electrolytes

Interventions
• BLACK BOX WARNING: Be aware that patient may be at increased
risk for CV events, GI bleeding; monitor accordingly.
• Administer drug with food or after meals if GI upset occurs.
• Establish safety measures if CNS, visual disturbances occur.
• Arrange for periodic ophthalmologic examination during long-term
therapy.
• WARNING: If overdose occurs, institute emergency procedures—
gastric lavage, induction of emesis, supportive therapy.
• Provide further comfort measures to reduce pain (eg, positioning,
environmental control) and to reduce inflammation (eg, warmth,
positioning, and rest).
PATIENT EDUCATION
• Instruct patient to take celecoxib exactly
as directed. Do not take more than
prescribed dose.
• Take drug with food or meals if GI upset
occurs.
• Advise patient to notify health care
professional promptly if signs or
symptoms of GI toxicity (abdominal pain,
black stools),
• May cause hypertension. Instruct patient
in correct technique for monitoring BP
and to notify health care professional if
significant changes occur.
• Advise patient to notify health care
professional if pregnancy is planned or
suspected or if breast feeding. Avoid
celecoxib after 30 weeks of gestation.
REFERENCES
Thornton, P. (2020). Celecoxib. Retrieved November 2, 2020, from
https://www.drugs.com/celecoxib.html#moreResources

Unbound Medicine (2020). Celecoxib. Retrieved November 2, 2020, from

https://nursing.unboundmedicine.com/nursingcentral/view/Davis-DrugGuide/51136/all/celecoxib#11

Nursing Drug Guide (2020). Nursing 2020 Drug Handbook. Philadelphia: Wolters Kluwer Health
THAN
K