REVISION DATE: November 2006

SAFETY DATA SHEET

MORPHOLINE 0.5M IN METHANOL

1 IDENTIFICATION OF THE SUBSTANCE/PREPARATION AND OF THE COMPANY/UNDERTAKING

PRODUCT NAME MORPHOLINE 0.5M IN METHANOL

PRODUCT NO. 2413
APPLICATION General chemical reagent
SUPPLIER Reagent Chemical Services
18 Aston Fields Road
Whitehouse Industrial Estate
Runcorn
Cheshire WA7 3DL
T: 01928 716903
F: 01928 716425
E: info@reagent.co.uk

2 HAZARDS IDENTIFICATION

Highly flammable. Toxic by inhalation, in contact with skin and if swallowed. Irritating to eyes and skin. Toxic: danger of very serious
irreversible effects through inhalation, in contact with skin and if swallowed.
CLASSIFICATION T;R23/24/25, R39/23/24/25. Xi;R36/38. F;R11.

ENVIRONMENT
The product is mildly toxic to aquatic organisms.

HUMAN HEALTH
Contains a substance which has been shown to cause cancer in laboratory animals.

3 COMPOSITION/INFORMATION ON INGREDIENTS

Name EC No. CAS-No. Content Classification

METHANOL 200-659-6 67-56-1 60-100% F;R11 T;R23/24/25,R39/23/24/25

MORPHOLINE 203-815-1 110-91-8 5-10% R10 C;R34 Xn;R20/21/22

The Full Text for all R-Phrases are Displayed in Section 16

EU INDEX NO. 603-001-00-X
EC No. 200-659-6
CAS-No. 67-56-1

4 FIRST-AID MEASURES

INHALATION
Remove victim immediately from source of exposure. Move into fresh air and keep at rest. In case of severe exposure or if any discomfort
continues get medical attention.
INGESTION
Do not induce vomiting. Immediately rinse mouth and drink plenty of water. Get medical attention immediately!

SKIN CONTACT
Immediately remove contaminated clothing and wash before re-use. Wash the skin immediately with soap and water. In serious cases or if
discomfort continues after slight contact obtain medical attention.
EYE CONTACT
Promptly wash eyes with plenty of water or eye wash solution while lifting the eyelids.If possible remove any contact lenses and continue to
wash. Get medical attention immediately.

5 FIRE-FIGHTING MEASURES

EXTINGUISHING MEDIA
Water spray, dry powder or vaporising liquids

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MORPHOLINE 0.5M IN METHANOL

UNUSUAL FIRE & EXPLOSION HAZARDS
HIGHLY FLAMMABLE! Forms explosive mixtures with air.

SPECIFIC HAZARDS
In case of fire, toxic gases may be formed. Fire may create oxides of nitrogen.

PROTECTIVE MEASURES IN FIRE

Self contained breathing apparatus and full protective clothing must be worn in case of fire.

6 ACCIDENTAL RELEASE MEASURES

PERSONAL PRECAUTIONS
Wear protective clothing as described in Section 8 of this safety data sheet.

SPILL CLEAN UP METHODS

Remove sources of ignition. Small Spillages Absorb with inert, non-combustible material. Large Spillages Dam and absorb spillages with
sand, earth or other non-combustible material. Collect spillage in containers, seal securely and deliver for disposal according to local
regulations. Containers with collected spillage must be properly labelled with correct contents and hazard symbol. Wash spillage site well
with water and detergent, be aware of the potential for surfaces to become slippery. Ventilate well. After spillages in enclosed areas test
atmosphere before using any potential ignition sources.

7 HANDLING AND STORAGE

USAGE PRECAUTIONS
Avoid spilling, skin and eye contact. Avoid inhalation of vapours and spray mists. Eliminate all sources of ignition. Static electricity and
formation of sparks must be prevented.
STORAGE PRECAUTIONS
Flammable/combustible - Keep away from oxidisers, heat and flames. Store in tightly closed original container in a dry and cool place.

STORAGE CLASS
Flammable liquid storage.

8 EXPOSURE CONTROLS/PERSONAL PROTECTION

Name Std TWA - 8 hrs STEL - 15 min Notes

MORPHOLINE OES 20 ppm(Sk) 72 mg/m3(Sk) 30 ppm(Sk) 109

mg/m3(Sk)
MORPHOLINE 0.5M IN METHANOL WEL 200 266 250 333
ppm(Sk) mg/m3(Sk) ppm(Sk) mg/m3(Sk)

WEL = Workplace Exposure Limit.

ENGINEERING MEASURES
Work in flameproof fume cupboard. Ensure occupational exposure limit is not exceeded.

RESPIRATORY EQUIPMENT
Wear respiratory protection if workplace exposure limits are exceeded due to inadequate ventilation or extraction. Wear suitable respiratory
protection if vapours or mists are generated.
HAND PROTECTION
Use protective gloves. Butyl rubber. Viton rubber (fluor rubber). Polyethylene/Ethylene Vinyl Alcohol (PE/EVAL). Be aware that the liquid
may penetrate the gloves. Frequent change is advisable. The most suitable glove must be chosen in consultation with the gloves supplier,
who can inform about the breakthrough time of the glove material.
EYE PROTECTION
Wear approved safety goggles.

OTHER PROTECTION
Wear suitable protective clothing and personal protective equipment to avoid skin contact with this substance. If there is a risk of splashing
then wear a face shield. Provide eyewash station and safety shower.
HYGIENE MEASURES
DO NOT SMOKE IN WORK AREA! Wash at the end of each work shift and before eating, smoking and using the toilet. Wash promptly if
skin becomes wet or contaminated. Promptly remove any clothing that becomes wet or contaminated. When using do not eat, drink or
smoke.

9 PHYSICAL AND CHEMICAL PROPERTIES

APPEARANCE Liquid
COLOUR Clear Green
ODOUR Characteristic

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MORPHOLINE 0.5M IN METHANOL

SOLUBILITY Miscible with water.

10 STABILITY AND REACTIVITY

STABILITY
Stable under normal temperature conditions.

CONDITIONS TO AVOID
Avoid heat, flames and other sources of ignition.

MATERIALS TO AVOID
Strong oxidising substances. Inorganic hydrides.

11 TOXICOLOGICAL INFORMATION

TOXIC DOSE 1 - LD 50 5628 (Methanol), 1050 (Morpholine) mg/kg (oral rat)

TOXIC CONC. - LC 50 22.2 (Morpholine) mg/l/1h (inh-rat), 64, 000 (Methanol) ppm/4h (inh-rat)

TOXICOLOGICAL INFORMATION
LDLo 143 mg/kg (Oral, human) (Methanol) Evidence of reproductive effects. Morpholine has been found to cause cancer in laboratory
animals and there is evidence of mutagenic effects.
INHALATION
Toxic by inhalation. Irritating to respiratory system. Dizziness Headache.

INGESTION
Toxic if swallowed.

SKIN CONTACT
Product has a defatting effect on skin. May be absorbed through the skin. Liquid may irritate skin.

EYE CONTACT
Irritating to eyes.

HEALTH WARNINGS
Absorption of large quantities may cause irreversible damage to the optic nerve (due to methanol), nausea, headache, vomiting, inebriation
and blindness.
ROUTE OF ENTRY
Inhalation. Skin absorption. Ingestion.

TARGET ORGANS
Systemic effect can lead to damage of the kidneys, liver and heart

12 ECOLOGICAL INFORMATION

ECOTOXICITY
Low acute toxicity to aquatic organisms.
LC 50, 96 Hrs, FISH mg/l Methanol-13, 000 (Salmo gairdneri), 29, 000 (Promephales promelas), 15, 400 (Lepomis mochrochirus).
Morpholine- 180 (Onchorynchus mykiss)
BIOACCUMULATION
Low bioaccumulation potential.

DEGRADABILITY
Good biodegradability

13 DISPOSAL CONSIDERATIONS

DISPOSAL METHODS
Dispose of waste and residues in accordance with local authority requirements.

14 TRANSPORT INFORMATION

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MORPHOLINE 0.5M IN METHANOL

UK ROAD CLASS 3
PROPER SHIPPING NAME FLAMMABLE LIQUID, TOXIC, N.O.S. (METHANOL, MORPHOLINE)
UN NO. ROAD 1992 UK ROAD PACK GR. II
ADR CLASS NO. 3 ADR CLASS Class 3: Flammable liquids.
ADR PACK GROUP II HAZARD No. (ADR) 336
ADR LABEL NO. 3 & 6.1 HAZCHEM CODE 3WE
CEFIC TEC(R) NO. 30GFT1-II RID CLASS NO. 3
RID PACK GROUP II UN NO. SEA 1992
IMDG CLASS 3 IMDG PAGE NO. 3 & 6.1
IMDG PACK GR. II EMS F-E, S-D
MFAG See Guide MARINE POLLUTANT No.
UN NO. AIR 1992 AIR CLASS 3
AIR SUB CLASS 6.1 AIR PACK GR. II

15 REGULATORY INFORMATION

LABELLING

Toxic Highly Flammable

CONTAINS METHANOL

RISK PHRASES
R11 Highly flammable.

R23/24/25 Toxic by inhalation, in contact with skin and if swallowed.

R36/38 Irritating to eyes and skin.

R39/23/24/25 Toxic: danger of very serious irreversible effects through inhalation, in contact with skin
and if swallowed.
SAFETY PHRASES
S9 Keep container in a well-ventilated place.

S16 Keep away from sources of ignition - No smoking.

S24/25 Avoid contact with skin and eyes.

S26 In case of contact with eyes, rinse immediately with plenty of water and seek medical
advice.
S27 Take off immediately all contaminated clothing.

S36/37/39 Wear suitable protective clothing, gloves and eye/face protection.

S38 In case of insufficient ventilation, wear suitable respiratory equipment.

S45 In case of accident or if you feel unwell, seek medical advice immediately (show label
where possible).
S60 This material and its container must be disposed of as hazardous waste.

UK REGULATORY REFERENCES
Highly Flammable Liquid Regulations 1972. Fire precautions Act 1971.

STATUTORY INSTRUMENTS
Chemicals (Hazard Information and Packaging) Regulations. Control of Substances Hazardous to Health.

APPROVED CODE OF PRACTICE

Classification and Labelling of Substances and Preparations Dangerous for Supply. COSHH essentials: Easy steps to control chemicals.
Control of Substances Hazardous to Health Regulations.
GUIDANCE NOTES
Workplace Exposure Limits EH40. Introduction to Local Exhaust Ventilation HS(G)37.

NATIONAL REGULATIONS
Control of Substances Hazardous to Health Regulations 2002 (as amended)

16 OTHER INFORMATION

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REVISION DATE: November 2006

MORPHOLINE 0.5M IN METHANOL

REVISION COMMENTS
This is first issue.
REVISION DATE November 2006
REV. NO./REPL. SDS GENERATED 1
SDS NO. 11205

SAFETY DATA SHEET STATUS

Approved.

RISK PHRASES IN FULL

R34 Causes burns.
R10 Flammable.
R20/21/22 Harmful by inhalation, in contact with skin and if swallowed.
R11 Highly flammable.
R23/24/25 Toxic by inhalation, in contact with skin and if swallowed.
R39/23/24/25 Toxic: danger of very serious irreversible effects through inhalation, in contact with skin and if swallowed.

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