Paper Code: MPH203T

M.Pharm : Semester-
EVEN SEMESTER THEORY EXAMINATION, 2022
COMPUTER AIDED DRUG DEVELOPMENT
Time: 03 Hours MM: 75
Course Outcomes (COs)
CO1: Understand the concept of computer in pharmaceutical research and development.
CO2: Understand the concept of computational modelling of drug disposition
CO3: Understand the concept of Computer aided formulation development.
CO4: Understand the concept of computer aided biopharmaceutical characterization,
computer simulation and computer in clinical development.
CO5: Understand the concept of Artificial Intelligence (AI), Robotics and computational
fluid dynamics.

Note: All questions are compulsory.

Course
Q. No. Questions Marks Outcomes
(COs)
What is Quality-by-Design (QbD)? Explain ICH Q8 Guidelines. Discuss the
industrial and regulatory views on QbD CO1
1 OR
Describe the historical developments in use of computers in Pharmaceutical
CO1
Research.
What is in silico ADMET modelling? Give its advantages. Explain the in
silico modelling approaches. Describe the in silico modelling targets of
CO2
drug absorption
2
OR
What are drug transporters? Give their classification. Write an account on
CO2
p-Glycoprotein
Explain the concept of optimization. Describe in details screening designs
and response surface designs CO3
3 OR
Write notes on (a) Legal protection of innovative uses of computers in
CO3
pharmaceutical research (b) Computers in market analysis
Discuss the theoretical background of GIT absorption simulation. Explain
the construction of model for GI simulation. Write an account on
CO4
4 parameter sensitivity analysis
OR
Write notes on (a) Computer simulation of cell (b) PBPK modelling CO4
Discuss the computational fluid dynamics and its applications in
pharmaceutical research CO5
5 OR
What is Artificial Intelligence? Discuss how the AI has revolutionized the
CO5
drug discovery and development process.

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