waktu Cp Ln Cp A*e^-kt R=A*e^-kt.

Cp Ln R
1 3.13 1.141 10.803 7.673 2.038
2 4.93 1.595 9.814 4.884 1.586
3 5.86 1.768 8.915 3.055 1.117
4 6.25 1.833 8.099 1.849 0.615
5 6.28 1.837 7.358 1.078 0.075
6 6.11 1.810      
7 5.81 1.760      
8 5.45 1.696      
9 5.06 1.621      
10 4.66 1.539      
12 3.9 1.361      
14 3.24 1.176      
16 2.67 0.982      
18 2.19 0.784      
24 1.2 0.182      
28 0.81 -0.211      
32 0.54 -0.616      
36 0.36 -1.022      

Diketahui:
a) Kel : 0.096 menit-1
b) A : 11.891
c) Kabs : 0.4897 menit-1
d) A : 12.871
e) Persamaan akhir :Cp : 0.4893 (e-0.096 t) – (e-0.4897t)
Ditanyakan:
a) T ½ =….?
b) Vd =….?
c) Clearance =….?
d) AUC =….?
Penyelesaian:
a) T ½
0.983 0.983
T ½absorbansi = = = 2.007 menit
K absorbansi 0.4897
0.983 0.983
T ½eliminasi = = = 10.239 menit
K eliminasi 0.096
 Ka
b) Vd = dosis x x (Kabsorbansi – K eliminasi)
A
0.4897
= 80 x x (0.4897 – 0.096)
11.891
= 80 x 0.0411 x 0.3937
= 1.2944
c) Clearance = K el X Vd
= 0.096 x 1,294 = 0,124
1 1
d) AUC = A x ( − ¿
K eliminasi K absorbansi
1 1
= 11.891 x ( − ¿
0.096 0.4897
= 11.891 x 8.37
= 99.527

KURVA ASPIRIN
7

6
f(x) = − 0.18 x + 6.1
5 R² = 0.79

0
0 5 10 15 20 25 30 35 40
 Eliminasi
2.000
f(x) = − 0.1 x + 2.48
1.500 R² = 1

1.000

0.500

0.000
0 5 10 15 20 25 30 35 40
-0.500

-1.000

-1.500

Absorbsi
2.500

2.000 f(x) = − 0.49 x + 2.55

R² = 1

1.500

1.000

0.500

0.000
0.5 1 1.5 2 2.5 3 3.5 4 4.5 5 5.5