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    The document outlines the processes of fat metabolism, including lipolysis, beta-oxidation of fatty acids, and lipogenesis. It discusses how lipolysis breaks down triglycerides into glycerol and fatty acids via hormone-sensitive lipases. Beta-oxidation is then explained as the breakdown of fatty acids into acetyl-CoA in the mitochondria through a multi-step process. Lipogenesis is also covered briefly as the synthesis of fatty acids and triglycerides. The key objectives are to outline these pathways and their functions in fat metabolism.

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    The document outlines the processes of fat metabolism, including lipolysis, beta-oxidation of fatty acids, and lipogenesis. It discusses how lipolysis breaks down triglycerides into glycerol and fatty acids via hormone-sensitive lipases. Beta-oxidation is then explained as the breakdown of fatty acids into acetyl-CoA in the mitochondria through a multi-step process. Lipogenesis is also covered briefly as the synthesis of fatty acids and triglycerides. The key objectives are to outline these pathways and their functions in fat metabolism.

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    © All Rights Reserved
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    2 views18 pages

    11 - Lipid Metabolism Tbl2 Minilecture

    Uploaded by

    amal amal
    The document outlines the processes of fat metabolism, including lipolysis, beta-oxidation of fatty acids, and lipogenesis. It discusses how lipolysis breaks down triglycerides into glycerol and fatty acids via hormone-sensitive lipases. Beta-oxidation is then explained as the breakdown of fatty acids into acetyl-CoA in the mitochondria through a multi-step process. Lipogenesis is also covered briefly as the synthesis of fatty acids and triglycerides. The key objectives are to outline these pathways and their functions in fat metabolism.

    Copyright:

    © All Rights Reserved
    Download as PDF, TXT or read online from Scribd
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    of 18

    Fat Metabolism

    Dr. Rabia Farooq


    Assistant professor
    College of Medicine
    University of Bisha
    .
    1 Date: 7 Dec 2020
    OUR OBJECTIVE

    BY THE SUCCESSFUL COMPLETION OF THIS


    PRESENTATION, YOU ARE EXPECTED TO:
    SPECIFIC LEARNING

    1. OUTLINE LIPOLYSIS AND ITS


    OUTCOMES

    FUNCTIONS
    2. EXPLAIN BETA-OXIDATION OF FATTY
    ACIDS
    3. OUTLINE LIPOGENESIS AND ITS
    FUNCTIONS

    2
    ß-OXIDATION

    ▪ Breakdown of fattyacids to Acetyl CoA


    ▪ Occurs in Mitochondria
    ▪ It occurs in many tissues except brain

    ▪ 3 stages
    1. Activation of fatty acids in the cytosol

    2. Transport of activated fatty acids in


    the mitochondria

    3. ß-oxidation in the mitochondrial matrix

    3
    . Activation of fatty acids in the cytosol

    4
    5
    STEPS OF ß-OXIDATION
    1. DEHYDROGENATION/OXIDATION FADH2
    2. HYDRATION H 2O
    3. DEHYDROGENATION/OXIDATION NADH2
    4. THIOLYTIC CLEVAGE ACETYL CO-A

    7
    REVISED ENERGETICS
    • 7 NADH2 = 7 X 2.5
    • 7 FADH2 = 7 X 1.5
    • ACETYL CO-A 3 NADH2 + 1 FADH2 + 1 GTP
    • TOTAL ATP PRODUCED = 108
    • NET ATP PRODUCED = 108 – 2 = 106

    10
    LIPOGENESIS

    11
    LIPOGENESIS

    12
    LIPOLYSIS
    TAG’s are transported via blood to
    adipose, muscles by VLDL.TG’s
    undergo lipolysis by Hormone sensitive
    14 lipases (HSL’s) which yields glycerol
    and fatty acids.
    15

    LIPOLYSIS
    16
    REFERENCES
    Richard A. Harvey, Lippincott’s Illustrated Reviews Biochemistry, 5th
    Edition “Chapter 16” Lipid Metabolism,

    17

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