Safety data sheet

Page: 1/11
BASF Safety data sheet
Date / Revised: 18.03.2021 Version: 5.0
Product: Retinol 50 C
(30054549/SDS_COS_PH/EN)
Date of print 19.03.2021

1. Substance/preparation and manufacturer/supplier identification

Retinol 50 C
Use: cosmetic ingredient

Manufacturer/supplier:
BASF Philippines, Inc.
Upper Penthouse CTP ASEAN Tower
Asean Drive, Spectrum District
Filinvest Corporate City, Alabang,
Muntinlupa City, 1781, Metro Manila
PHILIPPINES
Telephone: +63 2 811-8000
E-mail address: psr.ph@basf.com

Emergency information:
National emergency number:
+63 2 8831 5576
International emergency number:
Telephone: +49 180 2273-112

2. Hazard identification

Classification of the substance and mixture:

Skin corrosion/irritation: Cat. 2
Skin sensitization: Cat. 1
Reproductive toxicity: Cat. 1B (unborn child)
Hazardous to the aquatic environment - acute: Cat. 1
Hazardous to the aquatic environment - chronic: Cat. 1

M-factor acute: 10
M-factor chronic: 10
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BASF Safety data sheet
Date / Revised: 18.03.2021 Version: 5.0
Product: Retinol 50 C

(30054549/SDS_COS_PH/EN)
Date of print 19.03.2021

Label elements and precautionary statement:

Pictogram:

Signal Word:
Danger

Hazard Statement:
H315 Causes skin irritation.
H317 May cause an allergic skin reaction.
H360 May damage the unborn child.
H400 Very toxic to aquatic life.
H410 Very toxic to aquatic life with long lasting effects.

Precautionary Statements (Prevention):

P280 Wear protective gloves, protective clothing and eye protection or face
protection.
P273 Avoid release to the environment.
P261 Avoid breathing mist or vapour or spray.
P201 Obtain special instructions before use.
P202 Do not handle until all safety precautions have been read and
understood.
P272 Contaminated work clothing should not be allowed out of the workplace.
P264 Wash contaminated body parts thoroughly after handling.

Precautionary Statements (Response):

P302 + P352 IF ON SKIN: Wash with plenty of soap and water.
P333 + P313 If skin irritation or rash occurs: Get medical attention.
P308 + P313 IF exposed or concerned: Get medical attention.
P391 Collect spillage.
P332 + P313 If skin irritation occurs: Get medical attention.
P362 + P364 Take off contaminated clothing and wash it before reuse.

Precautionary Statements (Storage):

P405 Store locked up.

Precautionary Statements (Disposal):

P501 Dispose of contents and container to hazardous or special waste
collection point.

Other hazards which do not result in classification:

No specific dangers known, if the regulations/notes for storage and handling are considered.

3. Composition/information on ingredients
Chemical nature

INCI Name: Retinol (and) Polysorbate 20

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BASF Safety data sheet
Date / Revised: 18.03.2021 Version: 5.0
Product: Retinol 50 C

(30054549/SDS_COS_PH/EN)
Date of print 19.03.2021
Preparation based on: retinol, Sorbitan, monododecanoate, poly(oxy-1,2-ethanediyl) derivs.

stabilized with: 2,6-di-tert-butyl-p-cresol, tert-butyl-4-methoxyphenol

Hazardous ingredients

retinol
Content (W/W): >= 30 % - <= 50 % Acute Tox.: Cat. 5 (oral)
CAS Number: 68-26-8 Skin Corr./Irrit.: Cat. 3
Eye Dam./Irrit.: Cat. 2B
Skin Sens.: Cat. 1
Repr.: Cat. 1B (unborn child)
Aquatic Chronic: Cat. 4

2,6-di-tert-butyl-p-cresol
Content (W/W): >= 1 % - <= 5 % Aquatic Acute: Cat. 1
CAS Number: 128-37-0 Aquatic Chronic: Cat. 1
M-factor chronic: 1

4. First-Aid Measures

General advice:
First aid personnel should pay attention to their own safety. Remove contaminated clothing.

If adverse health effects develop seek medical attention.

If inhaled:
After inhalation of vapor: fresh air.

On skin contact:
Wash thoroughly with soap and water

On contact with eyes:

Wash affected eyes for at least 15 minutes under running water with eyelids held open. Seek
medical attention.

On ingestion:
Rinse mouth and then drink 200-300 ml of water.

Note to physician:
Symptoms: Information, i.e. additional information on symptoms and effects may be included in the
GHS labeling phrases available in Section 2 and in the Toxicological assessments available in
Section 11., (Further) symptoms and / or effects are not known so far
Hazards: Allergic skin reaction, bronchospasms and anaphylactic shock possible.
Treatment: Symptomatic treatment (decontamination, vital functions).

5. Fire-Fighting Measures
Suitable extinguishing media:
water spray, carbon dioxide, dry powder, foam
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BASF Safety data sheet
Date / Revised: 18.03.2021 Version: 5.0
Product: Retinol 50 C

(30054549/SDS_COS_PH/EN)
Date of print 19.03.2021
Specific hazards:
harmful vapours
Evolution of fumes/fog. The substances/groups of substances mentioned can be released in case of
fire.

Special protective equipment:

Wear self-contained breathing apparatus and chemical-protective clothing.

Further information:
Dispose of fire debris and contaminated extinguishing water in accordance with official regulations.

6. Accidental Release Measures

Personal precautions:
Do not breathe vapour/spray.

Use personal protective clothing.

Environmental precautions:
Do not discharge into drains/surface waters/groundwater.

Methods for cleaning up or taking up:

For small amounts: Pick up with suitable absorbent material (e.g. sand, sawdust, general-purpose
binder, kieselguhr).
For large amounts: Dike spillage. Vacuum up spilled product.
For residues: Contain with absorbent material (e.g. sand, silica gel, acid binder, general purpose
binder, sawdust).
Dispose of absorbed material in accordance with regulations.

7. Handling and Storage

Handling
Processing machines must be fitted with local exhaust ventilation. Avoid contact with the skin, eyes
and clothing.

Protection against fire and explosion:

Take precautionary measures against static discharges. Avoid all sources of ignition: heat, sparks,
open flame.

Temperature class: T3 (Autoignition temperature >200 °C).

Storage

Suitable materials for containers: High density polyethylene (HDPE), Low density polyethylene
(LDPE), Aluminium
Further information on storage conditions: Keep container tightly closed and dry; store in a cool
place. Keep under inert gas. Protect contents from the effects of light. Keep at temperature not
exceeding 20 °C.

Storage stability:
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BASF Safety data sheet
Date / Revised: 18.03.2021 Version: 5.0
Product: Retinol 50 C

(30054549/SDS_COS_PH/EN)
Date of print 19.03.2021
Storage temperature: 2 - 8 °C

Protect from temperatures below: 0 °C

Characteristics of the product are irreversibly changed below the limit temperature.
Protect from temperatures above: 50 °C
Damage by exceeding the maximum temperature is not reversible. The packed product must be
protected against exceeding the indicated temperature.

8. Exposure controls and personal protection

Components with occupational exposure limits

2,6-di-tert-butyl-p-cresol, 128-37-0;
TWA value 2 mg/m3 (ACGIHTLV), Inhalable fraction and vapor

Personal protective equipment

Respiratory protection:
Respiratory protection in case of vapour/aerosol release. Particle filter with medium efficiency for
solid and liquid particles (e.g. EN 143 or 149, Type P2 or FFP2)

Hand protection:
Suitable chemical resistant safety gloves (EN 374) also with prolonged, direct contact
(Recommended: Protective index 6, corresponding > 480 minutes of permeation time according to
EN 374): E.g. nitrile rubber (0.4 mm), chloroprene rubber (0.5 mm), butyl rubber (0.7 mm) etc.
Supplementary note: The specifications are based on tests, literature data and information of glove
manufacturers or are derived from similar substances by analogy. Due to many conditions (e.g.
temperature) it must be considered, that the practical usage of a chemical-protective glove in
practice may be much shorter than the permeation time determined through testing.

Eye protection:
Safety glasses with side-shields (frame goggles) (e.g. EN 166)

Body protection:
Body protection must be chosen depending on activity and possible exposure, e.g. apron, protecting
boots, chemical-protection suit (according to EN 14605 in case of splashes or EN ISO 13982 in case
of dust).

General safety and hygiene measures:

Under no circumstances should the product come into contact with the skin of pregnant women or be
inhaled by them. Handle in accordance with good industrial hygiene and safety practice. No eating,
drinking, smoking or tobacco use at the place of work. Handle in accordance with good industrial
hygiene and safety practice.

9. Physical and Chemical Properties

Form: highly viscous, liquid

Colour: yellow to amber
Odour: characteristic
Odour threshold: not determined
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BASF Safety data sheet
Date / Revised: 18.03.2021 Version: 5.0
Product: Retinol 50 C

(30054549/SDS_COS_PH/EN)
Date of print 19.03.2021

pH value:
substance/mixture is non-soluble (in
water), not relevant

Freezing point: -35 °C

Boiling point: 134 °C (OECD Guideline 103)

Flash point: 202 °C (ISO 2592)

Evaporation rate:
Value can be approximated from
Henry's Law Constant or vapor
pressure.

Flammability (solid/gas): not highly flammable

Lower explosion limit:
For liquids not relevant for
classification and labelling.
Upper explosion limit:
For liquids not relevant for
classification and labelling.
Ignition temperature: 286 °C (DIN EN 14522)

Thermal decomposition: No decomposition if stored and

handled as prescribed/indicated.
Self ignition: not self-igniting

Explosion hazard: Based on the chemical structure

there is no indication of explosive
properties.
Fire promoting properties: Based on its structural properties
the product is not classified as
oxidizing.

Vapour pressure: 12 hPa

(29 °C)
approx. 44 hPa
(50 °C)

Density: 1.025 g/cm3 (ISO 2811-3)

(20 °C)
Relative vapour density (air):
not determined

Solubility in water: of low solubility

Partitioning coefficient n-octanol/water (log Pow):
not determined

Viscosity, dynamic:
not determined
Viscosity, kinematic:
not determined
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BASF Safety data sheet
Date / Revised: 18.03.2021 Version: 5.0
Product: Retinol 50 C

(30054549/SDS_COS_PH/EN)
Date of print 19.03.2021
Other Information:
If necessary, information on other physical and chemical parameters is indicated in this section.
No further information available.

10. Stability and Reactivity

Conditions to avoid:
Avoid prolonged exposure to extreme heat. Avoid contact with air.

Thermal decomposition: No decomposition if stored and handled as

prescribed/indicated.

Substances to avoid:
oxidizing agents

Hazardous reactions:
No hazardous reactions if stored and handled as prescribed/indicated.

Hazardous decomposition products:

No hazardous decomposition products if stored and handled as prescribed/indicated.

11. Toxicological Information

Acute toxicity

Assessment of acute toxicity:

Virtually nontoxic after a single ingestion.

Experimental/calculated data:
LD50 rat (oral): > 2,000 mg/kg (BASF-Test)
The product has not been tested. The statement has been derived from substances/products of a
similar structure or composition.

Irritation

Assessment of irritating effects:

Not irritating to the eyes. Irritating to skin.

Experimental/calculated data:
Skin corrosion/irritation: (Epiderm Corrosivity Test)

Serious eye damage/irritation rabbit: (OECD Guideline 405)

Respiratory/Skin sensitization

Assessment of sensitization:
May cause sensitization by skin contact.

Experimental/calculated data:
Open epicutaneous test (OET) guinea pig: (OECD Guideline 406)

Germ cell mutagenicity

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BASF Safety data sheet
Date / Revised: 18.03.2021 Version: 5.0
Product: Retinol 50 C

(30054549/SDS_COS_PH/EN)
Date of print 19.03.2021

Assessment of mutagenicity:
The substance was not mutagenic in bacteria. The substance was not mutagenic in mammalian cell
culture.

Experimental/calculated data:
Ames-test
Bacteria: negative (Modified OECD Guideline 471)

Carcinogenicity

Assessment of carcinogenicity:
Results from a number of long-term carcinogenity studies are available. Taking into account all of the
information, there is no indication that the substance itself is carcinogenic. Literature data.

Reproductive toxicity

Assessment of reproduction toxicity:

The chemical structure does not suggest a specific alert for such an effect.

Developmental toxicity

Assessment of teratogenicity:
The substance caused malformations/developmental toxicity in laboratory animals. Literature data.

May cause harm to the unborn child.

Experiences in humans

Experimental/calculated data:

There are indications of coherence between the incorporation of high doses during pregnancy and
deformations at humans (newborn child).

Specific target organ toxicity (single exposure):

Assessment of STOT single:

Based on available Data, the classification criteria are not met.

Repeated dose toxicity and Specific target organ toxicity (repeated exposure)

Assessment of repeated dose toxicity:

Repeated exposure to large quantities may affect certain organs.

Aspiration hazard

No aspiration hazard expected.

12. Ecological Information

Ecotoxicity
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BASF Safety data sheet
Date / Revised: 18.03.2021 Version: 5.0
Product: Retinol 50 C

(30054549/SDS_COS_PH/EN)
Date of print 19.03.2021

Assessment of aquatic toxicity:

The inhibition of the degradation activity of activated sludge is not anticipated when introduced to
biological treatment plants in appropriate low concentrations. Very toxic (acute effect) to aquatic
organisms. May cause long-term adverse effects in the aquatic environment.

Aquatic invertebrates:
EC50 (48 h) 0.018 mg/l, Daphnia magna (OECD Guideline 202, part 1, static)
The statement of the toxic effect relates to the analytically determined concentration.

Microorganisms/Effect on activated sludge:

EC20 (3 h) > 1,000 mg/l, activated sludge, domestic (OECD Guideline 209, aerobic)
The details of the toxic effect relate to the nominal concentration.

Mobility

Assessment transport between environmental compartments:

not applicable

Persistence and degradability

Elimination information:
40 - 50 % BOD of the ThOD (28 d) (OECD 301F; ISO 9408; 92/69/EEC, C.4-D) (aerobic, activated
sludge, domestic)

Bioaccumulation potential

Assessment bioaccumulation potential:

No data available.

13. Disposal Considerations

Must be disposed of or incinerated in accordance with local regulations.

Contaminated packaging:
Uncontaminated packaging can be re-used.
Packs that cannot be cleaned should be disposed of in the same manner as the contents.

14. Transport Information

Domestic transport:
Packing group: III
ID number: UN 3082
Transport hazard class(es): 9, EHSM
Proper shipping name: ENVIRONMENTALLY HAZARDOUS SUBSTANCE, LIQUID,
N.O.S. (contains RETINOL, SORBITAN, MONOLAURATE,
ETHOXYLATED)

Sea transport
IMDG
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BASF Safety data sheet
Date / Revised: 18.03.2021 Version: 5.0
Product: Retinol 50 C

(30054549/SDS_COS_PH/EN)
Date of print 19.03.2021
Packing group: III
ID number: UN 3082
Transport hazard class(es): 9, EHSM
Marine pollutant: YES
Proper shipping name: ENVIRONMENTALLY HAZARDOUS SUBSTANCE, LIQUID,
N.O.S. (contains RETINOL, SORBITAN, MONOLAURATE,
ETHOXYLATED)

Air transport
IATA/ICAO
Packing group: III
ID number: UN 3082
Transport hazard class(es): 9, EHSM
Proper shipping name: ENVIRONMENTALLY HAZARDOUS SUBSTANCE, LIQUID,
N.O.S. (contains RETINOL, SORBITAN, MONOLAURATE,
ETHOXYLATED)

15. Regulatory Information

Hazard determining component(s) for labelling: RETINOL

Other regulations

1. Joint DTI-DENR-DA-DOF-DOH-DILG-DOLE-DOTC Administrative Order No. 01 Series of 2009 on

“The Adoption and Implementation of the Globally Harmonized System of Classification and Labeling
of Chemicals (GHS)”

2. DAO 2015-09 "Rules and Procedures for the Implementation of the Globally Harmonized System
(GHS) of Classification and Labelling of Chemicals in Prepration of Safety Data Sheet (SDS) and
Labelling Requirements of Toxic Chemical Substances”

3. Republic Act No. 6969, “Toxic Substances and Hazardous and Nuclear Wastes Control Act of
1990”

The regulatory information is not intended to be comprehensive. Other regulations may apply to the
material

Registration status:

PICCS, PH released / listed

PICCS, PH released / listed

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BASF Safety data sheet
Date / Revised: 18.03.2021 Version: 5.0
Product: Retinol 50 C

(30054549/SDS_COS_PH/EN)
Date of print 19.03.2021
16. Other Information

Information on intended use: This product is of industrial quality and unless otherwise specified or
agreed intended exclusively for industrial use. This includes the mentioned and recommended
usage. Any other intended applications should be discussed with the manufacturer. In particular this
concerns the application for products that are the object of special standards and regulations.

Vertical lines in the left hand margin indicate an amendment from the previous version.

The data contained in this safety data sheet are based on our current knowledge and experience and
describe the product only with regard to safety requirements. This safety data sheet is neither a
Certificate of Analysis (CoA) nor technical data sheet and shall not be mistaken for a specification
agreement. Identified uses in this safety data sheet do neither represent an agreement on the
corresponding contractual quality of the substance/mixture nor a contractually designated use. It is the
responsibility of the recipient of the product to ensure any proprietary rights and existing laws and
legislation are observed.