PMID- 26881045

OWN - NLM
STAT- MEDLINE
DCOM- 20161213
LR - 20211203
IS - 1942-0994 (Electronic)
IS - 1942-0900 (Print)
IS - 1942-0994 (Linking)
VI - 2016
DP - 2016
TI - Interplay between Superoxide Dismutase, Glutathione Peroxidase, and
Peroxisome
Proliferator Activated Receptor Gamma Polymorphisms on the Risk of End-Stage
Renal Disease among Han Chinese Patients.
PG - 8516748
LID - 10.1155/2016/8516748 [doi]
LID - 8516748
AB - Background. Single nucleotide polymorphisms (SNPs) of antioxidants, including
superoxide dismutase 2 (SOD2) and glutathione peroxidase 1 (GPX1), play an
important role in the risk for cancer and metabolic disorders. However,
little is
known regarding the effect of antioxidant SNPs on renal events. Methods. We
prospectively enrolled multicenter patients with end-stage renal disease
(ESRD)
and those without chronic kidney disease (CKD) of Han Chinese origin, with
SOD2
(Val16Ala), GPX1 (Pro197Leu), and PPAR-γ (Pro12Ala, C161T) genotyped.
Multiple
regression analyses were conducted to evaluate the significant risk
determinants
for ESRD. Results. Compared to ESRD patients, non-CKD subjects were more
likely
to have T allele at SOD2 Val16Ala (p = 0.036) and CC genotype at PPAR-γ
Pro12Ala
(p = 0.028). Regression analysis showed that TT genotype of SOD2 Val16Ala
conferred significantly lower ESRD risk among patients without diabetes (odds
ratio 0.699; p = 0.018). GPX1 SNP alone did not alter the risk. We detected
significant interactions between SNPs including PPAR-γ Pro12Ala, C161T, and
GPX1
regarding the risk of ESRD. Conclusion. This is the first and largest study
on
the association between adverse renal outcomes and antioxidant SNPs among Han
Chinese population. Determination of SOD2 and PPAR-γ SNPs status might assist
in
ESRD risk estimation.
FAU - Chao, Chia-Ter
AU - Chao CT
AD - Department of Medicine, National Taiwan University Hospital Jinshan Branch,
New
Taipei City, Taiwan; Graduate Institute of Toxicology, College of Medicine,
National Taiwan University, No. 1 Jen-Ai Road, Section 1, 10051 Taipei,
Taiwan.
FAU - Chen, Yen-Ching
AU - Chen YC
AD - Institute of Epidemiology and Preventive Medicine, College of Public Health,
National Taiwan University, No. 17 Xu-Zhou Road, 10055 Taipei, Taiwan.
FAU - Chiang, Chih-Kang
AU - Chiang CK
AD - Graduate Institute of Toxicology, College of Medicine, National Taiwan
 University, No. 1 Jen-Ai Road, Section 1, 10051 Taipei, Taiwan; Department of
Integrated Diagnostics & Therapeutics, National Taiwan University Hospital,
No. 7
Chung-Shan South Road, 10002 Taipei, Taiwan.
FAU - Huang, Jenq-Wen
AU - Huang JW
AD - Department of Internal Medicine, National Taiwan University Hospital, No. 7
Chung-Shan South Road, 10002 Taipei, Taiwan.
FAU - Fang, Cheng-Chung
AU - Fang CC
AD - Department of Emergency Medicine, National Taiwan University Hospital, No. 7
Chung-Shan South Road, 10002 Taipei, Taiwan.
FAU - Chang, Chen-Chih
AU - Chang CC
AD - Department of Internal Medicine, National Taiwan University Hospital, No. 7
Chung-Shan South Road, 10002 Taipei, Taiwan.
FAU - Yen, Chung-Jen
AU - Yen CJ
AD - Department of Internal Medicine, National Taiwan University Hospital, No. 7
Chung-Shan South Road, 10002 Taipei, Taiwan; Department of Geriatric Medicine
and
Gerontology, National Taiwan University Hospital, No. 7 Chung-Shan South
Road,
10002 Taipei, Taiwan.
LA - eng
PT - Journal Article
PT - Multicenter Study
PT - Research Support, Non-U.S. Gov't
DEP - 20160106
TA - Oxid Med Cell Longev
JT - Oxidative medicine and cellular longevity
JID - 101479826
RN - 0 (PPAR gamma)
RN - EC 1.11.1.- (glutathione peroxidase GPX1)
RN - EC 1.11.1.9 (Glutathione Peroxidase)
RN - EC 1.15.1.1 (Superoxide Dismutase)
RN - EC 1.15.1.1 (superoxide dismutase 2)
SB - IM
MH - Asians/*genetics
MH - Cohort Studies
MH - Ethnicity/*genetics
MH - Female
MH - Gene Frequency/genetics
MH - *Genetic Predisposition to Disease
MH - Glutathione Peroxidase/*genetics
MH - Humans
MH - Kidney Failure, Chronic/enzymology/*genetics
MH - Logistic Models
MH - Male
MH - Middle Aged
MH - Multivariate Analysis
MH - PPAR gamma/*genetics
MH - Polymerase Chain Reaction
MH - Polymorphism, Restriction Fragment Length
MH - Polymorphism, Single Nucleotide/*genetics
MH - Risk Factors
MH - Superoxide Dismutase/*genetics
PMC - PMC4736813
EDAT- 2016/02/18 06:00
MHDA- 2016/12/15 06:00
CRDT- 2016/02/17 06:00
PHST- 2015/09/05 00:00 [received]
PHST- 2015/11/25 00:00 [accepted]
PHST- 2016/02/17 06:00 [entrez]
PHST- 2016/02/18 06:00 [pubmed]
PHST- 2016/12/15 06:00 [medline]
AID - 10.1155/2016/8516748 [doi]
PST - ppublish
SO - Oxid Med Cell Longev. 2016;2016:8516748. doi: 10.1155/2016/8516748. Epub 2016
Jan
6.