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RESEARCH ARTICLE
ABSTRACT
Introduction: Attention Deficit Hyperactivity Disorder (ADHD) has been mainly studied in
children, even though it persists into adulthood; only recently has adult ADHD received the
required attention. ADHD research in Arab speaking countries is relatively scarce.
Objectives: This scoping review has as objectives to provide a comprehensive overview of adult
ADHD research in the 22 Arab countries, to identify gaps in the literature and inform future
research.
Methods: The scoping review is underpinned by the five-stage framework of Arksey and
O'Malley. Eight electronics databases were searched for published and unpublished literature as
well as conference proceedings from conception date of databases until February 2018.
Results: The literature search yielded 2,792 citations after removal of duplicates, out of which
11 articles and conference proceedings were included. Publications were concentrated in the
21st century. ADHD diagnosis and sample differed between each study, where a variety of
screening and diagnostic tools were used among clinical and community samples. National
prevalence of adult ADHD only exists for Lebanon and Iraq as they are part of the World Mental
Health (WMH) Surveys initiative. Also, adult ADHD is highly comorbid with bipolar and
Conclusions: This is the first methodologically rigorous scoping review focusing solely on adult
ADHD in the Arab region. We found that adult ADHD is quite prevalent in the Arab World
where studied, linked to serious impairment, and is highly comorbid, yet it is under-researched
and undertreated across the Middle East and North Africa.
3.2 Study Characteristics: The first was two, and Iraq with one. Of the four articles
published in 1997 and the last one in 2017. that included data from, Lebanon, three were
Egypt and Lebanon had the highest number part of the WMH Surveys, as well as one
of original research on adult ADHD with 4 article that includes Iraq (Table 2). The
articles each, Saudi Arabia followed with fourth source of data from Lebanon, is a
presentation conducted by two of the authors inpatients or outpatient facilities and the
of this manuscript during the “ADHD across remaining were epidemiological samples
the Lifespan” Conference in April 2017 in from household surveys, or university
Beirut, Lebanon, and currently under final students. All studies defined used the
preparation for publication. The samples of terminology ADHD, except one study that
participants recruited in all these 11 articles used the term “Behavioral Disorder-
were equally diverse, as 54.54% (n=6) were Hyperactive”.
clinical samples from either mental health
Khalil et al. Clinical: inpatients and N=97: 18-65 ADHD Screening: Arabic validated
(2016), outpatients screened years old, mean version of Adult ADHD Self-Report
Egypt positive for Alcohol, average=40.9 ± Scale (ASRS-v1.1) and a Symptom
Opioids, Amphetamine or 5.8 years old Checklist.
Cannabis, at the N=27 with ADHD Diagnosis: Patients who
Psychiatric Department of ADHD: mean answered positive for four or more
Mansoura University. average=34.2± questions were further interviewed
5.8 years old using Diagnostic Interview of Adult
N=70 without ADHD (DIVA)
ADHD: mean Substance use: Alcohol: Enzymatic
average=38.1± method by oxidation to acetaldehyde
5.8 years old with NADH+. Opiates, amphetamines
and cocaine: Immunoassay screening
for urine and gas chromatography-
mass spectroscopy.
Alosaimi et al. Clinical: Patients seeking N= 1,205 ADHD: Routine clinical interviews
(2017), psychiatric help at six patients: above using DSMIV-TR criteria
Saudi Arabia major Hospitals in Saudi 18 years old,
Arabia: King Khalid total mean
University Hospital in average=
Riyadh and Zulfi General 38.1±13.0
Hospital (central region), years old
Jeddah Mental Health N=443
Hospital (western region), inpatients:
Al Amal Complex for mean
Mental Health in average=8.4±1
Dammam (eastern region), 3.6 years old
Aljouf Mental Health N=762
Hospital (northern region), outpatients:
and Abha Mental Health mean
Hospital (southern region). average=37.4±
King Khalid University 12.0 years old
Hospital is a university-
affiliated governmental
hospital whereas the other
hospitals are government-
funded service hospitals
under the authority of the
Ministry of Health.
Fayyad et al. Epidemiological: Stratified Total ADHD: Version 3.0 of the WHO
(2017), multistage clustered area N=26,744 with Composite International Diagnostic
World Mental probability sample of ADHD: 18-44 Interview (CIDI 3.0), based on
Health Survey household residents. years old questions originally developed in the
including Iraq Lebanon Diagnostic Interview Schedule for
and Lebanon N=595 with DSM-IV.
ADHD Adult ADHD: Respondents classified
Iraq N=3227 retrospectively as having met full
ADHD criteria in childhood were
then asked a single question about
whether they continued to have any
current problems with attention or
hyperactivity–impulsivity.
Karam et al. Clinical: first time patients Total N= 1,305 Adult ADHD: Physician assistant and
(2017), presenting for a N= 236 with Psychiatrist diagnosed patients
Lebanon consultation at MIND ADHD rigorously based on the DSM-IV
Clinics in Saint Georges N=136 with criteria, but not following the
Hospital University ADHD and checklist systematically. Patients
Medical Center in Beirut, Bipolar classified as ADHD are patients with
Lebanon, between January Disorder either past or present ADHD or ADD
2014 and December 2016. N=100 with diagnosis and classified according to
ADHD and levels: Definite, Probable and
non-Bipolar Possible
Disorder
3.3 Methods of assessing adults ADHD: used in three studies in Egypt (Abdelkarim
Different methods were used to assess et al., 2015; Khalil et al., 2016; Salama,
ADHD in the selected studies. Three studies Ibrahim, El Magd, & Kerim, 2015), the other
used medical diagnosis (a medical and two studies (El Hay and Sawy (2011), and
clinical team diagnosed them based on Ashor (2012)) failed to mention if they used
medical definitions rather than using self- the Arabic or English version. The ASRS
administered questionnaires, or structured was developed in conjunction with the
interviews such as the CIDI) in order to revision of the CIDI, its 18 items are based
classify patients as ADHD: one failed to on the 18 DSM-IV criteria and symptoms of
mention the exact method used, yet patients ADHD. They are measured on a 5-point
were already in a rehabilitation center (Al- scale (0=never to 4=very often), yielding a
Sulaiman, 1997), while in another study possible score of 0 to 72. Items 1-9 cover the
psychiatric residents and staff were symptoms of inattention; and items 10-18
responsible for the chart review that had covers the symptoms of hyperactivity and
psychiatric diagnosis based on DSMIV-TR impulsivity (Adler, Kessler, & Spencer,
criteria (Alosaimi et al., 2017). The study 2003; Kessler et al., 2005). The ASRS is
done by the authors of this paper, diagnosed standardized and validated in individuals
patients rigorously based on the DSM above 18 years old (Kessler, Adler, Ames,
system of diagnosis, but not following the Demler, et al., 2005; Kessler, Adler,
checklist systematically. The patients were Barkley, et al., 2005; Kessler et al., 2007), in
diagnosed by both the physician’s assistant different languages (Evren et al., 2016; Kim,
and the psychiatrist. Patients with past or Lee, & Joung, 2013; Morin, Tran, & Caci,
present ADHD or ADD diagnosis were 2016; Ramos-Quiroga et al., 2009) and
classified according to levels: Definite, among patients with other comorbid
Probable and Possible (Karam, El Hayek, & disorders (Carlucci, Ivanova, Bissada, &
Farhat, 2017). Five papers used a self-rated Tasca, 2017; Chiasson et al., 2012; C. Daigre
screening test such as the short screening et al., 2009; Constanza Daigre et al., 2015;
version of the adult ADHD Self-Report Reyes et al., 2016; Van de Glind et al.,
Scale (ASRS). The Arabic version of the 2013). The ASRS V1.1 Screener used in the
ASRS V1.1 Screener (WHO, 2014) was three Egyptian studies is a subset of the
WHO’s 18 question ASRS, which measures investigators of the study at the same time,
the presence and frequency of current for the core symptoms of ADHD (El-Hay &
ADHD symptoms (WHO, 2003, 2014). It El Sawy, 2011). This time the complete
has 6 items rated on a 5-item Likert scale version of the ASRS V1.1 was used, along
(scale 0-4), asking about the frequency of the with Barkley childhood ADHD symptom
symptoms of ADHD during adulthood. scale, and the ADHD current Symptom
There are four questions pertaining to the Scale (Barkley & Murphy, 1998; WHO,
theme of inattention and two questions 2003). While the Barkley childhood ADHD
related to hyperactivity, when four or more symptom scale focuses on the retrospective
marks appear in darkly shaded boxes, then assessment of the 18 DSM-IV criteria, the
there is suspicion of adult ADHD, prompting adult scale looks at the patients’ behavior
for further tests, and diagnosis (WHO, during the past 6 months only. It is
2003). Abdelkarim et al., (2015) and Salama composed of questions corresponding to the
et al., (2015) used in addition to the ASRS nine symptoms of inattention and the nine
V1.1, the Arabic version, the Wender Utah symptoms of hyperactivity/impulsivity
Rating Scale for the retrospective according to the DSM-IV, using a scale from
assessment of childhood ADHD with a cut 0-3 (with 0=never/rarely, 1= sometimes,
off of 46 (Wender, 1998). To verify the 2=often and 3=very often) ( Barkley &
results of the ASRS V1.1 and make a final Murphy, 1998). The WMH surveys
diagnosis, patients in one study were evaluated retrospectively childhood ADHD
subjected to the Diagnostic Interview for with Version 3.0 of the WHO CIDI as a part
ADHD in Adults (DIVA 2.0) (Khalil et al., of the assessment of different mental health
2016). This structured interview is divided disorders (de Graaf et al., 2008; Fayyad et
into three parts that are each applied to both al., 2007; Fayyad et al., 2017; Kessler &
childhood and adulthood, the criteria for Üstün, 2004). The module that assessed
attention deficit, the criteria for ADHD was originally developed from the
hyperactivity-impulsivity, the age of onset Diagnostic Interview Schedule for DSM-IV
and impairment accounted for by ADHD (DIS) (Robins, Cottler, Bucholz, &
symptoms. The patients are diagnosed as Compton, 1995). When respondents meet
having adult ADHD if they scored six or the full childhood ADHD criteria, they are
more for each of the symptom domains of asked a single question whether they
attention deficit and hyperactivity- continued to have any current problems with
impulsivity in childhood and during adult attention or hyperactivity-impulsivity.
life with evidence of life-long persistent Based on a pilot clinical reappraisal
course with impairment in at least two interview done in the US, a transformation
situations and these symptoms not explained rule was developed to convert responses to
by another psychiatric disorder (Kooij et al., the CIDI ADHD symptom-recency
2005; Sandra Kooij et al., 2008). In another questions into a predicted probability of
study in Egypt as well, students above the adult ADHD for each respondent in the
age of 18 years with positive screening of larger samples (Fayyad et al., 2007; Kessler
ADHD were assessed individually by both et al., 2006).
the second part of this study, there was a source of legal problems for 38.9% of this
comparison among different types of sample (Salama et al., 2015). In view of
smokers such as non-smokers, light substances consumption, the ADHD group
smokers, and heavy smokers assessed using had a higher cocaine use with 11.1% (n=4)
the Fagerström Test for Nicotine compared to 0% among non-ADHD. The
Dependence (FTND). Therefore, two third multivariate regression pointed out that
(66.7%) of heavy smokers reported ADHD and SUD patients prefer 2.6 times to
symptoms of ADHD in comparison with sniff heroin more than only SUD patients.
31.7% of light smokers, and 11% of non- They are also, admitted to the hospital 1.13
smokers. Also, heavy smoking was times more than their non ADHD
associated with significant deterioration in counterparts. They start SUD use at earlier
the inattentive and total ASRS scores in with a ratio of 0.9. When comparing SUD
comparison with none and light smokers. patients with a history of childhood ADHD
The hyperactivity symptoms scores and SUD patients with adult ADHD, the
significantly differed between nonsmokers latter consumed substances at an earlier age
in comparison with light and heavy smokers. (13.2±2.6 versus 14.9±2.9), had more
A correlation was established between exposure to legal problems (38.9%, n=14
ASRS and FTND scores, showing that versus 14.3%, n=4), and a shorter duration of
students with a high FTND score tend to start abstinence (124.5±171.9 versus
smoking earlier (r=-0.432, p=0.001), and to 271.5±363.9). Nevertheless both groups had
have higher inattentive (r=0.391, p=0.001), a similar mean average for the number of
and total ASRS scores (r=0.330, p=0.004) times to be admitted to the hospital (6.8±8.1
(Ashor, 2012). and 4.2±4.9) (Salama et al., 2015).
Similarly, a study conducted among
3.5.3 Clinical Population Studies: Two
inpatients and outpatients at the psychiatric
studies conducted in the Addiction Center of
department of Mansoura University
Al Maamoura psychiatric Hospital,
explored ADHD among SUD patients. The
investigated patterns of substance use and
SUD with ADHD group had an earlier age
ADHD. The first study observed that mean
of onset with 20.2±2.1 years when compared
age of substance use was lower in the ADHD
to SUD without ADHD who had a mean age
group with 13.2±2.6 years compared to
of onset of 32.8±6.2 years. Besides, they had
15.6±3.8 years in the non ADHD group.
a longer period of substance use (12.4±6.1
Also, comorbid ADHD and SUD led to
years versus 4.3±4.1 years). The study
double the number of hospital admissions
indicated that they relapsed about three
with 6.8±8.1 times compared to 3.4±4.0
times more than SUD patients without
times or the non ADHD and SUD group. The
ADHD (3.9±1.4 versus 1.1±1.2), yet this
latter was able to have a longer period of
finding was borderline significant with a p-
abstinence with 209.8±282.0 compared to
value of 0.056 (Khalil et al., 2016). In the
124.5±171.9 days for SUD patients with
study conducted in Lebanon in MIND
ADHD (Abdelkarim et al., 2015). The
clinics referred to above, ADHD patients
comorbidity of ADHD and SUD might be a
(n=236) had higher rates of Bipolar disorder,
and SUD compared to non-ADHD patients adults with ADHD received any treatment
(n=1,069) with 57.6% (n=136) versus 33.6% specifically for ADHD, but 0.8% in Lebanon
(n=359) and 28.4% (n=67) versus 13.8% (and none in Iraq) received mental health
(n=147) respectively (Karam et al., 2017). treatment for other mental disorders (Fayyad
Adjusting for age and gender bipolar and et al., 2007; Fayyad et al., 2017).
SUD patients were 2.3 (95% CI= 1.5, 3.6)
3.8 ADHD and family history of
and 1.8 (95% CI= 1.1, 2.8) times more likely
Psychiatric disorders: Only one article
to have ADHD. More analysis is underway
examined the consequences of the presence
at present in a larger sample.
of a family history of psychiatric disorders
3.6 ADHD and work performance: De and ADHD among the offspring (El-Hay &
Graaf et al. (2008) described the loss of role El Sawy, 2011). As it turns out, family
performance among workers as part of the history of psychiatric disorders was more
WMH surveys. On an individual level, common among students with ADHD
compared to subjects without ADHD, (59.0%) compared to students without
adjusting for age, gender, education and ADHD (28.2%). In particular, a family
occupation, employed/self-employed history of ADHD, and Major Depression
patients with ADHD, were out of role for Disorder were more prevalent among
19.4 days, yet this was not statistically students with ADHD with 28.2% and 23.1%
significant. On a national level (in millions respectively, compared to 5.1% for both
of days), the overall days out of role was 0.3 disorders in the control group (El-Hay & El
(de Graaf et al., 2008). This article also Sawy, 2011).
stated that socio-demographics among
Lebanese could predict total role
4. Discussion: To the extent of our
knowledge this is the first scoping review
performance for ADHD workers (p-
that specifically discusses adult ADHD in
value=0.044), yet the effect size was not
the Arab region. In this review we managed
presented, as the table showed associations
to map out the different methodologies used
for the total sample of 10 countries (de Graaf
to assess adult ADHD in the different papers
et al., 2008). In Egypt, university students
and extrapolate findings related to the
with ADHD, scored lower on the Global
prevalence of ADHD and its comorbidities.
Assessment of Functioning (GAF) a scale
This review have several strengths: its
that evaluates their overall functioning. The
protocol was developed following the
mean average was 56.7 compared to 86.0 for
methodological framework of Arksey and
the control group (El-Hay & El Sawy, 2011).
O’Malley and more recently the Joanna
3.7 ADHD treatment: Patterns of treatment Briggs Institute (Arksey & O'Malley, 2005;
for mental health disorders were computed Peters et al., 2015). Various search engines:
in the WMH surveys: as such 1.1% and 0.7% Medline, PubMed, Embase, Scopus,
of ADHD patients received any professional CINAHL, in addition to IDRAAC’s search
help during the last 12 –months in Lebanon engine, Google scholar and Google were
and Iraq respectively (Fayyad et al., 2007; used to look for articles, conference
Fayyad et al., 2017). However, none of the abstracts, presentations and reports in
English, French and Arabic; pertaining to the significant findings. Twelve-month adult
objective of this review. In addition, the ADHD was significantly and positively
authors contacted key ADHD stakeholders comorbid with 12-month prevalence of other
in the region for unpublished and un-indexed DSM-IV/CIDI disorders considered in the
reports and research papers. WMH surveys (Fayyad et al., 2017).
University students with ADHD were found
This review yielded significant findings. The
to have more lifetime psychiatric
results of the WMH surveys demonstrated
comorbidities, notably depression and
that not only childhood but also adult ADHD
anxiety (El-Hay & El Sawy, 2011), whereas
is quite prevalent (1.8% in Lebanon and
outpatients showed a higher rate of BD
0.6% in Iraq) (Fayyad et al., 2007; Fayyad et
(Karam et al., 2017).
al., 2017), seriously impairing, and highly
comorbid but greatly under-recognized and Quite significantly, adult ADHD seems to be
undertreated across countries and cultures. highly comorbid with SUDs in the Arab
Most importantly, it proved that adult region. In Lebanon, ADHD patients had
ADHD is possibly more prevalent than higher rates of SUD (Karam et al., 2017). In
childhood ADHD probably due to the other clinical studies an earlier age of
conversion of sub-threshold cases of onset of substance used was noticed
childhood ADHD, as the data from WMH (Abdelkarim et al., 2015; Khalil et al., 2016;
surveys across 20 countries showed (in Salama et al., 2015), as well as higher rates
addition to non-childhood onset of ADHD) of cocaine use and preference for heroin
(Fayyad et al., 2017). De Graaf et al. (2008), (Salama et al., 2015). Additionally, more
showed higher rates of absenteeism and than one study (Ashor, 2012; El-Hay & El
lower productivity amongst ADHD workers Sawy, 2011), found that university students
pointing to the importance of providing who had ADHD consumed more cigarettes
assistance and accommodations to workers and abused more substances. Furthermore,
struggling with ADHD. Further WMH comorbid adult ADHD in SUD patients
surveys are on the way in the Arab region, prolonged the course of SUD and
rendering nationally representative data on contributed to higher relapse rates in these
mental health disorders available soon. groups of patients (Ashor, 2012; Khalil et
Indeed, the survey in Saudi Arabia has just al., 2016).
been completed (Hyder et al., 2017; Shahab
These findings point to the need for
et al., 2017), yet the results are not out at the
providing clinical scrutiny in adults who
time of writing of this manuscript.
suffer from ADHD in general but also those
Furthermore, Qatar will be implementing its
suffering from other mental disorders
own survey soon.
(including substance use disorders) who
Various studies pointed to the co-occurrence might as well have comorbid ADHD. In
of ADHD with other mental disorders. addition, adult ADHD may be frequently not
Although the WMH surveys did not discuss diagnosed by clinicians because of the false
comorbidities by country but rather as one impression that ADHD occurs only in
general sample, it is important to note their childhood and adolescence.
4.1 Limitations: Limitations of this review university, and relying on clinical interviews
were due to those of the existing literature to diagnose ADHD were significant
and included lack of standardization of limitations to their study.
assessment tools and difficulties with
4.1.3 Limitations of Clinical Population
random sampling. This limited our ability to
Studies: In clinical population studies,
compare cross-national results.
limitations were small sample size (Ashor,
4.1.1 Limitations of the World Mental 2012; Khalil et al., 2016), patients belonging
Health Cross-National Studies: In the to one institution or a clinical facility (Ashor,
well-known international WMH surveys 2012; Karam et al., 2017), absence of female
which has comprised so far 31 countries patients (Abdelkarim et al., 2015; Salama et
used DSM-IV criteria for ADHD that were al., 2015), and the use of different diagnostic
developed for children, and offered limited tools that are not the Structured Clinical
guidance regarding adult diagnosis, Interview for DSM-IV (SCID) (Alosaimi et
childhood ADHD was assessed al., 2017; Ashor, 2012), or not following
retrospectively, leaving room for recall bias strictly the SCID interview format (Karam et
as per the authors of those studies (de Graaf al., 2017). The cross-sectional design of the
et al., 2008; Fayyad et al., 2007; Fayyad et studies selected prevents from making any
al., 2017). Furthermore, adult ADHD was causal inferences on the association of
diagnosed based entirely on adult respondent ADHD with demographics, other psychiatric
self-report which typically leads to disorders, family history of psychiatric
inaccuracies. In addition, adult ADHD was disorders, work performance, and treatment.
estimated from an imputation model carried Nevertheless, only two studies
in the US only, rather than directly (de Graaf acknowledged this (Alosaimi et al., 2017;
et al., 2008; Fayyad et al., 2007; Fayyad et Khalil et al., 2016). Additionally, one
al., 2017). clinical study acknowledged not looking at
Oppositional Defiance Disorder, and anti-
4.1.2 Limitations of University Studies:
social personality disorder (Karam et al.,
University studies such as El-Hay and El
2017).
Sawy (2011), noticed that unlike childhood
ADHD studies, no gender differences were Furthermore, all the clinical and university
seen in the adult population, proposing that studies used convenient sampling, when
the standard Hyperactivity/Impulsive compared to the WMH national surveys,
diagnostic criteria might not be suitable for resulting in the non-generalizability of the
the adult population. In addition these results.
findings might not apply to all college
Despite the limitations of the studies
students, and the theoretical possibility that
involved, there are various implications for
the use of screening tools not necessarily
future research and clinical practices. The
standardized for the Egyptian culture (El-
presence of only one study (El-Hay & El
Hay & El Sawy, 2011) In addition, Ashor
Sawy, 2011), examining family history of
(2012) themselves highlighted that small
psychiatric disorders and ADHD among the
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