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1. Astonishing hypothesis
So here's where things begin for real.
I want to welcome people to the course and I want to welcome people
to the first
series of lectures, which is on the brain, on neuroscience.
And I want to begin this series of lectures and
the course itself, with a story about a man named Phineas Gage, and
an event that happened to Gage in the summer of 1848 in Cavendish,
Vermont.
Play video starting at ::24 and follow transcript0:24
So Gage was a blasting foreman working on a railway construction
project and
his job, at that time, was to clear away rock so that they could lay
down tracks.
And to do so, his routine during those days,
was that he would bore a hole in the rocks.
Inside the hole, he put blasting powder and a fuse in.
Then he would cover that up with dirt and sand and
take a tamping iron, which he carried with him.
A big piece of steel, looked like a javelin and
use it to tamp down the sand and
dirt, so that later they could set the fuse and cause the explosions.
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Well one day, something didn't work.
Nobody's exactly sure why, maybe he just forgot to put in the sand
and the dirt.
But regardless, he put the tamping iron into the hole, the powder
exploded.
[SOUND] The tamping iron shot away from his hand and went into his
face.
It entered the left side of Gage's jaw, moving in an upward direction,
it passed behind the left eye through the left side of the brain and
it went out the top of his skull and landed several feet away of the
clutter.
Now miraculously Gage wasn't killed on the spot.
He lost consciousness for a little bit, but then he staggered to his feet.
Play video starting at :1:45 and follow transcript1:45
And in some regards, Gage was very lucky.
So he underwent a series of operations, he had infections, he got
sick.
At times, his life was at risk.
But months later, he was, in certain regards, pretty much recovered.
He was able to see,
he wasn't deaf, he wasn't paralyzed, he didn't lose the ability to speak
or
understand language, he didn't lose his intellectual capacities in any
simple way.
Play video starting at :2:14 and follow transcript2:14
But in another sense Gage was very unlucky
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because Gage has been transformed by this incident.
Someone who knew Gage describes the transformation like this.
Before the accident Gage was, quote the most efficient and capable
man, a man of
temperate habits, considerable energy of character, a sharp shrewd
businessman.
Play video starting at :2:36 and follow transcript2:36
After the accident, Gage was no longer Gage.
He was fitful, irreverent, indulging at times in the grossest profanity
manifesting but little deference for his fellows.
He ended up losing his job.
He traveled through the states taking up different jobs,
engaging in different relationships.
And ultimately ended up in an exhibit in a travelling circus,
holding a tamping iron and telling people about this terrible story
about how it
went through his head and went through his brain, and changed his
life.
Play video starting at :3:9 and follow transcript3:09
So, why am I telling you this story?
Well, as I said, I want to begin the course by talking about the brain.
And the story of Phineas Gage illustrates something which we have
abundant reason to
believe, which is that the brain is the source of mental life.
And so damage to the brain can have profound effects on
who we are and what we are.
Play video starting at :3:31 and follow transcript3:31
An idea here is nicely summarized by the Nobel prize winning
biologist Francis Crick, he calls it the Astonishing Hypothesis.
As he writes, the Astonishing Hypothesis is that You, your joys and
your sorrows,
your memories and your ambitions, your sense of personal identity
and free will,
are in fact no more than the behavior of a vast assembly of nerve
cells and
their associated molecules.
Play video starting at :3:57 and follow transcript3:57
Now this assembly of nerve cells is of course the brain, the brain and
parts of the spinal cord, but we're going to talk about the brain here.
Play video starting at :4:5 and follow transcript4:05
An the idea then, as sometimes people like to put it the mind is the
brain or
that the mind is what the brain does or the mental life emerges from
the brain.
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The official term for this is materialism that we are material beings.
Everybody accepts that our arms and legs and our heart and
kidneys are made of the same sort of stuff as rabbits and automobiles
and cups.
But the idea is that our mental life, what makes us special,
our most intimate feelings and thoughts also arise from these material
things.
And this the idea that makes possible the discipline of neuroscience
and
much of psychology.
2. dualism
We're talking about materialism,
the idea that our mental life emerges from our physical brain.
If you're listening closely,
if you're thinking about this,
I hope you acknowledged that this is an odd and unnatural
view.
I don't expect you to believe it,
at least not at first.
And in fact, for the most part,
people are far more attracted to the doctrine called "Dualism."
Dualism is an idea that's been found in just about every religion
and every philosophy.
It's made explicit in Plato, for instance.
But I think the most thoughtful and articulate defender
of dualism was the philosopher, Rene Descartes.
Descartes believed that animals were material things.
He thought that the doctrine of materialism was correct about
non-human animals.
"But humans are different," Descartes argued.
For humans, there's a duality.
We possess two sorts of things.
We are composed of two sorts of things.
We are in part material,
but we're also in part spiritual, separate, mental, psychological.
In some way that doesn't reduce to the material.
He made two arguments for this,
and they're both reasonably good arguments,
at least quite persuasive at his time,
and have persuaded many people and continue to persuade
many people.
The first arguments for
a non-material nature is that humans are capable of doing
things that no machine,
no material entity ever could.
So, it might surprise you to hear this,
but Descartes in the 17th century was familiar with robots.
He knew about the French Royal Gardens,
which is like a 17th century Disneyland or Euro Disney,
which had robots that react when you approach them or when
you step on certain stones.
For instance, you might approach Diana,
and then Neptune would jump out from the bushes holding a
trident.
This was done not of electricity, but with water.
So, Descartes knew about these robots,
and Descartes asked, "Well,
maybe we're such things,
maybe we're just machines responding to the environment."
And he said that we can't be.
He said maybe animals,
non-human animals can be,
but human behavior is far more complicated,
and variegated, and subtle to be explained in such simple
ways.
We'll return to this point later on in the course when we talk
about
Noam Chomsky and Noam Chomsky's critique of behaviorism,
which argued that basically humans respond
in a relatively reflexive way to environmental stimuli.
Descartes along with Chomsky said, "That can't be.
Our behavior's far too complicated for that.
So, we can't be machines."
His second argument is probably better now,
and it's based on intuition.
And his claim was we don't feel like bodies.
So, to put it more technically,
he applied what was called a method of doubt.
He asked the question,
"What do we know for sure,
and what can we question?"
So, for instance, you might believe you were born in such and
so place.
You could be wrong.
You could be deceived.
You might believe that the Earth is thousands or millions of
years old.
But maybe the Earth was created 100 years ago and
all the memories that your grandparents have of the past were
just manufactured.
You might believe, said Descartes,
that you live in a world of things,
that you're sitting on a chair or there's a wall in
front of you or there's a computer near your hands.
But Descartes observe that we often believe
such things when we're in dreams, but weren't mistaken.
He observed that people who are mentally ill,
or were deranged in some way,
might have such beliefs,
but don't be mistaken.
So, you could be wrong that there's a physical world around
you.
You could be wrong that there is a body that you have.
This is an ancient concern of course,
but it's best articulated in the movie, The Matrix,
which maintains that we think we're running around in the
physical world, but actually,
with the lucky exception of our heroes like Neo and Trinity,
we're actually just plugged into some sort of system.
Another version of this is that we're brains in a vat.
If you were a brain,
just the brain sitting in a vat with electrical wires
stimulating your experiences, you couldn't help.
Maybe you are such things.
Modern-day philosophers for instance,
will argue that there's an excellent chance that
we are simulations, we computer simulations.
So, Descartes and people following Descartes said,
"There's a lot we can't be sure of.
The things that we are seemingly most confident about in real
world can't be shaken."
But Descartes said, "There's one thing you can't doubt.
You can't doubt your own consciousness.
You can't doubt your own existence."
The famous line is,
"I think, therefore I am."
And spelling out this intuition,
building from the fact you could doubt that you have a body,
but you can't doubt that you have a mind.
Descartes wrote, "I knew that I was
a substance the whole essence or nature of which is to think,
and that for its existence there is no need of any place,
nor does it dependent in a material thing.. that is to say,
the soul by which I am what I am,
is entirely distinct from body."
So, that's a philosophical case for dualism.
But as I said,
dualism is also emerged out of common sense.
Think about how you describe your body.
You describe your body's if you possess it.
My arm, my heart, my body,
my brain, as if it's something separate from you that you have.
Or consider your intuitions about personal identity.
So, typically, as people age,
their consciousness follows their body.
So, I get 10 years older,
my mind 10 years older,
my brain is 10 years older,
it all connects together,
but we easily accept at least infection that people can hop from
one body to another.
There are many comedies that involve body switching, body
swamps.
There are movies that involve somebody going to
sleep one morning as one person and waking up as another.
We understand they're fiction, they aren't real.
But they make sense to us.
There's an intuitive rationale to this.
We don't walk out of the theory and say,
"I am totally confused what happened there."
Rather, at least with our naive conception of the self,
we accept that least of the possibility,
that you can hop from one body to another.
None of this is limited to modern-day movies,
the most famous short story of history by Franz Kafka begins
with the sentence,
"As Gregor Samsa awoke one morning from uneasy dreams,
he found himself transformed in his bed into a gigantic insect."
Metamorphosis involves that transformation and along before
that in Ulysses the characters are transformed.
Some of the characters are transformed by an evil witch into
pigs.
It's non of you took to people and turn them into pigs rather it's
much worse.
They put them in the body of pigs.
As the passage goes,
"They had the head and voice, and bristles,
and body of swine;
but their minds remained unchanged as before.
So they were penned there, weeping."
Our conception that bodies and cells are separate,
allows us to accept idea you had many people inhabiting one
body.
This is how many people think about multiple personality
disorder,
something we'll get to quite later on the course.
It's also at the root of a view that many people;
both religious and non-religious hold,
which is the idea of demonic possession.
Your body can be taken over by somebody else.
Another manifestation of dualism,
is you could believe in intelligent beings without bodies.
If mind and body are separate it raises
the possibility you could have one without the other.
Plainly you got to have bodies without minds.
That's what a corpse is.
But the argument goes you could also have minds without
bodies.
This is for instance what many people think about gods or
angels.
Which are the immaterial beings that can think, that can
observe,
that can act, but they don't have physical bodies in the same
sense that we do.
Finally, and maybe most important for people,
the idea that of dualism,
the idea you are not your physical body,
raises what must be for many and incredibly appealing
consequence,
which is that you can survive the destruction of the body.
In fact, if you ask most people;
religious and non-religious, what will happen after you body is
destroyed?
The answer is not well,
I'm dead then, that's it.
It's the end of things.
But rather the belief is that you can live on.
Maybe you'll end up in some spirit world,
maybe you will ascend to heaven,
if you're unlucky maybe will descend to hell.
Maybe you'll occupy some other body as an reincarnation.
But the idea is that the destruction of
your body need not be the destruction of you because you are
not your body.
All of these beliefs,
the beliefs about personal identity,
the beliefs about life after death,
about the existence of supernatural beings.
About God. All rest at least to some extent,
on a dualist perspective.
So, materialism, which says dualism is just playing wrong is an
audacious view,
and should be treated as such.
You shouldn't just shrug and write it down.
You should grapple with it, you should worry about it.
You should either be grudgingly accepted or fight against it.
So, why are modern-day psychologists and
neuroscientists so confident that dualism is mistaken?
Well, there are a few problems with it.
One is that it simply doesn't help us explain certain things that
need to be explained.
Appealing to an immaterial world to
an immaterial soul seems to dock certain questions that really
do deserve an answer.
So, throughout this course we'll ask questions like,
how do we learn language?
What do we find sexually attractive?
How does memory work?
These are questions about ourselves, about our minds.
To say, "Oh, it all happens some immaterial realm",
leaves us hopeless when it comes to answering them.
The second concern is that at the time, Descartes was correct,
to infer from the limitations of material things physical things,
that we probably are not physical things.
But by now we have a much better understanding what
physical things can do which makes it
entirely possible for many of us that we are set things.
So, I'm thinking for instance of computers and robots.
For Descartes, the idea that a physical thing can do something
as complicated as play a game of chess would seem ludicrous.
But now of course we know that physical things and
if you're looking at a computer you are looking at such a
physical thing,
can do exactly that.
They can understand language,
they could recognize objects,
they could store things in memory,
they can make inferences, and so on.
Now, for some of these things,
they don't do it anywhere near as well as people do.
So, when we talk about language development for instance we
see that,
a two-year-old child uses and understands language better
than any computer around.
So, we need to bear that in mind.
But still, it's no longer nuts to say that physical thing can do
all of the rich and psychologically
diverse and psychologically complicated things that people do.
Which means that we have to take seriously
the claim that we are in fact such physical things.
The final consideration is that there's
tremendous evidence that the brain is in fact the roots of mental
life.
So, put aside all that philosophical abstract,
arguments, there's just tons of direct evidence.
To some extent that direct evidence has always been there.
You don't have to be born in the 20th or 21st century to
appreciate that getting hit in the head could affect your
consciousness and your memory.
To appreciate that diseases like syphilis
can lead to disruption of the will and of consciousness.
Alzheimer's can rob you of your rationality.
That coffee and alcohol can inflame the passions.
It just is so evident in everyday life that if
physical events that affect the brain can affect ourselves,
suggesting that at the very least,
our mental life is intimately connected to the brain.
Over recent years something else has happened,
which is we've developed technologies that allow us to look
directly into the brain.
Look at the brains activation,
and infer from patterns of the brain activation what people are
thinking.
So, very crudely, you can put somebody into a scanner, an
fMRI scanner,
and you could tell whether or not are thinking about language,
or music, or sex.
The technology is increasing.
There is such a point that is not implausible
that for some of you by the time you're listening to this,
we can put a sleeping person under fMRI scanner,
and know from neural patterns of neural firings,
know what they're dreaming.
All of this I think it is very difficult to keep this in mind,
and hold on to the view of dualism.
I think materialism however uncomfortable,
however unpalatable is a view that the science forces us to
adopt.
3.neurons
So, what is the physical seed of thought?
What is the source of our emotions,
or decision-making, our passions,
or pains, and everything else?
Well, it's the brain,
and it's set to be the most complex mechanism in the known
universe.
You might expect, given all it is, and given all it does,
that will look very pretty,
Philips shimmering lights and glass tubes, and mysterious
colors.
But in fact, it looks really kind of gross,
it looks a the three-day old meatloaf.
It's gray when you take it out of the head,
and inside the head it's bright red because of all the blood.
In fact, it turns out very surprisingly that the source of our
mental life,
of our consciousness is meat.
In fact, you could eat it,
people have eaten brains,
I've had brain with cream sauce, not human brain,
mind you, but I've had brain with cream sauce.
It's not bad.
But it makes the puzzle all the more harder,
how can this fleshy thing give rise to mental life?
That's the question I want to explore in this lecture, and the rest
of the lectures.
I want to do so by starting with the smallest relevant parts,
different parts of neurons.
Then explore how the neurons are connected together,
how they're wired up,
how they form different subparts of the brain,
like the hypothalamus and the frontal lobe.
Finally, talking about the brain,
and the larger perspective,
looking at the two halves of the brain,
the left half and right half,
and how they interact.
Now, there's a lot of stuff in the brain,
a lot of chemical stuff,
a lot of different parts,
but where the action is,
the part that does the thinking,
the part that is the focus of most of our research, is the
neurons.
It's not an accident they call the study of the biological basis of
thought neuroscience,
because it all comes from the neurons.
So, you can see here pictures of neurons interacting together.
Here's a diagram that depicts a typical neuron.
So, what you see is the dendrites,
and dendrites receive signals from other neurons.
Either excitatory, like pluses, or inhibitory, minuses.
Then they get to the cell body,
which sums up these pluses and minuses.
When you reach a certain threshold,
a certain amount of pluses, there's neural firing.
Firing takes place through the axon,
and the axon is much longer than the dendrites.
In fact, for some motor neurons,
it's very long indeed.
There's axons running from your spinal cord,
all the way to your big toe.
You could think of it of the relative sizes of things in terms of a
basketball,
and a 40-mile garden hose.
Surrounding the axon is what's called a myelin sheath.
The myelin sheath is- you can think of it as insulation,
as fatty tissue like insulation on a wire.
So, the information comes through the dendrites,
and summed up in the cell body,
and it's transmitted through the axon.
So, what neurons do,
is they sum up and transmit information,
and we know that there's a lot of them.
By some estimates, it's 100 billion,
or the estimates tend to be very different and very rough,
but there's billions upon billions of neurons,
and each connect to thousands,
maybe tens of thousands of other neurons.
So, the fact that you have something of this degree of
complexity,
this degree of structure,
structure which there's no way to replicate in any machine,
the numbers are just too big is
why people might describe the brain as the most complicated
machine in the universe.
At least this is fitting, it's made of meat maybe.
Which is kind of disappointing,
but at least it shows its incredible internal structure.
So, neurons come in three flavors.
There are sensory neurons,
which take in information from the environment,
from the external world.
There's motor neurons, which go from the brain out to your
motor control.
So, if you touch something hot,
and you feel the pain,
that is sensory neurons,
if you rent your hand back,
or you reach for something, that's motor neurons.
Finally, there's interneurons, which
connect different neurons without making contact with external
world.
Either through sensation, or through motor action.
Now, the main thing to think about for neurons and
neuron firing is that it's all or nothing.
It's like firing a gun, or sneezing.
Neurons either fire, or they don't.
Now, you might think that's a little bit strange, particularly,
when you think about sensory neurons,
because your experience seems to be a continuum.
So, you have sensory neurons in your eyes,
and you can distinguish from a very dim light,
and a very bright light.
You have sensory neurons in your fingers,
and you could distinguish between gently touching something,
versus being stabbed on the tip of your finger, or something.
But still the neurons are all or nothing,
the way we get to this continuity of
experience is that neurons can code for intensity in different
ways.
So, one way is in terms of the number of neurons that fire.
If x neurons corresponds to a mild experience,
x times 10 neurons may correspond to an intense experience.
Another factor is the impulse frequency of individual neurons,
an individual neuron might denote a mild sensation by doing
fire, fire, fire, fire.
Well, it might denote an intense situation with fire,
fire, fire, fire, fire, fire.
So, you have neurons,
and the neurons talk to each other,
they talk to each other because axons,
an axon of one neuron will communicate with the dendrites of
another neuron.
A long time ago, people used to think that neurons were
wired up together like a computer,
but in fact, neurons don't actually touch one another.
There is a gap between the axon terminal of one neuron,
and the dendrite of another one.
A very tiny gap,
typically of like 1/110,000 of a meter wide.
This gap is known as a synapse.
When one neuron fires,
the axon releases neurotransmitters,
these are chemicals that shoot out over that gap,
and affect dendrites and other neurons.
As I said before,
the effect of these neurotransmitters could be excitatory,
which is that they raise the energy,
so they increase the likelihood of a neuron firing, or inhibitory.
So that they bring down the likelihood of a neuron firing.
What's interesting is that different neurons shoot out different
neurotransmitters.
So, they have different effects on other neurons that they made
contact with.
In fact, a lot of psychopharmacology,
both attempts to cure various psychological or physical
diseases by giving medicines,
or recreational psychopharmacology designed to increase
pleasure of different forms,
or sometimes help people work,
or help people focus.
Works by fiddling with the neurotransmitters and this can be
either antagonists,
they lower down intensity of things by binding to the dendrites,
making it hard to create more neurotransmitters,
or they can increase the amount of
neurotransmitters available in different ways agonists.
So, you're either pumping up the volume or turning down the
volume.
So, you think about different drugs and their effects.
There's a curare.
Curare, is a drug that used by South American Indians.
It's a antagonist.
It blocks motor neurons from affecting their muscle fibers.
It keeps your motor neurons from working,
and what it does is it paralyzes you,
and in large enough doses, it kills you,
because motor neurons also keep your heart beating.
So, shut that down and you die. There's alcohol.
Now, alcohol also has an inhibitory effect.
You might think that's strange because when I drink
alcohol I get all excited and happy and goofy.
But you have to keep this in mind here,
the way alcohol works is,
it inhibits part of your brain that does the inhibition.
So, you have part of your brain that says,
don't say that to the other person,
keep your pants on, stop yelling,
and alcohol basically inhibits that part of the brain,
making you more exuberant.
Then, over the course of things,
in the course of drinking too much,
it also inhibits other parts of the brain.
So, you could pass out and fall on the floor,
and in large enough doses, die.
So, both curare and alcohol,
in different ways bring things down.
Other drugs bring things up.
So, amphetamines, for instance,
increase the amount of norepinephrine,
which is another neurotransmitter,
that's responsible for genetic general arousal,
and this is how drugs like speed or cocaine work.
Other drugs like Prozac or L-Dopa,
influence neurotransmitters in ways that they increase,
for instance, the supply of dopamine or serotonin.
Which can be relevant for issues like parkinsons,
which seems to be related to too little dopamine,
and depression, which is related to too little serotonin.
So, these drugs work by influencing neurotransmitters,
either by directly pumping in more neurotransmitters,
or increasing the supply in different ways,
or stopping them from having effects by
binding them or sucking them up in different ways,
but they work through their effects on neurotransmitters.
So, the more general idea is,
the way neurons lead to thinking,
is that they form clusters or networks.
These clusters and networks,
are computational devices that do interesting things like
recognizing faces,
or walking up right,
or understanding sentences, or doing math,
or experiencing great sadness,
or falling in love, and so on.
We now know that, that's possible,
because we create computing machines that work in certain
ways.
That if you wire up a computing machine in certain complicated
ways,
it can do mathematics, play chess,
do flight simulator, and so on.
So, you may be interested in the project of
computational neuroscience which tries to ask the question,
how are neurons wired up to do interesting things,
and uses our own success at computational theory as a model.
Then, sometimes takes the inference the other way around,
which is you can see how people do it,
and then use this knowledge of how people do it,
to create computational systems that can do it as well.
So, how is the brain wired up?
Well, you might imagine that it's wired up like a portable
computer,
like a laptop, like the sort of computer you're looking at now.
Into some regards it is,
but there's a couple of reasons why it can't be,
and both of them have to do with how well the brain works.
So, first, the brain is highly resistant to damage.
If you get a knife to the brain,
if you get damage to the brain,
it won't typically shut down the whole system.
The information and capacitors somehow distributed across
neurons in such a way that makes them extremely resilient to
damage.
While in contrast, somebody could open up the back of your
laptop,
pull out a chip and the whole thing is ruined,
the whole thing will stop working.
But the brain is wired up in a certain way that makes it highly
resilient.
The second thing is, the brain is wired up in such a way that
makes it work very fast.
So, computers can do millions of operations per second,
because they're purely electrical,
but brain tissue is much slower and can spend the time to do
many steps.
So, to put it a different way,
if your brain was wired up like a computer,
it would be so slow,
as to be entirely unusable.
It has to be wired up in a way that's more efficient,
that allows for the slowness of brain tissues and
neurotransmitters,
and can still compute things at a level,
at a human level,
which is often blindingly fast.
Because of this, there has been a huge interest in
massively parallel systems and complicated neural networks,
which are wired up as we believe the brain does, and as such,
we are helping computers to do things based on
our understanding of the brain that they could never do before.
The details of this is something we're going to talk about
through the course.
We're not actually going to end up explaining
different capacities directly in terms of neurons,
because we can't, and because we want it to have higher level
explanation.
So, when I talk about how people learn language,
or how do they recognize faces,
we're not going to talk much about neurons in particular,
but we will talk about different brain areas and how they work.
Then the assumption is, the bet is,
that everything we talk about in more functional ways,
can ultimately reduce down to large networks of neural
systems,
and that in turn will ultimately reduce down to
the specific behaviors of the specific neurons that we're looking
at.
4. parts of brain
So, let's talk about the different parts of the brain and what they
do.
Parts of the brain are functionalized for different purposes,
they do different things.
Which is why damage to different parts of the brain has
different effects.
It's why when you look at an fMRI scan or
PET scan or some something that records neural activity,
you could figure out based on the location of the activity what's
going on.
So, the first thing to realize is I'm talking about the brain,
but I'd be more precise and more
inclusive if I talked about the brain and parts of the spinal cord.
So, you don't need your brain for everything.
There're certain activities we do that can happen without a
brain.
Like sucking in newborns or pulling your limb back to withdraw
from pain or vomiting.
But for everything else we talk about in this course,
we'll really be talking about the brain.
So, some of the structures of the brain that are highly relevant
are called subcortical,
which means they're below the cortex,
which means they're in the center of the brain.
This includes part of the brain like the medulla,
which control certain automatic function like your heart rate,
your blood pressure, swallowing, and so on.
It includes the cerebellum,
which is involved in body balance and muscle coordination.
It contains about 30 billion neurons.
So, this isn't small potatoes.
The hypothalamus, which is involved in
feeding and sex and thirst and different appetites.
We're going to talk about emotions or visceral desires,
we'll return to those parts of the brain.
But for the aspects of psychology that are distinctive for us,
that make us human,
we're mostly focused on the outer layer, the cerebral cortex.
So, the cerebral cortex it is all crumpled up.
If you were to take a brain,
pull out the cortex and straighten it out,
like you're removing a rug you got from
the trunk of your car and you have to straighten it out,
it's about two feet square.
So, it's lot of crumpling to get it in.
It's about three millimeters thick.
This is where the action is.
This is where at least for the things I'm interested in,
this is where it takes place.
Is where reasoning and language and complex perception
comes from.
Fish don't have any cerebral cortex,
reptiles and birds have a little bit,
but primates, including humans, have a lot.
When you look at the cortex, you'll see it has two halves.
It has a left half and a right half.
For each of these halves, when you look at it,
you can demarcate the brain,
the cortex into different lobes.
There's going from your forehead and swooping to the back.
You have the frontal lobe conveniently enough on the front.
The parietal lobe, the occipital lobe,
and the temporal lobe.
Each of these lobes,
there's different things, which we'll talk about in a bit.
Another thing about the cortex though which is super
interesting,
is that it includes maps.
What I mean by this is it includes topographical maps where
two things that are close together in the brain are similarly close
together in the body.
So, there is a motor area where if you were to shock,
parts of that brain,
parts of the body would twitch accordingly.
Just like you'd expect,
the middle finger is close to the thumb which is closer to elbow.
If it's close in the real-world and your body it's close to
the brain and there is a primary somatosensory area,
which is the sense organs.
There if you have somebody in the operating table and you
shocked people,
they would experience things, they might experience a sound
or
a flash of light or a touch.
In fact, in the occipital lobe,
you have a map for vision and in the temporal lobe,
you have a map for sound.
What's really cool is,
I said the map is topographical,
but the size of the brain areas don't correspond to the size of
the actual body areas,
but rather to the extent to which there's motor or sensory
function.
So, artists have drawn pictures of people if
their body was proportioned to the extent that their brain was.
You'd see the trunk of the body is relatively small,
but their hands are enormous and the face is
enormous because there's a whole lot of sensation.
There is much more sensation going on in your hand
than in your whole back even though the back is physically
apart.
So, part of the cortex is these projection areas.
But less than a quarter of the cortex contains projection areas.
As I said, the rest is involved with the cool stuff.
With language, with reasoning,
with moral thoughts, and so on.
Then the question comes in,
how do we know this?
How do we know what parts of the brain do what,
what parts of the brain are involved, and why?
There's different answers.
So, one answer is we can scan the brain.
We can use MRI, which is a high frequency magnetic field,
to look at the activity of the brain,
what parts are active when people do different things.
We can also look at so-called natural experiments
when people have tumors or strokes or motorcycle accidents.
In damaged part of your brain and we can ask the question,
what damage to which parts of the brain correspond to damage
to which functions?
Through these different methods,
we've learned about the different parts of the brain and what
they do.
We could talk about some certain specific things that can go
wrong due to brain damage or stroke or trauma.
So, for instance, there's Apraxia.
Apraxia is problems of actions.
So, you're unable to do an action like waving goodbye
or picking up before or can bring some food to your mouth.
You're not paralyze.
You can make the movements if you have to,
but you can't coordinate these basic movements into complex
actions. There's Agnosia.
Agnosia is a disorders of perception.
And they're not like you can't see,
but you can't recognize.
Some is called psychic blindness.
People of various forms of Agnosia can describe a picture in
terms of it's part,
but can't recognize the objects that are being depicted.
That's a form of visual Agnosia There's also a specific
Prosopagnosia,
where you can't recognize faces.
Oliver Sacks wrote a wonderful book
many years ago called The Man Who Mistook His Wife For a
Hat.
This was a series of profiles of people who had surprising
neurological disorders and
the title case of the book was
a man who actually had such an inability to recognize faces,
he couldn't distinguishes his wife's face from that of a hat.
Milder forms of Prosopagnosia,
which some people suffer from and to be honest,
I got a little bit of some terrible faces.
Is that you could recognize faces as faces,
but you can't recognize whose face they
are and it's very hard for you to recognize people.
There's problems of sensory neglect.
You get disorders that block out one part of the world.
You might have damage to parts of your brain that
would block out the left side of the world.
It's not just the sort of physical thing,
when you ask somebody with such a disorder to draw clock for
instance,
they'll put all the numbers from one to 12 on the right side of the
clock.
Is as if they don't think of the left side of the world again.
So, maybe it's not even a sensory problem,
but an attentional problem.
There's Aphasia, which refers to disorders of language.
Some forms of aphasia are expressive like a Broca's Aphasia,
where you can't really speak.
A famous case of somebody who can only use the word tan,
would say tan, tan,
tan, but couldn't say anything else.
Or then there's something that's called Receptive Aphasia,
where you can speak although what you say doesn't make
much sense,
but also you have a terrible time understanding other people.
Then there's all sorts of other disorders.
There's the disorder which we talked about with regard to
Phineas Gage and various forms of it.
Where damage to your brain,
it's debatable whether this is true Phineas Gage,
but there are other cases where it's much more clear.
Cause you to lose your moral sense,
your sense of right and wrong,
your ability to control yourself,
to restrain yourself perhaps your conscience.
Now, we're going to talk about all of these things through
the course but the moral here is that,
a, there's some localization of function.
There's some sense in which it correspond to different brain
areas.
B, again, this is an argument against dualism.
We can see that in that anyone who argued that
the mind isn't the brain would be hard-pressed to
explain why damage to the brain seems to affect
some very intimate and very important aspects of ourselves.
3. defense mechanisms
So, suppose you survive these developmental stages and
you're now an adult,
and you're not out of the woods yet,
there are all sorts of challenges and problems you're faced
with.
One problem is that your Id is sending up all sorts of desires,
all sorts of weird sick stuff,
sexual and violent, and these are forbidden by the super ego.
It's not merely that you can't act upon them,
so you shouldn't be thinking them,
and so they get pushed down or repressed.
You could even imagine a sort of a metaphor of you pushing
down something,
like some water spraying out from leaks on
a floor and you're jamming towels over it or something like that.
Some of this repressed stuff,
as in my fine metaphor,
spills out, you can't contain everything.
For Freud, it spills out in jokes and slips of the tongue and in
dreams.
But also for Freud,
there are other ways to cope with these desires.
There's other ways to repress
them and these are what Freud described as defense
mechanisms.
They defend the ego from this terrible stuff that's coming out
from the Id,
and some of these you may be familiar with.
We tend to use them in everyday language,
another example of Freud's influence.
There's displacement, where you redirect shameful thoughts to
more appropriate targets.
You can imagine a boy who hates his father,
and that's really unacceptable,
you shouldn't hate your father.
So instead, he bullies another kid or kicks the dog.
He turns his anger and his hatred towards
his father to a more appropriate and more acceptable target.
So, there's sublimation.
Sublimation you take desires that are
unacceptable and you displace them to more valuable
activities.
So for instance, somebody who has a strong sexual desires of
forbiddens might
devote a lot of energy to his or her work or studies.
There's projection. Projection is reducing anxiety by taking
these impulses you have that you're ashamed of and attributing
them to somebody else.
So, imagine a woman with strong homosexual desires,
and because of how she was raised,
her super ego tells her these are unacceptable, they're
inappropriate.
So she becomes unconscious of them.
But she comes to believe that there are other women are
sexually drawn to her.
Or you may really dislike somebody you shouldn't dislike,
and then come to a conclusion, "Oh my gosh,
this person must hate me."
Because your own shameful feelings are unacceptable,
you will project them onto somebody else.
There's rationalization, where you have certain anxiety-
producing thoughts
and you reason them away into more acceptable ways.
So for instance, somebody might get pleasure,
a father may get pleasure physically punishing his children.
But nobody wants to think that of themselves.
So the way he describes it to himself,
the way he really believes it at the level of the self,
the ego is that he's doing it for their own good.
You know in general, a lot of the bad things we do, we
rationalize.
There's regression, and you see this in children where the idea
is under
certain forms of stress or stressful desires and stressful
impulses from the Id,
you might retreat to a mode of behavior that's characteristic of
an earlier stage.
So you see this in some sense a child might suddenly act like a
much younger child.
Finally, there's reaction formation which is cool and of
unintuitive,
where you replace threatening wishes and fantasies with their
opposites.
So you might express and finally say,
"Oh, I love this person.
This person is my favorite person."
As a way to mask the fact that you really don't love them at all,
in fact, you hate them.
Now, these defense mechanisms proposed by Freud are just
everyday life,
we have them all the time.
But sometimes, we fail to properly repress the impulses from
the Id,
and then you get into some real problems.
You get what Freud called hysteria.
Hysteria according to Freud are these symptoms which showed
up quite
often in Freud's time and maybe show up now only they're
manifested in different ways,
such as blindness and deafness without any physical cause,
paralysis, tremblings, panic attacks,
gaps of memory including amnesia and so on.
For Freud, these are nothing more than symptoms.
They're ways in which we keep our impulses,
our memories, our desires under lock and key.
We keep forbidden stuff under lock and key.
The simplest example, for instance,
is you had this horrible event,
something you did, something you saw and you just can't cope
with it,
so you forget it.
You have a form of amnesia,
where you black it out.
Freud believed that when these memories are recovered or
when the impulses come to light,
there's what he called catharsis,
an explosive release, an emotional release of insight.
So, then when you're treating these hysterical symptoms,
you'd want to get to them through ways that could
facilitate this catharsis, facilitate this understanding.
Freud originally tried to get at this through hypnosis,
but later on moved to free association,
which is a tool that sometimes used.
The idea of free association is you give somebody a word and
he says something back,
but because it's so speeded,
they don't have time to censor it.
Ideally, you get the true insight into what's working in their mind
without
the filtering powers that the ego and the super ego have.
So, for instance, a fanciful example is,
we're in a session and I say, "Dog," and you say,
"Cat," and I say, "Lunch," and you say,
"Sandwich," and I say,
"Mother," and you say, "Sex."
Well, and then you're embarrassed. You offer resistance.
You say, "Oh, I didn't mean to say that."
You don't go to your next appointment.
You get angry at the therapist.
This is part of the dance of psychoanalysis.
Freud used these methods and many others to explore inner
conflicts,
and what goes on in psychoanalysis and
its success at reading people is
a topic that we're going to get to at the very end of this course.