UCSF Adult Vancomycin Dosing CalculatEnter information in fields outlined in red

Patient Information Calculated values in blue

*Disclaimer* Use of this tool does not replace clinical judgment.
Input Patient Parameters
Patient Age (years)
Gender Enter Conversion
Patient Total Body Weight (kg) Enter lbs to convert to kg 0
Height (cm) Enter inches to convert to cm 0
Serum creatinine (mg/L)

Assess Patient Clearance

Is patient on intermittent HD?
Is patient on CRRT?
Is patient's renal function stable?
Total Body Weight/Ideal Body Weight Ratio
Age>65 and SCr<1
NO If YES, see UCSF dosing card for correct dose
NO If YES, see UCSF dosing card for correct dose
YES IF NO, calculations will be unreliable. Suggest ad hoc dosing and following vancomycin levels.
0.000 If TBW/IBW>1.2, consider using Adjusted (method 2) or Ideal (method 3) Body Weight in CrCl calculation
NO If YES or patient with low muscle mass, consider rounding serum creatinine up to 1 in CrCl calculation (method 4)

Estimators of Creatinine Clearance

Cockroft-Gault
Cockroft-Gault using
using Total Body
Adjusted Weight
Body (TBW)
Weight #DIV/0! Method 1 (CrCl maximum capped at 200 ml/min)
(AdjBW) #DIV/0! Method 2 (CrCl maximum capped at 200 ml/min)
Cockroft-Gault
Cockroft-Gault using
using Ideal BodySCr
TBW and Weight (IBW)
rounded up #DIV/0! Method 3 (CrCl maximum capped at 200 ml/min)
to 1 0.00 Method 4 (CrCl maximum capped at 200 ml/min)
Input Custom CrCl estimation Method 5

Select Best Estimator of Creatinine Clearance 1 Select 1-5 from Methods Above

To select or evaluate an initial vancomycin dose, click here

To evaluate a vancomycin dosing regimen with a single trough level, click here
To evaluate a vancomycin dosing regimen with two postdistributional levels, click here
For technical information and references, click here
UCSF Adult Vancomycin Dosing CalculatEnter information in fields outlined in red
Select or Evaluate Initial Vancomycin Do Calculated values in blue

Select Vancomycin Dosing Regimen

Recommended Dosing Interval (hours) #DIV/0!
Chosen Dosing Interval (hours) 8

Recommended Vancomycin Dose (mg) #DIV/0!

Chosen Vancomycin Dose (mg) 1000

Predicted Vancomycin AUC24 #DIV/0!

Predicted Vancomycin Trough (mg/L) #DIV/0!
Predicted Vancomycin Peak (mg/L) #DIV/0!

Recommended Loading Dose (mg) 0

Monitoring
Vancomycin half-life #DIV/0!

To return to patient information tab, click here

To view calculation details, click here
Enter information in fields outlined in red
Calculated values in blue

Enter 6,8,12,24 hours

Dose to achieve a steady-state trough of 15 mg/L

Enter 250,500,750,1000,1250,1500,2000mg

Target AUC24 is 400-600

Acceptable vancomycin troughs should be <21 to reduce nephrotoxicity
Acceptable vancomycin peaks should be <50

Loading doses are recommended for patients with severe infections (round to nearest 250mg, cap at 2000mg)

Steady-state is approximately reached after 4 half-lives of continuous dosing

For routine monitoring, draw trough level before the 4th dose if dosing interval ≥ half-life
If loading dose given, draw draw trough level before the 4th dose of the maintenance regimen
If dosing interval substantially < half-life, draw level before next dose after 3 half-lives have passed
50mg, cap at 2000mg)
UCSF Adult Vancomycin Dosing Calculator Enter information in fields outlined in red
Evaluate vancomycin dosing regimen based
on single STEADY-STATE trough Calculated values in blue

Enter Vancomycin Dosing Regimen

Vancomycin Dose (mg) 1000
Vancomycin Frequency (hours) 8

Dose Revisions based on Single Steady-state Trough Note: assumes vancomycin volume of distribution is constant; c
Level drawn at steady-state (after >3 half-lives?) YES
Level drawn <= 30 min before end of dosing interval? YES
Enter vancomycin trough serum concentration (mg/L) 12

Select Revised Vancomycin Dosing Regimen

Recommended Dosing Interval (hours) #DIV/0!
Select New Dosing Interval (Hours) 8

Recommended Vancomycin Dose (mg) #DIV/0!

Chosen Vancomycin Dose (mg) 1250

Predicted Vancomycin AUC24 #DIV/0!

Predicted Vancomycin Trough (mg/L) #DIV/0!
Predicted Vancomycin Peak (mg/L) #DIV/0!

Monitoring
Vancomycin half-life #DIV/0!

To return to patient information tab, click here

To view calculation details, click here
Enter information in fields outlined in red

Calculated values in blue

Note: assumes vancomycin volume of distribution is constant; caution with obesity, fluid overload,
If NO, trough will be UNDERestimated and calculations unreliable
If NO, trough will be OVERestimated and calculations unreliable

Enter 6,8,12,24 hours

Dose to achieve a steady-state trough of 15 mg/L

Enter 250,500,750,1000,1250,1500,2000mg

Target AUC24 is 400-600

Acceptable vancomycin troughs should be <21 to reduce nephrotoxicity
Acceptable vancomycin peaks should be <50

Steady-state is approximately reached after 4 half-lives of continuous dosing

For routine monitoring, draw trough level before the 4th dose if dosing interval ≥ half-life
If loading dose given, draw draw trough level before the 4th dose of the maintenance regimen
If dosing interval substantially < half-life, draw level before next dose after 3 half-lives have passed
UCSF Adult Vancomycin Dosing Calculator Enter information in fields outlined in red
Evaluate vancomycin dosing regimen based two
levels Calculated values in blue

Enter Vancomycin Dosing Regimen

Vancomycin Dose (mg) 1000
Vancomycin Frequency (hours) 8

Dose Revisions based on Paired Vancomycin Levels

Initial vancomycin serum concentration (mg/L) 33
Time first level drawn AFTER end of infusion (hours) 1
Time BETWEEN serum concentrations (hours) 6
Second vancomycin serum concentration (mg/L) 15
Time level drawn BEFORE next dose (hours) 0

Vancomycin AUC24 595.68

Select Revised Vancomycin Dosing Regimen

Recommended Dosing Interval (hours) 8
Chosen Dosing Interval (Hours) 8

Recommended Vancomycin Dose (mg) 1068.68

Chosen Vancomycin Dose (mg) 1000

Predicted Vancomycin AUC24 616.24

Predicted Vancomycin Trough (mg/L) 14.04
Predicted Vancomycin Peak (mg/L) 37.63

Monitoring
Vancomycin half-life 5.27

To return to patient information tab, click here

To view calculation details, click here
Enter information in fields outlined in red

Calculated values in blue

Should be drawn AFTER distribution, at least 1 hour after end of infusion

Recommended to be trough concentration, no greater than 30 minutes before next dose

Target AUC24 is 400-600

Enter 6,8,12,24 hours

Dose to achieve a steady-state trough of 15 mg/L

Enter 250,500,750,1000,1250,1500,2000mg

Target AUC24 is 400-600

Acceptable vancomycin troughs should be <21 to reduce nephrotoxicity
Acceptable vancomycin peaks should be <50

Steady-state is approximately reached after 4 half-lives of continuous dosing

For routine monitoring, draw trough level before the 4th dose if dosing interval ≥ half-life
If loading dose given, draw draw trough level before the 4th dose of the maintenance regimen
If dosing interval substantially < half-life, draw level before next dose after 3 half-lives have passed
Patient Parameters
Age Weight (kg) Height (cm) SCr Female
0 0 0 0.00 0

IBW ABW TBW/IBW Elderly Flag Height (in)

-88 -52.8 0 NO 0

TBW AdjBW IBW TBW & Round SCr Forced CrCl

CrCl (ml/min)CrCl (ml/min) CrCl (ml/min) CrCl (ml/min) CrCl (ml/min)
#DIV/0! #DIV/0! #DIV/0! 0 0.00
Maximum cutoff 200 ml/min
#DIV/0! #DIV/0! #DIV/0! 0 0.00
CrCl (L/hr) CrCl (L/hr) CrCl (L/hr) CrCl (L/hr) CrCl (L/hr)
#DIV/0! #DIV/0! #DIV/0! 0 0
#DIV/0! #DIV/0! #DIV/0! 0.0044 0.0044
Select Dosing CrCl: 1 for TBW, 2 for ABW, 3 for IBW, 4 for TBW & Rounded SCr, 5 to force CrCl
1
Vanco Initial Dosing
Vd_vanc Clvanc k t1/2
0 #DIV/0! #DIV/0! #DIV/0!

Suggested T Chosen Tau Target trough (-kT) tinf (-ktinf)

#DIV/0! 8 15 #DIV/0! 1 #DIV/0!

Vanco dose Dose chosen Predicted peak Predicted trough Infusion Time AUCup
#DIV/0! 1000 #DIV/0! #DIV/0! 1 #DIV/0!

Daily Dose AUC Target Peak Loading Dose Loading DPeak1 AUC2
3000 #DIV/0! 35 0 2000 #DIV/0! #DIV/0!

Vanco Dose Revision: Single Trough Level

Initial Dose Calcs
Actual Trough
Interval Usedlevel calc field Dose Used tinf used
8 12 #DIV/0! 1000 1

k t1/2 Clvanc Predicted peak (-kT) (-ktinf) AUCup

#DIV/0! #DIV/0! #DIV/0! #DIV/0! #DIV/0! #DIV/0! #DIV/0!

Revised Dose Calcs

Suggested T Chosen T Target Trough (-kT) tinf (-ktinf)
#DIV/0! 8 15 #DIV/0! 1.5 #DIV/0!

Vanco dose Dose chosen Predicted peak Predicted trough Infusion Time AUCup
#DIV/0! 1250 #DIV/0! #DIV/0! 1.5 #DIV/0!

Daily Dose AUC Target Peak Loading Dose AUC2

3750 #DIV/0! 35 0 #DIV/0!
Vanco Dose Revision: Paired Levels
Initial Dose Calcs
Level 1 Level 1 time posInterval Level 2 time beforeLevel 2 Cpeak actual Ctrough actu
33 1 6 0 15 37.634347153 15

k t1/2 Clvanc Vvanc AUCup

0.13140956 5.27358892062 5.029985241317 38.277163693365 26.3171736

Revised Dose Calcs

Suggested T Chosen T Target Trough (-kT) tpeakmeas(-ktpeak)
8 8 15 -1.0512764804857 2 -0.13140956

Vanco dose Dose chosen Predicted peak Predicted trough Infusion Time AUCup
1068.679951 1000 37.634347152849 14.0360076801891 1 25.8351774

Daily Dose AUC Target Peak Loading Dose AUC2

3000 616.24121012 35 765.5432738673 596.4232
 MALE
FEMALE

YES
NO

1
2
3
4
5
0.49485029 -0.7035

AUCdown AUC total

#DIV/0! #DIV/0!

AUC color Trough color

#DIV/0! #DIV/0!

AUCdown AUCtotal
#DIV/0! #DIV/0!

AUCdown AUCtotal
#DIV/0! #DIV/0!

AUC color Trough color

#DIV/0! #DIV/0!
Dose Used T used tinf Used
1000 8 1

AUCdown AUCtotal AUC color

172.242774 595.6798 2

AUCdown AUCtotal
179.578559 616.2412

AUC color Trough color

3 2
Based on one-compartment population pharmacokinetic model
Volume of distribution is estimated as 0.7 L/kg as per Matzke et al Antimicrob A
Vancomycin elimination rate constant is estimated as 0.00083 * CrCl + 0.0044 a
ke et al Antimicrob Agents Chemother 1984;25:433-437
83 * CrCl + 0.0044 as per Matzke et al