68

Ge/68Ga generator
Datasheet

68
Ge/68Ga generator (half-life: 270 days) provides an
excellent source for the positron-emitting radionuclide
68
Application Ga (half-life: 68 min). 68Ga is mainly used for
radiolabelling peptides which is used chiefly in nuclear
medicine oncology for diagnostic applications

Manufacture of parent radionuclide (68Ge) Accelerator , 69Ga(p,2n)68Ge

Modified tin dioxide in a polyethylene column with
Column material /packing
polyethylene tubing with no metal parts
Eluting Medium 0.6M HCl (suprapure)
68
Ga yield in 6 ml of eluate not less than 100% at calibration time
68
Ge breakthrough ~ 0.001% at calibration time
68
Ge/68Ga generators are produced in quantities of: 10 mCi, 20 mCi, 30 mCi, 40 mCi or 50 mCi

Dimensions: diameter 127 mm and height 180 mm

Dimensions of generator
Weight: 26 kg
Upon receiving the generator, connect the in-line
(clearly marked) of the generator to your 6 ml syringe
and flush the system with 0.6 M HCl suprapure solution
(5-10 ml).

After 4-5 hours, determination of void volume:

Elute the column collecting 0.5ml fractions and
measure each fraction for 68Ga. See example of a
Fractionated Elution Procedure typical elution curve of the Breeman et. al. system,
below.

The fractions with the highest 68Ga specific activity are

generally used for labelling purposes.

After elution, wash the system with 6 ml suprapure

0.6M HCl. Ensure that both the “in” and “out” lines are
filled.

References
W.A.P. Breeman, M. de Jong, E. de Blois, B.F. Bernard, M. Konijnenberg, E.P. Krenning.
Radiolabelling DOTA-peptides with 68Ga, Eur. J Nuc Med and Molec Imag, 2005

E de Blois, H Sze Chan, C Naidoo, D Prince, E.P. Krenning, W.A.P. Breeman.

Characteristics of SnO2-based (68)Ge/(68)Ga generator and aspects of radiolabelling DOTA-peptides.
Appl. Radiat. Isot. 2011
 Specifications Sheet

Produced under cGMP approved facility YES

Eluent (5 ml) 0.6 M HCl (suprupure)

Yield, Ga-68 Not less than 100% on calibration date

Breakthrough, Ge-68 ~0.001% on calibration date

Metal Impurities (Ga, Ge, Zn, Ti, Sn, Fe, Al and Cu) <10 ppm

Endotoxins in eluate <175 EU/ml

Sterility of eluate Sterile

Size: diameter and height 127 mm and 180mm

Weight 26 kg

Shielding Lead

Surface dose (50 mCi)

Tin dioxide (modified) in a polyethylene
Column material column with no metal parts

Production of Ge-68 Ga-69 (p,2n) Ge-68

Half-life: Ge-68 270 days

Half-life: Ga-68 68 mins

Activities of generator 10, 20, 30, 40 or 50 mCi

Recommended shelf-life 9 months from calibration date

Do not disassemble the generator Warranty loss