1.

T C
0 100
2 90
4 80
6 70
8 60
10 50
12 40
Perhitungan kalkulator:
A = 100
B = -5 y = -5x + 100
2
R =1
a) Orde berapakah? → Orde nol
100
b) T1/2 = 0,5 x = 10 jam
5
𝐷𝑏 500
c) Vd = 𝐶𝑝 = 100 = 5
𝐶𝑜 100
d) AUC = = = 20
𝐾.𝑒𝑙 5
e) Klirens = Vd x K = 5 x 5 = 25
f) Persamaan Farmakokinetik:
C = -K0t + C0
90 = - K0 (2) + 100
-K0 = -10/-2 = 5
Persamaan → C = -5t + 100
2.
T C ln cp
1 65 4,1744
2 42 3,7377
3 27 3,2958
4 18 2,8904
6 8 2,0794
8 5 1,6094

Perhitungan kalkulator:
A = 4,4584
B = -0,3735 y = -0,3735x + 4,4584
2
R = 0,9887
a) Orde berapakah? → Orde satu
0,693 0,693
b) T1/2 = 𝐾.𝑒𝑙 = 0,3735 = 1,855
𝐷𝑏 500
c) Vd = = = 5,79
𝐶𝑝 86,349
𝐶𝑜 86,349
d) AUC = =
𝐾.𝑒𝑙 0,3735
= 231,188
e) Klirens = Vd x Ke = 5,790 x 0,3735 = 2,162
f) Persamaan → C = 86,349.e (0,3735t)
3. T C ln cp 1/Cp
1 30 3,401197 0,033333

2 13 2,564949 0,076923

3 6.5 1,871802 0,153846

4 4.2 1,435085 0,238095

6 2.2 0,788457 0,454545

8 1.4 0,336472 0,714286

Perhitungan kalkulator:
A = -0,1166
B = 0,0988 y = 0,0988x – 0,1166
2
R = 0,9887
a) Orde berapakah? → Orde dua
1 1
b) Cp : = = 8,5763
𝐴 0,1166
1 1
c) T1/2 = 𝐾𝑒𝑥𝐴 = 0,0988𝑥0,1166 = 86,80 𝑗𝑎𝑚
𝐷𝑏 500𝑚𝑔
d) Vd = 𝐶𝑝 = 8,5763 = 58, 30
𝐶𝑜 8,5763
e) AUC = = = 86,804
𝐾.𝑒𝑙 0,0988
f) Klirens = Vd x Ke = 58,30 x 0,0988 = 5,760
g) Persamaan → C = 8,5763.e (0,0988t)