Pylopass™ −

A new Approach to
Helicobacter pylori
control
 YSP in Malaysia: Pylopass™ supports the triple
therapy

• Formulation
200mg Pylopass™ per capsule
• Promoted with gastro portfolio:
- urea breath test
- antibiotics
- PPI
• Main positioning
increases eradication rate
• Dietary supplement
30 capsules per box
As a unique and
innovative 20.80 euro/box
product
YSP medical seminars to promote Pylobalance in
Penang, Kuala Lumpur and Johor Bahur, April 2019
 TianJin Pharma (China)
K-HP

• Pylopass™ content
200 mg per sachet
• Other ingredient
probiotic strain
• Claims
none
• Field of Application
dietary supplement

As a unique and
innovative
product
TianJin Pharma Launch Event in Singapore
26th of June 2019
 Pyloflush (India)
Lupin Pharma

• Pylopass™ content
200 mg in two caspule
• Other ingredients
excipients
• Claims
none
• Field of Application
dietary supplement
10 capsules per box
As a unique and
innovative
product
 Grupo Farma (Colombia)
Helicomb

• Pylopass™ content
200 mg in two capsules
• Other ingredient
none
• Claims
none
• Field of Application
dietary supplement
16 euro/28 capsules box
As a unique and
innovative
product
 Cinfa (Spain)
Pylocontrol

• Pylopass™ content
200 mg per capsule
• Other ingredients
Saccharomyces boulardii
• Claims
improves eradication treatement
improves tolerance to treatment
• Dietary supplement
to be taken with antibiotics
16 euro/28 capsules box
As a unique and
innovative
product
 Peroxfarma (Spain)
HELICOCID

• Pylopass™ content
Gastric
Wellbeing 200 mg in two tablets
• Other ingredients
calcium carbonate, chamomile
extract, biotin
• Claims
immediate acid control
supports a healthy gastric
mucosa
100% natural
• Dietary supplement
13 euro/box
 Viet Duc (Vietnam)
DeHP and DeHP Kids

• Pylopass™ content
Gastric
Wellbeing 200 mg in two capsules/sachets
• Other ingredients
licorice and curcumin
• Claims
helps release from the GI
tract naturally
reduces stomach upset
• Field of Application
dietary supplement 12.5 USD
adults: 20 capsules
kids: 20 sachets
DeHP Launch Event in HCMC (Saigon) in April 2019

•
iKang, an Alibaba company, is leveraging its health
centers to promote Pylopass™

• Formulation
300 mg Pylopass™ in two sachets with
fiber
• Promotion on social media:
prevents infection risk in social
gatherings
• Sales in the health centers where
H. pylori is diagnosed but also online
• Dietary supplement
30 sachets sold at 32 euro
As a unique and
innovative
product
Distributed in iKang health centers and pharmacies
Medical seminar in iKang Evergreen Medical Center
in June 2019
 The German pharma company STADA is very
successful in the CIS countries with Helinorm

• Formulation
200 mg Pylopass™ in one hard capsule
• 360° marketing
- KOL endorsement
- medical visits
- pharmacists training
- TV ads but also digital
• Key messages: gastric wellbeing, first line of treatment for
kids and in combination with antibiotics for adults
• Dietary supplement
As a unique and
innovative 15 euro/box sold in pharmacies and online
product
Marketing focus is shifting to digital communication
Grow Awareness and Consumption
«Keep your lifestyle and no change in your food consumption habits»

• Communication via Internet,

with less legal restrictions
• Focus on 10 major cities, where
is a high probability of buying
• Bloggers are KOL’s for target
audience (TA)
• Education of consumers via
search engine optimization (SEO)
In the USA, Life Extension and Stop Aging Now, a Clorox
company, focus on gastric wellbeing

• Formulation
Gastric
Wellbeing 2 capsules per day, Pylopass™ and botanical
extracts, antacids (AcidRelief)
• Claims
supports healthy stomach environment
help relieve occasional heartburn and
acid indigestion
• Dietary supplement
Gastro-Ease: 29.70 USD
AcidRelief: 29.90 USD
 In Germany and in the UK, Pylopass™ is mainly promoted by
health practitioners

• Formulation
200 mg Pylopass™ in two capsules
based on customer feedback, packaging
size was increased to 2-3 months
• Promotion
through medical visits and seminars
mainly online sales
• Dietary supplement marketed by health
practitioners
34.50 GBP for 120 capsules
As a unique and 85 euro for 180 capsules
innovative
product
 Siujiti (China)
Lb compound solid beverage

• Pylopass™ content
200 mg in one tablet
• Other ingredients
two probiotics strains
• Claims
none
• Field of Application
Dietary supplement

As a unique and
innovative
product
Product Seminar in Guangzhou (China)
 DKH (Vietnam)
HProtect

• Pylopass™ content
Gastric
Wellbeing 200 mg in two sachets
• Other ingredient
curcumin, aloe vera, B12
• Claims
protects against HP
• Field of Application
dietary supplement
 Hasan Pharma (Vietnam)
Pylo Mibe

• Pylopass™ content
200 mg in two tablets
• Other ingredient
none
• Claims
co-aggregates with H. pylori
• Field of Application
dietary supplement

As a unique and
innovative
product
 Aquilea (Italy)
Reflux

• Pylopass™ content
Gastric
Wellbeing 200 mg in two sachets
• Other ingredients
olive and cactus extracts
calcium alginate
potassium citrate
vitamin D3
• Claims
emollient and soothing
action
• Field of Application
dietary supplement
 Neim (Germany)
Pylocura

• Pylopass™ content
200 mg per capsule
• Other ingredients
none
• Claims
co-aggregates with
H. pylori and
• Field of Application
medical food
As a unique and
innovative
product
 Stada (Russia)
Helinorm

• Pylopass™ content
200 mg in one hard capsule
no other ingredient
14 capsules per box
• Position claim
Promoted through medical
channel at 10.40 euro/box
• Field of Application
Dietary supplement
1 capsule a day during a meal
As a unique and
innovative
product
 PharmaS (Croatia)
HelicoBalans

• Pylopass™ content
200mg in two hard capsules
• Other ingredients
Lactobacillus acidophilus
Bifidobacterium lactis
Balancing a
Lactobacillus casei
healthy
microbiota • Claims
Supports conventional
eradication therapy
• Field of Application
Dietary supplement
 DOGenesis (Germany)
Helicopter

• Pylopass™ content
200mg in two capsules
60 capsules per box
• Position claim
for the dietary management of
H. pylori infection
• Promoted through online video
and shops
• Field of Application
FSMP
As a unique and
innovative 30 euro/box
product
 Nutricare (Vietnam)
Gastro

• Pylopass™ content
200 mg in 50 g powder to be
added in 180 ml water
• Other ingredients
milk powder, fibers, nucleotides,
curcumin, 27 vitamins and minerals
• Claims
for stomach protection to be taken
before or after drinking alcohol
• Field of Application
As a unique and
innovative Food
product
 Laboratoires Copmed/Ineldea (France)
Probiotiques HPY

• Pylopass™ content
Gastric
Wellbeing 200 mg in two capsules
• Other ingredient
acacia fibre
• Claims
unique synergetic effect
• Field of Application
dietary supplement
30 capsules sold at 22 euro
 Laboratorios Novatech (Spain)
pylofim

• Pylopass™ content
Gastric
Wellbeing 200 mg per capsule
• Other ingredient
none
• Claims
helps to eliminate H. pylori
• Field of Application
dietary supplement
24,95 euro/30 capsules
 Kendy (Bulgaria)
Lactoflor Helico Protect

• Pylopass™ content
Gastric
Wellbeing 200 mg in one hard capsule
• Other active ingredient
zinc L-carnosine
• Claims
Controls H. pylori level in the
stomach
• Field of Application
Dietary supplement
 Matrix Pharma (Pakistan)
ENTPRO

• Pylopass™ content
200 mg in 2 capsules
• Other active ingredient
none
• Claims
H. pylori eradication,
gastritis and peptic ulcer
management
• Field of Application
Dietary supplement
As a unique and
innovative
product
 Pro Nutrition (Peru)
Gastrolife flora

• Pylopass™ content
200 mg per 10 g serving
• Other ingredients
maltodextrine, citric acid, lemon flavour,
lemon juice powder and sucralose.
• Claims
help to eliminate Helicobacter pylori
and gastric problems
• Field of Application
food: 10 g to be dissolved in 240 ml water
As a unique and
innovative 30 servings per plastic can
product
Launch to Inkafarma’s pharmacists
 Pharma Vision (Mongolia)
Pylopass™

• Pylopass™ content
Gastric
Wellbeing 200 mg in one capsule
• Other active ingredients
none
• Claims
Clinically proven to support the
reduction of H. pylori
• Field of Application
Dietary supplement
 Fleurance nature (France)
Probioboost

• Pylopass™ content
Gastric
Wellbeing 200 mg in one tablet
• Other active ingredient
dandelion root extract
• Claims
binds H. pylori without upsetting the
intestinal flora
dandelion root helps to preserve the pH
balance and promotes gastric comfort
• Field of Application
Dietary supplement
 Bioksan (Spain)
IROMAX

• Pylopass™ content
Gastric
Wellbeing 200 mg in 4 capsules
• Other ingredients
botanical extracts and
lactic acid bacteria strains
• Claims
none
• Field of Application
dietary supplement
 Dr. Kokia (Korea)
Pylo Probiotics

• Pylopass™ content
Gastric
Wellbeing 200 mg in one sachet
• Other active ingredient
probiotics and herbal extract
• Claims
related to other ingredients
• Field of Application
Health food sold in duty free outlets
and in hospitals
 Life Extension (USA)
Gastro-Ease

• Pylopass™ content
Gastric
Wellbeing 200 mg in two capsules
• Other active ingredient
zinc L-carnosine
• Claims
Supports a healthy,
comfortable stomach
environment
• Field of Application
Dietary supplement
44 USD for 60 capsules
 Nouveau Health (UK)
HeliPass™

• Pylopass™ content
200 mg in two capsules
• Other active ingredient
none
• Claims
shows coaggregation with H. pylori
• Field of Application
Dietary supplement marketed by health
practitioners
34.50 GBP for 120 capsules
As a unique and
innovative
product
 hathorvit (Spain)
HathorPro

• Pylopass™ content
Gastric
Wellbeing 200 mg per capsule
• Other active ingredients
aloe vera and probiotics
• Claims
Balancing a none
healthy
microbiota
• Field of Application
Dietary supplement sold
by practitionists
 IAM Health (Singapore)
Vicopyl™

• Pylopass™ content
200 mg per capsule
• Other active ingredient
inuline
• Claims
promote and restore
gastrointestinal health
• Field of Application
Dietary supplement
As a unique and
innovative
product
 Caring (Malaysia)
PYLORESS

• Pylopass™ content
Gastric
Wellbeing 200 mg in two sachets
• Other active ingredient
GOS
• Claims
Balancing a Partnering to win the battle
healthy
microbiota from within
Stop the problems, start living
• Field of Application
Dietary supplement sold exclusively in 3rd biggest
pharmacy chain
 Elmor (Mexico)
Helistop

• Pylopass™ content
200mg per hard capsule
fibres
30 capsules per box
• Position claim
Promoted through
medical channel
• Field of Application
Dietary supplement
As a unique and
innovative
product
 Parinat (France)
LAB Digest

• Pylopass™ content
Gastric
Wellbeing 200 mg in three capsules
• Other active ingredients
zinc and vitamin B12
• Claims
none
• Field of Application
Dietary supplement
Box with 90 capsules 32 €
 Laves Arzneimittel (Germany)
Pylosan

• Pylopass™ content
Gastric
Wellbeing 200 mg in two soft gels
• Other active ingredients
zinc and vitamin B12
• Claims
none
• Field of Application
Dietary supplement
Box with 30 and 60 soft gels
20 € and 38 €
 LV Pharm (Serbia)
Gastrolact

• Pylopass™ content
Gastric
Wellbeing 200 mg per sachet
• Other active ingredients
inulin, bromelain, licorice and
nettle extracts, vitamins
• Position claim
“can help to eradicate
Helicobacter pylori”
• Field of Application
dietary supplement
41 euro for 14 sachets
 Sakai (Spain)
Pylodigest

• Pylopass™ content
Gastric
Wellbeing
200mg in 2 chewable tablets
• Other active ingredients
Calcium carbonate
• Position claim
Gastric control
“ Calcium contributes to the normal function of digestive
enzymes “ (EFSA approved claim)”
• Field of Application
Dietary Supplement
 Santiveri (Spain)
beneflor™ Antacid

• Pylopass™ content
Gastric
Wellbeing 200 mg in one sachet
• Other ingredients
aloe vera
ginger
calcium, magnesium
and zinc
• Claims
Gastric well-being
Aloe vera and ginger
contribute to a normal gastro-intestinal function
• Field of Application
Dietary supplement
 Parinat (France)
LAB Digest

• Pylopass™ content
Gastric
Wellbeing 200 mg in three capsules
• Other active ingredients
zinc and vitamin B12
• Claims
none
• Field of Application
Dietary supplement
Box with 90 capsules 32 €
 Vitalys Alpes (France)
Stomacolon

• Pylopass™ content
Gastric
Wellbeing 200 mg in two capsules
• Other active ingredients
biotin and seaweed (ascophyllum
nodosum)
• Claims
Ascophyllum promotes gastro-
intestinal wellbeing and digestive
comfort
Biotin contributes to the maintenance of a healthy mucosa
• Field of Application
Dietary supplement
 Integrated Pharma (Philippines)
KlinGut

• Pylopass™ content
Gastric
Wellbeing 200 mg per capsule
• Other active ingredient
none
• Claims
natural stomach relief
• Field of Application
Dietary supplement

As a unique and
innovative
product
 Astel Medica (Belgium)
Helipyl

• Pylopass™ content
Gastric
Wellbeing 200 mg in one capsule
• Other active ingredients
zinc, licorice extract
• Claims
Contributes to a normal acid-base
metabolism, helps to maintain the
normal function of the gastric
mucosa, maintains digestive
balance and comfort
• Field of Application
Dietary supplement promoted through medical channel
 Best Natural Effect (UK)
Pylopass Strong

• Pylopass™ content
200 mg per capsule
• Position claim
Pylopass reduces the H. pylori
bacterial load
• Other ingredients
none
• Field of Application
dietary supplement
60 capsules per box
As a unique and
innovative 27 GBP on amazon.co.uk
product
 Dietmed (Portugal)
Ulcylori

• Pylopass™ content
Gastric
Wellbeing
200mg in 2 capsules
• Other active ingredients
Broccoli extract, vitamins and
1.5 mg zinc
• Position claim
Zinc contributes to normal acid-
base metabolism
(EFSA approved claim)
• Field of Application
Dietary supplement
 Fitnessfood (Germany)
Cleanse Pure Natural Extra

• Pylopass™ content
Gastric
Wellbeing 200mg in two hard
capsules
• Other ingredient
licorice and acai extract
senna leaves and flaxseed powder
• Position claim
natural bowel cleansing
• Field of Application
dietary supplement
 NU Green (Malaysia)
Hylori

• Pylopass™ content
200mg in two sachets
• Other ingredients
inulin
• Claim
Balancing a A new and safe approach in
healthy
microbiota H. pylori control
• Field of Application
Dietary supplement
30 sachets
125 RM (26.60 euro)
 Laboratoarele Remedia (Romania)
GastroRem

• Pylopass™ content
Gastric
Wellbeing
225 mg in three chewable
tablets
• Other active ingredients
Calcium carbonate,
magnesium, licorice extract
• Position claim
Neutralize gastric acidity
• Field of Application
Dietary supplement
 Kenay (Poland)
CarnoZinc

• Pylopass™ content
Gastric
Wellbeing 200mg in two capsules
• Other ingredients
zinc L-carnosine
• Claims
none
• Field of Application
Dietary supplement
60 capsules box
 Pharmatheka (Croatia)
HELPyred

• Pylopass™ content
Gastric
Wellbeing 200mg in two soft gels
• Other ingredients
Sunflower oil, calcium,
zinc and tocopherol
• Claims
Calcium contributes to the normal function of digestive
enzymes.
Zinc contributes to normal acid-base metabolsim.
Vitamin E contributes to the protection of cells from
oxidative stress.
• Field of Application
Dietary supplement
 SinoPlaSan (UK)
Pylopass Mono

• Pylopass™ content
200 mg in two capsules
• Position claim
for the dietary treatment of
Helicobacter pylori infections
• Other ingredient
none
• Field of Application
dietary supplement
As a unique and
innovative
product
 SinoPlaSan (Germany)
Pylopass Forte

• Pylopass™ content
Gastric
Wellbeing 200 mg in two capsules
• Position claim
B12 contributes to the reduction
of tiredness and fatigue
(EFSA claims)
• Other ingredients
olive leave extract
vitamin B12
• Field of Application
dietary supplement
45 euro/box with 60 capsules
 Fair Trade (Switzerland)
Combi Flora AntiPylori

• Pylopass™ content
200 mg per capsule
• Position claim
for dietetic treatment of
Helicobacter pylori infection
• Other ingredient
none
• Field of Application
FSMP
34.90 euro/60 capsules
As a unique and
innovative
product
 Nutribase (China)
Probiotics and Pylopass™

• Pylopass™ content
Gastric
Wellbeing 200 mg per tablet
• Other active ingredient
Bifidobacterium animalis subsp. Lactis BB12
• No claim
• Field of Application
food license
sold over WeChat
 By Health (China)
Hericium Erinaceus & Lactobacillus Reuteri

• Pylopass™ content
Gastric
Wellbeing 200 mg per sachet
• Other active ingredient
hericium erinaceus, soluble fiber
• Inherent claims
good for stomach:
hericium erinaceus is well known
for «improving digestion and nourishing
the stomach»
• Field of Application
Dietary supplement sold online at 30 RMB/day
 Biopharma (UAE)
Pylobay

• Pylopass™ content
200 mg in two soft gels
• Other active ingredient
none
• Claims
none
• Field of Application
Dietary supplement

As a unique and
innovative
product
 Biogena (Austria)
PyloPlex 200

• Pylopass™ content
200mg per capsule
• Position claim
none
• Field of Application
Dietary supplement

As a unique and
innovative
product
 SPM (Vietnam)
Pylodi

• Pylopass™ content
Gastric
Wellbeing
200mg in two tablets
• Other active ingredients
Magnesium and calcium
carbonates
• Position claim
Controls H. pylori levels
• Field of Application
Dietary supplement
Marketing activities
 Fiterman Pharma (Romania)
Pilorix

• Pylopass™ content
Gastric
Wellbeing
200 mg in 2 hard capsules
• Other active ingredients
Calcium carbonate and
licorice extract
• Position claim
“supports digestive health by ensuring normal gastric
acidity, gastric mucosal protection and reducing
colonization of Helicobacter pylori in stomach”
 Smart Nutrition (Luxembourg)
H. Pylori Fight

• Pylopass™ content
200mg in 2 hard capsules
• Position claim
The natural treatment for H. pylori
• Field of Application
Dietary supplement
60 capsules per bottle

As a unique and
innovative
product
 Althea Farmacia (Italy)
Gastri Bioma

• Pylopass™ content
Gastric
Wellbeing 200mg in two hard
capsules
• Other ingredient
licorice extract
• No claim
• Field of Application
dietary supplement
sold in Italy, Spain and Germany
18,80 euro for 30 capsules
 SinoPlaSan (Germany)
Pylopass Mono

• Pylopass™ content
200 mg in two capsules
• Position claim
for dietetic treatment of
Helicobacter pylori infection
• Other ingredient
none
• Field of Application
FSMP
32 euro/box with 60 capsules
As a unique and
innovative
product
 Laborest (Italy)
Grisu BST

• Pylopass™ content
Gastric
Wellbeing
200mg in two sachets
• Other active ingredients
Potassium citrate, magnesium
hydroxide, calcium alginate,
cactus and olive leave extracts
• Position claim
Relieving the gastro-intestinal
system
• Field of Application
Dietary supplement: 14.90 euro for 14 sachets
 Med Vial (Lebanon)
Pylo+C

• Pylopass™ content
200 mg in two soft gels
• Other active ingredients
none
• Position claim
none
• Field of Application
dietary supplement
As a unique and
innovative
product
 Laboratorios Lebudit (ES)
Gastro H

• Pylopass™ content
200 mg in one hard
capsule
• Other active ingredients
none
• Position claim
helps to recover gastric health
• Field of Application
As a unique and
innovative dietary supplement
product
promoted through medical visits
 DietiNat (ES)
Pyloprotect

• Pylopass™ content
Gastric
Wellbeing
200 mg in two hard
capsules
• Other active ingredients
Calcium and magnesium
carbonates
• Position claim
helps to recover gastric health
• Field of Application
dietary supplement
 Happy Gut (New Zealand)
Pylopass

• Pylopass™ content
200 mg in each hard
capsule
• Other active ingredients

Balancing a
none
healthy
microbiota • Position claim
http://ulcersnomore.com
• Field of Application
As a unique and
innovative Dietary supplement
product
 Homeotreat Lab (Israel)
Helico Bacstop

• Pylopass™ content
Gastric
Wellbeing 200 mg in one hard capsule
• Other active ingredients
10 probiotics strains
• Position claim
Protective probiotic
• Field of Application
Dietary supplement
68 euro/kg
 Artesania Agricola (Spain)
Pylogastris

• Pylopass™ content
Gastric
Wellbeing
200 mg in two hard
capsules
• Other active ingredients
Calcium and magnesium
carbonate
• Position claim
Gastric well-being
• Field of Application
Dietary supplement
 Synomed (Germany)
Enterobact pylori

• Pylopass™ content
Gastric
Wellbeing 200mg in one tablet
• Other ingredients
biotin
• Claim
Biotin contributes to the
maintenance of normal
mucous membranes
(EFSA claim)
• Field of Application
Dietary supplement
 Biocol (Portugal)
GASTROPyll

• Pylopass™ content
Gastric
Wellbeing
200mg in two hard
capsules
• Other active ingredients
Magnesium and calcium
carbonates
Licorice and curcuma
extracts
• Field of Application
Dietary supplement
Marketed in Kuwait
 Stop Aging Now (USA)
AcidRelief360 Ultra

• Pylopass™ content
Gastric
Wellbeing 200 mg in four capsules
• Other active ingredient
licorice extract, aloe vera, elm bark,
lemon balm and chamomile
• Claims
Advanced relief for occasional heartburn
• Field of Application
Dietary supplement
22.95 USD for 60 capsules
 Algawza Medical (Sudan)
Pilorix

• Pylopass™ content
Gastric
Wellbeing
200 mg in 2 hard capsules
• Other active ingredients
Calcium carbonate and
licorice extract
• Position claim
“favors the elimination of
Helicobacter pylori”
• Field of Application
Dietary Supplement
 TEVA (Mexico)
Pylobiotic

• Pylopass™ content
200mg per hard capsule
fibres
30 capsules per box
• Position claim
Promoted through
medical channel
• Field of Application
Dietary supplement
1 capsule a day
As a unique and
innovative 28.35 USD/box
product
 VByoticS (Spain)
Pylopass Capsule

• Pylopass™ content
Gastric
Wellbeing
200mg in two hard capsules
• Other active ingredients
Magnesium and calcium
carbonates
• Position claim
Controls H. pylori levels
• Field of Application
Dietary supplement
A Global Success Story

H. Pylori prevalence

<40%
40-59%
60-74%
>75%
Pylopass™ at a Glance

• Microbiome-based, unique and specific mode of action to

prevent gastritis and gastric ulcer

• Helicobacter pylori control clinically tested in human

studies

• Increasing number of reasons supporting H. pylori control

rather than eradication for asymptomatic people

• No adverse effects