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  • Toaz - Info Shift Reagentspdf PR

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    Jalpa Vadgama
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    Lanthanide shift reagents contain lanthanide ions like Eu3+ and Pr3+ that are coordinated by ligands to impart solubility and transiently interact with diamagnetic samples. This induces chemical shift changes through space interactions in NMR spectra, with Eu3+ causing downfield shifts and Pr3+ causing upfield shifts. Common ligands are β-diketonates that simplify spectra, and Pr(facam)3 is a chiral reagent that can determine enantiomeric excess through signal integration.

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    Lanthanide shift reagents contain lanthanide ions like Eu3+ and Pr3+ that are coordinated by ligands to impart solubility and transiently interact with diamagnetic samples. This induces chemical shift changes through space interactions in NMR spectra, with Eu3+ causing downfield shifts and Pr3+ causing upfield shifts. Common ligands are β-diketonates that simplify spectra, and Pr(facam)3 is a chiral reagent that can determine enantiomeric excess through signal integration.

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    3 views2 pages

    Toaz - Info Shift Reagentspdf PR

    Uploaded by

    Jalpa Vadgama
    Lanthanide shift reagents contain lanthanide ions like Eu3+ and Pr3+ that are coordinated by ligands to impart solubility and transiently interact with diamagnetic samples. This induces chemical shift changes through space interactions in NMR spectra, with Eu3+ causing downfield shifts and Pr3+ causing upfield shifts. Common ligands are β-diketonates that simplify spectra, and Pr(facam)3 is a chiral reagent that can determine enantiomeric excess through signal integration.

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    of 2

    Lanthanide shift reagents

    Most Ln3+ complexes are strongly paramagnetic


    do not give useful NMR spectroscopic data - unusual shifts and broadened

    lanthanide shift reagents – can be added to diamagnetic samples and induce


    chemical shift changes via through space interactions
    most common reagents are based upon Eu3+ and Pr3+ ions short relaxation times
    reducing broadening in 1H NMR spectra
    Eu3+ down field shifts and Pr3+up field
    coordinated by e.g β-diketonate (acac) ligands

    Ligands impart solubility


    transient coordination to the
    O O CF3
    O lanthanide centre. simplify the
    O O
    R R Eu O Pr(facam)3 spectrum
    O O O Pr
    -
    O 3
    Pr(facam)3 a chiral reagent
    O O
    allows the determination of ee
    by integration

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