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INTRODUCTION
Adolescence is a tough time for many teens; these young people face many pressures.
Menstruation is a vital sign of good reproductive health in females. Girls typically start to
menstruate during puberty or adolescence, typically between the ages of 11 to 19.
Adolescent girls constitute a vulnerable group, particularly in India where female child
is neglected one. Menstruation is still regarded as something unclean or dirty in Indian
society. The reaction to menstruation depends upon awareness and knowledge about the
subject.
The manner in which a girl learns about menstruation and its associated changes may
have an impact on her response to the event of menarche. If girls and women are to live
healthy productive life then menstrual hygiene is a priority.
Labia Majora
The vulva is bounded on each side by the elevation of skin and subcutaneous tissue,
which form the labia majora.
They are continuous where they join medially to form the posterior commissure in front
of the anus.
The inner surface of the labia majora are hairless. The labia majora are covered with
squamous epithelium and contain sebaceous glands, sweat glands and hair follicles.
The labia majora are homologous with the scrotum in the male.
Labia Minora
Labia minora are two thick folds of skin, devoid of fat, on either side just within the
labia majora.
Anteriorly, they each other in front and behind the clitoris to form the prepuce and
frenulum, respectively. The lower portion of the labia minora fuses across the midline
to form a fold of skin known as fourchette.
The labia minora do not contain hair follicle. The folds contain connective tissues,
numerous sebaceous glands, erectile muscle fibers and numerous vessels and nerve
endings.
It is homologous to the ventral aspect of the penis.
Clitoris
Clitoris is a small cylindrical erectile body, measuring about 2.5 cm situated in the
most anterior part of the vulva.
It consists of glans, a body and two crura. The glans is covered by squamous
epithelium and is richly supplied with nerves.
Clitoris is analogue to the penis in the male, but it differs basically in being entirely
separate from the urethra.
Vestibule
Vestibule is a
triangular space
bounded anteriorly by the clitoris, posteriorly by the fourchette and on either side by
labium minus.
There are four openings into the vestibule:
1. Urethral opening : The opening is situated in the midline, just in front of the vaginal
orifice about 1–1.5 cm below the pubic arch. The paraurethral ducts open either on the
posterior wall of the urethral orifice or directly into the vestibule.
2. Vaginal orifice and hymen : The vaginal orifice lies in the posterior end of the
vestibule and is of varying size and shape. It is incompletely closed by a septum of
mucous membrane, called hymen.
Bartholin’s Gland
The Bartholin’s glands are situated in the superficial perineal pouch, close to the
posterior end of the vestibular bulb. They are pea-sized, of about 0.5 cm and yellowish-
white in color.
Each gland has got a duct which measures about 2 cm and opens into the vestibule,
outside the hymen at the junction of the anterior two-third and posterior one-third in the
groove between the hymen and the labium minus.
The duct is lined by columnar epithelium but near its opening by stratified
squamous epithelium. The Bartholin’s gland corresponds to the bulbourethral
gland of male.
Veins: The veins form plexuses and drain into— (a) internal pudendal vein, (b) vesical
or vaginal venous plexus, and (c) long saphenous vein. Varicosities during pregnancy are
not uncommon and may rupture spontaneously causing visible bleeding or hematoma
formation.
Vagina
The vagina is a membranous sheath
communicating the uterine cavity with the
exterior at the vulva.
It constitutes the excretory channel for the
uterine secretion and menstrual blood. It is
the organ of copulation and forms the birth
canal of parturition.
The canal is directed upwards and
backwards forming an angle of 45° with
the horizontal in erect posture.
The diameter of the canal is about 2.5 cm,
being widest in the upper part and
narrowest at its introitus. It has got enough power of distensibility as evident during
childbirth.
The pH is acidic and varies during different phases of life and menstrual cycle.
The uterus
The uterus is a hollow pyriform muscular organ situated in the pelvis between the
bladder in front and the rectum behind .
Position: Its normal position is one of the anteversion and anteflexion.
Measurements and parts: The uterus measures about 8 cm long, 5 cm wide at the
fundus and its walls are about 1.25 cm thick. Its weight varies from 50–80 g. It has got
the following parts:
• Body or corpus • Isthmus • Cervix
Body or corpus: The body is further divided into fundus—the part which lies above the
openings of the uterine tubes. The body properly is triangular and lies between the
openings of the tubes and the isthmus.
Isthmus: The isthmus is a constricted part measuring about 0.5 cm situated between the
body and the cervix
Cervix: The cervix is the lowermost part of the uterus. It extends from the histological
internal os and ends at external os which opens into the vagina. It is almost cylindrical in
shape and measures about 2.5 cm in length and diameter. The physical and chemical
properties of the cervical secretion change with menstrual cycles and with pregnancy. The
cervical glands secrete an alkaline mucus with pH 7.8.
Fallopian tube (uterine tube) The uterine tubes are paired structures, measuring about
10 cm (4"). Each tube has got two openings, one communicating with the lateral angle
of the uterine cavity, called uterine opening and measures 1 mm in diameter, the other is
on the lateral end of the tube, called pelvic opening or abdominal ostium and measures
about 2mm in diameter.
Parts: There are four parts, from medial to lateral, they are—
(1) intramural or interstitial lying in the uterine wall and measures 1.25 cm (1/2") in length
and 1 mm in diameter;
(2) isthmus almost straight and measures about 2.5 cm (1") in length and 2.5 mm in
diameter;
(3) ampulla—tortuous part and measures about 5 cm (2") in length which ends in wide;
(4) infundibulum measuring about 1.25 cm (1/2") long with a maximum diameter of 6 mm.
The ovary
The ovaries are paired sex glands or gonads in female which are concerned with:
i. Germ cell maturation, storage and its release.
ii. Steroidogenesis.
Each gland is oval in shape and pinkish grey in color .
It measures about 3 cm in length, 2 cm in breadth and 1 cm in thickness.
Each ovary presents two ends—tubal and uterine, two borders—mesovarium and free
posterior and two surfaces—medial and lateral.
Structures: The ovary is covered by a single layer of cubical cell known as germinal
epithelium. The substance of the gland consists of outer cortex and inner medulla.
1. Cortex: It consists of stromal cells which are thickened beneath the germinal
epithelium to form tunica albuginea. During reproductive period (i.e.from puberty to
menopause), the cortex is studded with numerous follicular structures, called the
functional units of the ovary in various phases of their development. These are
related to sex hormone production and ovulation. The structures include primordial
follicles, maturing follicles, Graafian follicles and corpus luteum.
Definition:
Puberty is the period in life during which the reproductive organs reach maturity and
child changes to become an adult.
Puberty in girls is the period, which links childhood to adulthood. It is the period of
gradual development of secondary sexual characters.
There are profound biological, morphological, and psychological changes that lead to full
sexual maturity and eventually fertility.
Menstrual phase
When the ovum is not fertilised, the corpus
luteum starts to degenerate. (In the event of
pregnancy, the corpus luteum is supported
by human chorionic gonadotrophin [hCG]
secreted by the developing embryo.)
Progesterone and oestrogen levels therefore
fall, and the functional layer of the
endometrium, which is dependent on high
levels of these ovarian hormones, is shed in
menstruation.
The menstrual flow consists of the
secretions from endometrial glands,
endometrial cells, blood from the
degenerating capillaries and the unfertilized ovum.
During the menstrual phase, levels of oestrogen and progesterone are very low because
the corpus luteum that had been active during the second half of the previous cycle has
degenerated.
This means the hypothalamus and anterior pituitary can resume their cyclical activity,
and levels of FSH begin to rise, initiating a new cycle.
Proliferative phase
At this stage an ovarian follicle, stimulated by FSH, is growing towards maturity and is
producing oestrogen, which stimulates proliferation of the functional layer of the
endometrium in preparation for the reception of a fertilised ovum.
The endometrium thickens, becoming very vascular and rich in mucus-secreting
glands.
Rising levels of oestrogen are responsible for triggering a surge of LH approximately
mid-cycle. This LH surge triggers ovulation, marking the end of the proliferative
phase.
Secretory phase
After ovulation, LH from the anterior pituitary stimulates development of the corpus
luteum from the ruptured follicle, which produces progesterone, some oestrogen, and
inhibin.
Under the influence of progesterone, the endometrium becomes oedematous and the
secretory glands produce increased amounts of watery mucus. This assists the passage
of the spermatozoa through the uterus to the uterine tubes where the ovum is usually
fertilised.
There is a similar increase in secretion of watery mucus by the glands of the uterine
tubes and by cervical glands that lubricate the vagina. The ovum may survive in a
fertilisable form for a very short time after ovulation, probably as little as 8 hours.
The spermatozoa, deposited in the vagina during intercourse, may be capable of
fertilising the ovum for only about 24 hours although they can survive for several days.
This means that the period in each cycle during which fertilisation can occur is
relatively short.
Observable changes in the woman’s body occur around the time of ovulation. Cervical
mucus, normally thick and dry, becomes thin, elastic and watery, and body
temperature rises by about 1°C immediately following ovulation. Some women
experience abdominal discomfort in the middle of the cycle, thought to correspond to
rupture of the follicle and release of its contents into the abdominal cavity.
After ovulation, the combination of progesterone, oestrogen and inhibin from the
corpus luteum suppresses the hypothalamus and anterior pituitary, so FSH and LH
levels fall.
Low FSH levels in the second half of the cycle prevent further follicular development
in case a pregnancy results from the current cycle. If the ovum is not fertilised, falling
LH levels leads to degeneration and death of the corpus luteum, which is dependent on
LH for survival.
The resultant steady decline in circulating oestrogen, progesterone and inhibin leads to
degeneration of the uterine lining and menstruation, with the initiation of a new cycle.
MENOPAUSE
The menopause (climacteric) usually occurs between the ages of 45 and 55 years,
marking the end of the childbearing period.
It may occur suddenly or over a period of years, sometimes as long as 10 years, and is
caused by a progressive reduction in oestrogen levels, as the number of functional
follicles in the ovaries declines with age.
The ovaries gradually become less responsive to FSH and LH, and ovulation and the
menstrual cycle become irregular, eventually ceasing. Several other phenomena may
occur at the same time, including:
short-term unpredictable vasodilation with flushing, sweating and palpitations,
causing discomfort and disturbance of the normal sleep pattern
shrinkage of the breasts
axillary and pubic hair become sparse
atrophy of the sex organs
episodes of uncharacteristic behaviour, e.g. irritability, mood changes
gradual thinning of the skin
loss of bone mass predisposing to osteoporosis
slow increase in blood cholesterol levels that increase the risk of cardiovascular
disease in postmenopausal women to that in males of the same age.
Similar changes occur after bilateral irradiation or surgical removal of the ovaries.
MENSTRUAL IRREGULARITIES
INTRODUCTION:
Menstruation is the periodic discharge of blood, mucus, and epithelial cells from the uterus.
In normal healthy women, menarche occurs between the ages 10 and 16 years, mean age of
menarche being around 12.5 years. It usually occurs at monthly intervals throughout the
reproductive period, of life with an average rhythm of 28-30 days, inclusive of 4–6 days of
bleeding (except pregnancy lactation).
It is the end point in a series of events which begin in the cerebral cortex and
hypothalamus and ends at the uterus in the hypothalamic–pituitary–ovarian– uterine axis.
Any break in this axis creates menstrual problems. Excessive or inappropriately timed
menstruation and amenorrhoea are the most common complaints for which women seek
advice from medical healthcare providers.
(a)Primary Amenorrhoea:
Primary Amenorrhoea is the absence of menarche until age 16 years or the absence of the
development of secondary sex characteristics and menarche till age of 14 years.
Causes:
Congenital obstructive defects such as imperforate hymen, vaginal septum, vaginal atresia
and non canalization of cervix in presence of functioning uterus leads to collection of
menstrual blood inside the genital tract i.e cryptomenorrhea. The young girl presents with
amenorrhoea cyclical abdominal pain, abdominal lump and at times retention of urine.
Congenital absence or gross hypoplastic non-functioning uterus. The vagina too is absent.
Congenital ovarian failure, or streak ovaries seen in Turner syndrome. Chromosomal
abnormalities account for 20% of cases of primary amenorrhoea.
Adrenal gland. Addison’s disease.
Thyroid gland. Cretinism and childhood myxoedema.
Diabetes. Adolescence diabetes is associated with primary amenorrhea in 50% cases.
Nutritional. Very poor nutrition occasionally causes primary amenorrhea.
Hypothalmic disorders. Organic disorders such as tumours, encephalitis, fracture base of
the skull may cause primary amenorrhea.
Symptoms:
Failure to experience menarche when there has been development of secondary sex
characteristics.
No menarche and absence of development of secondary sex characteristics as in Turner’s
syndrome.
Assessment:
A medical assessments should include:
History of etiologic factors
Physical examination for:
Nutritional status
Weights, height and vital signs
Signs of eating disorder (hypothermia, bradycardia, hypertension, and reduced
subcutaneous fat)
Androgen excess e.g. facial hair and acne
Delayed puberty: absence of facial hair and axillary hair
Laboratory tests for:
U/S
Thyroid function test
Prolactine levels
If high level FSH: indicate ovarian failure
If high level of LH: indicate gonadal dysfunction
Leprascopy
Management:
Therapeutic interventions depend on the cause of amenorrhea:
Estrogen replacement therapy (ERT) to stimulate development of secondary sex
characteristics and to prevent osteoporosis.
Cryptomenorrhoea needs incision of the hymen. The vaginal septum needs excision and
drainage and later artificial vagina.
Hormonal therapy for uterine hypoplasia.
Improved nutrition.
Treatment of the cause. Hypopituitarism and hypothalamic disorder may require GnRH,
FSH and LH.
(b) Secondary Amenorrhea:
It is the absence of menstruation for at least 6 months or for three cycles after menarche.
Causes:
Physiologic response to pregnancy, lactation or anovulation.
Hypothyroidism or hyperthyroidism.
Adrenal disease
Chronic renal disease.
Polycystic ovary syndrome
Chronic hepatic disease.
Anorexia nervosa
Malnutrition
Vigorous athletic training.
Investigations:
Thyroid function test
Blood glucose level
Laparoscopy to check ovarian pathology
Ultrasound to check polycystic ovary syndrome.
Management:
Cyclic progesterone therapy if the cause is anovulation.
Oral contraceptives for women who desire contraception.
Bromocriptine if there is hyperprolactinemia.
Gonadotropin- releasing hormone (GnRH), when the cause is hypothalamic failure.
Thyroid hormone replacement for hypothyroidism
Calcium and estrogen to prevent development of osteoporosis.
2. MENORRHAGIA:
Definition: Menorrhagia is an abnormally heavy and prolonged menstrual period at
regular intervals. Normal menstrual cycle is 25-35 days in duration with bleeding lasting
an average of 5 days and a total blood flow between 25-80 ml .A blood loss greater than
80ml or lasting longer than 7 days constitutes menorrhagia (also called hypermenorrhea).
Causes:
Usually no causative abnormality can be identified and treatment is directed to the
symptom rather than a specific mechanism. An overview of causes includes the
following:
Uterine :
Endometrial polyp
Submucosal fibroid
Endometrial hyperplasia
Endometrial adenomyosis
Ovarian
Ovulatory DUB
Anovulatory DUB
Polycystic ovary syndrome
Others
Hematological causes
Leukemia
Hypothyroidism, hyperthyroidism
Diagnosis :
Pelvic and rectal examination
Pap smear
Pelvic ultrasound scan is the first line diagnostic study for identifying structural
abnormalities.
Endometrial biopsy to exclude atypical hyperplasia or endometrial cancer
Hysteroscopy
Treatment
When underlying cause can be identified, treatment may be directed at this. Clearly heavy
periods at menarche and menopause may settle spontaneously.
Medications
Iron supplements to counter anemia
Non-steroidal anti-inflammatory drugs to reduce blood loss.
Hormonal treatment for DUB:
- Oral contraceptives, usually combined estrogen, progesterone pills for few months
-Progesterone only pills or injection Depo- Provera
- Progesterone releasing intrauterine system (IUS)
Other options:
- Antifibrinolytics: Gonadotropin-releasing hormone agonists
Surgery:
Surgery treatment is rarely done to:
Endometrial ablation
Dilation and curettage
Hysteroscopic myomectomy to remove fibroids
Causes:
Dysfunctional uterine bleeding
Common in adolescence, preceding menopause and following delivery, abortion,
hyperstimulation of ovaries by the pituitary hormone may be the causative factor.
Ovarian hyperemia
Seen in PID or ovarian endometriosis.
Treatment:
Hormone Therapy
Estrogen and progestogen are generally prescribed either separately or as combined oral
pills. The preparations of progestogen used are norethisterone acetate and
medroxyprogesterone acetate. Progestin alone therapy is highly effective in an ovular
DUB, while combined preparations of progestogen and estrogen are effective in ovular
type.Norethisterone preparations (5 mg tablets) are used three times a day till bleeding
stops, which is usually 3-7 days. Low dose combined oral pills (estrogen and
progestogen) used as cyclic therapy from 5 th to 25th day for three cycles in ovular
bleeding.
4. METRORRHAGIA :
Metrorrhagia is defined as irregular, acyclic bleeding from the uterus. It is mostly related to
surface lesions in the uterus. When the bleeding is so irregular and excessive that the
menstruation cannot be identified, it is called menometrorrhagia.
Causes:
Acyclic Bleeding:
Dysfunctional uterine bleeding (during adolescence, following childbirth or abortion and
preceding menopause)
Submucous fibroid
Uterine polyp
Endometrial or cervical cancer
Contact Bleeding:
Carcinoma cervix
Mucous polyp of cervix
Infections : Chlamydial or tubercular cervicitis.
Cervical endometriosis.
Intermenstrual Bleeding :
Ovular Bleeding
Breakthrough bleeding in pill users
Intrauterine contraceptive device in utero.
5. OLIGOMENORRHEA:
Oligomenorrhea is defined as bleeding occurring more than 35 days apart and which
remains constant at that frequency.
Causes:
Age related : During adolescence and preceding menopause
Obesity
Vigorous exercise
Endocrine disorders : Polycystic ovary syndrome (PCOS), hypoprolactinemia,
hyperthyroidism.
Androgen producing tumors : Ovarian, adrenal
Tuberculous endometritis
Treatment:
Treatment according to the cause identified.
6. HYPOMENORRHEA
Hypomenorrhea is defined as menstrual bleeding that is unduly scanty and lasts for less than
2 days.
Causes:
Uterine synechiae
Endometrial tuberculosis
Use of oral contraceptives
Thyroid dysfunction
Malnutrition
Premenopausal period
7. DYSMENORRHOEA
Many girls experience pain or cramps
discomfort associated with menstruation is
called dysmenorrhoea .
Sometimes emotional changes are experienced like short temper, aggression, anger,
anxiety or panic, confusion, lack of concentration, irritability, nervous tension, fatigue,
or depression around the time of her period. Not everyone has these feelings – some do
not feel anything.
MENSTRUAL HYGIENE
Although menstruation is a natural process, it is linked with several misconceptions
and practices, which sometimes result into adverse health outcomes.
Hygiene-related practices of women during menstruation are of considerable
importance, as it has a health impact in terms of increased vulnerability to reproductive
tract infections (RTI). The interplay of socio-economic status, menstrual hygiene
practices and RTI are noticeable.
Today millions of women are sufferers of RTI and its complications and often the
infection is transmitted to the offspring of the pregnant mother.
Women having better knowledge regarding menstrual hygiene and safe practices are
less vulnerable to RTI and its consequences. Therefore, increased knowledge about
menstruation right from childhood may escalate safe practices and may help in
mitigating the suffering of millions of women.
Menstrual Hygiene is defined as 'Women and adolescent girls using a
clean menstrual management material to absorb or collect blood that can be changed
in privacy as often as necessary for the duration of the menstruation period.
Menstrual flow differs from individual to individual. For some, the flow is heavy only
on the first day, for others it’s for 2 to 3 days. Similarly for some the flow is heavier
during the day and for some in the night. Some napkins may absorb blood well and
prevent leakage, but cause irritation and itching in the thighs and genitals. If that’s the
case, one may want to change the napkin till she find a comfortable one. If the problem
persists, consult a physician.
The frequency of changing the napkins depends on the flow. If the flow is high, you
can change it once in 3 hours, otherwise you can keep it on for up to 5-6 hours. It’s
quite common for girls to not change the napkins frequently in order to save money.
However, keeping a napkin on for a long time may cause infection or at least irritation.
Each time you urinate and wash your genitals with water, the napkin absorbs the water
and eventually it loses its shape. This may lead to overflow, discomfort and bad odour.
Change the napkins regularly to keep yourself dry and comfortable.
Safe disposal of used napkins: The manner in which one dispose the napkins depends
on the facilities available. She needs to do any of the below:
- For disposal one can create a sanitary pit in the backyard. Dig a pit in the backyard,
keep dropping the newspaper wrapped used napkins in the pit. Cover the pit to stop
animals from pulling it outside. Keep dropping ash after use. Once the pit is filled up,
close the pit completely and u se another pit.
-One can wrap the napkin in an old newspaper/waste paper and drop it in the dust bin. If
there are no bins, then drop it in the general waste bin.
-Some toilets have incinerators that will burn the napkins.
-Wash your hands with water after disposing sanitary napkins.
-Never flush a sanitary napkin in the toilet to prevent clogging of drainage system and
flooding of toilets.
PMS can cause tension, anxiety, and irritability, Use the measures such as meditation, yoga,
exercise reading books talking with friends etc. whic helps to reduce anxiety
Exercise regularly:
Exercise has many health benefits that can help periods. It can help to maintain healthy
weight and is commonly recommended as part of a treatment plan for polycystic ovarian
syndrome (PCOS). PCOS can cause menstrual irregularity.
Women who performed the exercises reported less pain associated with their menstrual
periods.
Exercise can help control weight, which may, in turn, help to regulate menstrual periods.
It may also reduce pain before and during period. Thirty minutes of moderate physical
activity on most days of the week found effective during menstruation.
Massaging your stomach or back can reduce menstrual pain.
Yoga:
•Yoga has been shown to be an effective treatment for different menstrual issues.
•It reduces menstrual pain and emotional symptoms associated with menstruation, such as
depression and anxiety, and improve quality of life in women with primary dysmenorrhea.
Practicing yoga 35 to 40 minutes a day, 5 times a week, may help regulate hormones and
menstrual cycles. Yoga may also help reduce premenstrual symptoms
11. Belief: We should not go to temples, carry babies, wear flowers on the head, water
plants, touch pickles, or go out in the afternoons as the evil spirits might attack you.
Fact: None of these are true.
12. Belief: If birds fly over a sanitary napkin/cloth, you will be cursed by the bird.
Fact: Not true. This belief was probably promoted to ensure hygiene (so that the cloth
does not come in contact with bird droppings thereby causing infection) and safe
disposal of the napkins or cloth.