Drug Classification: Antacid & Antihistamine Student: Jill Hunt & Jen McMahon

Name of Drugs: Famotidine (Acid Control, Pepcid, Pepcid AC, Peptic Guard, & Ulcidine)

Indications: Short-term treatment of active Side Effects:

duodenal ulcers and benign gastric ulcers.
CNS: confusion, dizziness, drowsiness, hallucinations, headache.
Maintenance therapy for duodenal and gastric
ulcers after healing of active ulcers. CV: ARRHYTHMIAS.
Management of GERD. Treatment of heartburn,
acid indigestion, and sour stomach (OTC use). GI: constipation, diarrhea, drug-induced hepatitis (nizatidine,
cimetidine), nausea
Actions: Inhibits the action of histamine at the GU: ↓ sperm count, erectile dysfunction (cimetidine).
H2-receptor site located primarily in gastric
parietal cells, resulting in inhibition of gastric Endo: gynecomastia.
acid secretion. Hemat: AGRANULOCYTOSIS, APLASTIC ANEMIA, anemia, neutropenia,
thrombocytopenia.
Therapeutic Effects:
Local: pain at IM site.
Healing and prevention of ulcers. Misc: hypersensivity reactions, vasculitis.
Decreased symptoms of gastroesophageal
Dosages and Routes of administration: PO (Adults): Short-term
reflux.
treatment of active duodenal ulcers—40 mg/day at bedtime or
Decreased secretion of gastric acid. 20 mg twice daily for up to 8 wk. Treatment of benign gastric
ulcers—40 mg/day at bedtime. Maintenance treatment of
duodenal ulcers—20 mg once daily at bedtime. GERD—20 mg
twice daily for up to 6 wk; up to 40 mg twice daily for up to 12
wk for esophagitis with erosions, ulcerations, and continuing
symptoms. Gastric hypersecretory conditions—20 mg q 6 hr
initially, up to 160 mg q 6 hr. OTC use—10 mg for relief of
symptoms; for prevention—10 mg 60 min before eating or take
10 mg as chewable tablet 15 minutes before heartburn-inducing
foods or beverages (not to exceed 20 mg/24 hr for up to 2 wk).
PO, IV (Children 1–16 yr): Peptic ulcer—0.5 mg/kg/day as a
single bedtime dose or in 2 divided doses (up to 40 mg
daily); GERD—1 mg/kg/day in 2 divided doses(up to 80 mg
twice daily).
PO (Infonts >3 mo–1 yr): GERD—0.5 mg/kg/dose twice daily.
Nursing Care\Patient Safety:
PO (Infants
CAPITALS and
indicate life neonates
threatening effects<3 mo): GERD—0.5
Underlines mg/kg/dose
indicate most frequent
• Instruct patient to take medication as directed for the full course of therapy, even if feeling better. Take missed
once daily.
doses as soon as remembered but not if almost time for next dose. Do not double doses.
IV (Adults): 20 mg q 12 hr.
• Advise patients taking OTC preparations not to take the maximum dose continuously for more than 2 wk
without consulting health care professional. Notify health care professional if difficulty swallowing occurs or
abdominal pain persists.
• Inform patient that smoking interferes with the action of histamine antagonists. Encourage patient to quit
smoking or at least not to smoke after last dose of the day.
• May cause drowsiness or dizziness. Caution patient to avoid driving or other activities requiring alertness until
response to the drug is known.
• Advise patient to avoid alcohol, products containing aspirin or NSAIDs, and foods that may cause an increase
in GI irritation.
• Inform patient that increased fluid and fiber intake and exercise may minimize constipation.
• Advise patient to report onset of black, tarry stools; fever; sore throat; diarrhea; dizziness; rash; confusion; or
hallucinations to health care professional promptly.
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