UAS FARMAKOKINETIKA DASAR

OLEH :

SITTI FADHILAH RAHMAH (O1A119192)

KELAS D 2019

PROGRAM STUDI S1 FARMASI

FAKULTAS FARMASI

UNIVERSITAS HALU OLEO

KENDARI

2021
a. Gambar kurva kadar obat dalam darah terhadap waktu pada kertas semilogaritmik, bagaiman bentuk kurvanya,
mengapa demikian?
b. Berdasarkan kurva tersebut model mana (1 – atau 2 - kompartemen) yang tepat menerangkan profil kinetika
obat?

Waktu Cp Ln Cp
(Jam) (ug/mL)
0 0
0, 25 51, 33
0, 5 74, 05
0, 75 82, 91
1,0 85, 11
1,5 81, 76
2 75,51
3 62,98
4 52,32
6 36,08
8 24,88
12 11,83 2, 4706
18 3,88 1,3558
24 1,27 0,2390

Regresi Fase Eliminasi (t vs Ln Cp)

a = 4,7025

b = - 0,1859

r = 0,9999

y = bx + a

y = -0,1859x + 4,7025

B = anti Ln a

= 110,333

Persamaan eliminasi

C = B . e-β.t

Kadar ekstrapolasi B . e-β.t

t=0 ; Cs = B . e-β.t

= 110,2223 x e-0,1859.0 = 1100,2223 ug/mL

t = 0,25 ; Cs = B . e-β.t

= 110,2223 x e-0,1859.0,25 = 105,2169 ug/mL

t = 0,5 ; Cs = B . e-β.t

= 110,2223 x e-0,1859.0,5 = 100,4388 ug/mL

t = 0,75 ; Cs = B . e-β.t

= 110,2223 x e-0,1859.0,75 = 95,8777 ug/mL

t = 1,0 ; Cs = B . e-β.t

= 110,2223 x e-0,1859.1,0 = 91,5238 ug/mL

t = 1,5 ; Cs = B . e-β.t

= 110,2223 x e-0,1859.1,5 = 83,400 ug/mL

t=2 ; Cs = B . e-β.t

= 110,2223 x e-0,1859.2 = 75,9974 ug/mL

t=3 ; Cs = B . e-β.t

= 110,2223 x e-0,1859.3 = 63,1049 ug/mL

t=4 ; Cs = B . e-β.t

= 110,2223 x e-0,1859.4 = 52,3996 ug/mL

t=6 ; Cs = B . e-β.t

= 110,2223 x e-0,1859.6 = 36,1291 ug/mL

t=8 ; Cs = B . e-β.t

= 110,2223 x e-0,1859.8 = 24,9107 ug/mL

Kadar Residual 1 :

Cr = Cp – Cs tiap-tiapwaktu
t =0 Cr = 0 – 110,2223 = -110,2223
t = 0,25 Cr = 51,33 – 105,2169 = -53,8869
t = 0,5 Cr = 74,05 – 100,4388 = -26,3888
t = 0,75 Cr = 82,91 – 95,8777 = -12,9677
t = 1,0 Cr = 85,11 – 91,5238 = -6,4138
t = 1,5 Cr = 81,76 – 83,4000 = -1,6400
t =2 Cr = 75,51 - 75,9974 = -0,4874
t =3 Cr = 62,98 – 63,1049 = -0,1249
t =4 Cr = 52,32 – 52,3996 = -0,0796
t =6 Cr = 36,08 – 36,1291 = -0.0491
t =8 Cr = 24,88 – 24,9107 = -0,0307
Hitung t1/2 eliminasi dan absorbsi, C maks, T maks, AUC, Vd, Cl jika ketersediaan hayati 0,80

T1/2 Absorpsi = 0,693/Ka = 0,693/0,2357 = 2, 94 Jam

T1/2 Eliminasi = 0,693/k = 0,693/0,0688 = 10,07 Jam

Vd =

T Maks = = = = 3,259 Jam