TR-8000 Maintenance Manual

Document No.
ME-M-01-02
TR-8000 “YUGA”
Single Patient Dialysis Machine
Maintenance Manual
Adjustment and inspection method
Structure and function of P.C.B.
Description of the individual function and the relevant troubleshooting
Contents
Contents
1. Adjustment and inspection method...........................................................................................................................................................3
1-1. Power supply voltage, Driver current adjustment .........................................................................................3
1-1-1. Power supply voltage adjustment. ....................................................................................................................................... 3
1-1-2. DRV current adjustments for UF pump and syringe pump .................................................................................................. 4
1-2. Adjustment and inspection of temperature....................................................................................................5
1-2-1. Adjustment and inspection of the display temperature sensor ............................................................................................ 5
1-2-2. Adjustment and inspection of the control temperature sensor............................................................................................. 5
1-2-3. Adjustment and inspection of the control correction temperature sensor ............................................................................ 6
1-2-4. Adjustment and inspection of the temperature compensation sensor ................................................................................. 6
1-3. Adjustment and inspection of pressure .........................................................................................................7
1-3-1. Adjustment and inspection of venous pressure ................................................................................................................... 7
1-3-2. Adjustment and inspection of arterial pressure.................................................................................................................... 7
1-3-3. Adjustment and inspection of dialysate pressure................................................................................................................. 8
1-4. Adjust and inspection of blood pump ............................................................................................................9
1-5. Adjustment and inspection of air bubble detector .......................................................................................10
1-6. Adjustment of melody volume .....................................................................................................................11
1-7. Adjustment of negative pressure pump pressure .......................................................................................11
1-8. Flow pump performance/Acceptance time adjusting pressure adjustment ................................................12
1-9. Adjustment and inspection of changeover time ..........................................................................................12
1-10. Adjustment and inspection of UF counter accuracy..................................................................................13
1-11. Adjustment and inspection of concentrate infusion volume ......................................................................14
1-12. Adjustment and inspection of conductivity ................................................................................................15
1-13. Other adjustment .......................................................................................................................................16
1-13-1. Procedure for software rewrite......................................................................................................................................... 16
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Contents
2. Structure and function of P.C.B. ..................................................................................................................................................................18

2-1. TR-8000 “YUGA” P.C.B. structure...............................................................................................................18
2-2. TR-8000 “YUGA” function by the P.C.B. .....................................................................................................19
3. Description of the individual function and the relevant troubleshooting......................................................................25
3-1. Conductivity control/monitor ........................................................................................................................25
3-2. Temperature control/monitor .......................................................................................................................30
3-3. UF control/monitor .......................................................................................................................................33
3-4. Chamber changeover ..................................................................................................................................36
3-5. Blood pump control......................................................................................................................................40
3-6. Syringe pump control...................................................................................................................................43
3-7. Pressure (venous pressure, arterial pressure, dialysate pressure) monitor ...............................................46
3-8. Air bubble detector ......................................................................................................................................49
3-9. Blood leak detector......................................................................................................................................50
3-10. Drip chamber level adjustment..................................................................................................................52
3-11. Patrol lamp.................................................................................................................................................53
3-12. Speaker control .........................................................................................................................................53
3-13. Rinse/Disinfection (rinse port, coupler monitor) ........................................................................................54
3-14. Disinfectant monitor...................................................................................................................................60
3-15. Others (valve, switch, clamp) ....................................................................................................................61
3-16. Option pump control ..................................................................................................................................62
3-17. Substitution detector..................................................................................................................................63
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1. Adjustment and inspection method

1-1. Power supply voltage, Driver current adjustment
1-1-1. Power supply voltage adjustment.
Voltage adjustment of 5[V] and 24[V].
CN8
PD P.C.B.
24[V] power supply
5[V] power supply
24 [V] voltage adjustment

(1) Connect orange (+) and black (-) of the PD P.C.B. CN8 connector to the voltage meter.
※Although there are 2 orange lines and 2 black lines in the CN8 connector, you can connect either side of the wirings to the voltage meter.
(2) Adjust to 24.1 [V] by VR501 volume in 24 [V] power supply.
5 [V] voltage adjustment

(1) Connect brown (+) and black (-) of the PD P.C.B. CN8 connector to the voltage meter.
※Although there are 2 brown lines and 2 black lines in the CN8 connector, you can connect either side of the wirings to the voltage meter.
(2) Adjust to 5.214～5.217 [V] by SS501 volume in 5 [V] power supply.
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1-1-2. DRV current adjustments for UF pump and syringe pump

Current adjustment for UF pump DRV and syringe pump DRV.
UF pump DRV
Syringe pump DRV
UF pump 227
(1) Turn OFF the system power supply and connect the current meter to the UF pump DRV, CN1-1.
(2) Operate UF pump at 1.00 [L/h] and adjust an electric current value to 550 [mA] by VR for electric current adjustment of a driver.
(VR graduated approx. 2.5～3.5)
Syringe pump 138

(1) Turn OFF the system power supply and connect the current meter to the Syringe pump DRV, CN1-1.
(2) Operate syringe pump at 9.9 [mL/h] and adjust an electric current value to 165 [mA] by VR for electric current adjustment of a driver.
(VR middle point degree level.)
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1-2. Adjustment and inspection of temperature

1-2-1. Adjustment and inspection of the display temperature sensor
Adjustment of reference
Enter the system to “Stop” mode, connect a variable resistor to a connector (216) of a temperature sensor for display.
Call “Dialysate temperature” screen by selecting “MENU” → ”Initial setting”→ ”Reference” → Password input → “Confirm” → “Dialysate temperature”.
Adjust a value of the variable resistor to the equivalent of registered temperature and press a registration switch of the register window after pressing indication
temperature AD value switch of the temperature to be registered.
When the registration is completed safely, new AD data is indicated. Registration is carried out by the indicated 5 points. Temperature reference setting screen
Temperature inspection
Connect a variable resistor to a connector (216) of a temperature sensor for display.
On the reference setting; Check that the indicated temperature is in the standard value against the resistance value in
the display temperature on the dialysate temperature screen.
1-2-2. Adjustment and inspection of the control temperature sensor

Enter the system to “Stop” mode, connect a variable resistor to a connector (212) of a control temperature sensor. (Heater OUT)
Call “Dialysate temperature” screen by selecting “MENU” → ”Initial setting”→ ”Reference” → Password input
→ “Confirm” → “Dialysate temperature”.
Adjust a value of the variable resistor to the equivalent of registered temperature resistance value and press a registration
switch of the register window after pressing temperature control AD value switch of the temperature to be registered.
When the registration is completed safely, new AD data is indicated. Registration is carried out by the indicated 5 points.
Connect a variable resistor to a connector (212) of a temperature sensor for control. Temperature registration point
On the reference setting → Check that the indicated temperature is in the criteria value against the Registration temperature Resistance value
resistance value in the control temperature Temperature adjustment/inspection point 25 [℃] 5119 [Ω]
on the dialysate temperature screen. Resistance value Inspection temperature Criteria 35 [℃] 3514 [Ω]
5119 [Ω] 25 [℃] 25.0±0.3 [℃] 37 [℃] 3268 [Ω]
3268 [Ω] 37 [℃] 37.0±0.3 [℃] 40 [℃] 2935 [Ω]
705.3 [Ω] 85 [℃] 85.0±0.3 [℃] 85 [℃] 705.3 [Ω]
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1-2-3. Adjustment and inspection of the control correction temperature sensor

Enter the system to “Stop” mode, connect a variable resistor to a connector (232) of a control correction temperature sensor.
Adjust a value of the variable resistor to the equivalent of registered temperature value and press a registration switch of the register window after pressing control
correction AD value of the temperature to be registered.
When the registration is completed safely, new AD data is displayed. Registration is carried out by the indicated 5 points.
Connect a variable resistor to a connector (232) of a sensor for control correction temperature.
On the reference setting; Check that the indicated temperature is in the criteria value against the resistance value in the temperature compensation control on the
dialysate temperature screen.
1-2-4. Adjustment and inspection of the temperature compensation sensor

Enter the system to “Stop” mode, connect a variable resistor to a connector (233) of a temperature compensation sensor.
Adjust a value of the variable resistor to the equivalent of registered temperature of resistance value and press a registration switch of the register window after
pressing temperature compensation AD value of the temperature to be registered.
When the registration is completed safely, new AD data is displayed. Registration is carried out by the indicated 5 points.
Connect a variable resistor to a connector (233) of a sensor for temperature compensation.
On the reference setting; Check that the indicated temperature is in the criteria value against the resistance value in the compensation temperature on the
dialysate temperature screen.
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1-3. Adjustment and inspection of pressure

1-3-1. Adjustment and inspection of venous pressure
Registration of reference value Pressure reference setting screen
Enter the system to “Stop” mode, connect a tube of pressurizing adjustor to the venous pressure joint on the front panel.
Call “Pressure/Conductivity” screen by selecting “MENU” → ”Initial setting”→ ”Reference” → password input
→ “Confirm” → “Pressure/Conductivity”.
(1) Adjust the pressure of pressurizing adjustor to 0 [mmHg].

(2) Press an AD value switch of venous pressure at 0 [mmHg], and press the register switch on the register window.
(3) Adjust the pressure of pressurizing adjustor to +200 [mmHg].
(4) Press an AD value switch of venous pressure at +200 [mmHg], and press the register switch on the register window.
When the registration is completed safely, new AD data is displayed.
Pressure check
At the venous pressure display on the main display, check the indication value of venous pressure at the point on the table.
1-3-2. Adjustment and inspection of arterial pressure

Registration of reference value
Enter the system to “Stop” mode, connect a tube of pressurizing adjustor to the arterial pressure joint on the front panel.
Call “Pressure/Conductivity” screen by selecting “MENU” → ”Initial setting”→ ”Reference” → Password input
→ “Confirm” → “Pressure/Conductivity”.
Arterial/Venous pressure adjustment inspection
(1) Adjust the pressure of pressurizing adjustor to 0 [mmHg]. point
(2) Press an AD value switch of arterial pressure at 0 [mmHg], and press the register switch on the register window. Standard pressure Criteria
(3) Adjust the pressure of pressurizing adjustor to +200 [mmHg]. -100 [mmHg] -100±3 [mmHg]
(4) Press an AD value switch of arterial pressure at +200 [mmHg], and press the register switch on the register 0 [mmHg] 0±3 [mmHg]
window. +300 [mmHg] +300±3 [mmHg]
Pressure check
At the arterial pressure display on the main display, check the indication value of venous pressure at the point on the table.
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1-3-3. Adjustment and inspection of dialysate pressure

Registration of reference value
MENU” → ”Initial setting”→ ”Data setting” → Password input → Data setting table, Item No.66
Check that the setting value of dialysate pressure head correction is 0 [mmHg].
Enter the system to “Stop” mode, and hold the other side of the tube of dialysate pressure sensor with forceps, and connect a tube pressurizing adjustor.
Call “Pressure/Conductivity” screen by selecting “MENU” → ”Initial setting”→ ”Reference” → Password input → “Confirm” → “Pressure/Conductivity”.
(1) Adjust the pressure of pressurizing adjustor to -200 [mmHg].

(2) Press an AD value switch of dialysate pressure at -200 [mmHg], and press the register switch on the register window.
(3) Adjust the pressure of pressurizing adjustor to +200 [mmHg].
(4) Press an AD value switch of dialysate pressure at +200 [mmHg], and press the register switch on the register window.
Pressure check
At the dialysate pressure display on the main display, check the indication value of dialysate pressure at the point on the table.
Dialysate pressure adjustment inspection point

Standard pressure Criteria
-300 [mmHg] -300±3 [mmHg]
0 [mmHg] 0±3 [mmHg]
+300 [mmHg] +300±3 [mmHg]
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1-4. Adjust and inspection of blood pump

Reference setting
(1) Call “Blood pump/Substitution pump” by selecting “MENU” → ”Initial setting”→ ”Data setting” → “Reference” Blood pump reference setting screen
→ “Blood pump/Substitution pump” → “Blood pump/Substitution pump”, and perform reference setting of blood pump.
(2) Press a start switch after selecting low speed of blood pump reference. → the pump rotates at 50 [mL/min].
Press DA value (low speed) of blood pump, and enter the value that is going to be 50 [mL/min] for the substantial blood
pump rate (low speed rate) on the LCD screen. (The standard input value shall be 45～48 in the normal state.)
(3) Press high speed of blood pump reference, blood pump rotates at 400 [mL/min].
Press DA value (high speed) of blood pump, and enter the value that is going to be 400 [mL/min] for the actual blood
pump rate (high speed rate) on the LCD screen. (The standard input value shall be 385～395 in the normal state.)
Flow rate adjustment

(1) “MENU” → ”Initial setting”→ ”Function setting” → Password input → “Function setting” table, Item No.31.
Select the size of the using tube on the setting table.
(2) Collect fluid about a half level in a tank.
Set the predetermined tube to the blood pump, let the water suck from the tank after removing the air from he tube.
(3) By means of a blood flow rate adjusting knob, set the indication of the blood flow rate at 300 [mL/min].
Measure the actual flow volume for a minute.
standard 300±4 [mL]
Perform the inspection for 100 [mL/min] if it is in a standard range.
※Measured value by the graduated cylinder is out of the standard range, the following formula should be used for calculating a correction value.
Correction value = (300－substantial flow volume)÷300×100 (%)
The calculation result of the upper of the formula is rounded off below a decimal point, and the correction value should be registered
on the screen No.68 of the blood pump flow rate correction the screen.
It should be set by selecting “MENU” → ”Initial setting”→ ”Data setting” → Password input → “Data setting” table
※Perform the inspection and measurement again at 300 [mL/min].
※Measure the actual flow volume for a minute at the flow rate setting of 100 [mL],
and inspect that the value is within 100±5 [mL].
Measurement of flow volume, Criteria, A graduated cylinder for measurement chart

Measurement of flow volume Criteria A graduated cylinder for measurement chart
300 [mL/min] Within±4 [mL] 500 [mL]
100 [mL/min] Within±5 [mL] 250 [mL]
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1-5. Adjustment and inspection of air bubble detector

Method 1 for using oscilloscope
(1) Fill drip chamber with water ensuring there are no air bubbles and place it in the air bubble detector.
Set water filled blood lines (drip chamber) to the air bubble detector.
(2) Connect the probe of oscilloscope to TP2 (+) and TP7 (GND) on the P.C.B. of the air bubble detector (A39AS P.C.B.).
*The Voltmeter cannot be used.
(3) Turn ON the air bubble detector.
(4) Adjust the measured voltage to be maximum value by varying VR1.
(5) Adjust the voltage to be DC9.5±0.5 [V] by varying VR2.
(6) Remove. When the drip chamber is removes from air bubble detector,
confirm the measured voltage (between TP2 and TP7) is lower than 3 [V].
Method 2 when the oscilloscope cannot be used

(1) Fill drip chamber with water ensuring there are no air bubbles and place it in the air bubble detector.
Set water filled blood lines (drip chamber) to the air bubble detector.
(2) Turn ON the air bubble detector.
(3) Adjust VR2 on the P.C.B. of the air bubble detector (A39AS P.C.B.) so that only one green LED on the air bubble detector board is turned on. *do not touch VR1.
(4) Adjust VR2 on the P.C.B. of the air bubble detector (A39AS P.C.B.) so that two green LEDs on the air bubble detector board turned on. *do not touch VR1.
(5) Remove blood line (drip chamber) from air bubble detector and set again blood lines (drip chamber) back again to the air bubble detector.
(6) Repeat steps (3) and (4) again.
(7) Remove. When the drip chamber is removes from the air bubble detector and confirms the red LED on the air bubble detector board turns on.
Step (4) Step (7)
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1-6. Adjustment of melody volume

Adjustment of volume
“MENU” → ”Initial setting”→ ”Melody” → Call the “Melody” setting screen to set the alarm sound by selecting “Use” in melody function.
Let any alarm activate by the some reason. While the buzzer is sounding, adjust buzzer volume by VR1 of the AO P.C.B.
1-7. Adjustment of negative pressure pump pressure

Adjustment of the pressure
(1) “MENU” → ”Initial setting”→ ”Data setting” → Password input → “Data setting” table, Item No.66.
(2) Check that the setting value of dialysate pressure head correction is 0 [mmHg].
(3) Connect an outlet pressure meter to the OUT side of negative pressure pump (220).
※Outlet pressure meter shall be read by the position (height) of the negative pressure pump.
(4) Adjust the changeover time from 60.0～61.0 [seconds].
※Always check the changeover time while adjusting the pressure, adjust from 60.0～61.0 [seconds].
(5) After removing the air from the air bubble separator at “Rinse” mode, enter the system to “Dialyze” mode.
Adjust dialysate pressure 0±3 [mmHg] by rotating UF pump by hands. And adjust outlet pressure at the time to 0.100±0.005 [MPa] by 223 relief valve.
220
nut for fixation
decreased pressure
increased pressure
207
degassing pressure -700mmHg
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1-8. Flow pump performance/Acceptance time adjusting pressure adjustment

Adjustment of the pressure
(1) Connect a pressure meter to a flow pump (207) OUT side and IN side.
※Pressure meter shall be read on the position of the chamber.
(2) Enter the system to “Stand-by OK” mode.
(3) Call “Chamber operation” screen by selecting “MENU” → ”Monitor” → ”Chamber”.
(4) Both A chamber accepting time and B chamber accepting time shall be adjusted from 37～40 [seconds] by the pressure reducing valve.
At the same time, pressure meter of the flow pump OUT side shall be adjusted by the 209 relief valve to be 0.085±0.005 [MPa] of the chamber accepting
completion outlet pressure.
Dialysate pressure adjustment inspection point
(5) Check that the both A and B of chamber accepting pressure are lower than
Inspection items Specifications
0.050 [MPa], and the degassing pressure is lower than -600 [mmHg].
Degassing pressure Lower than -600 [mmHg]
(6) Connect a pressure meter to the pressure reducing valve (204) OUT side.
During acceptance/Outlet pressure Lower than 0.050 [MPa]
(7) The second pressure of the pressure reducing valve should be kept greater
A side/B side
than 0.010 [MPa]. 0.085±0.005 [MPa]
Acceptance completion pressure
※When it is outside of the spec, adjust it by pressure reducing valve, Both A and B 37～40 [seconds]
Acceptance time
210 capillary and 161 capillary. A side/B side Defference of A and B,
within 1 [seconds]
Negative pressure second Greater than 0.010 [MPa]
pressure
1-9. Adjustment and inspection of changeover time

Flow rate adjustment
Release the quick coupler into the poly tank filled with fluid, enter the system to “Dialyze” mode.
Call “Chamber operation” screen by selecting “MENU” → ”Monitor”→ ”Chamber”.
Adjust both A and B chamber changeover time to be 60～61 [seconds] by a flow rate adjusting valve.
※The time difference between A and B should be within 1 [seconds].
※Flow rate becomes high by turning flow rate adjusting valve left, and changeover time becomes shorter.
Flow rate becomes low by turning the valve right, and changeover time becomes longer.
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1-10. Adjustment and inspection of UF counter accuracy

Measurement and correction of dialysis 500 [mL] (1.00 [L/h])
(1) Enter the system to “Stop” mode.
Released quick couplers and a UF hose of outlet side are placed into the poly tank filled with fluid.
UF pump should be operated longer than 5 minutes at the UF rate 1.00 [L/h].
(2) Reset Dialyze time and Total UF. (By entering Rinsing mode, it is reset. This procedure should be always performed before the measurement.)
Set goal UF volume to 0.50 [L] and set UF rate 1.00 [L/h].
Place UF hose of outlet side in the 1000 [mL] in the graduated cylinder, enter the system to “Dialyze” mode after turning blood pump ON.
(When blood pump is off, dialyze time is not accumulated.)
(3) After 30 minutes, UF completion alarm is activated, check that the UF pump is automatically stopped.
Calculate UF rate correction value by the formula.
When the result is lower than ±1.0 [%], measure the 0.50 [L/h] of UF rate for the next step.
Total UF value － Measuring cylinder

UF rate correction value = ×100 [%]
Total UF value
(4) When the calculation result exceeds ±1.0 [%], enter the value on the following screen.
”MENU”→”Initial setting”→”Data setting”→Password input→Data setting screen→No.67 Correction of UF pump
Measure the UF volume again after entering the correction value on the UF pump correction screen, and make sure that the difference is within ±1.0 [%].
※Adjust amplitude of angle in UF pump when correction value is large.
Measurement of dialysis 500 [mL] (5.00 [L/h])

Set UF rate 5.00 [L/h] and UF goal volume 0.50 [L], Measure UF volume by means of measuring cylinder of 1000 [mL].
(UF completion after 15 minutes) → Error within ±2 [%]
Measurement of UF volume 0.50 [L] (0.50 [L/h])

Set measurement UF rate 0.20 [L/h] and UF goal volume 0.50 [L], Measure UF volume by means of measuring cylinder of 50 [mL].
(UF completion after 15 minutes) → Error within ±2 [%]
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1-11. Adjustment and inspection of concentrate infusion volume

“MENU”→”Setting”→”Conductivity setting”→”Conductivity setting” screen →Set conductivity step to step 2. Conductivity setting screen
”MENU”→”Function”→”Dialysate”→”Dialysate setting” screen →Set dialtysate type to bicarbonate.
Also select “Dialysate selection” (Standard, Conc.1 and Conc. 2)
At the same screen, check that the concentrate A correction value and the concentrate B ratio setting are appropriate value.
(At the dispatch from the factory, adjustment is completed in the standard setting, A→adjustment value, B→126 [%])
Concentrate A infusion volume correction

(1) Measure concentrate A infusion volume 10 times continuously by means of measuring pipet or weight meter.
(2) Calculate the average value of 10 times infusion volume, and the error over the fiducially point of 14.42 [mL] is calculated.
Concentrate infusion volume error = (14.42－average value)÷14.42×100 [%]

※Error is less than ±1.0 [%], difference of MIN and MAX is within 0.3 [mL].
(3) When the difference is greater than ±1.0 [%], ”MENU”→”Function”→”Dialysate”→”Dialysate setting” screen.
Enter the correction value on the concentrate A valve correction screen.
(4) Perform infusion volume measurement 10 times again, and adjust it to ±1.0 [%].
Inspection of concentrate B infusion volume Dialysate setting screen

(1) Measure concentrate B infusion volume 10 times continuously by means of measuring pipet or weight meter.
(2) Calculate the average value of 10 times infusion volume, and the ratio against the infusion volume of
concentrate A is calculated.
Concentrate B ratio = average value of Concentrate B infusion volume÷average value of Concentrate A infusion volume
※Concentrate B ratio within 126±2 [%], difference between MIN and MAX is within 0.3 [mL].
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1-12. Adjustment and inspection of conductivity

Reference setting by RO water
(1) “MENU”→”Setting”→”conductivity setting”→Set conductivity step 2 on the ”Conductivity setting” screen.
(2) “MENU”→”Function”→”Dialysate”→Select bicarbonate or acetate on “Dialysate setting” screen.
(3) Set the temperature setting 37 [℃], perform trial operation longer than 10 mminutes at “Stand-by” mode without dialysate suction.
(4) When the temperature is stabilized at 37±0.3 [℃], “MENU”→”Initial setting”→”Reference”→”Pressure/Conductivity”→Call “Pressure/Conductivity” of the
reference setting screen, perform registration of conductivity step “0”.
When the registration is completed, the new AD value is written.
Conductivity reference setting screen
Adjustment and inspection of conductivity step 2
(1) “MENU”→”Setting”→”Conductivity setting”→Set conductivity step 2 on the “Conductivity setting” screen.
(2) Connect a standard conductivity meter to a dialyzer “to” and “from” line.
(3) Set the temperature setting at 37 [℃], let dialysate take in, operate in “Stand-by” mode.
(4) When the temperature and conductivity have stabilized, inspect a standard conductivity meter.
→Appropriate value should be indicated, (AK solita DL→13.95～14.24 [mS/cm])
※When the value is not in standard, inspect the infusion volume of concentration fluid again.
Conductivity step 1 standard value setting

(1) Set conductivity step to 1.
(2) When conductivity is stabilized, call the reference setting screen of “Pressure/Conductivity”.
(3) Write the value of standard conductivity meter in the conductivity step 1 on the reference setting screen, and register it.
→Conductivity value of conductivity step 1= Value of conductivity 2－0.30±0.10 [mS/cm]
Conductivity step 9 standard value setting

(2) When conductivity is stabilized, call the reference setting screen of “Pressure/Conductivity”.
(3) Write the value of standard conductivity meter in the conductiviry step 9 on the reference setting screen, and register it.
→Conductivity step 9 standard value = Value of conductivity step 2 + 2.10±0.10 [mS/cm]
Inspection method
→M/C conductivity indication is within 14.1±0.1 [mS/cm], Standard conductivity meter indication value 13.95～14.24 [mS/cm].
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1-13. Other adjustment

1-13-1. Procedure for software rewrite
Recording of the machine data
CAUTION!
The original data in the machine shall be recorded using following data sheet before installation of the software or prepare the data sheet which is bundled with the
machine.
Because the original data in the machine will be deleted with installation procedure.
Mfg No. DATE:
Please don’t forger to record the unique data of each machine before the installation.
Conductivity
Display (216) Heater Control (212) Compensation (232)
℃ ℃ ℃ ℃ Compensation (233)
(Disp.T) (Control T.) (Control ADJ)
(Cond. sensor T.)
25.0 25.0 25.0 25.0
35.0 35.0 35.0 35.0
37.0 37.0 37.0 37.0
40.0 40.0 40.0 40.0
85.0 85.0 85.0 85.0
Press./Cond. Blood-P/OP.P
Venous Pressure Arterial Pressure Dialysate Pressure Blood/Option pump
℃ ℃ ℃
AD Value (V.Press) AD Value (A.Press) AD Value (D.Press) DA Value
0 0 -200 Low Speed 50

200 200 200 High Speed 400
Press./Cond. [Mainte] [Self-test1] [Setting] [Initial] [Data]

Conductivity
Conductivity Conductivity AD Value
STEP No. DATA Setting No. DATA Setting
(Cond. mS/cm) (Cond. A/D)
(Cond.Step)
0 0 1 Cond. standard mS/cm 64 Syringe speed ％
1 2 Cond. Lower limit mS/cm 67 UF pump correction ％
9 3 mS/cm 68 Blood pump flow ％
4 ℃ 76 Option pump ％
[Function] [Dialysate] 5 ℃
Concentrate select Conc. Pump % Solution B 6 mmHg [Initial] [Date/Time]

Standard % 7 mmHg CM
Concentrate 1 % 8 mmHg DM
Concentrate 2 % 9 mmHg MM
Hour meter
Blood leak BLD stain alarm upper volt Running time
BLD stain alarm lower volt
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Write the software to the Machine

Copy the software your PC to CF (Compact Flush) card before in installation.
SOFTWARE INSTALLATION PROCEDURE

Power Dip Switch #2 on the CM PCB Operation
1 2 3 4 5 6 7 8
Insert CF card on the CM PCB and dis-connect buzzer
1 0
and speaker.
1 0 0 0 0 0 0 1
2 1 Wait 5-7 min.
Remove CF card from the machine and insert CF card to

3 0
"FM-ONE" and connect "FM-ONE" to "MM" P.C.B.
Select "MM" on the "FM-ONE" and press the WRIT E
4 1 FM-ONE
switch to start the writing of software.
5 0 Connect "FM-ONE" to "DM" P.C.B.
1 1 1 1 0 0 1 0 Select "DM" on the "FM-ONE" and press the WRITE

6 1
switch to start the writing of software.
Remove "FM-ONE" from P.C.B.
7 0
Connect all cable to "MM" and "DM" P.C.B.
- Addressing of LCD ( 1, 2, 3, 4, 5)
8 1 - Input reference data as recorded correctly.
- Set installed options
9 0 CAU TION! C onnect buzzer and speaker.

1 1 0 0 0 0 0 0
10 1 Check the machine is working properly.
Check software version

Software version is indicated [Menu] – [Initial setting] – [Date/Time]
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2. Structure and function of P.C.B.

2-1. TR-8000 “YUGA” P.C.B. structure
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2-2. TR-8000 “YUGA” function by the P.C.B.

DM P.C.B. controls each functional components of the system. The control of input and output is performed by the components (function) in the following table.
DM P.C.B.
Drive system IO Contents Drive system device Fuse
Nurse call Nurse call signal input
Motor control power supply output of blood pump K4 F24
Blood pump Single input of blood pump cover open
Input and output of blood pump control signal
Heater thermo SW input
Heater overheating prevention input
Heater SSR control signal output for heater K5
Temperature sensor (Control correction) input
Temperature sensor (for Control) input
Supply water pressure SW input
Air bubble separator flow SW input
Flow switches
Supply water flow SW input
Chamber flow SW input
Negative pressure release valve output TR2-2 F6
Supply water stop valve output TR2-3 F7
Air release valve output TR2-4 F8
Hot water bypass valve output TR1-3 F3
Solenoid valves
ETCF valve 1 output TR3-2 F10
Flow control bypass valve output TR9 F25
DC level release valve 1 output TR1-1 F1
DC level DC level release valve 2 output TR1-2 F2
DC level adjustment pump output F23
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Negative pressure pump ON output TR2-1 F5
Negative pressure pump
Negative pressure pump level
Flow pump ON output TR3-1 F9
Flow pump
Flow pump level
Chamber changeover valve1 output TR4-1 F13
Chamber changeover valve module
Chamber changeover valve 8 output TR5-4 F20
Attach and detach signal input
Overflow detection signal input
Completion detection signal input
Syringe pump One-shot in progress signal input
Motor rotation in progress signal input
Overloaded detection signal input
Input and output of pulse motor driver control
One-shot in progress input
UF pump Motor rotation in progress input
Input and output of pulse motor driver control
Cooling fan Cooling fan (hot water rinsing) output TR1-4 F4
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MM P.C.B. performs alarm monitoring to maintain security of the system.

The control of input and output for the sensors and switches in the following table is performed.
MM P.C.B.
Blood pressure monitor Exterior start SW input
Blood pump Blood pump rotation detection signal input
UF pump UF pump rotation detection signal input
Syringe pump 1 rotation detection input
Syringe pump
Syringe pump 2 rotation detection input
Air bubble OP positive signal input
Air bubble detector OP ON/OFF output
Air bubble detector Air bubble STD positive signal input
Air bubble STD micro positive signal input
Air bubble detector STD ON/OFF output
Bypass coupler SW outlet port signal input
Flow switches Bypass coupler SW outlet port signal input
Bypass flow SW signal input
Dialysate pressure Dialysate pressure signal input
Temperature sensor (for conductivity correction) signal input
Conductivity sensor signal input
Conductivity sensor
Conductivity sensor self-test 1 output
Conductivity sensor self-test 2 output
Blood leak detector state signal input
Blood leak detector ANS signal input
Blood leak detector Blood leak detector sensor signal input
Blood leak detector LED changeover/self-test
Blood leak detector current control
Patrol lamp (yellow) output IC27 F1
Patrol lamp (blue) output IC27 F2
Patrol lamp
Patrol lamp (red) output IC27 F3
Patrol lamp (green) output IC27 F4
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NO clamp operation state signal input
NO clamp operation output TR1-1 F5
Clamper
NO clamp request
NO clamp fan output TR1-2 F6
Venous pressure sensor signal input
Pressure sensor
Arterial pressure sensor signal input
Pulse pressure self-test changeover 1 output
Pressure sensor self-test
Pulse pressure self-test changeover 2 output
Temperature sensor self-test changeover 1 output
Temperature sensor self-test
Temperature sensor self-test changeover 1 output
Temperature sensor Signal input for temperature sensor indication
Bypass valve 1 output TR2-1 F9
Bypass valves Bypass valve 2 output TR2-2 F10
Bypass valve 3 output TR2-3 F11
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OP P.C.B. performs controls monitoring for optional function (components).

OP P.C.B.
Speed control output
Direction control output
Brakes output
RAN output
OP pump U/V phase output
Rotation detection signal input
Alarm output
OP pump cover open signal input
OP pump power supply output K2 F7
NC clamp 1 operation signal input
NC clamp 1 output TR1-3 F3
Clamper
NC clamp 2 operation signal input
NC clamp 2 output TR1-4 F4
NC clamp 1 operation
NC clamp
NC clamp 2 operation
ON/OFF output
Substitution fluid shortage sensor
Detection signal input
Na infusion pump Na infusion pump output Q6 F5
DC level release valve 2-1 output TR1-1 F1
DC level DC level release valve 2-2 output TR1-2 F2
DC level adjustment pump 2 output F6
Reset
Internal blood pressure monitor Pump power supply ON
Control power supply ON
Pillow sensor Pillow sensor
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I/O P.C.B. performs control monitoring linked function of infusing concentrate and disinfectant.
I/O P.C.B.
Concentrate pump starting point signal input
Concentrate pump Concentrate pump RUN output
Concentrate pump power supply OFF K1 F13
Concentrate A changeover valve output TR1-1 F1
Concentrate B changeover valve output TR1-2 F2
NaCl fluid changeover valve output TR1-3 F3
Reserved output TR1-4 F4
Water changeover valve 1 output R3-3 F11
Water changeover valve 2 output TR3-4 F12
Acetic acid changeover valve output TR2-1 F5
Solenoid valves Rinsing changeover valve output TR2-2 F6
Sodium hypochlorite changeover valve output TR2-3 F7
Hot water rinsing valve output TR2-4 F8
Bicarbonate changeover valve 1 output TR3-1 F9
Bicarbonate changeover valve 2 output TR3-2 F10
Rinse port A changeover valve TR5-1 F18
Rinse port B changeover valve R5-2 F19
Rinse port Na changeover valve R5-3 F20
Blood pump Rotation detection signal 2 input
OP pump Rotation detection signal 2 input
Rinse port A connecting signal input
Rinse ports Rinse port B connection signal input
Rinse port Na connection signal input
Disinfectant detector detection signal input
Disinfectant detector
Disinfectant detector ON/OFF output
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3. Description of the individual function and the relevant troubleshooting

3-1. Conductivity control/monitor
Temperature compensation thermistor resistance table

Temperature [℃] Resistance [Ω] Temperature [℃] Resistance [Ω]
0.0 14563.0 39.0 3041.6
5.0 11659.4 40.0 2935.2
10.0 9400.0 41.0 2833.0
15.0 7628.8 45.0 2479.5
20.0 6230.5 50.0 2096.0
25.0 5119.0 55.0 1777.7
30.0 4229.9 60.0 1512.7
34.0 3645.0 65.0 1219.1
35.0 3514.0 70.0 1105.3
36.0 3388.5 80.0 817.3
37.0 3268.0 90.0 610.4
38.0 3152.4 100.0 460.7
【Conductivity control】
As the conductivity control system for TR-8000 “YUGA”, regulated volume of dialysate concentrate is kept in the fixed volume of chamber, and capacity control dilution
method is adopted.
In this method, the dialysate concentrate suction pump is rotated continuously, the valve opening time of concentrate A, concentrate B and water changeover valve for
those located on IN side are changed, then conductivity control is performed.
CM sends the information of concentrate A and B infusion volume against the 505 [mL] chamber to CM, which is calculated according to the set conductivity and
infusion volume correction value.
DM calculates rotation number (starting point pulse) of concentrate pump which is necessary for concentrate A and B infusion, based on the infusion volume sent from
CM plus remaining time, consequently, PLD counter of I/O is set.
After that, chamber changeover signal is received, concentrate A and B changeover valve is controlled for the time which is set by the rotation number (starting point
pulse) plus remaining time.
Water changeover valve rotates 3 times right after the chamber changeover, 3 times during concentrate A and B infusion, and operates after concentrate B infusion
completion to next chamber changeover.
Remaining time control for the starting point pulse + remaining time
One rotation time of concentrate pump is 167 [ms].
The operation during this one rotation is infusion operation for a first half from the detection of starting point and for the send-out half for the drain operation.
Theoretically, though, 50 [%] from the starting point is the infusion operation, infusion volume seems to be changed 67% (112 [mS]) from the starting point in the actual
measurement, therefore, the control is performed as 67 [%] of 1 rotation is recognized to be effective.
Example: Concentrate A infusion volume 14.55 [mL], 14.55/0.32 = 45 rotation and 0.15 [mL], 0.15/0.32×167×0.67=52 [mS] 45 rotation and 52mS, Open concentrate
A changeover valve.
Relation of conductivity step, Infusion volume, Rotation number, And Infusion time
※Chamber capacity : 505 [mL] Conductivity Concentrate A (correction value 0 [%]) Concentrate B
Concentrate pump rotation : 360 [rpm] (167 [ms]/rotation)
setting Infusion volume Rotation Infusion time According to the
Concentrate ratio : 1 (concentrate A) : 1.26 (concentrate B) : 32.74 (water)
Output volume : 0.32 [mL/rotation] (cc) number (second) ratio setting
Output volume of conductivity/step : 0.32 [mL] 1 14.10 44 7.33
2 14.42 45 7.50
3 14.74 46 7.67
4 15.06 47 7.83
5 15.38 48 8.00
6 15.70 49 8.17
7 16.02 50 8.33
8 16.34 51 8.50
9 16.66 52 8.67
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【Conductivity monitoring】
Conductivity of dialysate which sent to the dialyzer is detected by means of electrical
conductivity (conductivity sensor 258) between the electrodes.
Conductivity reference average value
MM reads conductivity measurement data which is digitally converted by ADC.
Register point Conductivity value Reference value
Measurement data of the temperature compensative sensor (233) is also read CPLD after the
0 0.0 4776
AD conversion.
Step 1 13.8 40995
MM calculates measurement data based on the information of the reference setting to conductivity
Step 9 16.1 46414
value and temperature value.
After calculating temperature compensation, conductivity is displayed via CM on LCD.
【Conductivity alarm】
Conductivity alarm monitoring system monitors upper and lower limit setting against the conductivity standard value set at the initial settings.
Conductivity value of bicarbonate and conductivity step2 should be registered beforehand in the system as the standard conductivity value.
MM P.C.B. performs alarm monitoring by setting upper and lower limits for maximum of ±5 [%] against the conductivity standard value.
When conductivity step is corrected, conductivity upper and lower limit setting is calculated by adding or subtracting 0.3 [mS/cm] per step 1against the conductivity
standard value
Alarm recovery procedure of conductivity alarm activation.

Phenomenon Check point Distinction Recovery procedure
Substantial Concentrate type, concentrate Inspection of concentrate type, concentrate connection state Change to the proper concentrate change to the
conductivity is connection proper connection
high Conductivity step setting Conductivity step inspection Change to the proper conductivity step
Chamber accepting time (Short cycle) Measurement accepting time (37～40 [seconds]) by setting Normalize accepting time
dialysate flow rate to 500 [mL/min] (refer to the following items for the inspection)
Dialysate flow rate Inspection for the dialysate flow rate greater than 700 [mL/min]. Dialysate flow rate adjustment
(Acceptance is put of time)
Flow pump (207) Degassing pressure greater than 500 [mmHg] Replacement of pump head and motor,
Acceptance pressure greater than 0.085 [MPa] Adjustment of relief valve
Degassing side relief valve (209) Existence of the leak of the relief valve during the acceptance Relief valve replacement
Heater－buffer tank tube No clog for the capillary Cleaning, Replacement
Pressure reducing valve (204) Flow rate adjustment is appropriate. No clog. Flow rate adjustment, Replacement
Supply water Supply water flow rate should be securely maintained greater Rise supply water flow rate
than 700 [mL/min].
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Concentrate pump (113) Inspection of concentrate infusion volume. Infusion volume adjustment
(Step 2 concentrate A 14.4 [cc])
Infusion pump starting point detection is normally operated. Replacement of photo sensor, I/O P.C.B. replacement
Variation of the amplitude of angle. No looseness of the head. Fixation of the amplitude of angle,
Fixation of the looseness of the head
Relevant connector of above No loose connection. Insert or remove of the P.C.B.,
components Connector cleaning, Terminal replacement
Substantial Concentrate line Existence of air suction, Existence of the looseness of the Replacement of connection tubes, Tighten joint,
conductivity is low Concentrate infusion state solenoid valve joint, Failure of concentrate nozzle. Replacement of nozzle
No suction of the concentrate. Replacement of the connector filter,
Replacement of the clogged part
Concentrate pump (113) Inspection of concentrate infusion volume Infusion volume adjustment
(Step 2 concentrate A 14.4 [cc])
Normally rotated. No pauses. Replacement of motors, Replacement of drivers,
Replacement of F13, Replacement of I/O P.C.B.
Concentrate pump starting point detection is normally operated. Replacement of photo sensor,
I/O P.C.B. replacement
Concentrate pump lock. Variation of amplitude of angle. Lock cancellation, Fixation of amplitude of angle,
Base looseness. Fixation of head
Concentrate A valve (110) Clog, Cleaning, Replacement, I/O P.C.B. replacement,
No leak and back flow and no operation failure are found. F1 replacement
Concentrate B valve (111) Clog, Cleaning, Replacement, I/O P.C.B. replacement,
NaCl valve (140) Clog, Cleaning, Replacement, I/O P.C.B. replacement,
Water changeover valve (112) No leak and no failure operation is found. Cleaning, Replacement, I/O P.C.B. replacement,
F4 replacement
Broken diaphragm of chamber Measurement of chamber changeover time. Replacement of chamber diaphragm
(Unequal of time; within 2 seconds)
Relevant connector of above No loose connection. Remove and insert of the P.C.B.,
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Conductivity Conductivity sensor (258) No dirt on electrodes. Cleaning, Acetic acid rinsing
indication error Conductivity compensative sensor No resistance value error (Refer to the resistance value table) Cleaning, Replacement of sensor
(233)
Conductivity indication adjustment The reference value should be appropriate. Reset conductivity reference,
Replacement of MM P.C.B.
Relevant connector of above No loose connection. Remove and insert of the P.C.B., Connector cleaning,
components Terminal replacement
Recovery procedure of concentrate pump rotation alarm activation

Concentrate pump Concentrate pump Normally rotated. Replacement of motors, Replacement of drivers.
rotation alarm No pauses. Replacement of F13, Replacement of I/O P.C.B.
Starting point detection of concentrate pump is normally Replacement of photo sensor,
operated. Replacement of I/O P.C.B., Replacement of F13.
Concentrate pump lock, Variation of amplitude of angle, Lock cancellation, Fixation of amplitude of angle,
Base looseness Fixation of head
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3-2. Temperature control/monitor
Temperature display and control thermistor resistance table

Temperature [℃] Resistance [Ω] Temperature [℃] Resistance [Ω]
0.0 14563.0 39.0 3041.6
5.0 11659.4 40.0 2935.2
10.0 9400.0 41.0 2833.0
15.0 7628.8 45.0 2479.5
20.0 6230.5 50.0 2096.0
25.0 5119.0 55.0 1777.7
30.0 4229.9 60.0 1512.7
34.0 3645.0 65.0 1219.1
35.0 3514.0 70.0 1105.3
36.0 3388.5 80.0 817.3
37.0 3268.0 90.0 610.4
38.0 3152.4 100.0 460.7
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【Temperature control】
Temperature setting value which is set on the operation panel is sent to DM from CM. DM detects temperature at the heater outlet port by the temperature control
sensor (212),amplify analogue signal at ADC, and read the value from CPLD after the digital conversion, and calculate the time for “heater on” (MV calculation value)
from this measurement value and temperature setting value, so heater control is carried out by controlling ON/OFF of SSR.
The temperature of the dialysate falls slightly while it flows to the dialyzer, the difference with setting temperature arises after adjusting temperature. For this measure,
DM detects the temperature of dialysate before the dialyzer by the temperature correction sensor (232), ADC amplifies the analogue signal, and the value after digital
conversion is read from CPLD, the difference between measured value and temperature setting value is added for the correction to the control temperature as the
temperature correction value, so the heater control is performed.
Temperature control
The heater control performs the control by calculating heater-on time as a MV operation value for every cycles of 2.5 seconds.
MV operation value = P operation value + Differentiation value + offset value
Offset value: The average rate of ON with the cycles of 2.5 seconds P operation value: Goal temperature – Control temperature ÷ 2
Differentiation value: (Previous control temperature – control temperature)×2
Temperature correction
Temperature correction proceeds in a cycle of 1 minute.
When the temperature change for 5 minutes is settled within 1℃, a correction value is calculated and correction is added to the control temperature.
Correction value = setting temperature －display temperature
The value is rectified when the difference of setting temperature and a control correction sensor exceeds 0.2 [℃].
Alarm detection performed with DM (control side)

SSR is turned off by the detection of the abnormal temperature rise of the heater by the attached thermostat (206). → Detection temperature 120 [℃]
SSR is turned OFF by the comparing the output of the control correction sensor (232).→ Detection temperature 42 [℃]
【Temperature monitor】
Temperature reference average value
The temperature of the dislysate sent to the dialyzer is detected by the
Setting Indication Control temperature Control correction
temperature display sensor (216). temperature [℃] temperature (216) (212) (232)
MM amplifies analogue signal at ADC, read the data from CPLD after its 25 39881 39815 39894
digital conversion, and the temperature is displayed on LCD via CM after 35 34033 33970 34043
calculating temperature value based on the reference setting. 37 32889 32823 32875
40 31160 31099 31172
【Temperature alarm】
85 11941 11893 11944
MM monitors temperature read by the temperature sensor (216) at the upper
and lower limit setting value of the initial setting.
Temperature upper lower limit alarm is activated when the temperature indication value exceeds upper lower limit alarm setting value.
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Alarm recovery procedure of temperature alarm

Substantial Shot cycle (Heat an empty container) Accepting time should be 37～40 seconds. Normalization of acceptance and changeover time
temperature is changeover time of the chamber should be 60±5 seconds.
high Heater control (SSR operation) CN12 43～44G signal check. SSR replacement
(Upper limit alarm DC24V ON/OFF; positive. Heater ON all times; negative.
activation) Temperature control sensor (212) Separation from the holder, No resistance value error should be Cleaning and replacement of sensor
required (refer to the resistance value chart)
Control correction sensor (232) Separation from the holder, No resistance value error should be Cleaning and replacement of sensor
required (refer to the resistance chart)
Temperature control sensor Reference value should be appropriate, Resetting of temperature control reference,
adjustment Temperature value should be appropriate DM P.C.B. replacement
Adjustment of control correction Reference value should be appropriate. Resetting of temperature control reference,
sensor Temperature value should be appropriate DM P.C.B. replacement
Relevant connector of above No loose connection Insert or remove of the P.C.B.,
Substantial Thermostat 206 (overheating sensor) Overheating sensor has operated (OFF). Thermostat 206 replacement.
temperature is low Thermostat (Heater off directly) Overheating sensor has operated (OFF). Thermostat (Heater off directly), Reset switch ON
(Lower limit alarm Heater (205) Heater or wire burnout (heater resistance 10 [Ω]), Loose connection Heater replacement
activation) Heater control (SSR operation) CN12 43～44G signal check, SSR replacement
DC24V ON/OFF; positive. Heater ON all times; negative
Temperature control sensor (212) Separation from the holder, No resistance value error should be Cleaning and replacement of the sensor
Control correction sensor (232) Separation from the holder, No resistance value error should be Cleaning and replacement of the sensor
Temperature control sensor Reference value should be appropriate, Resetting of temperature control reference,
adjustment Temperature value should be appropriate DM P.C.B. replacement.
Adjustment of control correction Reference value should be appropriate, Resetting of control correction reference,
sensor Temperature value should be appropriate DM P.C.B. replacement
Relevant connector of above No loose connection. Remove and insert of the P.C.B.,
components Connector cleaning terminal replacement
Temperature Temperature sensor (216) Separation from the holder, No resistance value error should be Cleaning and Replacement of sensor
indication error required (Refer to the resistance value chart)
Adjustment of temperature indication Reference value should be appropriate, Reset temperature indication reference,
sensor Temperature value should be appropriate. Replacement of MM P.C.B.
Relevant connector of above No loose connection Insert or remove of the P.C.B.,
components Connector cleaning terminal replacement.
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3-3. UF control/monitor
Specifications of UF pump
DC24V 3-phase stepping motor
Outlet : 0.5 [cc/1 rotation]
Rotation detection : Encoder and photo sensor attach on rotor
Motor driver CN1 signal

Port Signal name Function TR-8000 ”YUGA”
1 VM 12～36[V] power supply connection of the motor driving DC24V input
2 COM Power supply ground for driving the motor GND
3 5V DC Connection of the power supply DC5V for control. DC5V input
4 GND Power supply ground for control GND
5 CW Driving pulse fro CW direction Speed control
6 CCW Driving pulse for CCW direction H : fixed
7 C0 Motor current setting 0 At the Dilaysate rate setting time (at the operation) : L
8 C1 Motor current setting 1 At the Dilaysate rate setting time (at the operation) : L
9 GND Signal ground Not connected
※Although substantial rotation is CCW direction, CW is used for the control. (V is changed to W for the motor driving signal.)
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【UF rate control monitor】

TR-8000"YUGA" makes closed circuit for all the dialysate courses including the dialyzer, dialysate sent to the dialyzer and returning are set to be the same volume.
The closed system of capacity control method performs UF by applying convection pressure with UF pump from the inside of this closed circuit system.
CM sends the mode information and set UF rate (L/hr) to DM.
DM performs speed control of UF pump (227) via motor driver according to the calculated correction value plus 0.5cc/rotation (3pulse) when the operation is possible by
the result from the mode information etc.
MM calculates UF volume by reading pulse from the disk slit attached on the rotating axis of UF pump using photo sensor.
CM displays total UF calculated by MM on LCD.
【UF pump rotation alarm monitoring】

MM monitors regularly two values, estimated rotation rate of UF pump based on the UF rate setting and substantial rate (photo sensor pulse), and it stops dialysis
course with the activation of the alarm when the deviation becomes greater than ±10 [%].
Recovery procedure of UF error activation

Too much draw UF pump (227) Inspection of the outlet volume error of UF. Outlet adjustment of UF pump rate correction or
Total UF ＜ Total UF － outlet volume/outlet volume×100＜±1[%] amplified angle.
Weight reduce Pump head vertical leak inspection 1drop/within 10 seconds. Replacement of pump head.
(UF pump outlet leak at stand-by mode)
Amplified angle variation owing to the looseness of centre volt Increase tighten up.
or amplified angle adjustment screw etc.
Clog or leak of inlet/outlet line of pump head. Increase tighten up, replacement of the parts
Closed circuit system structural state No NG at self-test or closed circuit leak test Investigation of troubling components (Following items)
Chamber valve (214) Drawn to the negative pressure either of the chamber Negative pressure pump, Flow pump pressure
changeover time or a half side of the chamber adjustment, chamber changeover valve or valve sheet
replacement
Air release valve (222) Drawn to the negative pressure direction regardless of a Air release valve, Valve sheet replacement
chamber changeover Intercept by the forceps of IN sideNo
problem by the leak test
Air bubble separator (221) Float in the air bubble separator S/W connection point closed all Replacement of the float in the air bubble separator
times
Air inflow state of the air bubble・fluid Frequent occurrence of air bubble separator operation by air Deletion of the reason of the air infusion
separator inflow
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Too much draw UF pump (227) Inspection of the outlet volume error of UF. Outlet adjustment of UF pump rate correction or
Total UF ＞ Total UF － outlet volume/outlet volume×100＜±1[%] amplified angle.
Weight reduce Amplified angle variation owing to the looseness of centre volt or Increase tighten up.
amplified angle adjustment screw etc.
Closed circuit system structural state No NG at self-test or closed circuit leak test Investigation of troubling point (Following items)
Negative pressure release valve (226) Negative pressure is applied Negative pressure – shift to 0mmHg Negative pressure release valve,
at once Valve sheet replacement
Chamber valve (214) Apply positive pressure at the acceptance completion by the time Negative pressure pump, Flow pump pressure
of chamber changeover time or a half side of chamber. adjustment, chamber changeover valve or valve sheet
replacement
Alarm recovery procedure of temperature alarm

UF pump rotation UF pump (227) Normally rotated, No pauses Replacement of the motor, Replacement of the driver,
alarm Replacement of the DM P.C.B.
No problem at the UF pulse check (self-test) Replacement of the photo sensor,
Replacement of the MM P.C.B.
UF pump lock inspection Lock release
Relevant connectors of above No loose connection Extraction and insertion of P.C.B., Connector cleaning,
components Replacement of the contact terminal
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3-4. Chamber changeover
【Chamber changeover control】

TR-8000 "YUGA" performs UF control with the closed system of capacity control method.
This closed circuit system is constructed by two chambers with a silicone membrane; dialysate is always supplied to the dialyzer by changing them in turn.
Each chamber has the capacity of 505mL, and generally pours fresh dialysate to the dialyzer through the chamber membrane with the negative pressure pump (220) by
dialysate flow 500 [mL/min]. At this time, fresh dialysate in the closed circuit side chamber is changed to the used dialysate for 60 seconds, and stops the fluid flow.
Another chamber filled with fresh dialysate is changed by detecting chamber changeover flow switch (218) that status.
On the other hand, chamber filled with used dialysate receives supply of fresh dialysate as soon as discharging used dialysate with a flow pump (207).
Since this system operates by the flow rate approx. 750 [mL/min], fresh dialysate is filled in about 37 seconds, and the next change is prepared with this procedure.
These controls perform DM according to the mode information from CM.
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【Alarm monitoring】
The signals of a chamber changeover flow switch (218) and a supply water flow switch (252) are detect by DM, MM read that signal via communication memory, and
MM monitors the following alarm monitoring from the information.
Chamber alarm: Chamber changeover flow switch does not turn ON longer than 2 minutes.
Clog the flow: Chamber changeover flow switch is ON longer than 5 seconds continuously.
Supply water alarm: OFF time of the supply water flow switch is shorter than 20 seconds, ON time is shorter than 2 seconds.
These conditions continue 3 times continuously.
Recovery procedure of chamber alarm activation

Chamber Chamber membrane Difference of changeover time of A and B acceptance is within 2 Replacement of chamber diaphragm
changeover seconds.
longer than 2 Chamber changeover valve (214) No leak, no clog, smooth operation. Replacement of chamber changeover valve or valve
minutes sheet, Overhaul cleaning.
Chamber changeover flow switch No adhesion of calcium carbonate, smooth operation. Overhaul cleaning of flow switch, Replacement
(218) Switch should be ON at the dropping time of the float, Inspect it Flow switch replacement.
by 218 connector.
Flow switch is displayed to be ON/OFF on the operation check DM PWB replacement.
screen.
DM P.C.B. No breakage of the above components, the fuse should not be Fuse replacement.
run out. Replacement of DM P.C.B.
components Terminal replacement.
Decreasing of the Negative pressure pump (220) Outlet pressure of the pump, greater than 0.100 [MPa] Adjustment for outlet pressure of the pump.
dialysate flow Replacement of head and pump.
Lower than 250 Relief valve (223) Outlet pressure of the pump, 0.100 [MPa] with smooth operation. Overhaul cleaning, Replacement.
[mL/min] Bypass valve 1,2,3 (255, 256, 257) Large difference of flow volume between dialysis and bypass. Replacement of bypass valve or valve sheet,
Overhaul cleaning
Flow rate regulating valve (217) That is, the regulation is not extracted too much. Flow rate adjustment, Overhaul cleaning,
Replacement
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Alarm recovery procedure of water short 1 activation

Procedure flow Negative pressure pump (220) Outlet pressure of the pump, greater than 0.100 [MPa] Adjustment for outlet pressure of the pump,
switch is Replacement of head and pump.
continuously ON Chamber changeover valve No leak, No clog, Smooth operation Replacement of chamber changeover valve or valve
longer than 5 sheet, Overhaul cleaning.
seconds Chamber changeover flow switch No adhesion of calcium carbonate, Smooth operation. Overhaul cleaning of flow switch, Replacement.
(218) Switch should be OFF at the increasing time of the float, Inspect Flow switch replacement.
it by connector 218.
Flow switch is displayed to be ON/OFF on the operation check DM P.C.B. replacement.
screen.
Bypass valve No leak, No clog, Smooth operation. Overhaul cleaning, Replacement of bypass valve or
valve sheet.
DM P.C.B. No TR breakage of the above components, The fuse should not Fuse replacement, Replacement of DM P.C.B.
be run out.
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Alarm recovery procedure of water short 2 activation

Procedure supply Supply water filter (Line filter) No clog, No dirt. Filter cleaning, Replacement.
water flow switch Supply water stop valve (203) No leak, No clog, Smooth operation. Overhaul cleaning, Replacement of supply water stop
OFF time is valve or valve sheet.
shorter than 20 Supply water flow switch (252) No adhesion of calcium carbonate, Smooth operation. Overhaul cleaning of flow switch, Replacement.
seconds Switch should be OFF at the upper position of the float, Inspect it Flow switch replacement.
ON time is shorter by connector 252.
than 1 seconds Flow switch is displayed to be ON/OFF on the operation check DM P.C.B. replacement.
screen.
Chamber accept time check Measure accepting time (37～40 seconds) by setting dialysate Normalize accepting time (refer to the following items
flow rate to 500 [mL/min]. for the inspection)
Dialysate side flow rate Inspection for the dialysate flow volume greater than 700 Adjust dialysate flow volume lower than 700 [mL/min].
[mL/min].
Acceptance is out of time.
Flow pump (207) Degassing pressure greater than 600 [mmHg]. Adjustment of pump head, Motor, Replacement and
Acceptance completion pressure greater than 0.85 [kg/cm2] relief valve.
Degassing side relief valve (209) Existence of the leak of the relief valve during the acceptance. Relief valve replacement.
Heater → Buffer tank piping No stuck for the capillary Cleaning, Replacement
Pressure reducing valve (204) Flow rate adjustment is appropriate, No clog. Flow rate adjustment, Replacement.
Supply water Supply water flow rate should be securely maintained greater Increase the supply water flow rate.
that 700 [mL/min].
DM P.C.B. No TR breakage of the above components, The fuse should not Fuse replacement, Replacement of DM P.C.B.
be run out.
※For the troubleshooting, refer to “Operation check/test for the components” of a maintenance function.
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3-5. Blood pump control
Driver connector No. CN3 (137D)

Driver connector No. CN2 (137M)
1 HU OUT Rotation signal output 8 pulse/rotation
Port Signal name Function
2 HV OUT Rotation signal output 8 pulse/rotation
1 MU Coil U phase output
3 ALARM OUT Out put H: Normal time, L: At the operation time of protective function Normal time : H
2 MV Coil V phase output
4 VR Power supply output for exterior speed setting 0～10 [V] Not used
3 MW Coil W phase output
5 VS Signal input for speed setting 0～10 [V] DC 0～10 [V]
4 N・C －
6 GND Speed rate setting GND GND
5 HW Signal input of Hole IC
7 GND GND for I/O signal GND
6 HV Signal input of Hole IC
8 F/R IN Input H: CCW, L: CW H : fixed
7 HU Signal input of Hole IC
9 BRAKE Input H: No brake, L: Brake operation Normal time : H
8 GND Power supply GND for Hole IC signal
10 RUN Input H: Motor stop, L: Motor rotation in driving In driving : L
9 VH12V Power supply for Hole IC signal
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※Although substantial rotation is CW direction, CCW is used for the control. (U is changed to W for the motor driving signal.)
【Blood pump speed rate control】

CM sends the information of blood pump ON/OFF operation to DM and MM, DM operates blood pump (137) via motor driver at the blood flow setting value and the
reading operation information.
The blood flow setting value is given as DC voltage (VS) to the motor driver, and controls speed rate of the motor.
In the concrete, blood pump rotation speed rate is computed from a flow rate setting value, the digital value (0～131071) proportional to the speed rate is changed into
an analogue value (DC 0～10 [V]) in DAC, and gives it to the motor driver.
Example: In order to control in 0～10 [V] for the rotation number of the motor at the time of flow volume 200 [mL/min] by tube L size setting of 200/8.70=23 [rpm] 0～
100 [rpm],It gives the voltage of 2.3 [V] as a speed rate setting signal (VS) in 23 [rpm].
Blood pump specifications The blood pump control ranges 0, 3 ～100 [rpm] (rotation number of the motor 0, 85～2500rpm * rated 1500rpm, Gear ratio 1/25)
Rotation speed rate calculation tube S size → 5.48 [mL/rotation] tube L size → 8.70 [mL/rotation]
Blood flow setting: Rotary encoder.
Reference setting of the blood pump/Setting of the flow rate correction reference
Reference setting
Blood pump reference mean value
Registration point Registration value
Low speed rate 50 [mL/min] 48
High speed rate 400 [mL/min] 375
DM gives the digital value proportional to the blood pump speed rate setting 0～600 [mL/min] to DAC.
DAC outputs VS (DC voltage) to the pump driver. In here, an error arises from the variation in DAC and peripheral circuit between the substantial numbers of
rotations. This variation is rectified by the reference setting function.
“Initial setting” → “Reference” → “Blood pump/Substitution pump” Set the reference setting function.
A reference rectifies (registration) two points, a low speed rate (50 [mL/min]) and high speed rate (400 [mL/min]).
Blood flow rate correction

The blood pump for blood flow correction is based on the outlet volume of the tube S size → 5.48 [mL/ 1 rotation], and tube L size → 8.70 [mL/1 rotation], However,
the speed rate correction of this outlet volume difference depends on the variation in a blood circuit is carried out by “Initial setting” → “Data setting” → “Blood pump
correction”.
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【Blood flow monitor】

MM displays a blood flow setting value on LCD.
【Monitoring of a pump rotation alarm and reversed rotation alarm】

Rotation alarm
MM monitors blood flow rate setting value and substantial blood pump rotation numbers (from the signal of the rotation detection sensor of blood pump rotor) by
comparing them. Alarm is activated when the substantial rotation numbers deviates remarkably against the setting value.
DM receives this signal, alarm recovery of a blood pump stop etc. is performed, and CM displays the alarm.
Reverse rotation alarm
MM reads the rotation signal detected by another Hole IC other the above-mentioned rotation signal through the I/O P.C.B.
The abnormalities in reverse rotation are monitored by the timing of these 2 rotation signals.
【Detection of pump cover open】

The opening and closing state of a blood pump cover is detected by the limit switch.
DM receives this signal, The pump stops at the cover open, and the procedure of the operation is carried out by RUN signal at the cover closed
Recovery procedure of the blood pump relevant alarm

Blood pump Blood pump (137) Normally rotated, No pauses. Replacement of the motor, Replacement driver,
rotation alarm Replacement of the DM P.C.B.
Pulse check for the rotation detection. Replacement of the photo sensor,
A normal indication of the substantial speed is given by the blood Replacement of the MM P.C.B.
pump reference setting screen or maintenance auxiliary blood
pump substantial speed indication.
Blood flow volume Actual measurement of blood flow Measurement for 1 minute by the setting flow rate 300 [mL/min], Re-setup of reference,
difference volume in a used circuit. 200 [mL/min] ±4 [mL]. Blood pump speed rate correction.
Blood pump Rotor gap adjustment In accordance with a used circuit, It is adjusted appropriately. Rotor gap adjustment.
rotation change
Cover open alarm Cover open detection switch SW signal input state is checked on a check screen of the Replacement of SW, Replacement of MM P.C.B.
(Not cancelled) operation.
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3-6. Syringe pump control
Motor driver CN1 signal

1 VM 12～36 [V] power supply connection of the motor driving DC24V input
2 COM Power supply ground for driving the motor GND
3 5VDC Connection of the power supply DC5V for control DC24V input
4 GND Power supply ground for control GND
5 CW Driving pulse for CW direction Speed control
6 CCW Driving pulse for CCW direction H : fixed
7 C0 Motor current setting 0 At syringe ON time (on operation) : L
8 C1 Motor current setting 1 H : fixed
9 GND Signal ground GND
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【Speed control】
DM drives a syringe pump motor (stepping motor) via pulse motor driver according to the infusion rate set by CM.
Syringe type and standard size Unit: mm

Syringe Outer Inner Length of the Flange 1 Flange 2 Scale Calibration
cylinder cylinder cylinder length (1 [mL])
10 [mL] φ17.6 φ15.8 75 2.3 1.7 50.8 5.08
20 [mL] φ22.3 φ20.2 93 2.3 1.7 62.8 3.14
30 [mL] φ25.4 φ23.1 106 2.7 2.1 71.5 2.38
Driving motor : Stepping motor (KT35FM1-017) 1.2°
Driver model : FTD3S2P18
Deceleration ratio : 1/2
Sending screw : φ8×1.25
Rapid speed : Corresponds at 1800 [mL/h]
Completion alarm → DM monitors syringe completion detection Hole IC, and stops a syringe pump when Hole IC turns on at the stroke end.
Moreover, this signal is read by MM via communication memory, and reports syringe completion at turning ON.
Overloaded alarm → DM monitors overload detection SW, and stops a syringe pump, when SW turns ON by the overload, etc.
Moreover, this signal is read by MM via communication memory, and reports syringe overload alarm at overload detection SW turning
ON.
※Syringe overload detection pressure → Syringe OUT pressure greater than 0.12 [MPa]
Syringe rotation alarm → MM checks whether the number of pulses of the rotation detection photo sensor against the syringe speed rate sent from CM is normal,
and activates rotation alarm when pulse gap of ±10 [%] or greater arises.
Syringe attach/detach monitoring → MM monitors syringe attach/detach detection SW via communication memory, when syringe is not set at the syringe pump ON and it
separates on the way, MM reports an alarm and stops a syringe pump.
Recovery procedure from syringe pump relevant alarm activation
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Recovery procedure of syringe pump relevant alarm

Syringe pump Syringe pump (138) Normally rotated, No pauses. Replacement of the motor, Replacement driver,
rotation alarm Replacement of the DM P.C.B.
The rotation detection pulse check is inputted into MM. Replacement of the photo sensor, Replacement of the
MM P.C.B.
Relevant connector No loose connection. Insert or remove of the P.C.B., Connector cleaning,
Terminal replacement.
Syringe Syringe pump (138) SW signal input state is checked on a check screen of the operation, Sensor replacement, Replacement of DM P.C.B.
completion Normal operation is required.
alarm error The completion detection PWB is adjusted its position according to Hole IC P.C.B. position adjustment.
the syringe.
Relevant connector No loose connection. Remove and insert of the P.C.B., Connector cleaning,
Overload Syringe pump (138) SW signal input state is checked on a check screen of the operation, Sensor replacement, Replacement of DM P.C.B.
alarm error (Overload detection limit SW) Normal operation is required.
Syringe overload pressure Overload detection limit re-adjustment.
Detection should be performed greater than 0.12 [MPa].
Blood line No clog in the infusing line.
Relevant connector No loose connection. Insert or remove of the P.C.B., Connector cleaning,
Syringe Syringe pump (138) SW signal input state is checked on a check screen of the operation. Replacement of SW, Replacement of MM P.C.B.
attach/detach Normal operation is required.
alarm error Relevant connector No loose connection. Insert or remove of the P.C.B., Connector cleaning,
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3-7. Pressure (venous pressure, arterial pressure, dialysate pressure) monitor
【Dialysate pressure diaplay】

The pressure in a closed line (dialysate pressure) is measured by the pressure sensor (219).
MM amplifies measurement data by ADC, and calculate dialysate pressure value based on the reference setting after reading AD converted data via CPLD.
CM displayed dialysate pressure value which read via communication memory on the LCD.
【Venous pressure display】

The pressure in a blood line (venous pressure) is measured by the pressure sensor (PS1) on MM P.C.B.
MM amplifies measurement data at ADC, and calculates a venous pressure value based on the reference setup, after reading A/D converted data.
CM displays the venous pressure value read through the communication memory on LCD.
【Arterial pressure display】

The pressure in a blood line (arterial pressure) is measured by the pressure sensor (PS2) on MM P.C.B.
MM amplifies measurement data at ADC, and calculates an arterial pressure value based on the reference setup, after reading A/D converted data.
CM displays the arterial pressure value read through the communication memory on LCD.
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Dialysate pressure alarm : MM sets up the upper lower alarm value to a dialysate pressure indication value.
An alarm is activated when a dialysate pressure indication value goes out the upper lower alarm value.
Moreover, the bypass valve control stops dialysate flow to the dialyzer side at this time.
Venous pressure alarm : MM sets up the upper lower alarm value against the venous pressure indication value.
An alarm is activated when a venous pressure indication value goes out the upper lower alarm value.
Moreover, the bypass valve control stops dialysate flow to the dialyzer side, the circuit clamp interception and blood pump stop processing are also
performed.
Arterial pressure alarm : MM sets up the upper lower limit alarm value against the arterial pressure indication value.
An alarm is activated when the arterial pressure indication value goes out the upper lower limit alarm value.
Moreover, the bypass valve control stops dialysate flow to the dialyzer side, and the blood pump stop processing are also performed.
Pressure reference average value

Dialysate pressure Venous pressure Arterial pressure
Registration Reference Registration Reference Registration Reference
value value value value value value
-200 28996 0 32971 0 32917
+200 36666 200 36633 200 36607
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Recovery procedure of dialysate pressure alarm activation

Used dialysate Dialyzer UF rate against UFR should be an appropriate value. Resetting of UF rate.
pressure becomes Chamber changeover valve (214) No leak, Smooth operation Replacement of the solenoid valve,
minus deflect Replacement of the valve sheet.
Air release valve (222) No leak, Smooth operation. Replacement of the solenoid valve,
Replacement of the valve sheet.
UF pump (227) No vertical leak. Replacement of pump head.
Flow pump (207) Degassing pressure lower than -80 [KPa]. Replacement of pump head, Replacement of motor,
Acceptance completion pressure greater than 0.100 [MPa] Relief valve adjustment.
Degassing side relief valve (209) No leak, Smooth operation Replacement of relief valve.
Air bubble separator (221) Float should be in normal operation. Float cleaning and replacement.
Closed circuit line A normal judging should be given by the self-test function. Repair of the leak section.
Dialysate Chamber changeover valve(214) No leak, Smooth operation. Replacement of the solenoid valve,
pressure goes Replacement of the valve sheet.
plus deflect Negative pressure release valve No leak, Smooth operation. Replacement of the solenoid valve,
Replacement of the valve sheet.
Blood line No venous pressure increase owing to the clog and occlusion of Remove blockage.
the line.
Drain line No clog and occlusion of the piping. Remove blockage.
Dialysate Dialysate pressure sensor Resistance between each lead shows 3.0～5.1 [kΩ]. Replacement of the sensor.
pressure meter Adjustment of the dialysate pressure Suitable reference value, Suitable pressure value indication. Dialysate pressure reference resetting,
indication error sensor Replacement of MM P.C.B.
Relevant connector No loose connection. Extraction and insertion of P.C.B., Connector cleaning,
Replacement of the contact terminal.
※For the troubleshooting, refer to “Operation check/test for the components” of the maintenance function.
Recovery procedure of venous/arterial pressure alarm

Venous/Arterial Blood access Normally punctured. Inspection of the blood access part.
pressure alarm Dialyzer, Blood line No clog and occlusion Remove blockage.
Air filter No block, No leak, No penetration of fluid etc. Replacement of a filter.
Lure lock connector (pressure port) No block, No leak. Connector cleaning, Re-connection.
Venous/Arterial Venous/Arterial pressure sensor Suitable reference value, Suitable pressure value. Re-set of venous/arterial pressure reference,
pressure meter Replacement of a sensor, Replacement of MM P.C.B.
indication error Relevant connector No loose connection. Extraction and insertion of P.C.B., Connector cleaning,
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3-8. Air bubble detector
【Air bubble alarm monitoring】

MM P.C.B. and AS air bubble P.C.B. perform control and monitoring of the air bubble detector, 2 piezo-electricity ceramic resonator by the side of an oscillation and
reception is built into the air bubble detector, and a blood circuit is set between them. The air bubble P.C.B. is equipped with the oscillation circuit and the ultrasonic
wave is applied to the wave transducer by the oscillation side. Although an ultrasonic wave gets across to a reception side wave transducer in the state where liquid is in
a tube, if air bubbles pass in a tube, air bubbles will attenuate an ultrasonic wave. This is detected as the change of a voltage value by the reception side circuit, and an
alarm is activated. MM reads the alarm output from AS P.C.B., and emits as an air bubble alarm. At the same time, it stops solution flow by the dialyzer side from bypass
valve control, and then circuit clamp interception and blood pump stop processing are also performed.
Recovery procedure of air bubble alarm operation error

Air bubble alarm Air bubble detector (502) The sensor and the blood circuit have cohered. Inspection of the blood access part.
operation error Inspection of the alarm action, The ALM signal is not outputted from AS Output adjustment, Replacement of air bubble
P.C.B. detector, Replacement of AS P.C.B.
Inspection of the alarm action, The ALM signal is outputted from AS P.C.B. Replacement of MM P.C.B.
Relevant connector No loose connection. Extraction and insertion of P.C.B., Connector
cleaning, Replacement of the contact terminal.
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3-9. Blood leak detector
Sensor output
Normal : 7.2～8.8 [V] (LED green lighting)
Alarm : approx. 3.5 [V] or less (LED red lighting)
Dirt detection setting value : 5 [V] or less
Alarm output
Alarm : H, Normal : L
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【Blood leak alarm detection】

The blood leak detector is controlled and monitored by MM P.C.B. and the blood leak detector P.C.B. which incorporated in the blood leak detector.
The infrared rays Light Emitting Diode for luminescence and the acceptance side photo-transistor are built in the blood leak detector, and the alarm is activated when
the acceptance side circuit detects turbidity (transmittance) of the fluid (fluid returned from dialyzer) as the change of a voltage value by the lower limit of the fixed
voltage. MM reads the alarm output from AS P.C.B., and emits as a blood leak alarm.
At the same time, It stops solution flow to the dialyzer side by the bypass valve control, and then blood pump stop processing are also performed.
【Blood leak detector dirt detection】

Change of transmissibility is outputted from the blood leak detector as a voltage value other than above-mentioned alarm output. This signal is converted in ADC and
MM P.C.B. has read as the digital value. When the value falls to the voltage of the initial setting value, “blood leak detector dirt" alarm is activated. This voltage value can
be checked on a reference screen.
Recovery procedure of blood leak alarm error activation

Blood leak alarm Blood leak detector (254) LED red lighting up, Much of calcium carbonate dirt. Glass window cleaning of the blood leak detector.
error (LED lighting state) LED red lighting up, No dirt. VR1 output adjustment,
Replacement of blood leak detector.
LED red not lighting up. Replacement of MM P.C.B.
D/L hose, piping Air suction, No inflow to blood leak detector. Repair of leaked air suction part
Relevant connector No loose connection. Extraction and insertion of P.C.B., Connector cleaning,
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3-10. Drip chamber level adjustment
Venous side drip chamber level is controlled by DM P.C.B. and arterial side drip chamber level adjustment is controlled by OP P.C.B. (only at level 2-1), from the
information of CM about the level up/down.
Venous chamber level up : Level valve 1-1 open, Level valve 1-2 open, Level pump stop, Level rising by plus pressure of venous pressure.
Venous chamber level down : Level valve 1-1 open, Level valve 1-2 closed, Level pump operation, Level decreasing by outlet pressure of level pump.
Arterial chamber level up : Level valve 2-1 open, Level valve 1-2 open, Level pump stop, Level rising by plus pressure of arterial pressure, Rising level.
Arterial chamber level down : Level valve 2-1 open, Level valve 1-2 closed, Level pump operation, Level decreasing by outlet pressure of level pump.
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3-11. Patrol lamp
MM controls patrol lamp based on the mode and alarm information.
3-12. Speaker control
AO P.C.B. controls speaker based on RS485 communication information and system error detection/reset signal from MM.
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3-13. Rinse/Disinfection (rinse port, coupler monitor)

CM P.C.B. DM P.C.B. I/O P.C.B.
ＬＣＤ
H8S/ ＰＬＤ
LCD ＣＭ 2633 ＰＬＤ
driver ＣＭＰＬＤ
Driver Fuse
Acetic acid valve CN42
CN13 Fuse Driver Hot water TR2-1 Ｆ5 14-15G
Mode bypass valve Sodium hypochlorite valve
33-34G Ｆ3 TR1-3 TR2-2 Ｆ6 16-17G
Control panel
information ＳＨ３ Rinse changeover valve

-ＤＳＰ F- TR2-3 Ｆ7 18-19G
ROM Hot water valve
MM P.C.B. TR2-4 Ｆ8 20-21G
Rinse port A valve TR5- CN44
Touch panel Ｆ18 27-28G
H8S/ Rinse port B valve 1
TR5-
controller ＣＭＰＬＤ F19 29-30G
2633 Rinse port Na valve 2
TR5-
Ｆ20 31-32G
3
CN23 CN43
1 5V 4 Coupler From 1 DC5V 4 DC5V 7 DC5V
Hot water GND 5V Rinse port A Rinse port B Rinse port Na
bypass valve 2 5 2 5 8
(211) 3 Coupler To 6 GND 3 GND 6 GND 9 GND
230V 230Ａ
Hole element signal DC5V DC5V 136
1 1
Connected (ON) → L A,B,Na Concentrate B valve
Un-connected (OFF) →H 2 Port To 2 Port From
1 5V
3 GND 3 GND Concentrate A valve
2 Rinse port
H･S 3 GND NaCl valve (OP)
Rinse port Rinse port valve

Na Drain
Acetic acid Acetic acid valve C

(167) NC NO
Sodium Sodium hypochlorite valve

hypochlorite C Hot water
(166) NO valve (235) Hot water
NC bypass valve
(211)
C NO
Disinfectant
release valve NC
Supply water (200) Air filter
Heater
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【Coupler connection monitoring function】

MM performs connection monitoring for dialyzer coupler by Hole IC. As the standard condition, couplers are set in the disinfection mode, and they should be separated
in the dislyze mode. When the abnormality is detected, the alarm is generated.
【Rinse port connection monitoring function】

MM monitors rinse port connection via I/O by means of Hole IC, and rinse separation is generated when the rinse port connection failure is detected in the disinfection
mode. DM receives the connection/un-connected information from each rinse port, and performs each rinse port valve control via I/O.
At rinse port connection: Rinse port valve ON
At rinse port un-connection: Rinse port valve OFF
【Rinsing/Disinfection operation】
Rinse mode Disinfection mode
Rinse-1 Disinfection Rinse-2 Rinse-1 Acetic acid Dwell-1 Rinse-2 Disinfection Heat (OP) Hot water (OP) Dewll-2 Night dwell Pre-rinse
Each mode operation time of the rinse/disinfection by the initial setting is saved by CM. When rinse/disinfection switch is pressed, DM controls pumps and solenoid
valves etc. by the instructions from CM. MM monitors the connection of rinse ports and couplers, when they are not set on the system, the mode shift is not to be
accepted. Moreover, monitoring coupler connection, chamber alarm, water shortage2, and supply water alarm etc during the mode operation, the inadequate rinsing
alarm is activated when the abnormal state and alarm stop happened after acetic acid rinsing (or disinfection).
Mode operation details

Rinse-1 1. 20 seconds before the start, rinse port fluid filling operation.
Stop mode, Flow pump, Concentrate A valve, Concentrate B valve, Water changeover valve, Supply water stop valve ON. (at NaCl infusion/positive; NaCl valve
ON)
2. After 20 seconds, water rinsing operation enforcement.
During rinsing, flow volume of concentrate A, concentrate B, and NaCl line pour fluid at 80 rotation of concentrate pump into each line by the every chamber
change. (Valves of A, B, NaCl are opened for 80 rotations)
Acetic acid 1. At the start, rinse port acetic acid filling operation.
Stop mode, Acetic acid valve, Concentrate pump ON,
Concentrate A valve is ON for 20 seconds → Concentrate B valve is ON for 20 seconds → (At NaCl/positive; NaCl valve is ON for 20 seconds)
2. After that, Acetic acid rinsing operation is implemented,
Acetic acid valve ON, Chamber changeover → Concentrate pump 3 rotations water changeover valve ON → Concentrate pump 16 rotations concentrate A
valve ON → Concentrate pump 3 rotations water changeover valve ON → Concentrate pump 16 rotations concentrate B valve ON → Water changeover
valve ON until chamber changeover.
※Infuse concentrate A and B 5 [mL] each.
In NaCl/Use, infusion volume of concentrate A and B is changed as dwelling-1 for approx 10 rotations of concentrate pump.
Dwell-1
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Rinse-2 1. Drain the disinfectant in the sheath of rinse port (#136)

Perform the following operations 18 seconds
Sodium hypochlorite valve (#166) : ON
Disinfectant release valve (#200) : OFF
Acetic acid valve (#167) : OFF
Concentrate pump (#113) : ON
Rinse port A valve (#309) ON
Rinse port B valve (#310) OFF
Concentrate A valve (#110) ON
Concentrate B valve (#111) OFF
Sodium hypochlorite valve (#166) : ON
Rinse port A Valve (#309) : OFF
Rinse port B valve (#310) : ON
Concentrate A valve (#110) : OFF
Concentrate B valve (#111) : ON
2. Rinse the inside of the sheath of rinse port (#136)
Sodium hypochlorite valve (#166) : OFF
Rinse port A valve (#309) : ON
Rinse port B valve (#310) : OFF
Concentrate A valve (#110) : ON
Concentrate B valve (#111) : OFF
Rinse port A valve (#309) : OFF
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3. Fill RO water into the sheath of rinse port (#136)

Flow pump (#207) : ON
Water changeover valve (#112) : ON
Concentrate pump (#113) : OFF
Rinse port A valve (#309) : ON
Rinse port B valve (#310) : OFF
Concentrate A valve (#110) : ON
Concentrate B valve (#111) : OFF
Flow pump (#207) : ON
Water changeover valve (#112) : ON
Concentrate pump (#113) : OFF
Rinse port A valve (#309) : OFF
4. Flush ETRF (If ETRF option is equipped)
1 ETRF is equipped : 3 minutes
2 ETRF are equipped : 5 minutes
Remaining rinsing time is not subtracted by flush of ETRF.
5. Rinsing process starts afterward (Repeat the following procedure in every chamber changeover)
(1) Chamber changeover
(2) 3 rotations of Concentrate pump (#113) and turn on Water changeover valve (#112)
(3) 90 rotations of Concentrate pump (#113) and turn on Concentrate A valve (#110)
(4) 3 rotations of Concentrate pump (#113) and turn on Water changeover valve (#112)
(5) 90 rotations of Concentrate pump (#113) and turn on Concentrate B valve (#111)
(6) Turn on Water changeover valve (#112) until the next changeover
・ When ETRF is equipped, ETRF flashing starts after 2 times of changeover.
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Disinfection 1. At the start, rinse port disinfectant filling operation.

Stop mode. Rinse changeover valve, Sodium hypochlorite valve, Concentrate pump ON.
Concentrate A valve is ON for 20 seconds → Concentrate B valve is ON for 20 seconds → (At NaCl/Use; NaCl valve is ON for 20 seconds)
2. After that, disinfectant rinsing operation is implemented. Rinse changeover valve, Sodium hypochlorite valve ON.
Chamber changeover → Concentrate pump 3 rotations water changeover valve ON → Concentrate pump 16 rotations concentrate A valve ON →
concentrate pump 3 rotations water changeover valve ON → concentrate pump 16 rotations concentrate B valve ON → Water changeover valve ON until
chamber changeover.
※Infuse concentrate A and B 5 [mL] each.
In NaCl/Use, infusion volume of concentrate A and B is changed to approx 10 rotations of concentrate pump.
Heat 1. An hot water bypass valve and a hot water valve are turned on. Heater controls 87 [℃]. No correction of the temperature control.
(OP) 2. When the indication temperature is detected as 80 [℃] or greater, it shifts to hot water rinsing mode automatically.
”Inadequate rinsing” is generates and shifting stop mode by the setting time deadline.
Control sensor monitors greater than 92 [℃].
When 92 [℃] is detected, “hot water rinsing alarm” is generates and it shifts stop mode with “inadequate rinsing” generation.
Hot water 1. An hot water bypass valve and a hot water valve are turned on. Heater controls 87 [℃]. No correction of the temperature control.
(OP) The heater is returned to be a heating mode, when 87 [℃] control indication temperature becomes lower than 80 [℃].
Hot water rinsing mode control sensor monitors greater than 92 [℃] after 80 [℃].
When 92 [℃] is detested, “hot water rinsing alarm” is generates and it shifts stop mode with “inadequate rinsing” generation.
Dwell-2 1. At the start, supply side rinsing operation.
Stop mode, Concentrate pump ON, Concentrate A valve ON for 2 minutes → Concentrate B valve ON for 2 minutes → Water changeover valve ON for 1
minutes.
2. After that, Dwelling operation.
Rinse-3 1. Same as Rinse-2.
Night dwell 1. When no disinfection (0 minute) is required, At the start, rinse port disinfectant filling operation.
Rinse changeover valve, Sodium hypochlorite valve, Concentrate pump ON.
Concentrate A valve is ON for 20 seconds → Concentrate B valve is ON for 20 seconds → (At NaCl/Use; NaCl valve is ON for 20 seconds)
2. Low level conductivity sodium hypochlorite adjustment operation for 20 minutes. Rinse changeover valve, Sodium hypochlorite valve, Concentrate pump ON.
Chamber changeover → Concentrate pump 3 rotations water changeover vale ON → concentrate pump 1 rotations concentrate A valve ON → Water
changeover valve ON until chamber changeover → Chamber changeover → Concentrate pump 3 rotations water changeover valve ON → Concentrate
pump 1 rotations concentrate B valve ON → Water changeover vale ON until chamber changeover.
3. 20 minutes after the completion, rinse port disinfectant draining operation for 60 seconds.
Stop mode, Flow pump, Concentrate A valve, Concentrate B valve, Water changeover valve, Supply water stop valve ON. (At NaCl/Use; NaCl valve ON)
Pre-rinse 1. 20 seconds before the start, rinse port fluid filling operation.
Stop mode, Flow pump, Concentrate A valve, Concentrate B valve, Water changeover valve, Supply water stop valve ON. (At NaCl/Use; NaCl valve ON)
2. After 20 seconds, Water rinsing operation enforcement.
During rinsing, flow volume of concentrate A, concentrate B and NaCl line pour fluid at 80 rotations of concentrate pump into each line by the every chamber
change. (Valves of A, B, NaCl are opened for 80 rotations)
58/63
Recovery procedure of Rinsing/Disinfection alarm error activation

No suction of Disinfectant, No air suction from the connected parts etc. Adjustment and correction of troubling part.
disinfectant Concentrate line
Concentrate pump (113) No lock on the pump head. Lock release.
Sodium hypochlorite valve (166) No clog, No operational error, No air suction. Solenoid valve, Valve sheet replacement, I/O P.C.B. TR, F
replacement.
Acetic acid valve (167) No clog, No operational error, No air suction. Solenoid valve, Valve sheet replacement, I/O P.C.B. TR, F
replacement.
Rinse port A/B/Na valve No clog, No operational error, No air suction. Solenoid valve, Valve sheet replacement, I/O P.C.B. TR, F
replacement.
Rinse port (136) No deteriorated O-ring, No air suction. Replacement of O-ring.
Relevant connector No loose connection Extraction and insertion of substrate, Connector cleaning,
Replacement of the contact terminal
Inadequate rinsing
Inadequate Alarm condition of the system Alarm existence check by the alarm history → Alarm existence Recovery procedure depends on the alarm contents,
rinsing (Chamber, Supply water etc.) (Water rinsing implementation)
Alarm existence check by the alarm history → No alarm existence Implementation of Rinsing/Disinfection.
→ Power failure
Coupler Coupler (Connection monitoring Inspect SW signal input state on the operation check screen, Normal Sensor replacement, MM P.C.B. replacement.
ON/OFF error sensor) operation.
Relevant connector No loose connection Extraction and insertion of P.C.B., Connector cleaning,
Inadequate rinsing
Rinse port Rinse port (Connection Inspect SW signal input state on the operation check screen, Normal Sensor replacement, I/O P.C.B. replacement.
separation monitoring sensor) operation.
Relevant connector No loose connection Extraction and insertion of P.C.B., Connector cleaning,
Inadequate rinsing
59/63
3-14. Disinfectant monitor
MM P.C.B. I/O P.C.B. Acetic acid valve

C (167)
Acetic acid NC NO
VR1
H8S/ CN42 282 Sodium
ＣＭ 2633 270kHz hypochlorite
Osillator 1 Sender 1 Sender valve (166)
Sodium C
2 GND 2 GND hypochlorite NC NO
ＰＬＤ TP3 VR2
TP4 3 Receiver
3 Receiver Air filter
4 GND C NO
4 GND Disinfectant detector
4V (282) Disinfectnt
NC release valve
(200)
Normal L, Alarm H Output adjustment

Oscillation frequency ：Adjust to Max voltage by VR1, TP3-TPG
Output ： Adjust to 9.5±0.5V by VR2, TP3-TPG　
MM monitors the disinfectant existence state of the sodium hypochlorite infusing line through I/O by the disinfectant monitoring sensor (a piezo-electric ceramic
resonator, * refer to air-bubble detector).
Rinse/disinfection mode disinfectant infusing time : Sodium hypochlorite valve, Disinfectant release valve ON, sodium hypochlorite suction by the
concentrate infusion pump.
At this time, Disinfectant monitoring sensor monitors existence of the fluid.
Stand-by, Dialyze, Bypass mode : Except Disinfectant infusion mode, since the Disinfectant release valve turns off, No →COM serves as
air release, and a disinfectant falls into a tank.
Disinfectant monitoring sensor monitors there is no fluid.
60/63
3-15. Others (valve, switch, clamp)
61/63
3-16. Option pump control
62/63
3-17. Substitution detector
63/63
Single Patient Dialysis Machine Toray Medical Co., Ltd.
TR-8000 “YUGA”
8-1, Mihama 1-chome, Urayasu,
Maintenance Manual Chiba 279-8555, JAPAN
Ｔelephone : +81-47-700-7537
First version published, 08/ 20/ 2004 Telefax : +81-47-700-7558
Second version published, 09/ 11/ 2009
Third version published, 04/ 28/ 2010
Printed in Japan

TR-8000 Maintenance Manual

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2. Structure and function of P.C.B. ..................................................................................................................................................................18

1. Adjustment and inspection method

5[V] power supply

24 [V] voltage adjustment

5 [V] voltage adjustment

1-1-2. DRV current adjustments for UF pump and syringe pump

Syringe pump DRV

Syringe pump 138

1-2. Adjustment and inspection of temperature

1-2-2. Adjustment and inspection of the control temperature sensor

1-2-3. Adjustment and inspection of the control correction temperature sensor

1-2-4. Adjustment and inspection of the temperature compensation sensor

1-3. Adjustment and inspection of pressure

(1) Adjust the pressure of pressurizing adjustor to 0 [mmHg].

1-3-2. Adjustment and inspection of arterial pressure

1-3-3. Adjustment and inspection of dialysate pressure

(1) Adjust the pressure of pressurizing adjustor to -200 [mmHg].

Dialysate pressure adjustment inspection point

1-4. Adjust and inspection of blood pump

Flow rate adjustment

Measurement of flow volume, Criteria, A graduated cylinder for measurement chart

1-5. Adjustment and inspection of air bubble detector

Method 2 when the oscilloscope cannot be used

Step (4) Step (7)

1-6. Adjustment of melody volume

1-7. Adjustment of negative pressure pump pressure

1-8. Flow pump performance/Acceptance time adjusting pressure adjustment

1-9. Adjustment and inspection of changeover time

1-10. Adjustment and inspection of UF counter accuracy

Total UF value － Measuring cylinder

Measurement of dialysis 500 [mL] (5.00 [L/h])

Measurement of UF volume 0.50 [L] (0.50 [L/h])

1-11. Adjustment and inspection of concentrate infusion volume

Concentrate A infusion volume correction

Concentrate infusion volume error = (14.42－average value)÷14.42×100 [%]

Inspection of concentrate B infusion volume Dialysate setting screen

1-12. Adjustment and inspection of conductivity

Conductivity step 1 standard value setting

Conductivity step 9 standard value setting

1-13. Other adjustment

Mfg No. DATE:

0 0 -200 Low Speed 50

Press./Cond. [Mainte] [Self-test1] [Setting] [Initial] [Data]

1 2 Cond. Lower limit mS/cm 67 UF pump correction ％

9 3 mS/cm 68 Blood pump flow ％

Concentrate select Conc. Pump % Solution B 6 mmHg [Initial] [Date/Time]

Write the software to the Machine

SOFTWARE INSTALLATION PROCEDURE

Remove CF card from the machine and insert CF card to

5 0 Connect "FM-ONE" to "DM" P.C.B.

1 1 1 1 0 0 1 0 Select "DM" on the "FM-ONE" and press the WRITE

9 0 CAU TION! C onnect buzzer and speaker.

Check software version

2. Structure and function of P.C.B.

2-2. TR-8000 “YUGA” function by the P.C.B.

Drive system IO Contents Drive system device Fuse

MM P.C.B. performs alarm monitoring to maintain security of the system.

Drive system IO Contents Drive system device Fuse

OP P.C.B. performs controls monitoring for optional function (components).

3. Description of the individual function and the relevant troubleshooting

Temperature compensation thermistor resistance table

Alarm recovery procedure of conductivity alarm activation.