Lanthanide shift reagents contain lanthanide ions like Eu3+ and Pr3+ that are coordinated by ligands to impart solubility and transiently interact with diamagnetic samples. This induces chemical shift changes through space interactions in NMR spectra, with Eu3+ causing downfield shifts and Pr3+ causing upfield shifts. Common ligands are β-diketonates that simplify spectra, and Pr(facam)3 is a chiral reagent that can determine enantiomeric excess through signal integration.
Lanthanide shift reagents contain lanthanide ions like Eu3+ and Pr3+ that are coordinated by ligands to impart solubility and transiently interact with diamagnetic samples. This induces chemical shift changes through space interactions in NMR spectra, with Eu3+ causing downfield shifts and Pr3+ causing upfield shifts. Common ligands are β-diketonates that simplify spectra, and Pr(facam)3 is a chiral reagent that can determine enantiomeric excess through signal integration.
Lanthanide shift reagents contain lanthanide ions like Eu3+ and Pr3+ that are coordinated by ligands to impart solubility and transiently interact with diamagnetic samples. This induces chemical shift changes through space interactions in NMR spectra, with Eu3+ causing downfield shifts and Pr3+ causing upfield shifts. Common ligands are β-diketonates that simplify spectra, and Pr(facam)3 is a chiral reagent that can determine enantiomeric excess through signal integration.
do not give useful NMR spectroscopic data - unusual shifts and broadened
lanthanide shift reagents – can be added to diamagnetic samples and induce
chemical shift changes via through space interactions most common reagents are based upon Eu3+ and Pr3+ ions short relaxation times reducing broadening in 1H NMR spectra Eu3+ down field shifts and Pr3+up field coordinated by e.g β-diketonate (acac) ligands
Ligands impart solubility
transient coordination to the O O CF3 O lanthanide centre. simplify the O O R R Eu O Pr(facam)3 spectrum O O O Pr - O 3 Pr(facam)3 a chiral reagent O O allows the determination of ee by integration