PMID- 17214994

OWN - NLM
STAT- MEDLINE
DCOM- 20080229
LR - 20200704
IS - 1879-1484 (Electronic)
IS - 0021-9150 (Linking)
VI - 196
IP - 1
DP - 2008 Jan
TI - NAD(P)H oxidase polymorphism (C242T) and high HDL cholesterol associate with
recurrent coronary events in postinfarction patients.
PG - 461-468
LID - S0021-9150(06)00748-9 [pii]
LID - 10.1016/j.atherosclerosis.2006.12.007 [doi]
AB - We recently identified a subgroup of postinfarction patients at high-risk for

recurrent coronary events defined by inflammation (high C-reactive protein)

(CRP)
and hypercholesterolemia. Within this subgroup, only elevated high-density
lipoprotein cholesterol (HDL-C) from a set of metabolic, inflammatory and
thrombogenic blood markers was associated with additional risk. To
investigate
the role of oxidative stress in this high-risk subgroup, we examined effects
on
risk of a polymorphism known to affect functional activity of NAD(P)H
oxidase, an
oxidative enzyme associated with generation of reactive oxygen species. The
study
population comprised non-diabetic patients of thrombogenic factors and
recurrent
coronary events (THROMBO) postinfarction study having complete blood marker
and
genotyping results (N=663) for C242T polymorphism of p22phox subunit (T
allele
associated with decreased activity). Cox multivariable regression, adjusted
for
significant clinical covariates, was used to assess within-subgroup risk
associated with blood markers and polymorphism. In addition to elevated HDL-C

(hazard ratio, 95% CI and p-value; 2.62, 1.05-6.55 and 0.039), significant
independent risk was found for C242T (CC versus CT plus TT: 3.14, 1.34-7.35
and
0.0084). We conclude that oxidative stress plays a significant role in
establishment of risk for recurrent coronary events in a high-risk subgroup
of
postinfarction patients defined by inflammation and hypercholesterolemia.
FAU - Corsetti, James P
AU - Corsetti JP
AD - Department of Pathology and Laboratory Medicine, University of Rochester
School
of Medicine and Dentistry, Rochester, NY, USA.
FAU - Ryan, Dan
AU - Ryan D
AD - Department of Pathology and Laboratory Medicine, University of Rochester
School
of Medicine and Dentistry, Rochester, NY, USA.
FAU - Moss, Arthur J
AU - Moss AJ
AD - Department of Medicine-Cardiology Unit, University of Rochester School of
Medicine and Dentistry, Rochester, NY, USA.
FAU - Zareba, Wojciech
AU - Zareba W
AD - Department of Medicine-Cardiology Unit, University of Rochester School of
Medicine and Dentistry, Rochester, NY, USA.
FAU - Sparks, Charles E
AU - Sparks CE
AD - Department of Pathology and Laboratory Medicine, University of Rochester
School
of Medicine and Dentistry, Rochester, NY, USA. Electronic address:
Charles_Sparks@urmc.rochester.edu.
LA - eng
GR - HL-48259/HL/NHLBI NIH HHS/United States
PT - Journal Article
PT - Research Support, N.I.H., Extramural
PT - Research Support, Non-U.S. Gov't
DEP - 20070109
PL - Ireland
TA - Atherosclerosis
JT - Atherosclerosis
JID - 0242543
RN - 0 (Cholesterol, HDL)
RN - 9007-41-4 (C-Reactive Protein)
RN - EC 1.6.3.- (NADPH Oxidases)
SB - IM
MH - C-Reactive Protein/immunology
MH - Cholesterol, HDL/*blood
MH - Female
MH - Follow-Up Studies
MH - Genetic Predisposition to Disease
MH - Humans
MH - Inflammation/physiopathology
MH - Male
MH - Middle Aged
MH - Myocardial Infarction/*genetics/*physiopathology
MH - NADPH Oxidases/*genetics
MH - Oxidative Stress/physiology
MH - Polymorphism, Single Nucleotide/*genetics
MH - Recurrence
EDAT- 2007/01/12 09:00
MHDA- 2008/03/01 09:00
CRDT- 2007/01/12 09:00
PHST- 2006/07/10 00:00 [received]
PHST- 2006/10/27 00:00 [revised]
PHST- 2006/12/01 00:00 [accepted]
PHST- 2007/01/12 09:00 [pubmed]
PHST- 2008/03/01 09:00 [medline]
PHST- 2007/01/12 09:00 [entrez]
AID - S0021-9150(06)00748-9 [pii]
AID - 10.1016/j.atherosclerosis.2006.12.007 [doi]
PST - ppublish
SO - Atherosclerosis. 2008 Jan;196(1):461-468. doi:
10.1016/j.atherosclerosis.2006.12.007. Epub 2007 Jan 9.