Professional Documents
Culture Documents
Nonsurgical Rhinoplasty
Umang Mehta, MDa,*, Zachary Fridirici, MDb
KEYWORDS
Rhinoplasty Nose Filler Nonsurgical rhinoplasty Injection rhinoplasty Hyaluronic acid fillers
Advanced techniques Tip rotation
KEY POINTS
Nonsurgical rhinoplasty represents a safe and efficacious treatment when filler is placed in the nose
carefully and judiciously.
The injector must have an intimate knowledge of the nasal vascular anatomy and understand what
to do in situations of vascular compromise.
Hyaluronic acid filler in the nose can be used for dorsal augmentation as well as camouflaging of the
nasal hump.
Advanced techniques include increasing tip rotation and projection, straightening the nose,
lowering alar rims, and perhaps improving nasal valve function.
several years may be performed before reaching rhinoplasty. The nasal framework is draped by a
the cost of a surgical rhinoplasty. Limited down- soft tissue envelope comprising 5 layers that
time and risk associated with nasal fillers may overlie the perichondrium or periosteum base.
make them an attractive long-term solution. These From superficial to deep, these layers are the
benefits are particularly true of patients with epidermis, dermis, superficial fatty layer, fibro-
smaller noses, lower dorsums, and shorter sep- muscular layer (continuation of the superficial
tums, for whom primary nasal surgery may neces- musculoaponeurotic system [SMAS]), and deep
sitate ear or rib cartilage harvest. fatty layer (Fig. 1).2
Fifth, rhinoplasty surgeons may find placement The vascular network of the nose originates
of filler following rhinoplasty to be invaluable. The from both the external and the internal carotid ar-
ability to smooth minor nasal contour indentations teries via the facial artery and ophthalmic artery,
or rotate/project/straighten the tip can help to respectively.3 The facial artery and its course
reduce the likelihood of revision rhinoplasty and along the nasolabial fold are categorized as 1 of
its associated expenses, risks, and downtime. 3 types, as described by Saban and colleagues.3
Overall, nonsurgical rhinoplasty offers a quick, In their study using cadavers and ultrasound imag-
safe, and effective treatment, if the proper filler is ing, they found that in 80% of the cases the artery
placed judiciously. This article provides an over- coursed medial to the nasolabial fold (type I). In
view of the relevant nasal vascular anatomy, dis- 15% of the cases, the artery coursed into the
cusses safety considerations in nonsurgical cheek, lateral to the nasolabial fold (type II). In
rhinoplasty, explores complications related to 5% of cases, they found the facial artery termi-
nasal filler placement, and reviews both basic nated in the parasymphyseal region, with the
and advanced techniques. contralateral facial artery providing vascular sup-
ply to both sides of the nose (type III). There are
Nasal Vascular Anatomy 4 constant arteries: the subnasal artery, angular
An intimate knowledge of nasal anatomy is para- artery, dorsal nasal artery, and lateral nasal artery,
mount to the safe practice of nonsurgical as depicted in Fig. 2.
Fig. 1. The layers of the skin and soft tissue envelope of the nose include (from superficial to deep) the epidermis,
dermis, superficial fatty layer, fibromuscular layer, and deep fatty layer. Underneath the skin/soft tissue envelope
lie the perichondrium or periosteum and the cartilage or bone.
Advanced Techniques in Nonsurgical Rhinoplasty 357
Fig. 3. Polygonal system. (From Saban Y, Andretto Amodeo C, Bouaziz D, et al. Nasal Arterial Vasculature: medical
and surgical applications. Arch Facial Plast Surg 2012;14(6): 429-36; with permission.)
358 Mehta & Fridirici
duration, and stiffness. Reversibility is paramount Cannula use should not obviate other safety con-
in terms of safety. When arterial insufficiency or siderations, such as depth, location, and
venous congestion is suspected, reversal of the aspiration.
filler may help to alleviate these issues or minimize
their sequelae. For this reason, HA fillers are the COMPLICATIONS
optimal choices for nonsurgical rhinoplasty.
HA fillers bring an additional benefit over cal- Nonsurgical rhinoplasty is a generally safe proced-
cium hydroxyapatite. If surgery is performed after ure, with most complications avoided through pa-
a patient has had prior nonsurgical rhinoplasty, tient selection, product selection, and practicing
HA fillers are reversible if they have not yet the techniques mentioned above. Complication
resorbed. They are also easily removed during sur- rates are low, but need to be thoroughly discussed
gery, if needed. In addition, the tissue planes with patients before injection (Table 1).
remain clean and easily separated during surgery. The most severe, major complication of nonsur-
Calcium hydroxyapatite tends to create additional gical rhinoplasty is vascular compromise, which
fibrosis, which can add complexity to the lifting of has the potential for dermal necrosis and blind-
the skin and soft tissue envelope. ness. The mechanism is categorized as extravas-
The safest injection depth is in the rhinoplasty cular, intravascular, or combined. Extravascular
plane of dissection, just superficial to the peri- compromise is due to filler producing a mass ef-
chondrium and periosteum. The vascular plexus fect and vascular compression (specifically
of the nose should obviously be avoided. Depth venous). Intravascular compromise is secondary
of injection can be determined by placing the nee- to injection of filler into the vessel lumen with sub-
dle or cannula down on the level of the bone and sequent direct obstruction, embolism, or endothe-
cartilage. lial damage.6 During injection, the surgeon must
Nasal filler should be injected very slowly, while be vigilant to watch for dermal blanching with or
carefully watching for skin color changes. Aspira- without complaints of severe, spreading pain.
tion before injection is critical as well. A flash of Local tissue ischemia progresses to geographic
blood in the syringe indicates intravascular intro- (vascular territory) edema, erythema, and necro-
duction of the needle tip. Filler must not be pushed sis. Furthermore, intra-arterial injection (especially
forward immediately following this flash. One under high pressure) carries the risk of retrograde
should remove the needle, apply pressure, and arterial embolism to the ophthalmic and retinal ar-
then reintroduce it from a different entry point tery with the potential of ocular issues and
and at a different depth. blindness.
“Danger zones” of the nose include the area just Early recognition and intervention are critical in
lateral to the alar facial junction, nasal tip, alar rims, the setting of vascular compromise. If any signs
alar creases, and the area superior to the nose, in are noted, injections should be ceased and filler
the glabella. Injection in these areas necessitates dissolved.7 All clinics should have an Emergency
even greater caution, and the decision of whether Kit (Box 1) ready, to permit rapid intervention
or not to inject should be weighed more carefully. with massage, warm compresses, 2% nitroglyc-
erin paste, hyaluronidase injection, and aspirin
CANNULA USE administration. High-dose hyaluronidase injection
(200–300 U) should be performed to the entire
When possible, use of blunt cannulas may reduce
the risk of intravascular injection, although there Table 1
have been reports of blindness and skin necrosis Immediate and delayed complications
despite cannula use. In the senior author’s prac- following filler injection
tice, cannulas are useful in areas such as the tear
troughs, cheeks, and nasal dorsum, where the Immediate (<24 h)/Early
number of needle introduction points can be mini- (24 h to 4 wk) Delayed (>4 wk)
mized. Cannulas should result in reduced bruising, Edema, erythema, Granulomatous
both from atraumatic passage through tissue and itching, Tyndall inflammation,
from fewer skin penetrations. effect, allergic foreign body
For the nose, cannula use is most useful for reaction, inflammatory reaction,
long, straight vectors of placement, such as a nodules, herpes migration of
continuous dorsum without a significant hump. In outbreak, the filler,
the senior author’s practice, the 27-gauge cannula vascular compromise scarring,
asymmetry,
is used for most indications. The cannula port
discoloration
should be directed away from the skin envelope.
Advanced Techniques in Nonsurgical Rhinoplasty 359
1. 2% Nitroglycerin paste
BASIC TECHNIQUES
2. Sublingual nitroglycerin 0.6 mg Dorsal Augmentation
3. Aspirin 325 mg
When performing nonsurgical rhinoplasty, one
4. Warm compresses should think in terms of cartilage grafts, rather
5. Hyaluronidase than simply contour. On the dorsum, filler place-
6. Topical timolol 0.5% and/or acetazolamide ment is an alternative to surgical diced cartilage
500 mg placement. Patients with a low dorsum, most typi-
cally those of Asian or African descent, often
7. Paper bag
desire a taller, narrower-appearing dorsum. These
patients often have a shorter quadrangular carti-
lage, and ear or rib cartilage may be needed,
area, with repeat injection hourly until clinical res- even in primary rhinoplasty. Even with meticulous
olution is achieved or doses nearing 1500 U have surgical technique, dorsal diced cartilage grafts
been reached.8 Injections should then be per- may result in minor contour irregularities as the
formed daily until signs or symptoms are reversed. skin and soft tissue envelope shrinks back down.
Adjunct procedures, such as oxygen administra- The smoothness and ease of dorsal filler place-
tion or hyperbaric oxygen treatments, should be ment may make this an attractive alternative.
strongly considered. Some resources advocate In patients with a lower dorsum, it is important to
for the injection of 10 mg of prostaglandin E1 daily consider the natural nasal starting point, typically
for 5 days.9 After the initial time period, local at the midpupillary line. Computer simulation can
wound care and antibiotic therapy may be indi- be helpful to determine whether the patient is
cated. Critical to any major, procedural complica- seeking this lower starting point or one which sits
tion is a solid rapport and open communication at the level of the superior lid crease.
with the patient. To fill the dorsum, one may use a cannula, intro-
Vision loss or changes indicate retrograde em- duced in the supratip. The bevel is placed down-
bolism affecting the retinal artery. In the event of ward toward the perichondrium or periosteum. If
central retinal artery occlusion, irreversible the cannula is in the proper plane, it should glide
changes and blindness occur within 60 to 90 mi- easily. There have been cases of blindness re-
nutes.10 All of the above measures should be per- ported in the literature with injections in and
formed with the addition of ocular massage (firm around the radix/glabella.11 For this reason, it is
pressure to a closed eye for 5 seconds with a recommended to tent the skin/soft tissue envelope
quick release), 1 drop of topical timolol 0.5%, sub- up while keeping one’s fingers along the nasal
lingual nitroglycerin 0.6 mg, rebreathing into a pa- sidewalls. This technique also keeps the product
per bag, and rapid referral to an ophthalmology in the midline. The cannula tip should be kept
center, for possible retrobulbar injection of hyal- below the level of the nasion. The product can
uronidase, anterior chamber paracentesis, ste- be massaged upwards easily after injection, if
roids, and mannitol.11 desired.
Early hyaluronidase administration (<4 hours) is In most patients, 0.4 to 0.6 mL of filler is enough
critical. Delayed (>24 hours) injection efficacy is to provide enough dorsal height, depending on the
still a point of controversy anecdotally and in ani- native height and the desired effect. A dorsal hump
mal model studies12 (see Box 1). can be created with filler. Increased tip projection
may be advisable when augmenting the dorsum,
GENERAL PRINCIPLES OF NONSURGICAL to avoid a hooked-appearing profile (Fig. 4).
RHINOPLASTY
CAMOUFLAGING A HUMP
In the nose, fillers with a higher G0 tend to be more
effective than those with a lower G0 . G0 is known as Reduction of the nasal hump is the most common
the elastic modulus, and it is a representation of request in surgical rhinoplasty. It follows that this is
the ability of a filler to resist deformation. Stiffer a common request in nonsurgical rhinoplasty as
fillers, such as a high G0 , large-particle HA gel, well. Many patients who present for this maneuver
more closely mimic natural bone and cartilage, may actually be better surgical candidates, espe-
yielding results that are more defined, precise, cially in the case of a large hump or a shallower ra-
and sharp. Softer, more pliable fillers can provide dix. Computer imaging can be a helpful way to
360 Mehta & Fridirici
Fig. 4. Dorsal augmentation: 0.55 mL of a high G0, large-particle HA gel placed with 27-gauge cannula on the
dorsum and 0.15 mL placed at tip.
illustrate this to patients, because a very tall radix depth and vascular anatomy. That said, these
may be undesirable. techniques can be safely and effectively per-
Placement of filler above and below the dorsal formed, providing patients with predictable results
hump is a straightforward maneuver. If the hump that can approximate, to some extent, what can be
is small, this can be done with a cannula in the achieved with nasal surgery.
supratip. For larger humps, placement at 2 points
may be indicated, cephalad and caudal. A 29- Tip Rotation
gauge needle is most commonly used in the senior
author’s practice for this placement. Placement of Rotation of a droopy nasal tip is a common request
the filler at the proper depth and aspiration, in of patients who present to a facial plastic surgery
particular at the radix, is very important. Depend- office. A ptotic tip can cause an aged appearance,
ing on hump size relative to the radix, 0.2 to because the nasal tip tends to counterrotate with
0.3 mL of filler cephalic and 0.1 to 0.2 mL distal time. In addition, feminine noses may appear
to the hump are generally sufficient. more masculine if the tip is ptotic. The ideal tip
Similar to dorsal augmentation, the natural nasal angle for feminine noses is 95 to 105 , whereas
starting point must be assessed. Distally, some this same angle should be 90 to 95 for male
patients desire a supratip break, whereas others noses.
prefer a straight dorsum (Fig. 5). The Tripod Theory is a well-established principle
in rhinoplasty.13 Each lateral crus represents 1 leg
ADVANCED TECHNIQUES of the tripod, whereas the paired medial crura
represent the third. Rotation of the tip can be
More experienced injectors may elect to perform accomplished by shortening the lateral crura with
advanced nasal filler maneuvers. These maneu- an overlay procedure, lengthening the medial
vers require deeper consideration of the safety crura, or setting the entire tripod on a more prom-
factors previously discussed, including injection inent base. Surgically, the senior author uses a
Advanced Techniques in Nonsurgical Rhinoplasty 361
Fig. 5. Camouflaging a hump: 0.25 mL of a high G0, large-particle HA gel placed proximal to the hump and
0.25 mL placed distal in lower dorsum. Also, 0.2 mL is placed at the tip to increase projection and 0.25 mL placed
at the base of the columella for rotation.
intravascular injection. Aspiration is important, of straighten the middle vault, and the mid and lower
course. The filler should be placed very slowly, dorsum. Clocking sutures can also be helpful.
immediately upon the perichondrium of the tip car- Finally, at the tip, it is important to properly
tilages. The filler can then be shaped with the fin- assess the cause of the tip deviation. Most
gers. If desired, the infratip can be slightly commonly, this occurs due to deviation of the
lengthened using this technique as well, if the filler caudal septum, in which case a caudal septal
is in the form of a shield graft. A small amount of repositioning or reconstruction may be required.
additional filler in the supratip may be advisable, A caudal septal extension graft is also often used
if the increased projection accentuates the supra- in the senior author’s practice, to create a midline
tip break (Fig. 6) (Video 1). point to which the tip can be attached.
Differential heights of the premaxilla on each
side can also contribute to tip deviation. During
Straightening the Nose
the consultation, the surgeon should palpate the
Because facial symmetry has long been perceived premaxilla bilaterally to determine if there is a uni-
as aesthetically desirable, a crooked nose can be lateral deficiency. Often the ala appears higher and
problematic. Deviation of the nose can occur at smaller on the affected side, in what has been
the upper dorsum, lower dorsum, and tip, and called the “hidden ala syndrome.” Augmentation
often some combination of all 3. Surgically, of the affected side with cartilage or filler can
straightening the upper dorsum of the nose often create more symmetry on front and base views,
requires medial and lateral osteotomies, with while straightening the nasal tip. Surgically, this
possible spreader graft placement to support the is done with a few small fragments of cartilage
previously infractured nasal bone and narrowed placed under the alar base through an intranasal
upper lateral cartilage. A unilateral spreader graft incision and is commonly known as a premaxillary
or bilateral grafts of different width are used to or subnasal graft.
Fig. 6. Tip rotation and projection: 0.15 mL of a high G, large-particle HA gel placed at the base of the columella
to increase tip rotation, and 0.2 mL placed at the tip, for projection. Also, 0.35 mL was placed proximal to the
hump and 0.1 mL distal to the hump in the lower dorsum.
Advanced Techniques in Nonsurgical Rhinoplasty 363
Fig. 7. Straightening the nose: 0.35 mL of a high G0, large-particle HA gel was placed in the right premaxillary
area, 0.5 mL in the left middle vault, and 0.5 mL placed proximal to the hump. Filler was placed over 2 sessions,
spaced one week apart.
364 Mehta & Fridirici
injectors with proper precautions. Composite carries a small risk of implant extrusion or visibility
graft placement (under local anesthesia 1/- oral through the skin. Cost must also be considered,
sedation) is an alternative to filler for lowering because the price of a syringe of filler is perhaps
alar rims (Fig. 8). one-third that of the implant. The final factor is
longevity. It is unclear if the stiffness and fibrosis
created by HA filler can endure as long as those
FUNCTIONAL APPLICATIONS
created by the Latera implant.
Narrow internal or external valves, either at rest or To improve breathing, filler has been placed by the
during inspiration, can cause nasal obstruction. senior author in the internal valves, in the scroll, and
Surgically, a variety of approaches have been externally along the nasal sidewalls. The internal
used to improve the valves, including spreader valve placement consists of 0.1 mL placed intrana-
grafts, autospreader grafts, butterfly grafts, alar sally, with a 29-gauge needle, in the space between
batten grafts, strut grafts, alar spanning sutures, the upper lateral cartilage and the top of the septum.
composite grafts, bone-anchored suture fixation, The scroll placement consists of less than 0.1 mL
and rim grafts. placed endonasally, between the cephalic border
An implant consisting of poly-L-lactic acid (Lat- of the LLC and the caudal edge of the upper lateral
era) has been used for nasal valve collapse.15 cartilage. Finally, external placement of 0.2 to
Although studies show effectiveness, there could 0.3 mL can be done for the nasal sidewalls. The rec-
be some potential benefits or disadvantages of ommended plane of injection is again down on the
HA fillers versus Latera. The first benefit is patient perichondrium. Patients who have received filler in
comfort, because Latera deployment requires in- these locations have reported an improvement in
jection of local anesthetic followed by introduction their breathing and appear to have reduced dynamic
and advancement of a large cannula. Latera collapse of the nose (Video 2).
Fig. 8. Placement of 0.1 mL of HA filler along the alar rim can help correct mild cases of alar retraction and/or
asymmetry. This area must be injected very slowly with frequent aspiration to reduce the risk of vascular
compromise.
Advanced Techniques in Nonsurgical Rhinoplasty 365
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