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Concentration of enzyme
As you increase the concentration of the
enzyme, you increase the rate of
reaction.
This is because there are a lot more enzyme that are ready to work and react and
therefore the rate of reaction increases with the concentration of enzymes
Temperature
o Most enzymes in the body have an optimal temperature of 37degrees Celsius.
o When the temperature increases beyond the optimal temperature—the enzyme denatures
(it changes shape or is broken down so it can no longer bond with the substrate)
o All enzymes are proteins. At high temperature the protein breaks down. The active site is
changes or denatures, so the substrate no longer fits into it active site, we say that the
enzyme has been denatured and it no longer work
When you have a fever of more than 40 degrees Celsius, the enzymes in the body will denature as
the temperature has exceeded the optimal temperature. And due to the denaturing of the temp, the
chemical reactions in the body will fluctuate and digestion will not occur. As the enzymes have
denatured and the proteins or substrates will not be fitting into the enzymes or the locks
How pH affects enzymes?
o Enzymes function best within a certain pH range—each enzyme is different
o All enzymes are different! And so, they all work with different pH levels. Enzyme activity
is at its maximum value at the optimum ph.
o 1-7 is acidic and 7-14 is basic. 7 is neutral!
o The reason pH affects enzyme activity because the fold in the enzyme molecules are
created by hydrogen bonds.
o Addition of positively charged hydrogen ions in acids affects the hydrogen bonds
o The 3-D shape of the enzyme is altered with a change in ph.
o Changing the pH of its surroundings will also change the shape of the active site of an
enzyme. ... This contributes to the folding of the enzyme molecule, its shape, and the
shape of the active site. A change in the structure of the enzyme affects the rate of reaction
some substrates can’t fit into the enzyme
Concentration of substrate
o The greater the number of substrate molecules, the greater the number of collisions
between molecules and the faster the rate of reaction
o As the concentration of the substrate increase, so the does rate of enzyme reactivity.
o However, the rate of enzyme activity does not increase forever. This is because a point
will be reached when the enzymes become saturated, and no more substrates can fit at any
one time even though there is plenty of substrate available.
o A continued increase in substrate concentration results in the same activity as there are not
enough enzyme molecules available to break down the excess substrate molecules.
The bines of the skeleton provide the structural support for the organs of the digestive system.
The jaw or the mandible provides the mechanical pressure for chewing and the teeth are anchored
into it.
You calso have a floating bone in your neck that keep your tongue in place. Its called the hyoid
bone
Many muscles play an important role int eh digestive system
o Yrou lips (orbicularis oris) allow for gasphin of food
o The masseter msucels of you jaw works the kaw bone (mandiabel) (This is the reason that
chemisign is termed mastication)
o The tongue is likely the most important muscles, as it swisses and mixes all the food.
The mouth
As you chew, yoru tongue moves food around and helps positon it between yoru theet
Chewing is a form of mechanical diegstio—the pshycail rpocesss f breaking food into smaller
pieces- it prepares the foos for chemical digestion
Teeth!
o The incisors – cutting food—8 in total
o Cuspids or cannies—tear or shred food—4 in total
o Moalrs—crush and grind the food—12 molars and 8 molars
A normal adult has 332 teeth without wisdom teeth.
The hard palate—protects your sinus and nasal cavities from the food that enter your mouth
Inside a tooth
o Teeth are made up of multiple layers
Enamel—a protective covering
Dentin—body of teeth
Pulp cavity—inner core, blood vessels and never
Tongue
o The tongue s attached to the flood of the mouth
o It is made of numerous skeleton muscles covered with mucous membrane
o The surface of the tongue contains many small raised area called pili.
Some of these pili are used to provide a rough surface to move food
around or basically add in mechanical digestion
Others are used to send chemical messages to the brain regarding taste
Taste buds for different tastes-have different shape and size.
Buccal cavity or Mouth
The Mouth
Once you’ve thoroughly chewed the food, yoru tongue shapes it into a balled called a bolus and
you swallow it.
Food moves from the mouth to the stomach through the esophagus
Peristalsis is a series of involuntary (no thinking; your body just does it on its own, no effort by
you) smooth muscle contractions along the walls of the digestive tract
Peristalsis is the reason you can drink a glass of water while standing on yoru head
The epiglottis
When you eat, the food enter the pharynx usually a flap of cartilage called the epiglottis closes
over the opening to the respiratory tract as you swallow, preventing goof from entering. (You can’t
eat and breath)
After the food passes into your esophagus, the epiglottis opens again
Mucous
The esophagus, like most of the area in the digestive system, is lined with mucus
Mucus helps food travel easily through the digestive system, and protects the gut form digestive
enzymes and acid
It keeps everything moist and lubricated,
Sphincters in the stomach
Once the chewed food bolus reaches the end of yoru esophagus, it goes through the esophageal
sphincter and into your stomach
Sphincter—a ring of muscle that contracts to close and opening. It is basically an opening that
opens and closes
The stomach
The stomach lining secretes mucus, which forms a protective layer between it and the acidic
environment of the stomach
A Gastric ulcer is a small hole in the lining of the stomach, caused by weakness in the mucous
layer
Stomach
A Gastric ulcer is a small hole in the lining of the stomach, caused by weakness in the mucous
layer
The small intestine
When we last left the digestion process, food (now in the form chyme) was exiting the stomach
through the pyloric sphincter into the small intestine.
The small intestine is ~7 m long!
The diameter of the small intestine is only ~2.5 cm wide (hence the “small” part)
Digestion of food is completed in the small intestine.
Most digestion occurs in the first 25-30 cm of the small intestine, called the duodenum
the small intestine is broken up into 3 sections:
o Duodenum—most digestion happens
here
o Jejunum—most absorption happens
here
o Ileum—absorbs B12 and other
vitamins
Pancreas
Food does not actually pass through the pancreas or the liver!!
The pancreas is a soft triangular organ located between the stomach and the small intestine.
It secretes both digestive enzymes and hormones.
The pancreas is connected to the small intestine with a pancreatic duct
Neutralizing stomach acid
o The first thing that has to happen once chyme enters the small intestine is neutralization of
stomach acid
o When food enters the small intestine, a hormone called secretin is absorbed into the
bloodstream and signals the pancreas to release bicarbonate ions.
o The bicarbonate ions raise the pH of fluids from 2.5 to 9.0.
Pancreatic sections include all of the following:
o Bicarbonate ions
o Amylase ENZYME WORKS ON: CHANGES IT TO:
o Trypsin Trypsin Proteins Amino Acids
o Lipase
o Rennin Amylase Starch Complex Sugars
Lipase Fats Fatty acids & Glycerol
The liver
Remember that absorption is ethe entire reason that we eat in the first place
Our body is made of cells- these cells die, so we need to make more cells- in order to make those
cells I need to have STUFF to make them
The broken-up pieces of food are absorbed into our blood cells are transported around and provide
that STUFF
Villi
Most of the absorption in the digestive system occurs in the small intestine
Long figure like tubes called villi in the walls of the small intestine greatly increase the surface
area for absorption
Without villi, your small intestine would have to be 70m long to amount normal absorption
Each villus has blood capillaries and lymph vessels (Lacteals)
Some nutrients are absorbed directly by diffusion
Cells o the small intestine also expend energy to actively transport materials form the intestine into
the villus
Villas are made up of capillaries and lacteals
o Capillaries—carbohydrates and amino acids from proteins are absorbed
o Lacteals—fats are absorbed
Microvilli
The outer cell membranes of the cells that line the small intestine are folded to increase surface
area
The folded outer membrane structures are the microvilli
The large intestine
As indigestible materials passes through the large intestine, water and salt are absorbed by the
intestinal walls
Because of this, water is not wasted, and the materials left behind is more solid (poop or feces)
Vitamin synthesis in the large intestine
After 18-24 hours in the large intestine, the remaining indigestible material reached the rectum
Indigestible materials is called feces
The rectum is the last part of the digestive system,
The rectum contains stretch receptors that send messages that the body is ready to eliminate
Feces are eliminated from the rectum through the anus
The appendix
Brains effect the stomach—send messages to the stomach cells—secretes more fluid and is ready
Something is easier to digest that other—less fat content—simple cabs instead of complex carbs
Stress and illness also impact our ability to digest things
Disorders of the digestive system
DISORDERS OF THE DIGESTIVE SYSTEM
TYPE WHAT IT IS HOW IT IS SYMPOTOMS
CAUSED
Appendicitis Is a medical emergency The appendix is Extremely painful
In some cases the appendix must inflamed
be removed before it ruptures occasionally and is
swelled up
Anorexia Is an eating disorder characterized Refusal to maintain Obsessive fear of
Nervosa by refusal to maintain a healthy a healthy body gaining weight
body weight and an obsessive fear weight and just not Coupled with a
to gaining weight eating because of distorted self-image
fear of gaining
weight
Bulimia Illness in which a person binges on Just eating without Overeating, gain weight
food or has regular episodes of control excessively
overeating and a loss of control
The person overeats and
the person them forces
them self to vomit or
uses laxatives to avoid
absorbing calories
Malnutrition Is the condition that results from Eating unhealthy, Pain
taking an unbalanced diet in which or an unbalanced
nutrient are lacking, in excess or in diet in which
wring proportions certain nutrients are
lacking in excess or
in a wring
proportion
Ulcers A peptic ulcer is a hole int eh gut Occurs when the Pain
lining of the stomach, duodenum lining of these
or esophagus organs is corroded
but acidic digestive
juices which are
secreted by the
stomach cells
Caused by
weakening in the
mucous that lines
the digestive
system
Cancer Can strike any part of the digestive Caused by Vary according to the
system: the esophagus, stomach, abnormal growth of affected organ. But may
pancreases liver, gallbladder, abnormal cells int include the following:
intestines, rectum, anus eh body Bleeding gums, hair
falling
Liver cirrhosis Cirrhosis is scarring of the liver, Caused by heavy Include weakness, loss
due to long term disease or injury alcohol use, some of appetite, and weight
drugs and loss
infections or
hepatitis
Hemorrhoids Are painful, swollen veins in the Caused by straining Itchiness and pian in the
lower portion of the rectum or during bowel butt area
anus movements,
constipation and
sitting for long
period of time
Lactose Happens when the small intestine When your body Symptoms of lactose
intolerance doe no make enough of the lactase cant digest or break intolerance includes the
enzyme. down lactose, due following:
Lactase breaks down lactose- to a lack of the Abdominal bloating
simple type of sugar found in dairy lactase enzyme Cramping, diarrhea
products gas
Gallbladder/Bil The gallbladder stores bile, which Caused when there Symptoms may include
e problem breaks down fats into smaller is an issue with the pain discomfort
pieces gallbladder or bile
When there is a problem with the production. And
gall bladder or bile production, the the digest system is
digestive system is not able to unable to breaks
properly digest greasy food down or digest
greasy food.
ENZYMES IN THE DIGESTIVE PROCESS
ENZYME SECERETED BY PURPOSE FOUND WHERE BREAKS WHAT
DOWN
Salivary Amylase Salivary glands break starch into Mouth and Starch > mono and
disaccharides and stomach di ascarides
monosaccharides (simple sugars)