PATHOPHYSIOLOGY:

ACUTE MYOCARDIAL
INFARCTION

PREDISPOSING FACTOR
PRECIPITATING FACTOR

- Obesity
- Hereditary - Hypertension
- Sedentary lifestyle

ETIOLOGY
“Unknown”

Astherosclerosis

Change in conditions of
plaque in the coronary artery

Activation of platelets

Formation of thrombus

Prolonged narrowing

Cardiomyocyte is not
supplied with enough oxygen

Heart might die but will compensate first.

Stimulation of the
sympathetic nervous
system
 Brain receptor - Increase HR
release - Increase BP
adrenaline - Increase O2
demandleads to
Overused lead to  Elevated ST- shortness of breath,
damage of the heart Segment ECG Result
weakness or
muscle  Q-wave fatigue.
appears

Myocardial cell Protein will leak

death and release of
lysosomal
enzymes

Anaerobic Myocardial Heart can’t pump

glycolysis leads to irritability.
lactic acid
production.

- Dysrhytmias
Chest, stomach, -Palpitations Heart dies
back or -Shortness of
abdominal pain. -Heart
breath
Attack/Cardiac
-Difficulty
Arrest
breathing