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pH vs
solubility of
weak basic
drugs
6
Adjusting pH:
7
Perhitungan tonisitas:
Metoda perhitungan :
Tf = Liso . c
Keterangan : c = molar
E = 17. Liso / MW
Liso
Ion type Example
value
Sucrose, dextrose,
Non-electrolyte 1,9
gliserin
Weak electrolyte 2,0 Boric acid, citric acid
Divalent-divalent electrolyte 2,0 MgSO4, ZnSO4
Univalent-univalent electrolyte 3,4 NaCl, AgNO3
Atropin sulfate,
Univalent-divalent electrolyte 4,3
Na2CO3
Divalent-univalent electrolyte 4,8 CaCl2, Ca-gluconate
Univalent-trivalent electrolyte 5,2 Na-citrate, K-citrate
Trivalent-univalent electrolyte 6,0 AlCl3, FeCl3
Tetraborate 7,6 Na-borate, K-borate
No Ingredients Concentration
1 Anthazoline HCl 2.5 mg/ml
2 NaH2PO4 5.9 mg
3 Na2HPO4 0,392 mmol
4 Benzalkonium chloride 0,01%
5 Aqua p.i. Ad. 10 ml
How much is NaCl needed?
Calculate using NaCl equivalent method
1 : D = dagang, G= Generik
2 : K = keras, T = bebas terbatas, B= bebas, P = psichotropik
3 : L = dalam negeri, A = PMA
4 & 5 : tahun registrasi
6,7,8 : no pendaftaran di POM
9, 10, 11, 12, 13 : jenis obat
14 & 15 kode pabrik: menyatakan isi/komposisi
14 : Huruf A
15 : angka 1
TERIMA KASIH