Osler

alesan dx tinea :

-
ukkpasien → Khas tepi aklit → membeñkan gamba ran tinea
count
-
predileksi Kennan pasien →

-
PX KOH lot →. hita Panjang
-

tidaumemenuni Kñtotra DD lalnya

Or
0
-

÷
 MK 4- dermatotitosis

901 Jqmvr '" a" autivati

TIN@A
.

→ →
stratum respon 1mm
derma ma
korneum host
✓
.

crvrls ! mencema
Keratin
mlcospowm
tricophyton
epidermophyron

predileksinya pada daerah lipatan

Psoriasis seperti aksila, regio genito-kruris,
dan leher
inversa

7 Kalo psoriasis
( Suvarna Kosar
kenapaddmyainr ? I
• ukk plan eñtem barbatus togas disertai s④lma Kato tinea
•
predileksi daerah lipatan skvamg
hawse tipis

¥1:#
dikvlit
genut-ocwn.se/
Candidiasis
Inter triglnosa
•

•
bedanya

psoriasis
Kato di

→
Tckasvs
PI

ditemvkan
→

→
errtema
hiperpigmen

less di
,
• men
gau
gates
,
.

gate

tompat tanya .

•
pre dileksi =
lipatan kvlit , keltak genltoknral
,

Inter gluteal lnframamae Sela Jari

, ,

Psoriasis
•
ukk .
-
makuta enrtematosa barbatus tegas ,
C.f)f fq g M A
disen-aisk@amadan1etiSateUl_predi1ekgi-lipetanK.sinlntergw
:

Plak biasanya
bilateral tetapi "
biasanya gated Kaya tinea Mtramamae umbilicus seta Jan
'

•
Sama . . .
. ,

menyisakan UKK = Manila em-ematosahinggakeco.ca#berbamtgadgskvamahalu@

☐
-

penis dan •
FR = - lembab
skrotum, berbeda -
lmuntr -

biasanyaasimptomatik tapi Kawai selling Rangan gate 11

, .

dengan sarang ganli date man Seung Kook sisters, dg dermatofita ✓ ✓

-
-

kandidiasis -
pane Pakatan Ygganyerep -
FR =
-
Klim tembab / hang at
hrgiene bunk
hrgrene bunk
-

-
vsrg
-
lmvntr
-

hyperhidrosis
 tatalaksana
tinea . .

griseofulvin
Griseofulvin is FDA approved for and the drug of choice in tinea capitis.
Other indications include onychomycosis as well as superficial fungal
infections resistant to topical antifungal medications. mechanism of action :

It interacts with microtubules to affect the formation of the mitotic spindle. This
interference ultimately inhibits mitosis in dermatophytes.
although itraconazole and terbinafine have come to be more common choices
than griseofulvin for tinea capitis in adults.

Researchers found that among antifungal therapies for tinea capitis,

griseofulvin and terbinafine had the highest clinical and complete cure rates.
[2] In the same study, griseofulvin more
effectively treated Microsporum than Trichophyton

griseofulvin can treat superficial fungal infections that are resistant to

treatment with topical antifungal medications, with the exception being tinea
capitis, for which it is first-line, as mentioned above. It is usually the first-line
choice for this purpose in children. Practitioners can use it for severe and
diffuse superficial fungal infections. Examples of such infections include
tinea manuum, tinea unguium, tinea corporis, and tinea cruris.

tidakadadatayg
compare lebrheteuntmana
top /KAI
:

Penodobateenyacepat lower recaps

/ tapi pricey
terbinahne ,

↳ alilqmpn ,

↳
→
butenafrne
cloth'm azole

azole → mlconazoie
fpengobatanyalebihlamatapi
harganyauebrhmvrah I
ketokona +

1- 2^1 hair selama

2
pasienvdhpunya
1- 24 Mlnggv . . -
.

> pitman ! Karna

µ
> v1 Kronika recurrent
↳ lebihcepetaja
druse rashes
Oral eksoensrvea

weeks)
99 tetbinatine 280mg / d 12-4
paving femngdrpquie = 1 .

2.ltMCOna2 200mg / d ( 1 )
weeks

3. FLUCONAZOLE Lama → . . .

9. griseofulvin → capitis a ungvinvm

5. ketoconazole → hepatoroxkr

Topical therapy is generally successful unless the infection covers an

F
extensive area or is resistant to initial therapy. In these cases, systemic
therapy may be required. Tinea corporis and cruris infections are usually
treated for two weeks, while tinea pedis is treated for four weeks with an
azole or for one to two weeks with allylamine medication. Treatment
should continue for at least one week after clinical clearing of infection.

brasanya dg
fsebenemya
Karna vdn sembuh
> pasren pane oral
i. extensive area Pengobatan 2m99 tapi ,
brat ewnrarl

clearing dañjamvmya
2. recurrent
+ atleast
7- mrnggv . ..
toprkal .

• -

Mechanism of action
Itraconazole
ketouonarrol lanotterol disrupt whole
inhibit Pembennkan
membran cell
f
→
→ ,
ergosterol Cmembranjamvrj
ergosterol
✓ function
 Y

ketoKona201
mengganggu sintesis ergosterol membran
sel jamur, serta enzim tertentu. Seperti
semua agen antijamur azole,
ketoconazole bekerja terutama dengan
menghambat enzim sitokrom P450 14α-
demethylase (CYP51A1). Enzim ini
berpartisipasi dalam jalur biosintesis
sterol yang mengarah dari lanosterol ke
ergosterol

Hruconaeel
Itraconazole acts by inhibiting
the fungal cytochrome P-450
dependent enzyme lanosterol
14-α-demethylase. When this
enzyme is inhibited it blocks
the conversion of lanosterol to
ergosterol, which disrupts
fungal cell membrane
synthesis.