1: Gao T, Wang Z, Cao J, Dong Y, Chen Y.

Melatonin attenuates microbiota

dysbiosis of jejunum in short-term sleep deprived mice. J Microbiol. 2020
Jul;58(7):588-597. doi: 10.1007/s12275-020-0094-4. Epub 2020 May 18. PMID:
32424577.

2: Tanaka S. Transcriptional regulation of the hypocretin/orexin gene. Vitam

Horm. 2012;89:75-90. doi: 10.1016/B978-0-12-394623-2.00005-6. PMID: 22640609.

3: D'Almeida V, Hipólide DC, Raymond R, Barlow KB, Parkes JH, Pedrazzoli M,

Tufik S, Nobrega JN. Opposite effects of sleep rebound on orexin OX1 and OX2
receptor expression in rat brain. Brain Res Mol Brain Res. 2005 May
20;136(1-2):148-57. doi: 10.1016/j.molbrainres.2005.02.002. PMID: 15893599.

4: Bushey D, Tononi G, Cirelli C. The Drosophila fragile X mental retardation

gene regulates sleep need. J Neurosci. 2009 Feb 18;29(7):1948-61. doi:
10.1523/JNEUROSCI.4830-08.2009. PMID: 19228950; PMCID: PMC2750079.

5: Grønli J, Dagestad G, Milde AM, Murison R, Bramham CR. Post-transcriptional

effects and interactions between chronic mild stress and acute sleep
deprivation: regulation of translation factor and cytoplasmic polyadenylation
element-binding protein phosphorylation. Behav Brain Res. 2012 Dec
1;235(2):251-62. doi: 10.1016/j.bbr.2012.08.008. Epub 2012 Aug 16. PMID:
22917528.

6: Mang GM, La Spada F, Emmenegger Y, Chappuis S, Ripperger JA, Albrecht U,

Franken P. Altered Sleep Homeostasis in Rev-erbα Knockout Mice. Sleep. 2016 Mar
1;39(3):589-601. doi: 10.5665/sleep.5534. PMID: 26564124; PMCID: PMC4763348.

7: Deurveilher S, Golovin T, Hall S, Semba K. Microglia dynamics in sleep/wake

states and in response to sleep loss. Neurochem Int. 2021 Feb;143:104944. doi:
10.1016/j.neuint.2020.104944. Epub 2020 Dec 23. PMID: 33359188.

8: Bjorness TE, Kulkarni A, Rybalchenko V, Suzuki A, Bridges C, Harrington AJ,

Cowan CW, Takahashi JS, Konopka G, Greene RW. An essential role for MEF2C in the
cortical response to loss of sleep in mice. Elife. 2020 Aug 27;9:e58331. doi:
10.7554/eLife.58331. PMID: 32851972; PMCID: PMC7490011.

9: Petit JM, Gyger J, Burlet-Godinot S, Fiumelli H, Martin JL, Magistretti PJ.

Genes involved in the astrocyte-neuron lactate shuttle (ANLS) are specifically
regulated in cortical astrocytes following sleep deprivation in mice. Sleep.
2013 Oct 1;36(10):1445-58. doi: 10.5665/sleep.3034. PMID: 24082304; PMCID:
PMC3773194.

10: Toossi H, Del Cid-Pellitero E, Jones BE. Homeostatic regulation through GABA
and acetylcholine muscarinic receptors of motor trigeminal neurons following
sleep deprivation. Brain Struct Funct. 2017 Sep;222(7):3163-3178. doi:
10.1007/s00429-017-1392-4. Epub 2017 Mar 15. PMID: 28299422; PMCID: PMC5585289.

11: Ma C, Wu G, Wang Z, Wang P, Wu L, Zhu G, Zhao H. Effects of chronic sleep

deprivation on the extracellular signal-regulated kinase pathway in the
temporomandibular joint of rats. PLoS One. 2014 Sep 16;9(9):e107544. doi:
10.1371/journal.pone.0107544. Erratum in: PLoS One. 2014;9(12):e114988. PMID:
25226519; PMCID: PMC4167193.

12: Jan JE, Reiter RJ, Bax MC, Ribary U, Freeman RD, Wasdell MB. Long-term sleep
disturbances in children: a cause of neuronal loss. Eur J Paediatr Neurol. 2010
Sep;14(5):380-90. doi: 10.1016/j.ejpn.2010.05.001. Epub 2010 Jun 2. PMID:
20554229.
13: Williams JA, Sathyanarayanan S, Hendricks JC, Sehgal A. Interaction between
sleep and the immune response in Drosophila: a role for the NFkappaB relish.
Sleep. 2007 Apr;30(4):389-400. doi: 10.1093/sleep/30.4.389. PMID: 17520783;
PMCID: PMC2884379.

14: Pace M, Baracchi F, Gao B, Bassetti C. Identification of Sleep-Modulated

Pathways Involved in Neuroprotection from Stroke. Sleep. 2015 Nov
1;38(11):1707-18. doi: 10.5665/sleep.5148. PMID: 26085290; PMCID: PMC4813352.

15: Smith C, Trageser KJ, Wu H, Herman FJ, Iqbal UH, Sebastian-Valverde M,

Frolinger T, Zeng E, Pasinetti GM. Anxiolytic effects of NLRP3 inflammasome
inhibition in a model of chronic sleep deprivation. Transl Psychiatry. 2021 Jan
14;11(1):52. doi: 10.1038/s41398-020-01189-3. PMID: 33446652; PMCID: PMC7809257.

16: Naidoo N, Giang W, Galante RJ, Pack AI. Sleep deprivation induces the
unfolded protein response in mouse cerebral cortex. J Neurochem. 2005
Mar;92(5):1150-7. doi: 10.1111/j.1471-4159.2004.02952.x. PMID: 15715665.

17: Suzuki A, Yanagisawa M, Greene RW. Loss of <i>Arc</i> attenuates the

behavioral and molecular responses for sleep homeostasis in mice. Proc Natl Acad
Sci U S A. 2020 May 12;117(19):10547-10553. doi: 10.1073/pnas.1906840117. Epub
2020 Apr 29. PMID: 32350140; PMCID: PMC7229651.

18: Khalyfa A, Mutskov V, Carreras A, Khalyfa AA, Hakim F, Gozal D. Sleep

fragmentation during late gestation induces metabolic perturbations and
epigenetic changes in adiponectin gene expression in male adult offspring mice.
Diabetes. 2014 Oct;63(10):3230-41. doi: 10.2337/db14-0202. Epub 2014 May 8.
PMID: 24812424; PMCID: PMC4171662.

19: Ravassard P, Pachoud B, Comte JC, Mejia-Perez C, Scoté-Blachon C, Gay N,

Claustrat B, Touret M, Luppi PH, Salin PA. Paradoxical (REM) sleep deprivation
causes a large and rapidly reversible decrease in long-term potentiation,
synaptic transmission, glutamate receptor protein levels, and ERK/MAPK
activation in the dorsal hippocampus. Sleep. 2009 Feb;32(2):227-40. doi:
10.1093/sleep/32.2.227. PMID: 19238810; PMCID: PMC2635587.

20: Rodríguez-Vázquez J, Camacho-Arroyo I, Velázquez-Moctezuma J. Differential

impact of REM sleep deprivation on cytoskeletal proteins of brain regions
involved in sleep regulation. Neuropsychobiology. 2012;65(3):161-7. doi:
10.1159/000330010. Epub 2012 Mar 27. PMID: 22456537.

21: Landis CA, Collins BJ, Cribbs LL, Sukhatme VP, Bergmann BM, Rechtschaffen A,
Smalheiser NR. Expression of Egr-1 in the brain of sleep deprived rats. Brain
Res Mol Brain Res. 1993 Mar;17(3-4):300-6. doi: 10.1016/0169-328x(93)90015-h.
PMID: 8510502.

22: Mackiewicz M, Shockley KR, Romer MA, Galante RJ, Zimmerman JE, Naidoo N,
Baldwin DA, Jensen ST, Churchill GA, Pack AI. Macromolecule biosynthesis: a key
function of sleep. Physiol Genomics. 2007 Nov 14;31(3):441-57. doi:
10.1152/physiolgenomics.00275.2006. Epub 2007 Aug 14. PMID: 17698924.

23: Hoffman GE, Koban M. Hypothalamic L-Histidine Decarboxylase Is Up-Regulated

During Chronic REM Sleep Deprivation of Rats. PLoS One. 2016 Dec
20;11(12):e0152252. doi: 10.1371/journal.pone.0152252. PMID: 27997552; PMCID:
PMC5172538.

24: Rachalski A, Freyburger M, Mongrain V. Contribution of transcriptional and

translational mechanisms to the recovery aspect of sleep regulation. Ann Med.
2014 Mar;46(2):62-72. doi: 10.3109/07853890.2013.866439. Epub 2014 Jan 16. PMID:
24428734.

25: Bellesi M, Pfister-Genskow M, Maret S, Keles S, Tononi G, Cirelli C. Effects

of sleep and wake on oligodendrocytes and their precursors. J Neurosci. 2013 Sep
4;33(36):14288-300. doi: 10.1523/JNEUROSCI.5102-12.2013. PMID: 24005282; PMCID:
PMC3874087.

26: Archer SN, Oster H. How sleep and wakefulness influence circadian
rhythmicity: effects of insufficient and mistimed sleep on the animal and human
transcriptome. J Sleep Res. 2015 Oct;24(5):476-93. doi: 10.1111/jsr.12307. Epub
2015 Jun 8. PMID: 26059855.

27: Melhuish Beaupre LM, Brown GM, Braganza NA, Kennedy JL, Gonçalves VF.
Mitochondria's role in sleep: Novel insights from sleep deprivation and
restriction studies. World J Biol Psychiatry. 2021 May 6:1-13. doi:
10.1080/15622975.2021.1907723. Epub ahead of print. PMID: 33821750.

28: Baud MO, Magistretti PJ, Petit JM. Sustained sleep fragmentation induces
sleep homeostasis in mice. Sleep. 2015 Apr 1;38(4):567-79. doi:
10.5665/sleep.4572. PMID: 25325477; PMCID: PMC4355896.

29: Lu Y, Liu B, Ma J, Yang S, Huang J. Disruption of Circadian Transcriptome in

Lung by Acute Sleep Deprivation. Front Genet. 2021 Mar 30;12:664334. doi:
10.3389/fgene.2021.664334. PMID: 33859677; PMCID: PMC8042274.

30: Sehgal A, Joiner W, Crocker A, Koh K, Sathyanarayanan S, Fang Y, Wu M,

Williams JA, Zheng X. Molecular analysis of sleep: wake cycles in Drosophila.
Cold Spring Harb Symp Quant Biol. 2007;72:557-64. doi: 10.1101/sqb.2007.72.018.
PMID: 18419315.

31: Diessler S, Jan M, Emmenegger Y, Guex N, Middleton B, Skene DJ, Ibberson M,

Burdet F, Götz L, Pagni M, Sankar M, Liechti R, Hor CN, Xenarios I, Franken P. A
systems genetics resource and analysis of sleep regulation in the mouse. PLoS
Biol. 2018 Aug 9;16(8):e2005750. doi: 10.1371/journal.pbio.2005750. PMID:
30091978; PMCID: PMC6085075.

32: Morita K, Kuwada A, Fujihara H, Morita Y, Sei H. Influence of sleep

disturbance on steroid 5alpha-reductase mRNA levels in rat brain. Neuroscience.
2002;115(2):341-8. doi: 10.1016/s0306-4522(02)00456-6. PMID: 12421601.

33: Davis CJ, Taishi P, Honn KA, Koberstein JN, Krueger JM. P2X7 receptors in
body temperature, locomotor activity, and brain mRNA and lncRNA responses to
sleep deprivation. Am J Physiol Regul Integr Comp Physiol. 2016 Dec
1;311(6):R1004-R1012. doi: 10.1152/ajpregu.00167.2016. Epub 2016 Oct 5. PMID:
27707719; PMCID: PMC5256976.

34: Grønli J, Soulé J, Bramham CR. Sleep and protein synthesis-dependent

synaptic plasticity: impacts of sleep loss and stress. Front Behav Neurosci.
2014 Jan 21;7:224. doi: 10.3389/fnbeh.2013.00224. PMID: 24478645; PMCID:
PMC3896837.

35: Ollila HM, Kettunen J, Pietiläinen O, Aho V, Silander K, Kronholm E, Perola

M, Lahti J, Räikkönen K, Widen E, Palotie A, Eriksson JG, Partonen T, Kaprio J,
Salomaa V, Raitakari O, Lehtimäki T, Sallinen M, Härmä M, Porkka-Heiskanen T,
Paunio T. Genome-wide association study of sleep duration in the Finnish
population. J Sleep Res. 2014 Dec;23(6):609-618. doi: 10.1111/jsr.12175. Epub
2014 Aug 11. PMID: 25109461.

36: Cirelli C, Shaw PJ, Rechtschaffen A, Tononi G. No evidence of brain cell

degeneration after long-term sleep deprivation in rats. Brain Res. 1999 Sep
4;840(1-2):184-93. doi: 10.1016/s0006-8993(99)01768-0. PMID: 10517970.

37: Naidoo N. Cellular stress/the unfolded protein response: relevance to sleep

and sleep disorders. Sleep Med Rev. 2009 Jun;13(3):195-204. doi:
10.1016/j.smrv.2009.01.001. Epub 2009 Mar 28. PMID: 19329340; PMCID: PMC2964262.

38: Chen W, Guo X, Jin Z, Li R, Shen L, Li W, Cai W, Zhang G. Transcriptional

alterations of genes related to fertility decline in male rats induced by
chronic sleep restriction. Syst Biol Reprod Med. 2020 Apr;66(2):99-111. doi:
10.1080/19396368.2019.1678694. Epub 2020 Feb 10. PMID: 32040351.

39: Arnardottir ES, Mackiewicz M, Gislason T, Teff KL, Pack AI. Molecular
signatures of obstructive sleep apnea in adults: a review and perspective.
Sleep. 2009 Apr;32(4):447-70. doi: 10.1093/sleep/32.4.447. PMID: 19413140;
PMCID: PMC2663860.

40: Aho V, Ollila HM, Kronholm E, Bondia-Pons I, Soininen P, Kangas AJ, Hilvo M,
Seppälä I, Kettunen J, Oikonen M, Raitoharju E, Hyötyläinen T, Kähönen M,
Viikari JS, Härmä M, Sallinen M, Olkkonen VM, Alenius H, Jauhiainen M, Paunio T,
Lehtimäki T, Salomaa V, Orešič M, Raitakari OT, Ala-Korpela M, Porkka-Heiskanen
T. Prolonged sleep restriction induces changes in pathways involved in
cholesterol metabolism and inflammatory responses. Sci Rep. 2016 Apr 22;6:24828.
doi: 10.1038/srep24828. PMID: 27102866; PMCID: PMC4840329.

41: Xu HJ, Lin SZ, Shi K, Qiu JJ, Hu JM, Yu ZG, Dai DS, Zhang N, Liang M, Cai
HD, Zeng K, Wu XD. Identification of hub genes correlated with sleep deprivation
using co-expression analysis. Sleep Breath. 2021 Feb 22. doi:
10.1007/s11325-021-02321-3. Epub ahead of print. PMID: 33619665.

42: Cedernaes J, Osler ME, Voisin S, Broman JE, Vogel H, Dickson SL, Zierath JR,
Schiöth HB, Benedict C. Acute Sleep Loss Induces Tissue-Specific Epigenetic and
Transcriptional Alterations to Circadian Clock Genes in Men. J Clin Endocrinol
Metab. 2015 Sep;100(9):E1255-61. doi: 10.1210/JC.2015-2284. Epub 2015 Jul 13.
PMID: 26168277.

43: Ruiz FS, Andersen ML, Guindalini C, Araujo LP, Lopes JD, Tufik S. Sleep
influences the immune response and the rejection process alters sleep pattern:
Evidence from a skin allograft model in mice. Brain Behav Immun. 2017
Mar;61:274-288. doi: 10.1016/j.bbi.2016.12.027. Epub 2017 Jan 7. PMID: 28069386.

44: Sun H, Zhang J, Ma Y, Liu J. Integrative genomics analysis identifies five

promising genes implicated in insomnia risk based on multiple omics datasets.
Biosci Rep. 2020 Sep 30;40(9):BSR20201084. doi: 10.1042/BSR20201084. PMID:
32830860; PMCID: PMC7468094.

45: Wisor JP, Schmidt MA, Clegern WC. Evidence for neuroinflammatory and
microglial changes in the cerebral response to sleep loss. Sleep. 2011 Mar
1;34(3):261-72. doi: 10.1093/sleep/34.3.261. PMID: 21358843; PMCID: PMC3041702.

46: Mongrain V, La Spada F, Curie T, Franken P. Sleep loss reduces the DNA-
binding of BMAL1, CLOCK, and NPAS2 to specific clock genes in the mouse cerebral
cortex. PLoS One. 2011;6(10):e26622. doi: 10.1371/journal.pone.0026622. Epub
2011 Oct 24. PMID: 22039518; PMCID: PMC3200344.

47: Gharib SA, Khalyfa A, Abdelkarim A, Bhushan B, Gozal D. Integrative miRNA-

mRNA profiling of adipose tissue unravels transcriptional circuits induced by
sleep fragmentation. PLoS One. 2012;7(5):e37669. doi:
10.1371/journal.pone.0037669. Epub 2012 May 21. PMID: 22629440; PMCID:
PMC3357342.