Professional Documents
Culture Documents
i. Alkylamines
ii. Ethoxylatedamines
iii. Alkyl-Betains
7. Thickening Agents
usually added to make the preparation
thick -facilitates ease of handling
Ex: methyl cellulose, alginates polyvinyl alcohol,
polyethylene glycol
8. Perfumes
imparts good fragrance to the shampoo
neutralizes the undesirable odour of other
ingredients of formulation especially
surfactants
9. Preservatives
have the ability to prevent the growth of
microorganisms
usually added to maintain the stability of
the preparation for a desired period of time
Ex: Para-hydroxy benzoic acid and phenyl
mercuric nitrate
10. Colour
gives pleasant appearance to the preparation
must be water soluble and it should not
impart any colour to hair or scalp
PREPARATION
1. Initially the detergent is converted into a
solution form or a detergent solution ma ho
directly obtained from the manufacturer.
2. Take about half of the detergent solution
into a separate container. To it, add the total
amount of secondary surfactant i.e.,
alkanolamide.
3. Dissolve the alkanolamide along with
stirring. Sometimes, gentle heat is also
applied.
4. To the remaining half of the detergent
solution add suitable amount of
perfuming agent and dissolve it.
5. The perfume solution is then added to the
alkanolamide solution.
6. Colour and preservatives are dissolved
separately in sufficient volume of water
and then added to the main solution.
chloride.
7. The whole, solution is mixed well by gentle
stirring. Excessive stirring may lead to bubble
formation.
8. Final volume of the preparation is
usually adjusted by the addition of clear
sterile waste. This gives clear liquid shampoo.
9. However, when the preparation contains
lauryl alcohol ether sulphate. It is required to
adjust the viscosity of the shampoo.
10. Viscosity adjustment is done by using an
electrolyte solution. Usually, a solution of
sodium chloride is added subsequently with
constant stirring. Care must be taken to it
event the excess addition of sodium chloride
EVALUATION
* According to the regulatory authorities each
and every batch of shampoos must be evaluated
prior to marketing.
* Evaluation is a measure of activity and safety.
It also notifies the toxicity, if nowadays most of
the shampoos are prepared, from synthetic
detergents, hence evaluation becomes an
essential factor.
* However, there is also a need to evaluate
herbal shampoo, since it may contain natural
ingredient which are liable to contamination.
I. Evaluation of Safety
1. Skin Toxicity Test – using six albino rabbits
(shampoo is applied topically)
After efficient washing, the skin is examined for
any adverse reactions such as erythema, edema
etc. Based on the results obtained the shampoo is
considered as either safe or toxic.