Antibacterial, antifungal, and antiviral effects of three

essential oil blends

Amandine Brochot, Angèle Guilbot, Laïla Haddioui, Christine Roques

To cite this version:

Amandine Brochot, Angèle Guilbot, Laïla Haddioui, Christine Roques. Antibacterial, antifungal,
and antiviral effects of three essential oil blends. MicrobiologyOpen, Wiley, 2017, 6 (4), pp.1-6.
�10.1002/mbo3.459�. �hal-01883640�

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To link to this article : DOI:10.1002/mbo3.459

URL : https://doi.org/10.1002/mbo3.459

To cite this version :

Brochot, Amandine and Guilbot, Angèle and Haddioui, Laïla and Roques,
Christine Antibacterial, antifungal, and antiviral effects of three essential oil
blends. (2017) Microbiology Open, 6 (4). 1-6. ISSN 2045-8827

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ORIGINAL RESEARCH

Antibacterial, antifungal, and antiviral effects of three essential

oil blends

Amandine Brochot1Պ|Պm]࣏Ѵ;†bѴ0o|1Պ|Պ-ठѴ--77bo†b2Պ|Պ_ubv|bm;!ot†;v2,3

1
b;;ķ-ubv;7;ŠƐƔķ u-m1;
Abstract
2
om7;u;r_-uķ$o†Ѵo†v;;7;ŠƏƖķ u-m1;
;‰-];m|v|_-|-u;;==;1|bˆ;-]-bmv|1ollomr-|_o];mv-u;m;;7;7r-u|b1†Ѵ-uѴ‹=ou
3
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&!ƔƔƏƒķ -1†Ѵ|࣐7;v"1b;m1;v |_ov;u;vbv|-m||o1omˆ;m|bom-Ѵ-m|blb1uo0b-Ѵ-];m|vĺvv;m|b-ѴobѴvŐvő-u;hmo‰m=ou
_-ul-1;†|bt†;vķ&mbˆ;uvb|࣐-†Ѵ"-0-|b;uķ
|_;bu-m|blb1uo0b-Ѵ-1|bˆb|‹ĺ&vbm]|_;0uo|_lb1uo7bѴ†|boml;|_o7ķ‰;v_o‰;7|_-|ŐƐő
$o†Ѵo†v;ķ u-m1;
|‰o†mbt†;0Ѵ;m7vo=Cinnamomum zeylanicumķDaucus carotaķEucalyptus globulus-m7
ouu;vrom7;m1;
Rosmarinus officinalisvŐƐ-m7Ƒĸ1bmm-lomv=uol|‰o7b==;u;m|v†rrѴb;uvő
l-m7bm;uo1_o|ķb;;ķ-ubv;7;ŠƐƔķ
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l-bѴĹ-ĺ0uo1_o|ŠѴ-u;m-v-m|;ĺ1ol
bm1Ѵ†7bm] vol; -m|b0bo|b1Ŋu;vbv|-m| v|u-bmvĺ bmbl-Ѵ bm_b0b|ou‹ 1om1;m|u-|bomv Ővő
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ѵĺƏƏѷˆņˆĸŐƑő-0Ѵ;m7o=Cinnamomum zeylanicumķDaucus carota, Syzygium aromaticum,
Origanum vulgare v ‰-v -m|b=†m]-Ѵ |o |_; vbŠ Candida v|u-bmv |;v|;7ķ ‰b|_ v
u-m]bm]=uolƏĺƏƐѷ|oƏĺƏƔѷˆņˆ‰b|_lbmbl-Ѵ=†m]b1b7-Ѵ1om1;m|u-|bomv=uolƏĺƏƑѷ
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7†-Ѵ-1|bˆb|‹ķ-]-bmv|ƐƐ-m7-]-bmv|S. aureus-m7S. pneumoniaemo|-0Ѵ‹ķƐl-‹
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bm1Ѵ†7bm]|_ov;1-†v;70‹lb1uoou]-mbvlvu;vbv|-m||o-m|blb1uo0b-Ѵ7u†]vĺ

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Ɛ Պ|Պ  $ ! & $   
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pneumoniae _-ˆ; u;rou|;7 u;7†1;7 -m|b0bo|b1 v†v1;r|b0bѴb|‹ķ ‰_b1_
;Š1;;7;7 ƔƏѷ bm lov| 1o†m|ub;v |_-| ruoˆb7;7 7-|- |o |_; )
m|blb1uo0b-Ѵ!;vbv|-m1;Ѵo0-Ѵ!;rou|om"†uˆ;bѴѴ-m1;Ő)ķƑƏƐƓőĺ
-m7b7b-vbv_-v-Ѵvo0;1ol;v†0v|-m|b-ѴѴ‹ruo0Ѵ;l-|b1ķ‰b|_Candida
albicansv_o‰bm]bm1u;-v;7u;vbv|-m1;|o1ollom-m|b=†m]-Ѵ-];m|v
ub;7l-mķ ;mbh-ķ ş -m7u;ѴѴķ
Őom1-Ѵˆ;vķ "o†Œ-ķ _o‰7_-u‹ķ ;bvķ ş oѴol0oķ ƑƏƐѵĸ -‰v;u
ş o†]Ѵ-vķ ƐƖƖƔőĺ$_; u;1;m| r-m7;lb1 o= - moˆ;Ѵ ƐƐ bm=Ѵ†;mŒ-
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l-|b11olro†m7vŐ1bmm-l-Ѵ7;_‹7;-m7;†];moѴő_-ˆ;-m|blb1uo0b-Ѵ
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o= -1|bˆb|‹ Ő-vvoѴ; ş †Ѵb-mbķ ƑƏƐƑĸ
ƑƏƏƑĸ-m|-mķ-ublo_-u-lķ"-m|_-m-lķş-l-ѴķƑƏƏѶőĺ$_;-m|bŊ
lb1uo0b-Ѵ;==;1|vo=v-u;Ѵbmh;7|o|_;bu1olrovb|bom-m71‹|o|oŠb1
;==;1|vķ ‰_b1_ 1-†v; 1;ѴѴ l;l0u-m; 7-l-];ĺ  1olro†m7v -u;
ƑĺƑՊ|Պ-1|;ub-Ѵ-m7=†m]-Ѵv|u-bmv
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u-m1;őķ ou =uol 1Ѵbmb1-Ѵ v-lrѴ;v ŐEscherichia coli &$ѶƖ -m7
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m;Š|u;l;1-v;vķ1‹|o|oŠb1b|‹1-mѴ;-7|o-ror|ovbvķm;1uovbvķ-m7 ƔѵƓƐ$ķStreptococcus pneumoniaeƐƏƓƓƕƐķListeria monocytogenes
ou]-m=-bѴ†u;Ő$bvv;u-m7ş+o†m]ķƑƏƐƒőĺ$_;u;=ou;ķv_-ˆ;|o0; ѶƑƐƐƏ$ķ-m7Staphylococcus aureus!"$ƒƒƔƖƐĸ-m7|;m
†v;71-u;=†ѴѴ‹ķ‰b|_bm|_;7-bѴ‹bm|-h;Ѵblb|v7;=bm;70‹|_;u;Ѵ;ˆ-m| u-lŊm;]-|bˆ;v|u-bmvĹPseudomonas aeruginosaƐƏƒƓѵƕķProteus
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-m7 mirabilis  ƐƏƒƐѶƐ$ķ Escherichia coli "ķ Escherichia coli &$ ѶƖķ
)ƑƏƏƒőĺ Klebsiella pneumoniaeѶƑƖƐ$ķSalmonella typhimuriumѵƏѵƑ$ķ
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v =uol Cinnamomum zeylanicumķ Daucus carotaķ Eucalyptus glob- 7321T. Pseudomonas aeruginosa  ƐƏƒƓѵƕķ Staphylococcus aureus
ulusķ -m7 Rosmarinus officinalisķ‰_b1_ 7b==;u;7 omѴ‹ bm |_-| |_; 1bmŊ !"$ƒƒƔƖķ-m7Escherichia coli"‰;u;v;Ѵ;1|;7=ou|_;bu
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‰;u;v;Ѵ;1|;7=ou|_;bu-m|b0-1|;ub-Ѵ;==;1|v|_-|_-70;;mo0v;uˆ;7ķ $_; =oѴѴo‰bm] vbŠ =†m]-Ѵ v|u-bmv ‰;u; |;v|;7 -v =oѴѴo‰vĹ Candida
;b|_;u bm7bˆb7†-ѴѴ‹ ou bm r-buvķ bm ru;ˆbo†vѴ‹ r†0Ѵbv_;7 v|†7b;v albicans "ƐƒѶѵķCandida glabatra "ƐƐƑƑѵķCandida tropicalis IP
Ő=ou u;ˆb;‰ v;; -vvoѴ; ş †Ѵb-mbķ ƑƏƐƑőĺ Eucalyptus globulus -m7 ƑƐƓѶĺƖƒķCandida albicans
ƑѵķCandida albicans
ƒƔķ-m7Candida albi-
Cinnamomum Zeylanicumv-Ѵvo_-ˆ;0;;mu;rou|;7|o_-ˆ;-m|bŊ cans
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-0boķ †m7,;ѴѴh†Ѵ|†u;mŐ "őķom;=uol|_;-v|;†umv|b|†|;Őőķ-m7|_u;;

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őĺ
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ő 1om|-bm;7 v =uol Cinnamomum zeylanicumķ Daucus
carotaķ Syzygium aromaticumķ Origanum vulgareķ ‰_b1_ -u; hmo‰m
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=ou|_;bu-m|b=†m]-Ѵ-1|bˆb|‹Ő_-mş_l-7ķƑƏƐƐĸbm|oķ(-Ѵ;Ŋ"bѴˆ-ķ
-ˆ-Ѵ;buoķ ş "-Ѵ]†;buoķ ƑƏƏƖĸ $-ˆ-u;v ;|-Ѵĺķ ƑƏƏѶĸ ,ou;ķ $_-hu;ķ "|u-bmv‰;u;ru;v;uˆ;7-|ƴѶƏŦ-m7v†01†Ѵ|†u;7omŐƐő|u‹r1-v;vo‹
-7_-ˆķş-u†rr-‹bѴķƑƏƐƐőĺ -]-uŐbol࣐ub;†Šķu-romm;ķ
u-m1;ő†m7;u-;uo0b11om7b|bomv-|ƒѵŦ
$_;-m|b0-1|;ub-Ѵ-1|bˆb|‹o=Ɛ-m7Ƒ‰-v;ˆ-Ѵ†-|;7bmˆb|uo =ouP. aeruginosaƐƏƒƓѵƕķP. mirabilisƐƏƒƐѶƐ$ķE. coli&$ѶƖķ
-]-bmv|-v;Ѵ;1|bomo=u-lŊrovb|bˆ;-m7u-lŊm;]-|bˆ;0-1|;ub-ķ‰b|_ S. thyphimurium  ѵƏѵƑ$ķ Y. enterocolitica  ѶƏƑƕ$ķ K. pneumo-
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b|‹-m7
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ou -m-;uo0b1 1om7b|bomv -| ƒѵŦ =ou S. pyogenes  ƔѵƓƐ$ķ S. pneu-
moniae  ƐƏƓƓƕƐķ L. monocytogenes ѶƑƐƐƏ$ķ B. fragilis $
Ƒ Պ|Պ  $  !  "   $  "
ƑƔƑѶƔķ H. influenza  ƐƏƑƔƐƓ -m7 B. catarrhalis  ƕƒƑƐ$ĸ -m7 Őƒő
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ƑĺƐՊ|Պvv;m|b-ѴobѴ0Ѵ;m7v
‹;-v|vĺ"†vr;mvbomv‰;u;ru;r-u;7bmv|;ubѴ;7bv|bѴѴ;7‰-|;u|oo0|-bm-
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&/lѴ=ou0-1|;ub--m7ƐƏ7
&/lѴ=ou‹;-v|vĺ
Eucalyptus globulus $ 1bm;oѴ ŐѴ;-=ő -m7 Cinnamomum zeylanicum $ Ѵ;m7v Ɛ -m7 Ƒ ‰;u; |;v|;7 =ou |_;bu -m|b0-1|;ub-Ѵ -1|bˆb|‹
1bmm-l-Ѵ7;_‹7;Ő0-uhőķƒĺƏƏѷo=Rosmarinus officinalis$1bm;oѴŐѴ;-=őķ -m7
 =ou b|v -m|b=†m]-Ѵ -1|bˆb|‹ -11ou7bm] |o - ru;ˆbo†vѴ‹ u;rou|;7
ƐĺƏƓѷ o= Daucus carota $ 1-uo|oѴ Őv;;7őķ -m7 ѶѶĺƖƏѷ o= Camelina lb1uol;|_o7 Ő0u-_bl ;|-Ѵĺķ ƑƏƐƑőĺ $;v|v ‰;u; -Ѵvo r;u=oul;7 ‰b|_
sativaobѴŐv;;7őĺ -loŠb1bѴѴbm=ou0-1|;ub--m7-lr_o|;ub1bm=ou‹;-v|v-v-1om|uoѴ=ou
Ѵ;m7
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lanicum $ 1bmm-l-Ѵ7;_‹7; Ő0-uhőķ Syzygium aromaticum $ ;†];moѴ -1_ 0Ѵ;m7 ‰-v 7bѴ†|;7ķ †vbm] |‰o=oѴ7 v|;rv bm lb1uo|b|;u rѴ-|;v
Ő"‹mom‹lo†vĹ Eugenia caryophyllus "ru;m];Ѵķ 1Ѵoˆ;vőķ -m7 Origanum bm 1†Ѵ|†u; l;7b†lĹ ŐƐő †ѴѴ;u bm|om Őő 0uo|_ Őbol࣐ub;†Šő =ou
vulgare$1-uˆ-1oѴŐ-;ub-Ѵr-u|vőķƐĺƏƓѷ o=Daucus carota$1-uo|oѴ P. mirabilis  ƐƏƒƐѶƐ$ķ E. coli &$ ѶƖķ S. typhimurium  ѵƏѵƑ$ķ
Őv;;7őķ-m7ѶѶĺƒƔѷo=Camelina sativaobѴŐv;;7őĺ Y. enterocoliticaѶƏƑƕ$ķK. pneumoniaeѶƑƖƐ$ķS. aureus!"
ѴѴ v ‰;u; ruoˆb7;7 0‹ oѴ];ll- Ővr࣐u-Œ-ķ
u-m1;ő ;Š1;r| $ƒƒƔƖƐķP. aeruginosaƐƏƒƓѵƕķ-m7E. coli"ĸŐƑő0uo|_
=ou C. zeylanicum bm Ɛ ‰_b1_ ‰-v =uol om|o†Š Ő"-bm|Ŋ†0bmŊv†uŊ v†rrѴ;l;m|;7‰b|_ƐƏѷ=;|-Ѵ1-Ѵ=v;u†lŐŊ †|v1_;uő†m7;u2
ѴĽ†ˆ࣏Œ;ķ
u-m1;őĺCamelina sativaobѴ‰-vruoˆb7;70‹oѴ-ubvŐѴ;†ˆ;mķ ou -m-;uo0b1 1om7b|bomv -| ƒѵŦ =ou S. pyogenes  ƔѵƓƐ$ķ S. pneu-

u-m1;őĺѴ;m7v‰;u;v|ou;7-|ƓŦ†m|bѴ†v;7ĺ moniae  ƐƏƓƓƕƐķ L. monocytogenes  ѶƑƐƐƏ$ķ B. fragilis $
$_;  ;Š|u-1|bom l;|_o7 -m7 1olrovb|bom -u; ruoˆb7;7 -v ƑƔƑѶƔķ-m7B. catarrhalisƕƒƑƐ$ĸŐƒő0uo|_v†rrѴ;l;m|;7‰b|_
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=ou v|;ubѴb|‹ 1om|uoѴ Չb|_o†| ruo7†1| ou lb1uoou]-mbvlvő -m7 ]uo‰|_
1om|uoѴՉb|_o†|ruo7†1|-m7‰b|_lb1uoou]-mbvlvőĺ$_;|‰o=oѴ77bѴ†Ŋ
|bomvѴ;7|o;l†Ѵvbomv-ѴѴo‰bm]|_;1om7†1|o=|;v|vĺmo1†Ѵ-|bom‰-v
r;u=oul;7ķ†vbm]-l†Ѵ|brobm|bmo1†Ѵ-|ouŐ ;mѴ;‹ő†m7;u-ˆoѴ†l;o=
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0-|;7-v7;v1ub0;7-0oˆ;ĺ
bmbl-Ѵ bm_b0b|ou‹ 1om1;m|u-|bom Őő ‰-v 7;=bm;7 -v |_; 1omŊ
1;m|u-|bomo=|;v|1olro†m7-|‰_b1_mol-1uov1orb1vb]mo=1;ѴѴ†Ѵ-u
]uo‰|_‰-v7;|;1|;7bm1olr-ubvom|o|_;1om|uoѴ‰b|_o†|1olro†m7ĺ
|‰-v7;|;ulbm;7=ou0-1|;ub--=|;ubm1†0-|bom-|ƒѵŦ=ouƑƓ_u-m7
‹;-v|v-|ƒƏŦ=ouƑƓ_ubm|_;ru;v;m1;o=v;ub-Ѵ7bѴ†|bomvo=|_;|;v|
1olro†m7vĺbmbl-Ѵ];ulb1b7-Ѵ1om1;m|u-|bomv=ou0-1|;ub-Őőou
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mol-1uov1orb1vb]mo=1;ѴѴ†Ѵ-u]uo‰|_‰-v7;|;1|;71olr-u;7|o|_;
1om|uoѴ †rom v†01†Ѵ|†ubm]ĺ $_;v; 1om1;m|u-|bomv ‰;u; 7;|;ulbm;7
0‹ v†01†Ѵ|bˆ-|bm] om 1ouu;vrom7bm] -]-u rѴ-|;v Ő -]-u ou v†rrѴ;Ŋ
l;m|;7ou"-0o†u-†7-]-uő-=|;ubm1†0-|bm]0-1|;ub-Ѵ-m7=†m]-Ѵ
v|u-bmvĺ
ѴѴ ;Šr;ubl;m|v‰;u; r;u=oul;7 bm 7†rѴb1-|; -| ;-1_ 1om1;m|u-Ŋ
|bomķ†vbm]-lb1uol;|_o7-m-Ѵ‹vbv0-v;7om|_;Ŋ"
]†b7;Ѵbm;vĺ
1;ѴѴvbml;7b†lŐŊ †|v1_;uőĺ(bu†vv†vr;mvbom‰-v-77;7|o
|_;|;v|1olro†m7‰b|_bm|;u=;ubm]v†0v|-m1;†m7;u1Ѵ;-m1om7b|bomv
ŐƐѷ"ķ"b]l-Ѵ7ub1_őĺ$_bvlbŠ|†u;‰-vl-bm|-bm;7-|ƒƔŦƼƐ=ou
ѵƏlbmƼƐƏĺ$_;-1|bˆb|‹‰-vv|orr;70‹|_;loѴ;1†Ѵ-uvb;ˆbm]l;|_o7ķ
†vbm]-vb;ˆ;=bѴ|;uŐ";r_-7;ŠƑƏőĺ;†|u-ѴbŒ-|bomo=|_;ruo7†1|‰-v
ˆ-Ѵb7-|;70‹r-vvbm]b||_uo†]_";r_-7;Š-|-7bѴ†|bomƐņƐƏĺ
(bu†v|b|u-|bomom1;ѴѴvbmv†vr;mvbom‰-vr;u=oul;7bmlb1uorѴ-|;vĺ
 7bѴ†|bom v;ub;v ‰b|_ - =-1|ou o= =o†u ‰-v ru;r-u;7 bm -m b1;Ŋ1oѴ7
l;7b†l=ouƒƏlbmbm]Ѵ-vv|†0;vĺ$_;7bѴ†|bom‰-v|_;m|u-mv=;uu;7
bm|o lb1uo|b|;u rѴ-|;v 0;=ou; |_; 1;ѴѴ v†vr;mvbom ‰-v -77;7 bm ;-1_
‰;ѴѴĺ(bu-Ѵ 1‹|or-|_b1 ;==;1|‰-v u;-7 †m7;u -m bmˆ;u|;7 lb1uov1or;
-=|;u Ɠ7-‹v o= bm1†0-|bom -m7 7;|;ulbm;7 0‹ |_; "r;-ul-mŋ࢜u0;u
l;|_o7Őou;mŒşo];ѴķƐƖƕƒő-11ou7bm]|o|_;=oѴѴo‰bm]=oul†Ѵ-Ĺ
;]-|bˆ;Ѵo]-ub|_lo=ƔƏѷ;m7robm|Ʒm;]-|bˆ;Ѵo]-ub|_lo=|_;
_b]_;v|ˆbu†v1om1;m|u-|bom†v;7ŋŐŒ"†lo=ѷ-==;1|;7-|;-1_7bѴ†Ŋ
|bomņƐƏƏŊƏĺƔœ*ŒѴo]o=7bѴ†|bomœő
!;7†1|bom bmˆbu†v bm=;1|bˆb|‹ ‰-v 1-Ѵ1†Ѵ-|;7 =uol |_; 7b==;u;m1;
o=Ѵo]ˆbu†v|b|;uv0;=ou;-m7-=|;u|u;-|l;m|ĺ$_;ruo7†1|‰-v1omvb7Ŋ
;u;7|o0;ˆbu†1b7-Ѵ‰_;mѴo]u;7†1|bom‰-vƾƓĺ
ƒ Պ|Պ !  "&$"   " &""  

ƒĺƐՊ|Պm|b0-1|;ub-Ѵ-1|bˆb|‹o=Ɛ-m7Ƒ
ƑĺƓՊ|Պ(bu-Ѵv|u-bmv-m7-m|bˆbu-Ѵ-1|bˆb|‹
Ѵ;m7v Ɛ -m7 Ƒ ;Š_b0b|;7 0o|_ 0-1|;ubov|-|b1 -m7 0-1|;ub1b7-Ѵ
m|bˆbu-Ѵ-1|bˆb|‹o=Ɛ‰-v|;v|;7‰b|_bm=Ѵ†;mŒ-ƐƐ$(!Ŋ! ;==;1|v-]-bmv|-ѴѴu-lŊrovb|bˆ;-m7u-lŊm;]-|bˆ;0-1|;ub-|;v|;7ķ
ƐƔƑƏ-m7ou-Ѵ_;ur;vvblrѴ;Š"(Ɛ$(!ŊƐƒѶƒĺ$;v|v‰;u;r;uŊ ‰b|_vu-m]bm]=uolƏĺƏƐѷ|oƒѷˆņˆ-m7v=uolƺƏĺƏƐѷ|o
=oul;7-11ou7bm]|o ƐƓƓƕѵŐ !ƑƏƐƔőĺ$_;ƐƐv|u-bm ѵѷ ˆņˆ Ő$-0Ѵ;Ɛőĺ $_;v; =bm7bm]v -u; 1omvbv|;m| ‰b|_ ru;ˆbo†v v|†7Ŋ
‰-v -lrѴb=b;7 om   1;ѴѴv ŐŊƒƓķ $ő -m7 "(Ɛ om (! b;vķ †vbm] v =uol |_; v-l; rѴ-m|v =uol ‰_b1_ o†u 0Ѵ;m7v ‰;u;

$      Ɛ Պ bmbl-Ѵbm_b0b|ou‹
  ņu-|bo
1om1;m|u-|bomvŐvőķlbmbl-Ѵ0-1|;ub1b7-Ѵ
1om1;m|u-|bomvŐvőķ-m7ņ "|u-bmv AB1 AB2 AB1 AB2 AB1 AB2
u-|bo=ou0Ѵ;m7vƐ-m7ƑŐѷˆņˆő
u-lŊrovb|bˆ;
Staphylococcus aureus MRSA ƏĺƒѶ ƏĺƒѶ ƏĺƒѶ 0.75 1.00 2.00
$ƒƒƔƖƐ-
Streptococcus pyogenesƔѵƓƐ$ 0.09 0.19 0.19 0.19 2.00 1.00
Streptococcus pneumoniaeƐƏƓƓƕƐ ƏĺƒѶ 0.05 ƏĺƒѶ 0.19 1.00 4.00
Listeria monocytogenesѶƑƐƐƏ$ ƏĺƒѶ ƏĺƒѶ ƏĺƒѶ ƏĺƒѶ 1.00 1.00
u-lŊm;]-|bˆ;
Pseudomonas aeruginosaƐƏƒƓѵƕ- 3.00 3.00 6.00 3.00 2.00 1.00
Proteus mirabilisƐƏƒƐѶƐ$ 0.75 ƏĺƒѶ 0.75 ƏĺƒѶ 1.00 1.00
Escherichia coli ESBLѴbmb1-Ѵ- 0.75 ƏĺƒѶ 1.50 0.75 2.00 2.00
Escherichia coli uropathogen&$ѶƖ ƏĺƒѶ ƏĺƒѶ 1.50 1.50 4.00 4.00
Klebsiella pneumoniaeѶƑƖƐ$ ƏĺƒѶ ƏĺƒѶ 0.75 0.75 2.00 2.00
Salmonella typhimuriumѵƏѵƑ$ 0.75 0.75 3.00 0.75 4.00 1.00
Yersinia enterocoliticaѶƏƑƕ$ 0.09 0.02 ƏĺƒѶ 0.05 4.00 2.50
Bacteriodes fragilis$ƑƔƑѶƔ 0.01 0.02 0.01 0.09 1.00 4.50
Haemophilus influenza IP 102514 ŋ 0.09 ŋ 0.09 ŋ 1.00
Branhamella catarrhalisƕƒƑƐ$ ŋ ƺƏĺƏƐ ŋ ƺƏĺƏƐ ŋ 1.00
-
"|u-bm‰b|_u;vbv|-m1;|o-m|b0bo|b1vĺ
7;ubˆ;7 -m7 |;v|;7 -]-bmv| |_; v-l; vr;1b;v o= 0-1|;ub-ķ 0†| 7b==;uŊ $      Ƒ Պ bmbl-Ѵbm_b0b|ou‹1om1;m|u-|bomvŐvőķlbmbl-Ѵ
;m|v|u-bmv|o|_ov;|;v|;7bmo†uv|†7‹Ő!oh0;mb;|-ѴĺķƑƏƐƒĸ"-Ѵ-ubķ =†m]b1b7-Ѵ1om1;m|u-|bomvŐ vő-m7 ņu-|bo=ou0Ѵ;m7 Őѷ
lbm;ķ "_bu-Œbķ -=;Œbķ ş o_-ll-7‹ro†uķ ƑƏƏѵĸ &mѴ†ķ u];m;ķ ˆņˆő

&mѴ†ķ,;‹|bmo]Ѵ†ķş(†u-ѴķƑƏƐƏĸ)-m]ķbķ†oķ,†ķş==;u|_ķƑƏƐƑőĺ "|u-bmv     ņu-|bo

Ѵ;m7vƐ-m7Ƒ‰;u;;==;1|bˆ;-]-bmv|-m|b0bo|b1Ŋu;vbv|-m|v|u-bmv
Pseudomonas aeruginosa  ƐƏƒƓѵƕķ Staphylococcus aureus !"
$ ƒƒƔƖķ -m7 Escherichia coli " Ő$-0Ѵ;Ɛőĺ o‰;ˆ;uķ P. aerugi-
Ƒѵ 0.02 0.02 1.00
nosaƐƏƒƓѵƕ‰-v|_;Ѵ;-v|v;mvb|bˆ;|o|_;0Ѵ;m7v|;v|;7ŐĹ
ƒƔ 0.02 0.02 1.00
ƒѷˆņˆ=ouƑ-m7ѵѷˆņˆ=ouƐőĺ$_bvu;v†Ѵ|‰-vmo|v†urubvbm]-v
ƕѶ 0.02 0.02 1.00
|_; m-|†u-Ѵ u;vbv|-m1; o= P. aeruginosa _-v 0;;m ru;ˆbo†vѴ‹ u;rou|;7
Őom]0o||olķ -uvomķ -ll;uķ ;;ķ ş !bѴ;‹ķ ƑƏƏƓĸ -r-7oro†Ѵovķ
-uvomķ_-m]ķş!bѴ;‹ķƑƏƏѶőĺ1ol0bm-|bomo=l;1_-mbvlvruo|;1|v
|_bv 0-1|;ub-ĺ $_; ;Š|;um-Ѵ l;l0u-m; bv r-u|b1†Ѵ-uѴ‹ blr;ul;-0Ѵ; |o
7u†]v -m7 _-v roubm;Ŋ7;r;m7;m| bm_b0b|bom -m7 ;==Ѵ†Š l;1_-mbvlv
Ő-r-7oro†Ѵov;|-ѴĺķƑƏƏѶőĺP. aeruginosa;lrѴo‹v-l†Ѵ|b7u†];==Ѵ†Š
v‹v|;l|_-|;Š|u†7;v1olro†m7vv†1_-vƐķѶŊ1bm;oѴ;ķ-lomo|;ur;m;
=o†m7bm_b]_Ѵ;ˆ;Ѵvbmo†u0Ѵ;m7vŐƻƓƏѷ=ouR. officinalis-m7ƻѶƏѷ
in E. globulusĸv;;"†rrou|bm]bm=oul-|bomőĺ
lom] |_; u-lŊrovb|bˆ; 0-1|;ub-ķ Ɛ -m7 Ƒ 0o|_ v_o‰;7
|_; Ѵo‰;v|  -]-bmv| S. pyogenes ŐƏĺƐƖѷ =ouƐ -m7 ƏĺƏƑѷ ˆņˆ
=ouƑőĺ
ou u-lŊm;]-|bˆ; 0-1|;ub-ķƐ v_o‰;7 |_; Ѵo‰;v|  Ѵ;m7Ɛvb]mb=b1-m|Ѵ‹u;7†1;7ˆbu-Ѵ†mb|v=ouƐƐ-m7"(Ɛĺ
ou
-]-bmv| B. fragilis ŐĹ ƏĺƏƐѷ ˆņˆő -m7 Ƒ -]-bmv| B. catarrhalis
ŐĹƺƏĺƏƐѷˆņˆĸ$-0Ѵ;Ɛőĺ); o0v;uˆ;7 mo l-uh;7 7b==;u;m1;v bm
|;ulv o= v;mvb|bˆb|‹ 0;|‰;;m u-lŊrovb|bˆ; -m7 u-lŊm;]-|bˆ; 0-1Ŋ
ou"(Ɛķ-u;7†1|bom
|;ub-ķ u;v†Ѵ|v |_-| 1o†Ѵ7 0; -||ub0†|-0Ѵ; |o - 1ol0bm;7 ;==;1| o= |_;
vouo=vol;o=|_;bu1olrom;m|vĺ!;v†Ѵ|v=uol|_;Ѵb|;u-|†u;-u;
1om=Ѵb1|bm]ĺu-lŊm;]-|bˆ;0-1|;ub-‰;u;u;rou|;7|o0;lou;v;mvbŊ
|bˆ; |o bm7bˆb7†-Ѵ v Őblķ -uv_-ѴѴķ ş);bķ ƐƖƖƔőĺ o‰;ˆ;uķ o|_;u
v|†7b;v=o†m7v‰;u;lou;;==;1|bˆ;-]-bmv|u-lŊrovb|bˆ;0-1|;ub-
ou ;Š-lrѴ;ķ
ou-Ѵ-1ho=v;Ѵ;1|bˆb|‹=ou1;u|-bmvŐ-ll;uķ-uvomķş!bѴ;‹ķƐƖƖƖĸ
u-0†v;;mbˆ-v-mķ-‹-h†l-uķş]m-1bl†|_†ķƑƏƏѵőĺ
m|_;0-vbvo=ņu-|bovķ|_;0-1|;ub1b7-Ѵ;==;1|‰-v1omŊ
=bul;7 =ou Ɛ -m7 Ƒ =ou lov| v|u-bmv |;v|;7 Őu-|bovƽƑő ;Š1;r|
=ou E. coli &$ѶƖ -m7 Y. enterocolitica =ou |_; |‰o 0Ѵ;m7vķ S. thyph-
imurium =ou Ɛ -m7 S. pneumoniae -m7 B. fragilis =ou Ƒ Ő$-0Ѵ;Ɛőĺ
bv1u;r-m1b;v 0;|‰;;m 0Ѵ;m7v l-‹ 0; ;ŠrѴ-bm;7 0‹ |_; 7b==;u;m|
1_;lb1-Ѵ 1olrovb|bom o= |_; |‰o 7b==;u;m| 1bmm-lom vĺѴ|_o†]_
1_;lo|‹r;v o=|_;|‰o1bmm-lom v‰;u;|_; v-l;Ő$1bmm-l-Ŋ
7;_‹7;őķ|_;1bmm-l-Ѵ7;_‹7;1om1;m|u-|bombm|_;1bmm-lom‰-v
-Ѵlov||‰o=oѴ7_b]_;ubmƑ|_-mbmƐ-m7|_;;†];moѴ1om1;m|u-Ŋ
|bom‰-vƻƒƏѷbmƐ1olr-u;7|oŜƑѷbmƑĺ
ƒĺƑՊ|Պm|b=†m]-Ѵ;==;1|o=
Ѵ;m7
_-7=†m]bv|-|b1-m7=†m]b1b7-Ѵ-1|bˆb|b;v-]-bmv|-ѴѴCandida bm|;u;v||o|u;-|bm=Ѵ†;mŒ--m7-Ѵvorov|bm=Ѵ†;mŒ-0-1|;ub-Ѵrm;†lomb-
v|u-bmv |;v|;7 ‰b|_ v u-m]bm] =uol ƏĺƏƐѷ |o ƏĺƏƔѷ ˆņˆ -m7
lbmbl-Ѵ =†m]b1b7-Ѵ 1om1;m|u-|bomv Ő
vő =uol ƏĺƏƑѷ |o ƏĺƏƔѷ ˆņˆ $_bvbmˆb|uov|†7‹v_o‰v|_-|0Ѵ;m7vƐ-m7Ƒo=C. zeylani-
Ő$-0Ѵ;Ƒőĺ $_; 
ņ u-|bo ‰-v ƽƑ =ou -ѴѴ v|u-bmv |;v|;7 Չb|_o†| cumķD. carotaķE. globulusķ-m7R. officinalisvrovv;vv-_b]_Ѵ‹-m|bŊ
vr;1b=b1 u;vbv|-m1; |o 1ollom -m|b=†m]-Ѵ 7u†]vőĺ $_;v; u;v†Ѵ|v -u;
1omvbv|;m| ‰b|_ o|_;u v|†7b;v v_o‰bm] |_-| v =uol C. zeylanicumķ
Ŋ1om|-bmbm] C.
E. caryophyllusķ-m7O. vulgare-m7|_;bul-bm1olro†m7vŐ1bmm-l-Ѵ7;Ŋ
_‹7;ķ;†];moѴķ-m71-uˆ-1uoѴő‰;u;=†m]b1b7-Ѵ-]-bmv|C. albicans-m7
other Candidavr;1b;v‰_;|_;uoumo||_;‹‰;u;u;vbv|-m||o1ollom
Candida albicans 0.02 0.02 1.00
"ƐƒѶѵ
Candida albicans
Candida albicans
Candida albicans
Candida tropicalis IP 0.01 0.02 2.00
ƑƐƓѶĺƖƒ
Candida glabatra " 0.05 0.05 1.00
11226
-m|b=†m]-Ѵ7u†]vŐ=Ѵ†1om-ŒoѴ;ou-lr_o|;ub1bmĸ$-lrb;ub;|-ѴĺķƑƏƏƔĸ
bm|o;|-ѴĺķƑƏƏѵĸ_ovu-ˆb;|-ѴĺķƑƏƐƐĸ"_u;-Œ;|-ѴĺķƑƏƐƐőĺ
ƒĺƒՊ|Պm|bˆbu-Ѵ-1|bˆb|‹o=Ɛ
ƐƐķ-u;7†1|bom]u;-|;u|_-mƖƖѷŐƻƑѴo]ő‰-vo0v;uˆ;7‰b|_Ɛѷ
Ɛ‰b|_-ѵƏŊlbm1om|-1||bl;-m7-u;7†1|bom]u;-|;u|_-mƖƖĺƖƖѷ
ŐƻƓѴo]ő‰b|_ѶƏѷ-m7ƓƏѷƐ-=|;uѵƏlbmĺ
]u;-|;u|_-mƖƖѷ‰-vo0|-bm;7‰b|_Ɛѷ-m7ƓƏѷƐ-=|;uѵƏŊlbm
1om|-1||bl;-m7-ƖƖĺƖƖѷu;7†1|bom-|ѶƏѷƐ=ouѵƏlbmĺ$_;v;
u;v†Ѵ|v-u;1omvbv|;m|‰b|_ru;ˆbo†v‰ouhķ‰_b1_v_o‰;7|_-|E. globu-
lus -m7 C. zeylanicum v _-7 -m|bˆbu-Ѵ -1|bˆb|‹ om ƐƐ -m7 "(Ɛ
Őv|-mb ;|-Ѵĺķ ƑƏƐƏĸ (bl-Ѵ-m-|_-m ş †7vomķ ƑƏƐƓőĺ
;†1-Ѵ‹r|†v  -m7 b|v 1olro†m7v ƐķѶ 1bm;oѴ; -m7 βŊ1-u‹or_‹ѴѴ;m;
;Š_b0b|-m-m|bŊ"(Ɛ-1|bˆb|‹0‹7bu;1|Ѵ‹bm-1|bˆ-|bm]=u;;Ŋˆbu†vr-u|bŊ
1Ѵ;v-m7lb]_|bm|;u=;u;‰b|_ˆbubom;mˆ;Ѵor;v|u†1|†u;vu;t†bu;7=ou
;m|u‹bm|o_ov|1;ѴѴvŐv|-mbķ!;b1_Ѵbm]ķş"1_mb|ŒѴ;uķƑƏƐƐĸv|-mb;|-Ѵĺķ
ƑƏƐƏőĺollomѴ‹†v;7-m|bˆbu-Ѵl;7b1-|bomŐ;ĺ]ĺķ-1‹1Ѵoˆbu-m7]-m1bŊ
1Ѵoˆbuőbm_b0b| roѴ‹l;u-v;vĺ7;m|b=‹bm]v†0v|-m1;v‰b|_ˆbu-Ѵ|-uŊ
];|vo|_;u|_-m roѴ‹l;u-v;v-u;o=r-u|b1†Ѵ-ubm|;u;v||o-ˆob7
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