Saboy, Jelly March B.

Practical Research 1

STEM 12 E

Module 3 (Performance Check)

ARTICLE 1 Ethical Consideration and Community Engagement in HIV cure-related research.

Authors Introduction Methodology Findings Discussion

Collier, Ann C. Statement of Summary of the Sample population Data gathering Ethical Practice Relevant Support Findings Conclusion Limitations
the problem. background. instrument and Findings
Dube, karine gathering.
Louella, Sylla -The research -Perceptions were -Nineteen -Participants -To elicit the Combination Departmennt of C&GT is a rapidly 1.This is the
Luter, Stuart seeks to deeply embedded participants(age 33- viewed gene perspective of antiretroviral Global Health and involving field first qualitative
provide in lived 66 years) modification as people living Theraphy. Psychology(Dube offering the study to
Mohamed, insight into experiences of being invasive with HIV et.al)They noticed potential for examine
Zahra H. perception People Living 9 male and expressed specific to those Community that some groups therapeutic and perception,
and views with HIV liking their novel perspective may have had curative strategies beliefs and
Patel, Hursch 9 female regarding
about Cell and (PLWH) and bodies the way approaches, the limited prior aimed at managing acceptance of
Gene Therapy sociocultural they are. They researcher C&GT exprosure to C&GT persistent HIV. C&GT for
Sylla, Laurie 1 transgender
(C&GT) for meanings of viewed C&GT as conducted 4 and held doubts Their findings curing HIV
Formative focus
curing HIV disease and being a risky focus groups about HIV research underscore the infection.
group
infection research. Most approach to discussions with based on conspiracy importance of
discussion 2. Their study
among men C&GT curing HIV a diverse group theories. integrating
regarding novel extends the
and women approaches in the infection that of 19 English sociobahavioral
approaches. The researchers literature on
living with field of HIV cure could possibly speaking men sciences during the
HIV in the research are lead to and women found significant development of HIV cure
There has been
northwest aimed at making significant pain living with HIV overlap in themes strategies to cure research
limited
United states. cells resistant to and side effects. in care at a large and convergence in HIV. Most modality,
exploration of
HIV infection or academic HIV concerns about importantly, rather than the
public and
enhancing the Time since HIV clinic in C&GT. The research understanding end- accepta-biliity
community
immune systems’ diagnosis(yrs) northwestern desired more user perspective is of HIV cure
perception
capacity to clear United States. research on the critical in research in
6-10 yrs- 4 around C&GT
HIV infection Participants effects of designing general
to cure HIV
cells. At present, were recruited combination interventions that
>10 yrs- 15 infection among 3.Data build on
most C&GT by research antiretroviral therapy are acceptable and
any group. previous
strategies toward Total 19 personel who on specific organs in attractive to
the body and empirical
HIV cure remain presented the Some population of
 in the preclinical Prior injection study and participants discussed the interest for HIV research
stage of drug use. assigned would consider incurability of HIV cure research. regarding
development, but interested C& GT if they and expressed accepta-bility
some have No-14 individuals to could see general aversion to of C&GT in on
entered human specific grp another person participating C&GT non HIV
Yes-5
testing. The base on time cured first. research. disease areas
researcher aim to Analysis availability and Lastly it and on recent
answer this prespecified highlighted an U.S. surveys of
question: Such -Thematic criteria. aversion to public attitudes
studies require Analysis gene around gene
altruistic modification therapy.
participation of -Empirical Data
and mistrust of
people living with analysis 4.The
government-
HIV, as those participants
funded clinical
participating will willingness to
not benefit direct trials.
participate.
from the testing and
indeed may risk
adverse effect, how
can you deal with
that matter?

References:

Collier, A. C., Dube, k., Louella, S., Luter, S., Mohamed, Z. H., Patel, H. and Sylla, L.(2019), Acceptability of Cell and Gene Therapy for curing HIV infection among people living with HIV in the
Northwestern United States., AIDS research and human retroviruses 35(7), 649-659.

ARTICLE 2 Ethical Consideration and Community Engagement in HIV cure-related research.

Authors Introduction Methods Findings Discussion

Auerbach, Judith Statement Back ground Sample Data gathering, Ethical Relevant Support of findings Conclusion Limitation and
D. population instrument and Practice Findings recommendation
Of the Problem analysis
Dube, Karine
The research Global interest 4 U.S Cities They conducted This research Participants had Participants The study brings -This was a
Evans, David conducted 10 and investment in a total of 76 intentio-nally generally not appeared to care the voice of people qualitative study of a
focus group in 4 the search for an Seattle WA-21 participants recruited the been exposed to more about living with HIV diverse group of
Gilbertson, U.S cities in HIV cure has male, 9 female, interviewed partici-pants much reputation and infections to the people living with
Adam cure clinical increased. 1 transgender about their for their information qualification of the forefront of the HIV conducted at
research sites to Research has and 1 queer. definition of willingness to about the researchers and HIV cure research only 4 U.S sites.
Palm, David provide useful focused on what cure, their provide specific their affiliated agenda. Cure has
information experts refer to as Los Angeles attitudes toward consent and method-logies research institution powerful meaning -This study was a
Sylla, Laurie CA-4 male, 5 community
about the a sterilizing or eradicating and give their being explored than the other beyond the
general eradicating cure, female and 1 functional cures, opinions about for either an goups. biomedical participatory project
Taylor, Jeff
perception of Where HIV is transgender. expectations of HIV cure eradicating or domain. More and each site
HIV cure related eliminated from biomedical HIV research, functional cure. Qualitative resources will need recruited study
San Diego understanding of participants locally.
research among the body, and on cure researchers comfortable Some had to be invested to be
People living what is often and factors that discussing difficulty over all emerging invested to inform
NC- 8 male -It was not possible
with HIV. called a would affect HIV cure grasping what a community people living with
and 1 female to assess thematic or
functional cure, their willingness research with functional cure perceptions related HIV and engage in
to HIV cure data saturation since
where HIV Durham NC- to participate in other people would actually meaningful
research. the number of
remains, kept 13 male and 12 HIV cure-related living with be like. The dialogue with
participants was
durably female. studies. HIV and term functional communities about
(Dube et al.2018) determined by their
suppressed in the willing to keep cure itself was the realities of
Total:76 Analysis study budget and
absence of information meaningless to potential cure
time constraints for
antiretroviral shared in the many in their methodologies and
1.Demogra-phic implementation.
treatment and focus groups sample. Many their risk and
data analysis
therapy. Many confidential. were skeptical benefits. Careful -They recommended
believe that a 2.Thematic about the management that future social
functional cure is Analysis durability of a regarding sciences studies
likely to be found functional cure, expectations incorporate specific
first. HIV cure 3.Data gathering and had associated with information about
studies will Analysis significant fears HIV cure research HIV cure related
require active like(ground related to will be essential research before
participation by theory and potential viral and will be of soliciting opinions of
people living with phenomeno-logy re-emergence. paramount respondents about
HIV infection. analysis. importance. this complex body of
Their desire and work.
perception will be
important to
effectively recruit
study participants
and for the uptake
of any future
strategy that
demonstrate
safety and
efficacy.
References

Auerbach, J.D., Dube, K., Evans,D., Gilbertson, A., Palm, D., Sylla, L., Taylor, J.(2017), Perception of HIV cure-related research by people living with HIV in four US cities: A qualitative focus group
study., AIDS research and human retroviruses 34(1) 56-66.

ARTICLE 3 Ethical Consideration and Community Engagement in HIV cure-related research.

Authors Introduction Methodology Findings Discussion

Statement of Summary of the Research design, Data gathering Ethical Practice Relevant findings Support of the Conclusion Limitation of
the problem. background. methods, instrument and findings the study
approach. gathering.

In the context This study The initial search They then This research They found a They concluded The research A limitation of
Ashraf, kage of the global Identifies some of yielded 893 titles obtained full text search the diversity of ways in that the literature concluded that this study is
effort to the caveats and and abstracts, articles for all following which community of community the interpretation that it was not
De Wet, develop an pitfalls associated which were studies that both bibliographical engagement has engagement in the of good possible to
Anneliese effective and with researching independently team members data bases for the been operetiona- context of HIV participatory conduct as
safe HIV community. These reviewed by recorded as years 1990-2016 lised and utilized, clinical trials was practice systematic
Kafaar, Zuhayr vaccine, are as follows ; the members of their potentially using the search thus making not amenable in guidelines may review and
clinical trials lack of consensus research team. relevant for the terms in Web of comparisons of identifying vary depending apply the
Lesch, Anthea
investigators of what review science, Scopus, definition across overarching lesson on the preferred
are faced with community Their abstract PubMed, study difficult. lerned. An context(HIV reporting
Swartz, Leslie
the question of engagement is and reviewed 64 They then Academic search exception to this vaccine trials) items for
Newman, Peter how best to how it is practiced, articles being obtained the full- premier and A common feature trend is a detailed staff rotations, systematic
A. enroll large the sometimes included in the text article and PsyARTICLES. of the literature was 4 country case and funders reviews and
number of paradoxidal role of next stage of the arrived at This research did that community study, which involved. meta-analyses
HIV-negative community study. consensus about not include engagement was identifies three criteria to
individuals in advisory boards as whether or not the conference discussed without cross cutting Supervision and literature.
studies of community article should be proceeding or being specifically themes as central support to staff Given the
vaccine representatives and included. unpublished defined or to community on the coalface disparate
challenges articles in their operationalized. engagement. These of interacting nature of the
The variable that with the
 efficacy. associated with were analysed search. The (Newman P.A) are trial literacy, community to literature in
information emerged keyword they mistrust of ensure consistent CE and its
dissemination in organically search are In the context of researchers due to practice in terms varied
communities. through their community HIV vaccine trials historical of community definition,
engagement in the reading and engagement, community exploitation and engagement such as
context of HIV review of the participants engagement the importance of activities is systematic
vaccine trials. Also article that they engagement, activities facilitate engaging in therefore worth approach to
This study selected. empowerment, community participatory considering. review was not
identifies a set of decision making members to make process. (Newman possible,
consideration for Two team and HIV clinical informed decisions et.al) The meaning of which reflects
community members trials. This review about whether to community a lack of
engagement independently paper did not participate in the An implication of engagement in a readiness of
practitioner, trial extracted data on involved human future vaccine trials these interrelation- specific context the field for
investigators and the ways in which subject. or not. (slack et.al) ship is that in HIV requires such study.
social scientists authors used the context where exploration and
when conducting terms community Analysis there are high consensus by -They
community engagement in the levels of mistrust stakeholders at recommend
context of HIV Data collection and it is possible the start of the that the use of
engagement.
vaccine trials. and analysis. that process of these terms are
communicating vaccine trials, better suited to
trial related that is upon localized and
concepts may be entering the context
more difficult to community. specific usage.
achieve in low-
trust environments
in context where
trust is grater.
(Neman and
Rubincam 2014)

References:

Ashraf, k., De Wet, A., Kafaar, Z., Lesch, A., Swartz, L. and Newman, P. A. (2017), Caveats and pitfalls associated with researching community engagement in the context of HIV vaccine trials., Journal of
the health psychology 25(1), 82-91.