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Guidelines
Article history: Context: The European Association of Urology (EAU) Trauma Guidelines Panel presents
Accepted May 28, 2012 an updated iatrogenic trauma section of their guidelines. Iatrogenic injuries are known
Published online ahead of complications of surgery to the urinary tract. Timely and adequate intervention is key to
their management.
print on June 5, 2012 Objective: To assess the optimal evaluation and management of iatrogenic injuries and
present an update of the iatrogenic section of the EAU Trauma Guidelines.
Keywords: Evidence acquisition: A systematic search of the literature was conducted, consulting
Medline and the Cochrane Register of Systematic reviews. No time limitations were
Iatrogenic trauma
applied, although the focus was on more recent publications.
Kidney Evidence synthesis: The expert panel developed statements and recommendations.
Ureter Statements were rated according to their level of evidence, and recommendations
Urinary bladder received a grade following a rating system modified from the Oxford Centre for
Urethra Evidence-based Medicine. Currently, only limited high-powered studies are available
addressing iatrogenic injuries. Because the reporting of complications or sequelae of
Genitalia interventions is now increasingly becoming a standard requirement, this situation will
Injury likely change in the future.
Reconstructive surgical Conclusions: This section of the trauma guidelines presents an updated overview of the
procedures treatment of iatrogenic trauma that will be incorporated in the trauma guidelines
available at the EAU Web site (http://www. uroweb.org/guidelines/online-guidelines/).
Foreign bodies
# 2012 European Association of Urology. Published by Elsevier B.V. All rights reserved.
EAU guidelines
0302-2838/$ – see back matter # 2012 European Association of Urology. Published by Elsevier B.V. All rights reserved.
http://dx.doi.org/10.1016/j.eururo.2012.05.058
EUROPEAN UROLOGY 62 (2012) 628–639 629
Table 1 – Incidence and aetiology of the most common iatrogenic renal traumas during various procedures
Procedure Haemorrhage AVF Pseudoaneurysm Renal pelvis injury Aortocaliceal fistula Foreign body
Nephrostomy + + + +
Biopsy + (0.5–1.5%) + (0.9%)
PCNL + + +
Laparoscopic surgery (oncology) +
Open surgery (oncology) + + (0.43%) +
Transplantation + + + +
Endopyelotomy + + +
Endovascular procedure + (1.6%)
on trauma [1]. With the exception of inadvertent injuries transplantation is rare and presents in the early postop-
caused by circumcision, this paper deals only with erative period [8].
iatrogenic trauma in the adult and not the paediatric IRT associated with endopyelotomy is classified as major
population. (vascular injury) or minor (urinoma) [9]. Patients undergo-
This paper concentrates on the immediate diagnosis and ing cryoablation for small masses via the percutaneous or
initial management of iatrogenic urologic trauma (IUT). A the laparoscopic approach may have minor IRT including
new system of nomenclature is introduced to distinguish asymptomatic perinephric haematoma and self-limited
between different organs while retaining a degree of urine leakage [10]. Vascular injury is a rare complication
standardisation. (1.6%) of endovascular intervention, in contrast to patients
with surgical injuries; the renal vessels are vulnerable
2. Iatrogenic renal trauma mainly during oncologic procedures. Renal foreign bodies,
such as retained sponges or wires during open or
2.1. Introduction endourologic procedures, are uncommon.
Iatrogenic renal trauma (IRT) is rare but can lead to 2.3. Diagnosis: clinical signs and imaging
significant morbidity.
Haematuria is common after nephrostomy, but massive
2.2. Incidence and aetiology retroperitoneal haemorrhage is rare. If a nephrostomy
catheter appears to transfix the renal pelvis, significant
Table 1 lists the most common causes of IRT [2]. Large arterial injury is possible. The misplaced catheter should
haematomas after biopsy (0.5–1.5%) are caused by lacera- be withdrawn over a guidewire; embolisation may arrest
tion or arterial damage [3]. Renal artery and intraparenchy- the haemorrhage. Computed tomography (CT) can also
mal pseudoaneurysms (0.9%) may be caused by successfully guide repositioning of the catheter into the
percutaneous biopsy, nephrostomy, and partial nephrec- collecting system [11]. Haemorrhage can be prevented by
tomy (0.43%) [4]. In percutaneous nephrolithotomy (PCNL), avoiding puncture in patients receiving anticoagulation
haemorrhage is the most dangerous IRT. Vascular injuries treatment or in those with coagulopathy by carefully
may occur at any stage of the procedure, especially when targeting the calices and avoiding medial puncture.
punctures are too medial or directly of the renal pelvis. Injuries to the renal pelvis are less likely to occur if the
Other injuries include arteriovenous fistula (AVF) or tears in dilator is not advanced further than the calix; sheaths are
the pelvicaliceal system, causing extravasation and absorp- handled with care, especially during advancement around
tion of irrigation fluid. the pelviureteric junction; and kinking of the guidewires
IRT in renal transplantation is more common and is avoided [12]. After percutaneous biopsy, AVF may
includes AVF, intrarenal pseudoaneurysm, arterial dissec- present with severe hypertension. Pseudoaneurysm
tion, and arteriocaliceal fistula. Pseudoaneurysm is a rare should be suspected if the patient presents with flank
complication of allograft biopsy. Although the overall pain and decreasing haematocrit, even in the absence of
complication rate with biopsies in transplanted kidneys is haematuria.
9% (including haematoma, AVF, macroscopic haematuria, During PCNL, acute bleeding may be caused by injury to
and infection), vascular complications requiring interven- the anterior or posterior segmental arteries, or late
tion account for 0.2–2.0% [5]. Predisposing factors include postoperative bleeding may be caused by interlobar and
hypertension, renal medullary disease, central biopsies, lower-pole arterial lesions, AVF, and post-traumatic aneu-
and numerous needle passes [6]. AVF and pseudoaneur- rysm [13]. Duplex ultrasound and CT angiography can be
ysm can occur in 1–18% of allograft biopsies and used to diagnose vascular injuries. Irrigation fluid input
may coexist in up to 30% of cases [7]. Extrarenal and output should be monitored closely to ensure early
pseudoaneurysm after transplantation procedures gener- recognition of ‘‘fluid’’ extravasation. Intraoperative evalu-
ally occurs at the anastomosis, in association with local or ation of serum electrolytes, acid-base status, oxygenation,
haematogenous infection. Arterial dissection related to and monitoring of airway pressure are good indicators of
630 EUROPEAN UROLOGY 62 (2012) 628–639
this complication because metabolic acidosis, hyponatrae- Most surgical venous injuries have partial lacerations
mia, hypokalaemia, peritonitis, and ileus may occur. that can be managed with techniques such as venorrhaphy,
In arterial dissection related to transplantation, symp- patch angioplasty with autologous vein, or an expanded
toms include anuria and prolonged dependence on dialysis. polytetrafluoroethylene graft [23]. If conservative mea-
Doppler ultrasound can demonstrate compromised arterial sures fail in pseudoaneurysm and clinical symptoms or a
flow. Dissection can lead to thrombosis of the renal artery relevant decrease in haemoglobin occurs, transarterial
and/or vein. embolisation should be considered [24]. The success rate is
After angioplasty and stent-graft placement in the renal similar for initial and repeat interventions; therefore,
artery, during which wire or catheters may enter the repeat intervention is justified when the clinical course
parenchyma and penetrate through the capsule, possible allows [25].
radiologic findings include AVF, pseudoaneurysm, arterial Traditionally, patients with postoperative haemorrhage
dissection, and contrast extravasation. Common symptoms following intra-abdominal laparoscopic surgery of the
of pseudoaneurysm are flank pain and gross haematuria kidney required laparotomy. Pseudoaneurysm and AVF
within 2 or 3 wk after surgery [14]. Transplant AVF and are uncommon after minimally invasive partial nephrec-
pseudoaneurysm may be asymptomatic or cause gross tomy but can lead to significant morbidity. Temporary
haematuria and/or hypovolaemia due to shunting and haemostasis occurs with coagulation and/or tamponade,
‘‘steal’’ phenomenon, renal insufficiency, hypertension, but later degradation of the clot, connection with the
and high-output cardiac failure. Patients with extrarenal extravascular space, and possible fistulisation with the
pseudoaneurysm may present with infection/bleeding, collecting system may develop. Patients typically present
swelling, pain, and intermittent claudication. Doppler with gross haematuria, although they may also experience
ultrasound findings for AVF include high-velocity low- flank pain, dizziness, and fever. Embolisation is the
resistance spectral waveforms with focal areas of dis- reference standard for both diagnosis and treatment in
organised colour flow outside the normal vascular borders, the acute setting, although CT can be used if the symptoms
and possibly a dilated vein [15]. Pseudoaneurysm appears are not severe and/or the diagnosis is ambiguous. Reports
on ultrasound as an anechoic cyst, with intracystic flow on have described a good preservation of renal function after
colour Doppler. embolisation [26].
Potential complications of retained sponges include Endoluminal management after renal transplantation
abscess formation, fistulisation to the skin or intestinal tract, consists of stabilising the intimal flap with stent placement.
and sepsis. Retained sponges may cause pseudotumours Embolisation is the treatment of choice for a symptomatic
or appear as solid masses. Magnetic resonance imaging transplant AVF or enlarging pseudoaneurysm [8]. Super-
clearly shows the characteristic features [16]. Absorbable selective embolisation with a coaxial catheter and metallic
haemostatic agents may also produce a foreign body giant coils helps limit the loss of normal functioning graft tissue
cell reaction, but the imaging characteristics are not specific. [27]. A success rate of 71–100% has been reported, with
Retained stents, wires, or fractured Acucise cutting wires may alleviation of symptoms in 57–88% of cases. Major infarcts
also present as foreign bodies and can serve as a nidus for involving >30–50% of the allograft and leading to allograft
stone formation [17]. loss have been reported in up to 28.6% of cases in which
combined coil embolisation and polyvinyl alcohol or
2.4. Management Gelfoam were used. If symptoms persist, a second angio-
gram with possible repeat embolisation is warranted [28].
Small subcapsular haematoma after nephrostomy resolves Failure of embolisation is associated with a high nephrec-
spontaneously, whereas AVF is best managed by embolisa- tomy rate. The long-term outcome depends on the course of
tion. AVF and pseudoaneurysm after biopsy are also the transplant and the amount of contrast medium used
managed by embolisation [18]. during the procedure. Surgery for AVF consists of partial or
During PCNL, bleeding can be venous or arterial. In major total nephrectomy or arterial ligation, which results in the
venous trauma with haemorrhage, patients with concomi- loss of part or the entire transplant.
tant renal insufficiency can be treated without open Surgery has to date been the main approach for the
exploration or angiographic embolisation using a Council- treatment of renovascular injuries. In patients with
tip balloon catheter [19]. In case of profuse bleeding at retroperitoneal haematoma, AVF, and haemorrhagic
the end of PCNL, conservative management is usually shock, intervention is associated with a lower level of
effective (placing the patient in a supine position, clamping risk than surgery [29]. Renal arteriography followed by
the nephrostomy catheter, and forcing diuresis). Super- selective embolisation can confirm the injury. In injuries
selective embolisation is required in <1% of cases and has during angioplasty and stent-graft placement, transcath-
proved effective in >90% [20]. Short-term deleterious eter embolisation is the first choice [30]. The treatment
effects are more pronounced in patients with a solitary for acute iatrogenic rupture of the main renal artery is
kidney, but long-term follow-up shows functional and balloon tamponade. If this fails, the immediate availability
morphologic improvements [21]. Termination of PCNL if the of a stent graft is vital [31]. The true nature of lesions
renal pelvis is torn or ruptured is a safe choice. Management caused by foreign bodies is revealed after exploration.
requires close monitoring, placement of an abdominal or Table 2 lists the statements and recommendations
retroperitoneal drain, and supportive measures [22]. regarding IRT.
EUROPEAN UROLOGY 62 (2012) 628–639 631
Table 2 – Statements and recommendations regarding iatrogenic used [38,39]. Risk factors for IUeT include conditions that
renal trauma
alter normal anatomy such as advanced malignancy, prior
Statements LE surgery or irradiation, diverticulitis, endometriosis, ana-
tomic abnormalities, and major haemorrhage [32,34,39].
IRT is procedure dependent (1.8–15%). 3
Significant injury requiring intervention is rare. 3 Nevertheless, most IUeT has no identifiable risk factors
Most common injuries are vascular. 3 [32,37,40].
Renal allografts are more susceptible. 3
Injuries occurring during surgery are 3
3.1. Diagnosis
rectified immediately.
Symptoms suggestive of significant injury 3
require investigation. Diagnosis can be difficult and is delayed in most cases
Recommendations GR (65–80%) [32,35,41]. IUeT may be noticed during the
primary procedure or later, when it is typically discovered
Patients with minor injuries should be treated B
conservatively.
by flank pain, urinary incontinence, vaginal or drain urinary
Severe or persistent injuries require intervention B leakage, haematuria, fever, azotemia, or urinoma. When
with embolisation. the diagnosis is missed, the complication rate increases
In stable patients, repeat embolisation should be C [32,35,37]. Early recognition facilitates immediate repair
considered for failure.
and provides the best outcome. Delayed diagnosis predis-
IRT = iatrogenic renal trauma; LE = level of evidence; GR = grade of
poses the patient to pain, infection, and renal damage [39].
recommendation.
Clinical diagnosis is generally supported by imaging
studies. Extravasation of contrast medium in CT or
intravenous pyelography is the hallmark sign of IUeT, but
3. Ureteric iatrogenic trauma often hydronephrosis, ascites, urinoma, or only mild
ureteric dilation is noticed. Retrograde or antegrade
Iatrogenic ureteric trauma (IUeT) is the most common cause urography is the gold standard for the confirmation of
of ureteric injury. It occurs in open, laparoscopic or IUeT [32].
endoscopic procedures and is often not recognised intra-
operatively. It may result in severe sequelae. 3.2. Prevention
Gynaecologic surgical procedures are the most common
cause of IUeT [32–35] (Table 1) and usually involve damage Prevention of IUeT is based on visual identification of the
to the lower third of the ureter. Colorectal (especially ureters and cautious intraoperative dissection [32,33,37].
abdominoperineal resection and sigmoid colectomy) and Prophylactic preoperative ureteric stent insertion assists
urologic operations (especially endoscopic) also cause IUeT. visualisation and palpation, and it is commonly used in
In ureteroscopic procedures, most injuries are minor but complicated cases. However, it does not decrease the rate of
may sometimes be serious (eg, complete ureteric avulsion). injury [32]. Apart from its evident disadvantages (potential
The incidence of urologic IUeT has diminished in the past complications and cost), a stent may alter the location of the
20 yr [32,36] with improvements in technique, instruments, ureter and diminish flexibility [33,42]. Stenting is probably
and experience. Table 3 describes the incidence of ureteral useful as secondary prevention by facilitating detection of
injury in various procedures. IUeT [33]. Routine prophylactic stenting is usually not cost
IUeT can result from various mechanisms: ligation or effective [33], and it is estimated to become cost effective in
kinking with a suture, crushing from a clamp, partial, or hysterectomy when the rate of IUeT exceeds 3.2% [39];
complete transaction, thermal injury, or ischaemia from therefore, it is advocated only in selected patients with risk
devascularisation [32,34,37]. Occult ureteric injury occurs factors [42].
more often than reported, and not all injuries are diagnosed Another form of secondary prevention is intraoperative
intraoperatively. In gynaecologic surgery, IUeT is almost cystoscopy after intravenous indigo carmine, which offers
five times higher if routine intraoperative cystoscopy is confirmation of ureteric patency [35]. Routine cystoscopy
has minimal risks and markedly increases the rate of IUeT
detection [38]. However, its universal use incurs significant
costs. It was estimated for benign gynaecologic operations
Table 3 – Incidence of ureteral injury in various procedures
to be cost saving above a threshold IUeT rate of 1.5–2% [35].
Procedure %
Table 4 – Statements and recommendations regarding iatrogenic Table 5 – Incidence of bladder perforation during various
ureteric trauma procedures
Statements LE Procedure %
Statements LE
The bladder is the urologic organ most commonly injured during surgery, with obstetric and gynaecologic procedures as the main causes. 2
Intraoperatively, visual inspection is the most reliable method of assessing bladder integrity. 3
Meshes represent most of the foreign bodies found in the female bladder. 2
Recommendations GR
Cystoscopy is recommended after suburethral sling operations via the retropubic route and major gynaecologic operations. B
Cystoscopy is optional after any other type of sling procedure or transvaginal mesh procedure. C
Cystography is the standard examination for diagnosing postoperative bladder injury. B
For diagnosing iatrogenic foreign bodies, cystoscopy is the examination method of choice. C
External bladder perforations that are recognised intraoperatively should be closed with two-layer vesicorrhaphy. A*
Extraperitoneal bladder perforations that are not recognised during surgery or are caused by endourologic procedures B
should be treated conservatively.
For intraperitoneal bladder perforations that are not recognised at the time of surgery, the standard of care is surgical repair. B
Conservative management is an option for small uncomplicated intraperitoneal bladder perforations. C
For extraperitoneal injuries, conservative treatment with stricture formation. Women undergoing abdominal surgery
bladder drainage (5 d) and antibiotic prophylaxis is advised are also at risk during catheterisation. The size and type of
[48]. Large extraperitoneal perforations complicated by catheter used have an important impact on urethral
symptomatic extravesical collections require drainage, with stricture formation. Current data indicate that silicone
or without closure of the perforation [52]. catheters and small-calibre Foley catheters are associated
If perforation occurs during TURB, immediate intra- with less urethral morbidity [65].
vesical instillation with chemotherapeutic agents should
not be performed [55]. If bladder perforation is encoun- 5.2.2. Transurethral surgery
tered during midurethral sling or transvaginal mesh Transurethral procedures are a common cause of IUhT.
procedures, sling reinsertion and urethral catheterisation Electrical dispersion generated by unipolar current and the
(1–2 d) should be performed [56]. diameter of the instruments used are factors that may
influence the development of iatrogenic endoscopic ure-
4.4.2. Intravesical foreign body thral strictures [66] (LE: 1b).
For perforated or eroded meshes, the intravesical portion Predisposing factors most strongly associated with
must be removed by open cystotomy or endoscopically stricture formation in patients undergoing transurethral
[50,57]. The choice depends on the surgeon’s level of resection of the prostate (TURP) are increasing prostate
experience and the location of the mesh. For other types of volume, prostate cancer, and surgeons’ experience [67].
foreign body, cystoscopic removal is performed or a Meatal strictures occur as a result of disproportion
cystotomy if that fails [47]. Table 7 lists the statements between the size of the instrument and the diameter of the
and recommendations regarding bladder injury. urethral meatus. Bulbar strictures occur due to insufficient
insulation by the lubricant, causing monopolar current to
5. Iatrogenic urethral trauma leak. To prevent strictures, lubricant gel should be applied
carefully in the urethra. The lubricant must be reapplied
5.1. Introduction when the resection time is prolonged. Internal urethrotomy
must be performed before TURP if there are preexisting
The most common type of urethral trauma seen in modern meatal or urethral strictures [68].
urologic practice is iatrogenic, due to catheterisation, There appears to be no relationship with the duration of
instrumentation, or surgery [58,59]. New treatment meth- procedures or the method used—holmium laser or tradi-
ods and applied energy sources can also injure the urethra. tional TURP—on the rate of stricture formation [69].
In most cases, iatrogenic urethral lesions require surgery
due to strictures, which vary in their location and degree 5.2.3. Surgical treatment for prostate cancer
and require different management strategies [60]. Urethral stricture following prostate cancer treatment can
occur anywhere from the bladder neck to the urethral
5.2. Causes of iatrogenic urethral trauma meatus. The rate of bladder neck constriction after radical
prostatectomy varies with the definition of the stricture
5.2.1. Transurethral catheterisation used and individual practice [70,71] (LE: 2a). The Cancer
Iatrogenic urethral trauma (IUhT), most of which results from of the Prostate Strategic Urologic Research Endeavour
improper or prolonged catheterisation, accounts for 32% of (CaPSURE) database shows an incidence of urethral
strictures. Most of these affect the bulbar urethra [60]. stricture after various forms of prostate cancer therapy of
In incorrectly placed transurethral catheters, the pressure 1.1–8.4%. The risk is greatest after radical prostatectomy if
needed to fill the balloon and the force associated with combined with external-beam radiation therapy. In a
manual extraction are much greater than when the catheter multivariate analysis, primary treatment type, age, and
is placed correctly. This leads to a greater probability of obesity were found to be significant predictors for stricture
urethral lesions [61]. Improper urethral catheter insertion is a development [70] (LE: 2b).
preventable source of urethral trauma in male patients [62]. Robot-assisted prostatectomy also affects urinary func-
The risk of this type of urethral injury occurring during a tion and the risk of iatrogenic trauma. Iatrogenic complica-
hospital stay has been estimated at 3.2 per 1000 cases [60]. tions involving the bladder neck account for 2.2%,
Stricture formation due to indwelling catheters is a corresponding to the stricture rate seen with conventional
common problem [58] that primarily affects the anterior treatment for localised prostate cancer [72] (LE: 2b).
urethra. The bladder neck is rarely affected in such Anastomotic stricture is also a complication in conven-
cases [63]. tional laparoscopic prostatectomy. Taking only prospective
It is possible to prevent or reduce the frequency of a wide studies into account, there is no significant difference in
range of iatrogenic urethral injuries. Implementing training anastomotic stricture rate between laparoscopic and robot-
programmes may significantly decrease the incidence, assisted radical prostatectomy [73] (LE: 3b).
increasing patient safety and reducing the negative long-
term effects [58,64] (level of evidence [LE]: 2b). 5.2.4. Radiotherapy for prostate cancer
Male patients undergoing cardiac surgery, such as The development of urinary fistulae has been reported after
bypass and other major operations associated with a need brachytherapy and radical prostatectomy, with incidences
for catheterisation, are at risk for urethral trauma and of 0.3–3.0% and 0–0.6%, respectively. Most fistulae involve
EUROPEAN UROLOGY 62 (2012) 628–639 635
Procedure Percentage
TURB = transurethral resection of the bladder; TURP = transurethral resection of the bladder; LRP = radical prostatectomy; RALP = robot-assisted laparoscopic
prostatectomy; EBRT = external-beam radiation therapy.
the rectum [74,75] (LE: 3). Brachytherapy is a recognised Endoscopic management, either with incision or resec-
cause of strictures in patients with localised prostate cancer, tion, can successfully treat iatrogenic prostatic urethral
as the CaPSURE study has shown [76]. Previous TURP strictures. Indwelling catheter placement or an open proce-
increases the risk of stricture formation [77,78]. dure, associated with increased morbidity, are alternatives
[85] (LE: 2b).
5.2.5. Major abdominal surgery and cystectomy Urethral lesions following radiotherapy are often more
Iatrogenic injuries to the urethra are not a rare complication difficult to treat and may require complex reconstructive
of abdominal and pelvic procedures. Bladder and urethral surgery [74,75]. Table 9 lists the statements and recom-
catheterisation must therefore be carried out preoperative- mendations regarding the iatrogenic causes of IUhT.
ly to prevent these complications [79] (LE: 2). Radical
cystectomy and subsequent urinary diversion may also 6. Iatrogenic genital trauma
cause urethral trauma [80]. Table 8 lists the most common
causes of urethral trauma. 6.1. Introduction
5.3. Symptoms of iatrogenic urethral injury Iatrogenic injury to the external genital organs can vary
from trivial to devastating. Its prevalence is not known, and
Symptoms of urethral lesions caused by improper cathe- it can occur during any genital procedure (eg, operations for
terisation or instrumentation are penile and/or perineal penile congenital anomalies, penile prosthesis insertion,
pain (100%) and urethral bleeding (86%) [63] (LE: 2b). penile enlargement procedures, and circumcision). Iatro-
Failure to diagnose accurately and treat urethral injuries genic injury to the epididymis, vas deferens, or spermatic
may lead to significant long-term sequelae, in most cases
presenting as strictures [81,82].
Table 9 – Statements and recommendations regarding iatrogenic
urethral trauma
5.4. Diagnosis
Statements LE
Uroflowmetry, urethrography, and/or urethroscopy are the
Iatrogenic causes are the most common type of urethral 2a
key investigations in diagnosis, and the algorithm is the injury in Europe and therefore the most common
same for acute and delayed symptoms. In the acute phase, cause of urethral stricture formation.
the symptoms are bleeding and difficulty during catheter- Implementing training programmes on urinary catheter 2b
insertion significantly improves the rate of catheter-related
isation. Delayed symptoms include worsening of flow and
complications.
other symptoms of obstruction. New technologies represent an additional source of 3
urethral injury.
vessels may occur during scrotal, inguinal, or even pelvic Table 10 – Statements and recommendations regarding
circumcision
and abdominal procedures, and it may not be noticed until
the patient presents for fertility evaluation. This section is Statements
limited to complications of circumcision.
Circumcision is very common.
Complication rates vary considerably.
6.2. Iatrogenic injury in circumcision The vast majority of complications due to circumcision are minor and
easily treated.
or patents filed, received, or pending), are the following: Duncan J. [19] Wang MQ, Xie CM, Wang ZP, Guan J, Gu XF, Liu FY. Treatment of
Summerton receives company speaker honoraria from Lilly/AMS/ acquired arteriovenous fistulas with interventional minimally in-
Coloplast and GSK. The other authors have nothing to disclose. vasive techniques [in Chinese]. Zhonghua Wai Ke Za Zhi 2004;42:
687–91.
Funding/Support and role of the sponsor: None.
[20] Morris CS, Bonnevie GJ, Najarian KE. Nonsurgical treatment of acute
Acknowledgment statement: The authors acknowledge support by Dr. iatrogenic renal artery injuries occurring after renal artery angio-
Franklin Emmanuel Kühhas (Department of Urology, Medical University plasty and stenting. AJR Am J Roentgenol 2001;177:1353–7.
of Vienna, Vienna, Austria) for the section on urethral trauma. [21] Oderich GS, Panneton JM, Hofer J, et al. Iatrogenic operative injuries
of abdominal and pelvic veins: a potentially lethal complication.
J Vasc Surg 2004;39:931–6.
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