Mindanao State University – Iligan Institute of Technology Student: JOHN PEARL A.

FERNANDEZ Block: CCC

COLLEGE OF NURSING MARIA ANTOINETTE SICLOT

PHARMACOLOGICAL MANAGEMENT

DRUG STUDY

Brand Name: NORVASC Generic Name AMLODIPINE Drug Classification: CALCIUM CHANNEL BLOCKER

Dosage, Route & Frequency Drug-Drug & Drug-Food Side Effects Adverse Reactions
Drug Action Indications Contraindications
Recommended Prescribed Interactions (By System) (By System)

Adult: PO 5–10 5 mg 1 tab Amlodipine is a calcium Drug: Adenosine may Treatment of Hypersensitivity to CV: palpitations, CV: peripheral or
mg once daily pc supper channel blocking agent that increase the risk of mild to amlodipine; flushing, tachycardia, facial edema
selectively blocks calcium ion bradycardia; bosentan may moderate pregnancy (category bradycardia, chest
reflux across cell membranes of decrease efficacy of hypertension C). pain, syncope, GI: dyspepsia,
cardiac and vascular smooth amlodipine; additive and angina. postural hypotension dysphagia
muscle without changing serum hypotensive effects with
CNS: light- UG: sexual
calcium concentrations. It other ANTIHYPERTENSIVE
headedness, fatigue, dysfunction
predominantly acts on the AGENTS; AZOLE
peripheral circulation, ANTIFUNGALS (e.g., flucona headache
RESPI: dyspnea
decreasing peripheral vascular zole, itraconazole) may inhibit
GI: abdominal pain,
resistance, and increases metabolism of
nausea, anorexia,
cardiac output. amlodipine; itraconazole may
constipation, diarrhea,
increase
Absorption: >90% absorbed flatulence, vomiting
edema. Food: Grapefruit
from GI tract.  juice may increase amlodipine UG: nocturia
levels. Herbal: Ephedra, Ma
Onset: Gradual. 
Huang, melatonin may SKIN: flushing, rash
Peak: 6–9 h.  antagonize antihypertensive
effects. OTHER: cramps,
Duration: 24 h.  myalgia

Distribution: >95% protein
bound. 

Patient’s Name / Room No. | 1

 Metabolism: Extensively
metabolized in the liver to
inactive metabolites. 

Elimination: Inactive
metabolites primarily excreted
in urine (<5–10% excreted
unchanged), 20–25% excreted
in feces. 

Half-Life: <45 y: 28–69 h; >60

y: 40–120 h.

Responsibilities in the Nursing Process (ADPIE) Responsibilities in the Nursing Process (ADPIE)

A: Obtain a drug and herbal history from patient of current drugs taken. Report if drug-drug or drug-
herbal interaction is probable. Obtain baseline vital signs for future comparisons. Check laboratory
values for serum protein, albumin, blood urea nitrogen (BUN), creatinine, potassium, and white blood
cell count, and compare with future serum levels.
D: Deficient knowledge related to drug regimen
P: Patient’s blood pressure will be within desired range.
I: Monitor blood pressure. A sudden drop in blood pressure should be reported. Monitor
laboratory tests related to renal function (BUN, creatinine, protein) and blood glucose
levels. Do not confuse amlodipine with amiloride. Do not confuse Norvasc with Navane.
PO:May be administered without regard to meals. Advice patient to take medication as
directed, even if feeling well. Take missed doses as soon as possible unless almost time
for next dose; do not double doses. May need to be discontinued gradually. Advise patient
to avoid large amounts (6– 8 glasses of grapefruit juice/day) during therapy
E: Evaluate effectiveness of drug therapy (absence of severe side effects, blood pressure
return to desired range). Evaluate patient’s renal function.

Patient’s Name / Room No. | 2