Chemotherapy list

Medications Pharmacological Uses : Side effects :

name : class :
Actinomycin Antineoplastic, Ewing sarcoma Hematologic: bone marrow
antibiotics. Gastrointestinal suppression anemia, febrile
carcinoma neutropenia, Leukopenia
 Metastatic. and thrombocytopenia.
Wilms' tumor Increase risk of getting Infection
“neophroblastoma”
Dermatological: alopecia, erythema,
Rhabdomyosarcoma
inflammation and skin pigmentation.
Gastrointestinal: diarrhea,
dysphagia, loss of appetite, nausea
and vomiting.
Hepatic: hepatotoxicity, ascites,
hepatomegaly and hepatic veno-
occlusive disease.

Alematuzmab Antineoplastic Multiple sclerosis. Dermatologic: flushing, pruritus, rash

Immunosuppress Rheumatoid arthritis. and urticarial.
ant agent , B-cell chronic
lymphocytic leukemia. Gastrointestinal: abdominal pain,
diarrhea, nausea and vomiting.
Musculoskeletal: arthralgia, backache,
pain in limb.
Neurologic: dizziness,
Headache, insomnia and paresthesia.
Renal: Urinary tract infectious disease.
Respiratory: nasopharyngitis, pain in
throat, sinusitis and upper respiratory
infection.
 Asparginase Antineoplastic Acute lymphocytic Injection site reaction.
leukemia (ALL) Endocrine metabolic: hyperglycemia.
Hematologic: hemorrhage.
Chronic myeloid Hepatic: high liver enzymes.
leukemia. Gastrointestinal: nausea and
vomiting.
Malignant lymphoma.

Bevacizumab Antineoplastic Ovarian cancer. Cardiovascular: Hypertension

Immunosuppress Metastatic colorectal Endocrine metabolic: hyperglycemia
ant agent. cancer. Gastrointestinal: abdominal pain,
Nonsquamous non-small constipation and diarrhea.
cell  Hematologic: hemorrhage
Lung cancer. Immunologic: Infectious disease
Glioblastoma Musculoskeletal: Arthralgia.
Renal cell carcinoma

Bleomycin Antineoplastic, Hodgkin's and non Pulmonary fibrosis.

antibiotics. Hodgkin’s disease. Lethal anaphylactic reactions.
Testicular cancer. Dermatological: alopecia, erythema,
Squamous cell carcinoma inflammation and skin pigmentation.
of cervix.
Squamous cell carcinoma
of head and neck.
Squamous cell carcinoma
of nasopharynx.

Bortezomib Antineoplastic Mantle cell lymphoma Cardiovascular: Hypotension .

agent ,proteasom Multiple myeloma Dermatologic: Rash
e Inhibitor. Gastrointestinal: constipation,
diarrhea, loss of appetite, nausea,
vomiting.
Hematologic: Anemia, leukopenia,
neutropenia.
Neurologic: dizziness, dysesthesia,
headache, neuralgia, paresthesia,
peripheral neuropathy.
Respiratory: cough, dyspnea, lower
respiratory tract infection.
Fatigue and fever.

carboplatin Antineoplastic Ovarian cancer Dermatologic: Alopecia

Small cell lung cancer.
Metabolic: hypocalcemia,
Non-small lung cancer.
Leukemia hypokalemia, hypomagnesemia,
hyponatremia.
 Gastrointestinal: nausea, vomiting.
Hematologic: anemia, leukopenia,
neutropenia, thrombocytopenia.
myelosuppression ,nephrotoxicity .

cetuximab Antineoplastic Metastatic colorectal Hematologic: Neutropenia

Immunosuppress cancer Immunologic: Infectious disease
ant agent , Gastric cancer Neurologic: Asthenia, headache.
Respiratory: Dyspnea
Dermatologic : rash ,alopecia ,
pruritus
Endocrine metabolic: 
Hypomagnesemia, weight loss.
Gastrointestinal: Constipation,
diarrhea, nausea.
Cisplatin Antineoplastic Bladder cancer Renal : nephrotoxicity
Metastatic malignant
Neurotoxicity and ototoxicity
tumor of testis
Metastatic ovarian tumor Gastrointestinal: Nausea and
Non-small cell lung vomiting.
cancer Hematologic: Myelosuppression.

Cyclophospha Antineoplastic Acute lymphoid leukemia Urinary tract hemorrhagic cystitis

mide Ovarian cancer
Dermatologic: alopecia, nail damage,
Ewing's sarcoma of bone
Hodgkin’s disease rash
Breast cancer Gastrointestinal: abdominal
discomfort, diarrhea, loss of appetite,
nausea and vomiting.
Hematologic: leukopenia,
neutropenia.
Cytarabine Antineoplastic Acute myeloid leukemia Cardiovascular: thrombophlebitis.
Hodgkin's disease
Dermatologic: rash.
Meningeal leukemia
Gastrointestinal: anal inflammation,
diarrhea, loss of appetite, nausea.
Hepatic: decreased liver function
 Fever, neurotoxicity.

Dacarbazine Antineoplastic Hodgkin's disease Gastrointestinal: loss of appetite,

Sarcoma of soft tissue nausea and vomiting.
Metastatic malignant Dermatologic: alopecia
melanoma
Hematologic: myelosuppression,
Influenza-like illness.
Daunorubicin Cytotoxic Acute lymphoid leukemia Dermatologic: Alopecia
antibiotics Non-Hodgkin's
Gastrointestinal: nausea and
lymphoma
vomiting.
Cardiac toxicity, bone marrow
suppression.

Docetaxel Antineoplastic Breast cancer Cardiovascular: body fluid

Agent ,Mitotic Hormone refractory retention.
Inhibitor. prostate cancer
Non-small cell lung Dermatologic: alopecia ,nail damage.
cancer Gastrointestinal: diarrhea,
Ovarian cancer inflammatory disease of mucous
membrane, nausea, stomatitis,
vomiting.
Hematologic: Anemia, leukopenia,
neutropenia.

Doxorubicin Cytotoxic Acute lymphoid leukemia Dermatologic: Alopecia

antibiotics AIDS-related Kaposi's
Gastrointestinal: Nausea and
sarcoma
Ovarian cancer vomiting
Breast cancer Cardiac toxicity
Bone marrow suppression

Epirubicin Cytotoxic Breast cancer Dermatologic: alopecia, flushing

antibiotics Ovarian cancer ,itching, rash
Small cell carcinoma of
lung Gastrointestinal: diarrhea, nausea
and vomiting
Hematologic: anemia, leukopenia,
neutropenia, thrombocytopenia
Neurologic: Lethargy
Reproductive: Amenorrhea

Etoposide Antineoplastic Small cell carcinoma of Dermatologic: Alopecia

lung
Gastrointestinal: Diarrhea, Loss of
Testicular cancer,
refractory appetite, Nausea and vomiting
Hematologic: Leukopenia,
Thrombocytopenia.

Fludarabine Antimetabolites B-cell chronic Gastrointestinal: Loss of appetite

lymphocytic leukemia
Neurologic: asthenia
 Respiratory: Cough
 Fatigue, Fever, Infectious disease.
Hematologic: decreased hemoglobin,
hemolytic anemia, neutropenia,
pancytopenia, and thrombocytopenia.

Fluorouracil Antimetabolites Colorectal cancer Dermatologic: allergic contact

prostate cancer dermatitis, burning sensation, pruritus,
pancreatic cancer ulcer of skin or mucosa.
Gastrointestinal: diarrhea,
Inflammatory disease of mucous
membrane.
Hematologic: Leukocytosis.

Folinic Acid Antimetabolites Colorectal cancer Gastrointestinal: Diarrhea, Nausea,

Megaloblastic anemia Stomatitis, Vomiting.
Gastric cancer
 Fatigue

Gemcitabine Antimetabolites Non-small cell lung Dermatologic: Alopecia

cancer
Gastrointestinal: nausea and vomiting
Ovarian cancer Pancreatic
cancer  Hematologic: Anemia, neutropenia,
Thrombocytopenia.
Fatigue
Immunosuppress Crohn's disease Abdominal pain, nausea, Infusion site
Infliximab ant agent  Psoriasis reaction, headache, urticarial,
Rheumatoid arthritis tachycardia and dyspnea.
Ulcerative colitis

Irinotecan Antineoplastic Metastatic colorectal Dermatologic: Alopecia

cancer
Endocrine metabolic: Weight
Extensive stage small cell
lung cancer decreased
Acute lymphoid leukemia Gastrointestinal: Abdominal pain,
Constipation, Diarrhea.
Hematologic: Anemia, leukopenia,
Neutropenia, thrombocytopenia.
Hepatic: Increased bilirubin level
Neurologic: Asthenia
Fatigue

Methotrexate Antimetabolite Rheumatoid arthritis GI epithelial damage, mucosal ulcers,

Psoriasis  nausea.
Acute myeloid leukemia
Bone marrow suppression
Carcinoma of bladder
Pulmonary fibrosis.
 Elevation of liver enzymes.

Mitomycin Cytotoxic Gastric cancer Gastrointestinal: loss of appetite,

antibiotics Pancreatic cancer nausea and vomiting.
Carcinoma of bladder
Myelosuppression, fever.

Mitozantrone Cytotoxic Acute myeloid leukemia Dermatologic: Alopecia

antibiotics Multiple sclerosis
Gastrointestinal: Diarrhea,
Non-Hodgkin's
lymphoma Refractory Inflammatory disease of mucous
prostate cancer membrane, Nausea, Vomiting
Hematologic: Leukopenia

oxaplatin Antineoplastic Ovarian cancer Gastrointestinal: diarrhea, nausea.

Colon cancer
Peripheral neuropathy
Non-Hodgkin's
lymphoma Hematologic: Anemia
Non-small cell lung Fatigue
cancer
Antineoplastic Ovarian cancer Peripheral neuropathy, nausea, vomiting,
Paclitaxel Agent ,Mitotic Breast cancer alopecia, hypersensitivity reactions.
Inhibitor Non-small cell lung
cancer Hematologic: anemia, leukopenia,
AIDS-related Kaposi's neutropenia, thrombocytopenia.
sarcoma
Pemetrexed Antimetabolite  Malignant Dermatologic: itching
mesothelioma of pleura Gastrointestinal: Constipation,
diarrhea, nausea, pharyngitis, stomatitis,
vomiting.
Hematologic: anemia, leukopenia,
neutropenia.
fatigue

Rituximab Antineoplastic Rheumatoid arthritis Severe infusion reaction

,Immunosuppres Non-Hodgkin's
Tumor lysis syndrome
sant agent lymphoma
Rash, increase risk of infection.
tochlizumab Antineoplastic  Polyarticular Hepatic: ALT/SGPT level raised
,Immunosuppres juvenile rheumatoid AST/SGOT level raised, AST/SGOT level
sant agent arthritis raised, Infusion reaction.
 Rheumatoid
arthritis

tratuzumab Antineoplastic Breast cancer, Adjuvant, Dermatologic: Rash

,Immunosuppres HER2 overexpression
Endocrine metabolic: Weight
sant agent Gastric cancer
 Malignant meningitis decreased
Gastrointestinal: Diarrhea, Nausea,
Stomatitis, Vomiting.
Hematologic: anemia, neutropenia,
thrombocytopenia
Immunologic: Infectious disease
Cough, fatigue.

vinablastin Antineoplastic Breast cancer, Myelosuppression

Agent ,Mitotic Unresponsive to
GIT ulceration, constipation
Inhibitor. endocrine surgery and
hormonal therapy
Non-Hodgkin's lymphom
Vincrisin Antineoplastic Hodgkin's disease dermatologic: Alopecia
Agent ,Mitotic Non-Hodgkin's
Gastrointestinal: Constipation,
Inhibitor. lymphoma
Rhabdomyosarcoma Nausea and vomiting
Ewing's sarcoma of bone Endocrine metabolic: Syndrome of
inappropriate antidiuretic hormone
secretion (SIADH).
Neurotoxicity

Vinorelbine Antineoplastic Non small lung cancer Dermatologic: Alopecia ,Injection site

Agent ,Mitotic reaction
Inhibitor.
Endocrine metabolic: Weight
decreased.
Gastrointestinal: Nausea, Vomiting.
Renal: Serum creatinine raised
Fatigue.

Zoledronic Bisphosphonate   Bone metastasis - Flu like syndrome ,renal impairment

Acid Solid tumor ,osteonecrosis of the jaw “ONJ”
 Hypercalcemia of
malignancy
 Multiple
myeloma
Paget disease
Azacitidine antimetabolite Acute myeloid leukemia Gastrointestinal: constipation,
Myelodysplastic diarrhea, nausea, vomiting.
syndrome, Refractory
anemia Hematologic: Anemia, Leukopenia,
Neutropenia, thrombocytopenia

bendamustine Antimetabolite  Chronic lymphoid Gastrointestinal: constipation

nausea , vomiting
 leukemia Hematologic: decreased
 Non-Hodgkin's hemoglobin ,neutropenia , decreased
lymphoma platelet count

Bortezomib Antineoplastic  Mantle cell Gastrointestinal: , Diarrhea ,Nausea

lymphoma Hematologic: Anemia, neutropenia,
 Multiple thrombocytopenia
myeloma Fatigue

decitabine Antineoplastic Acute myeloid leukemia Respiratory: cough ,fatigue, fever

Hematologic: anemia,
myelosuppression, neutropenia ,
thrombocytopenia
Gastrointestinal: nausea,
constipation.
Etoposide Antineoplastic Small cell carcinoma of Dermatologic: alopecia
Agent ,Mitotic lung Gastrointestinal:  nausea and
Inhibitor Testicular cancer
vomiting
Acute lymphoid leukemia
Hematologic: leukopenia,
thrombocytopenia,
Ifosfamide Antineoplastic Testicular cancer Dermatologic: alopecia
Acute lymphoid leukemia
Gastrointestinal: nausea and vomiting
Hematologic: anemia, leukopenia
Hemorrhagic cystitis
irinotecan Antineoplastic Metastatic colorectal Dermatologic: Alopecia
cancer,
Gastrointestinal: abdominal pain ,
constipation, diarrhea, loss of appetite ,
nausea, vomiting
Hematologic: anemia, leukopenia,
neutropenia, , thrombocytopenia
Hepatic: Increased bilirubin level
fever

Mitoxantrone Cytotoxic Acute myeloid leukemia Dermatologic: alopecia

antibiotics Multiple sclerosis
Hematologic: decreased hemoglobin,
Advanced hormone-
refractory prostate cancer leukopenia
Hepatic: liver function tests
abnormal

Panitumumab Antineoplastic Metastatic colorectal Dermatologic: dermatologic toxicity,

,Immunosuppres cancer pruritus, rash.
sant agent Non-small cell lung
Gastrointestinal: abdominal pain,
 cancer, Advanced diarrhea

Pemetrexed Malignant mesothelioma Gastrointestinal: constipation,

of pleura vomiting
Non-small cell lung
cancer Hematologic: Anemia, leukopenia,
neutropenia
Fatigue
abatacept Immune Rheumatoid arthritis Immunologic: Infectious disease
modulator Neurologic: headache
Respiratory: nasopharyngitis, Upper
respiratory infection, nausea.
Eribulin Antineoplastic Metastatic breast cancer, Dermatologic: alopecia
Agent ,Mitotic After 2 or more
Gastrointestinal: constipation ,nausea
Inhibitor chemotherapy regimens
for metastatic disease Hematologic: anemia, neutropenia
Neurologic: peripheral neuropathy

Natalizumab Immune  Crohn's disease Dermatologic: Rash 

modulator
 Multiple sclerosis Neurologic: Headache
Upper respiratory tract infections

Panitumumab Agent, Metastatic colorectal  Pruritus, rash ,diarrhea

Immunological cancer
Non-small cell lung
cancer, Advanced
altepase Thrombolytic  Acute myocardial Bleeding , angioedema , pleural effusion,
infarction pulmonary edema , GI hemorrhage .
Cerebrovascular accident,
acute, Ischemic
Pulmonary embolism
Venous catheter
occlusion, Central

Granisetron Serotonin (5- Chemotherapy-induced Headache , constipation , increase

HT3) receptor nausea and vomiting hepatic enzyme level , QT prolongation
antagonist Erythema at injection site
uromitexan Antidote, Hemorrhagic cystitis,  Chest pain, edema , alopecia ,
Hemorrhagic Ifosfamide-induced;
hypokalemia , abdominal pain,
Cystitis Inhibitor Prophylaxis
constipation, diarrhea ,nausea, vomiting
Type of Breast cancer : Lung cancer: Ovarian Colorectal Acute lymphocytic
cancer cancer: cancer : leukemia (ALL):
Preferre Anthracyclines Platinum Taxane FOLFOX  Remission induction :
–taxane based plus (5-FU, Four combination
d agents
regimens . combination platinum leucovorin, therapy :
chemotherap regimen. and (Vincristine,anthracycli
y. oxaliplatin) ne ,dexamethasone and
or CapeO asparaginase .
(capecitabine
and Acute myeloid
oxaliplatin)
leukemia :
regimens.
Anthracyclines and the
antimetabolite
cytarabine .

Ahlam
Intern from PNU