Association Between the PDSS2 Gene and How People Consumer Coffee

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 Association Between the PDSS2 Gene and How People Consumer Coffee.

Introduction

Genetics plays a vital role in how different people react to caffeine in various ways due to

their genes. Genetics even determines the way people around the world consume coffee.

Understanding the connection in detail is essential as some research has evident that coffee

increases the quality of life. Caffeine can categorize people in terms of genes and the

consequences that the consumption of coffee brings into the various life functions. This paper

determines the genes that impact the way people consume coffee in their lives; the articles will

be compared by selecting the hypothesis used by the research scientist and the fundamental

research and what it meant to the thesis.

Hypothesis

The study by Higgins (2016) suggests that there is a gene that is known as PDSS2 that

plays a massive role in identifying the way people use coffee and how they metabolize caffeine

in different ways. The studies were conducted to determine the impact of gene PDSS2 in people

who consume coffee and how caffeine metabolizes through the consumption of coffee. The null

hypothesis of the articles is PDSS2 does not affect the way people drink coffee and does not

affect the way people metabolize caffeine (Higgins, 2016). The alternative hypothesis for the

articles is to study the impacts of PDSS2 on how people consume coffee and how they affect the

metabolisms of caffeine in different people. The study done by Higgins (2016) shows the effect

of the gene PDSS2 on how people metabolize caffeine and realized that those with the gene take

less coffee than those who have less or no pdss2 (Higgins, 2016). The research has answered the

hypothesis of the study. On the other hand, the article by Pirastu et al. (2016) has highlighted the
relationship between the PDSS2 gene and the consumption of coffee. The results have answered

the hypothesis of the article.

The Experiments for The Hypothesis

The first article is a news report that reports research conducted in a genome study

association to study the DNA and the discovered a gene known as the PDSS2 that affected how

people metabolize the caffeine's from coffees (Higgins, 2016). On the other hand, the article by

Pirastu et al. (2016) is conducted through the genome-wide association of study in Italians

pupation that was done through the use of additive, dominant and recessive models that

determines the association of the PDSS2 gene with the way people consume coffee. The

genome-wide association study (GWAS) is a research method used by genetics to relate the

specific variations of genes with a particular issue or disease (Uffelmann et al., 2021). This

method involves the scanning of the genomes from a different population. The main reason is to

look for a specific genetic marker and use the feature to identify and understand how genes can

contribute to the development of a disease and come up with strategies to prevent and treat the

diseases. Both articles have not given details on the experiment, although they emphasize the

results of the studies.

The Results of The Articles

The results of the article done by Higgins (2016) show that different people need to take

less coffee to feel the impact because their bodies are used to break down the caffeine in

different levels in the levels of a gene. On the other hand, the study by (Pirastu et al. 2016) found

out that the gene FDSS2 shows a negative regulation on the expression of the gene on caffeine,

and it is linked to coffee consumption. The articles reported similar results that were found in the
researches. However, the pieces are too short, and therefore it means that the reported results

were just reported briefly in both articles.

Conclusion

In essence, the PDSS2 gene affects and impacts the way people consume coffee and

affects caffeine's mentalism in different people. The results have shown that some people only

need to take less coffee to move coffee; hence, it negatively affects the amount of coffee they

consume. The new finding is similar to the results that are presented in the two articles.
 References

Higgins, M. (2016). Science says this is why you hate coffee. Yahoo.com. Retrieved 14 October

2021, from https://www.yahoo.com/news/science-says-why-hate-coffee-

141434203.html?

guccounter=1&guce_referrer=aHR0cHM6Ly9tYWlsLmdvb2dsZS5jb20v&guce_referrer

_sig=AQAAABAjaGzfjNm1p9XQ52d3dBa6AIXzS1YNtkp8V0aRFNi-

zUVmU7dZyK0vk2ROmPjMpucW3UYZJTb9XXrG5iu91F4ey8d_szh8rtvoDQ3TNuR0

onc5meToaHrw1YPMVUW00b5X1sAQ-

0_COOSwWnG5pMjSyaaUEfgbWOCcxYJDraKo.

Pirastu, N., Kooyman, M., Robino, A., Van Der Spek, A., Navarini, L., Amin, N., ... &

Gasparini, P. (2016). Non-additive genome-wide association scan reveals a new gene

associated with habitual coffee consumption. Scientific reports, 6(1), 1-6.

https://www.nature.com/articles/srep31590

Uffelmann, E., Huang, Q. Q., Munung, N. S., de Vries, J., Okada, Y., Martin, A. R., ... &

Posthuma, D. (2021). Genome-wide association studies. Nature Reviews Methods

Primers, 1(1), 1-21. https://www.nature.com/articles/s43586-021-00056-9